Wellington K Hsu

  • 3064 Citations
20032023
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Personal profile

Research Interests

The focus of my research efforts centered on the effect of bone graft substitutes in pre-clinical animal models. Our publications looked at the effects of viral-mediated gene therapy, bone morphogenetic protein (BMP), adipose-derived stem cells, and demineralized bone matrix in a variety of rodent bone healing models in the extremity and spine. Furthermore, our research group studied the effects of novel imaging to track in vivo bone formation and metabolic activity. My current focus of research is aligned with my research partner and wife, Dr. Erin Hsu, who is a Research Assistant Professor at Northwestern University. Our work investigates the role of the Aryl Hydrocarbon Receptor (Ahr) with a focus on gene and protein expression changes and downstream effects after activation by xenobiotics such as dioxin and its role on osteogenic differentiation and bone healing. This has led to publications suggesting that the mechanism in which smoking increases the risk of fracture nonunion is mediated by Ahr ligands and not nicotine. Another arm of our research aims to develop and evaluate novel technologies involving both nanomaterials and 3D-printing methodologies to ultimately produce a universally safe and effective bone graft substitute for use in humans. I serve as PI or Co-Investigator on all of these studies.

Certifications and Licenses

Orthopaedic Surgery

Training Experience

2007Residency, Univ. of CA-Los Angeles Med. Ctr.
2008Fellowship, Univ. of Wisconsin Hospital

Education/Academic qualification

MD, Vanderbilt U

… → 2001

Research interests

  • Biomaterials
  • Spinal Biomechanics

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Spine Medicine & Life Sciences
Athletes Medicine & Life Sciences
Diskectomy Medicine & Life Sciences
Spinal Fusion Medicine & Life Sciences
Football Medicine & Life Sciences
Arthrodesis Medicine & Life Sciences
Bone and Bones Medicine & Life Sciences
Sports Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2010 2023

Research Output 2003 2020

Stem Cells and Spinal Fusion

Shah, V. P. & Hsu, W. K., Jan 2020, In : Neurosurgery clinics of North America. 31, 1, p. 65-72 8 p.

Research output: Contribution to journalReview article

Spinal Fusion
Cell Fusion
Stem Cells
Pseudarthrosis
Bone Regeneration

A Comparison of Patient-Centered Outcome Measures to Evaluate Dysphagia and Dysphonia After Anterior Cervical Discectomy and Fusion

Rosenthal, B. D., McCarthy, M. H., Bhatt, S., Savage, J. W., Singh, K., Hsu, W. K. & Patel, A. A., Nov 15 2019, In : The Journal of the American Academy of Orthopaedic Surgeons. 27, 22, p. 848-853 6 p.

Research output: Contribution to journalArticle

Dysphonia
Diskectomy
Deglutition Disorders
Outcome Assessment (Health Care)
Visual Analog Scale

Advanced baseball metrics indicate significant decline in MLB pitcher value after Tommy John surgery

Selley, R. S., Portney, D. A., Lawton, C. D., Shockley, M. D., Christian, R. A., Saltzman, M. D. & Hsu, W. K., Jan 1 2019, In : Orthopedics. 42, 6, p. 349-354 6 p.

Research output: Contribution to journalArticle

Baseball
Confidence Intervals
Ulnar Collateral Ligament Reconstruction
Demography
Outcome Assessment (Health Care)
2 Citations (Scopus)

Anatomic Considerations in the Lateral Transpsoas Interbody Fusion: The Impact of Age, Sex, BMI, and Scoliosis

Mai, H. T., Schneider, A. D., Alvarez, A. P., Hashmi, S. Z., Smith, J. T., Freshman, R. D., Mitchell, S. M., Qin, C. D. & Hsu, W. K., Jun 1 2019, In : Clinical Spine Surgery. 32, 5, p. 215-221 7 p.

Research output: Contribution to journalArticle

Scoliosis
Anatomy
Blood Vessels
Lumbosacral Plexus
Anatomic Variation

Can the American College of Surgeons Risk Calculator Predict 30-Day Complications after Cervical Spine Surgery?

McCarthy, M. H., Singh, P., Maslak, J., Nayak, R., Jenkins, T. J., Hsu, W. K. & Patel, A. A., Nov 1 2019, In : Clinical spine surgery. 32, 9, p. 357-362 6 p.

Research output: Contribution to journalArticle

Spine
Current Procedural Terminology
Skilled Nursing Facilities
Body Mass Index
Logistic Models