Grants per year
Personal profile
Research Interests
The focus of my research efforts centered on the effect of bone graft substitutes in pre-clinical animal models. Our publications looked at the effects of viral-mediated gene therapy, bone morphogenetic protein (BMP), adipose-derived stem cells, and demineralized bone matrix in a variety of rodent bone healing models in the extremity and spine. Furthermore, our research group studied the effects of novel imaging to track in vivo bone formation and metabolic activity. My current focus of research is aligned with my research partner and wife, Dr. Erin Hsu, who is a Research Assistant Professor at Northwestern University. Our work investigates the role of the Aryl Hydrocarbon Receptor (Ahr) with a focus on gene and protein expression changes and downstream effects after activation by xenobiotics such as dioxin and its role on osteogenic differentiation and bone healing. This has led to publications suggesting that the mechanism in which smoking increases the risk of fracture nonunion is mediated by Ahr ligands and not nicotine. Another arm of our research aims to develop and evaluate novel technologies involving both nanomaterials and 3D-printing methodologies to ultimately produce a universally safe and effective bone graft substitute for use in humans. I serve as PI or Co-Investigator on all of these studies.
Certifications and Licenses
Orthopaedic Surgery |
Training Experience
2007 | Residency, Univ. of CA-Los Angeles Med. Ctr. |
2008 | Fellowship, Univ. of Wisconsin Hospital |
Education/Academic qualification
MD, Vanderbilt University
… → 2001
Research interests
- Biomaterials
- Spinal Biomechanics
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Grants
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Supramolecular nanofibers for recombinant growth factor-free spine fusion
Hsu, E. L., Hsu, W. K., Stock, S. R. & Stupp, S.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
7/12/18 → 4/30/23
Project: Research project
Research Output
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3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion
Driscoll, J. A., Lubbe, R., Jakus, A. E., Chang, K., Haleem, M., Yun, C., Singh, G., Schneider, A. D., Katchko, K. M., Soriano, C., Newton, M., Maerz, T., Li, X., Baker, K., Hsu, W. K., Shah, R. N., Stock, S. R. & Hsu, E. L., Feb 2020, In: Tissue Engineering - Part A. 26, 3-4, p. 157-166 10 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Association between Opioid Use and Patient-Reported Outcomes in a Randomized Trial Evaluating Basivertebral Nerve Ablation for the Relief of Chronic Low Back Pain
Markman, J. D., Rhyne, A. L., Sasso, R. C., Patel, A. A., Hsu, W. K., Fischgrund, J. S., Edidin, A. A. & Vajkoczy, P., Mar 1 2020, In: Clinical Neurosurgery. 86, 3, p. 343-347 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Burden of Sciatica on US Medicare Recipients
Maslak, J. P., Jenkins, T. J., Weiner, J. A., Kannan, A. S., Patoli, D. M., McCarthy, M. H., Hsu, W. K. & Patel, A. A., May 15 2020, In: The Journal of the American Academy of Orthopaedic Surgeons. 28, 10, p. e433-e439Research output: Contribution to journal › Article › peer-review
Open Access -
Can the American College of Surgeons Risk Calculator Predict 30-day Complications after Spine Surgery?
McCarthy, M. H., Singh, P., Nayak, R., Maslak, J. P., Jenkins, T. J., Patel, A. A. & Hsu, W. K., 2020, In: Spine. 45, 9, p. 621-628 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Consensus recommendations on the prehospital care of the injured athlete with a suspected catastrophic cervical spine injury
Mills, B. M., Conrick, K. M., Anderson, S., Bailes, J., Boden, B. P., Conway, D., Ellis, J., Feld, F., Grant, M., Hainline, B., Henry, G., Herring, S. A., Hsu, W. K., Isakov, A., Lindley, T. R., McNamara, L., Mihalik, J. P., Neal, T. L., Putukian, M., Rivara, F. P. & 4 others, , Jun 1 2020, In: Journal of Athletic Training. 55, 6, p. 563-572 10 p.Research output: Contribution to journal › Article › peer-review
Open Access