William J Gradishar

Professor, Medicine, Hematology Oncology Division
Betsy Bramsen Professorship of Breast Oncology, Medicine, Hematology Oncology Division

Phone+1 312 695 4541
Emailw-gradishar@northwestern.edu

Source: Scopus

Research activity per year

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Personal profile

Research Interests

My clinical domain is breast cancer management. My clinical research interest focuses on the development of novel therapies for the treatment of breast cancer. Clinical trials focusing on precision medicine for defining the right therapy, for the right patient at the right time is our goal. To that end, molecular interogation of breast tumors are leading to novel trial design that will hopefully translate into better outcomes for our patients. In conjuction with the developmental therapeutics program, novel agents are being incorporated into clinical trials for patients with both early and late stage disease.

Certifications and Licenses

	Internal Medicine
	Medical Oncology

Training Experience

1986	Residency, Michael Reese Medical Center
1990	Fellowship, University of Chicago Hospitals

Education/Academic qualification

MD, University of Illinois at Chicago

… → 1982

Medicine, MD, University of Illinois at Chicago

… → 1982

Research interests

Breast Cancer
Chemotherapy
Clinical Research
Drug Discovery
Drugs (clinical pharmacology)
Genomic Medicine/Personalized Medicine
Medical Education

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16 Active
98 Finished

Prot #CA2097FL: A Randomized, Multicenter, Double-blind, Placebo-controlled Phase 3 Study of Nivolumab Versus Placebo in Combination With Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy in Patients With High-risk, Estrogen Receptor-Positive (ER+),
Gradishar, W. J.
Bristol-Myers Squibb Company
2/5/21 → 2/5/24
Project: Research project
Prot #CT7001_001: A Modular, Multipart, Multi-arm, Open-label, Phase 1/2a Study to Evaluate the Safety and Tolerability of CT7001 Alone and in Combination with Anti-Cancer Treatments in Patients with Advanced Malignancies
Gradishar, W. J.
Emas Pharma Limited, Carrick Therapeutics Ltd
10/15/20 → 10/15/23
Project: Research project
Prot #CBYL719G12301: EPIK-B2: A Two Part, Phase III, Multicenter, Randomized (1:1), Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of Alpelisib (BYL719) in Combination with Trastuzumab and Pertuzumab as Maintenance Therapy in Pat
Gradishar, W. J.
Novartis Pharmaceuticals Corporation
7/1/20 → 12/31/24
Project: Research project
57148711: Assessing Treatment Patterns of CDK 4/6 Inhibitor Utilization in HR+/HER2- Metastatic Breast within Northwestern Medicine and Addressing Opportunities for Improvement
Gradishar, W. J.
Pfizer Inc.
12/16/19 → 3/31/21
Project: Research project
Prot #U31402-A-J101: Phase 1/2, Multicenter, Open-label, Multiple Dose First-In-Human Study of U3-1402, in Subjects with HER3 Positive Metastatic Breast Cancer
Gradishar, W. J.
Quintiles, Inc., Daiichi Sankyo, Inc.
3/13/19 → 3/13/22
Project: Research project

13849 Citations
206 Article
76 Review article
35 Comment/debate
13 Chapter
More

Phase III, randomized study of dual human epidermal growth factor receptor 2 (HER2) blockade with lapatinib plus trastuzumab in combination with an aromatase inhibitor in postmenopausal women with HER2-positive, hormone receptor–positive metastatic breast cancer: Updated results of alternative
Johnston, S. R. D., Hegg, R., Im, S. A., Park, I. H., Burdaeva, O., Kurteva, G., Press, M. F., Tjulandin, S., Iwata, H., Simon, S. D., Kenny, S., Sarp, S., Izquierdo, M. A., Williams, L. S. & Gradishar, W. J., Jan 1 2021, In: Journal of Clinical Oncology. 39, 1, p. 79-89 11 p.
Research output: Contribution to journal › Article › peer-review
Predictors and outcomes in breast cancer patients who did or did not pursue fertility preservation
Moravek, M. B., Confino, R., Lawson, A. K., Smith, K. N., Kazer, R., Klock, S. M., Gradishar, W. J., Jeruss, J. S. & Pavone, M. E., 2021, (Accepted/In press) In: Breast Cancer Research and Treatment.
Research output: Contribution to journal › Article › peer-review
Understanding the organ tropism of metastatic breast cancer through the combination of liquid biopsy tools
Gerratana, L., Davis, A. A., Polano, M., Zhang, Q., Shah, A. N., Lin, C., Basile, D., Toffoli, G., Wehbe, F., Puglisi, F., Behdad, A., Platanias, L. C., Gradishar, W. J. & Cristofanilli, M., Jan 2021, In: European Journal of Cancer. 143, p. 147-157 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Addressing Fertility: an Essential Aspect of Comprehensive Care for Young Patients with Breast Cancer
Shah, A. N., Luck, M., Goldman, K. & Gradishar, W., Dec 2020, In: Current Breast Cancer Reports. 12, 4, p. 381-390 10 p.
Research output: Contribution to journal › Review article › peer-review
Association of Tumor-Infiltrating Lymphocytes with Homologous Recombination Deficiency and BRCA1/2 Status in Patients with Early Triple-Negative Breast Cancer: A Pooled Analysis
Telli, M. L., Chu, C., Badve, S. S., Vinayak, S., Silver, D. P., Isakoff, S. J., Kaklamani, V., Gradishar, W., Stearns, V., Connolly, R. M., Ford, J. M., Gruber, J. J., Adams, S., Garber, J., Tung, N., Neff, C., Bernhisel, R., Timms, K. M. & Richardson, A. L., Jun 1 2020, In: Clinical Cancer Research. 26, 11, p. 2704-2710 7 p.
Research output: Contribution to journal › Article › peer-review
4 Scopus citations