Grants per year
Personal profile
Research Interests
The focus of my research efforts centered on the effect of bone graft substitutes in pre-clinical animal models. Our publications looked at the effects of viral-mediated gene therapy, bone morphogenetic protein (BMP), adipose-derived stem cells, and demineralized bone matrix in a variety of rodent bone healing models in the extremity and spine. Furthermore, our research group studied the effects of novel imaging to track in vivo bone formation and metabolic activity. My current focus of research is aligned with my research partner and wife, Dr. Erin Hsu, who is a Research Assistant Professor at Northwestern University. Our work investigates the role of the Aryl Hydrocarbon Receptor (Ahr) with a focus on gene and protein expression changes and downstream effects after activation by xenobiotics such as dioxin and its role on osteogenic differentiation and bone healing. This has led to publications suggesting that the mechanism in which smoking increases the risk of fracture nonunion is mediated by Ahr ligands and not nicotine. Another arm of our research aims to develop and evaluate novel technologies involving both nanomaterials and 3D-printing methodologies to ultimately produce a universally safe and effective bone graft substitute for use in humans. I serve as PI or Co-Investigator on all of these studies.
Certifications and Licenses
| Orthopaedic Surgery |
Training Experience
| 2007 | Residency, Univ. of CA-Los Angeles Med. Ctr. |
| 2008 | Fellowship, Univ. of Wisconsin Hospital |
Education/Academic qualification
MD, Vanderbilt University
… → 2001
Research interests
- Biomaterials
- Spinal Biomechanics
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Grants
Supramolecular nanofibers for recombinant growth factor-free spine fusion
Hsu, E. L., Hsu, W. K., Stock, S. R. & Stupp, S.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
7/12/18 → 4/30/23
Project: Research project
Prot#1006:An Assessment of P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion with Instrumentation
Emergent Clinical Consulting, LLC, Cerapedics, Inc.
6/26/18 → 6/25/21
Project: Research project
Research Output
3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion
Driscoll, J. A., Lubbe, R., Jakus, A. E., Chang, K., Haleem, M., Yun, C., Singh, G., Schneider, A. D., Katchko, K. M., Soriano, C., Newton, M., Maerz, T., Li, X., Baker, K., Hsu, W. K., Shah, R. N., Stock, S. R. & Hsu, E. L., Feb 2020, In : Tissue Engineering - Part A. 26, 3-4, p. 157-166 10 p.Research output: Contribution to journal › Article
No S.C.A.R.E. Protocol: A Streamlined Safety Protocol
Jenkins, T. J., Snowden, R. D., Smucker, J., Hsu, W. K., Riew, K. D. & Sasso, R. C., Jan 1 2020, In : The Journal of the American Academy of Orthopaedic Surgeons. 28, 1, p. 21-28 8 p.Research output: Contribution to journal › Article
Stem Cells and Spinal Fusion
Shah, V. P. & Hsu, W. K., Jan 2020, In : Neurosurgery clinics of North America. 31, 1, p. 65-72 8 p.Research output: Contribution to journal › Review article
The perceived efficacy and utility of spine bioskills curricula for resident and fellow education: Perceived Utility of Spine Bioskills Training
McCarthy, M. H., Boody, B. S., Swiatek, P. R., Rosenthal, B. D., Savage, J., Hsu, W. K. & Patel, A. A., Jul 1 2020, In : Journal of Orthopaedics. 20, p. 87-91 5 p.Research output: Contribution to journal › Article
Using machine learning to predict 30-day readmissions after posterior lumbar fusion: An NSQIP study involving 23,264 patients
Hopkins, B. S., Yamaguchi, J. T., Garcia, R., Kesavabhotla, K., Weiss, H., Hsu, W. K., Smith, Z. A. & Dahdaleh, N. S., Jan 1 2020, In : Journal of Neurosurgery: Spine. 32, 3, p. 399-406 8 p.Research output: Contribution to journal › Article