Grants per year
Personal profile
Research Interests
My clinical domain is breast cancer management. My clinical research interest focuses on the development of novel therapies for the treatment of breast cancer. Clinical trials focusing on precision medicine for defining the right therapy, for the right patient at the right time is our goal. To that end, molecular interogation of breast tumors are leading to novel trial design that will hopefully translate into better outcomes for our patients. In conjuction with the developmental therapeutics program, novel agents are being incorporated into clinical trials for patients with both early and late stage disease.
Certifications and Licenses
| Internal Medicine | |
| Medical Oncology |
Training Experience
| 1986 | Residency, Michael Reese Medical Center |
| 1990 | Fellowship, University of Chicago Hospitals |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, University of Illinois at Chicago
… → 1982
Research interests keywords
- Breast Cancer
- Chemotherapy
- Clinical Research
- Drug Discovery
- Drugs (clinical pharmacology)
- Genomic Medicine/Personalized Medicine
- Medical Education
Fingerprint
Dive into the research topics where William J Gradishar is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Novel functions of PlexinB2 in circulating tumor cell clusters
Liu, H. (PD/PI), Gradishar, W. J. (Co-Investigator) & Jia, Y. (Other)
2/21/25 → 1/31/30
Project: Research project
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Prot #DB-1303-O-3002: A Phase 3, Randomized, Multi-Center, Open-Label Study of DB-1303 Versus Investigator’s Choice Chemotherapy in Human Epidermal Growth Factor Receptor 2 (HER2)-Low, Hormone Receptor Positive (HR+) Metastatic Breast Cancer Patients
Gradishar, W. J. (PD/PI)
Quintiles, Inc., DualityBio Inc.
2/12/25 → 2/12/28
Project: Research project
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Potentiating long-lived antitumor effector CD8+ T cells for TNBC therapy
Zhang, B. (PD/PI), Zhang, B. (PD/PI), Cui, W. (Co-Investigator), Cui, W. (Co-Investigator), Gradishar, W. J. (Co-Investigator), Gradishar, W. J. (Co-Investigator), Chandel, N. (Other), Chandel, N. (Other), Ji, Z. (Other) & Ji, Z. (Other)
U.S. Army Medical Research and Materiel Command
12/15/24 → 12/14/27
Project: Research project
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Prot #STML-ELA-0322: ELACESTRANT in Women and Men with CDK4/6 Inhibitor-Naive Estrogen Receptor Positive, HER-2 Negative Metastatic Breast Cancer: An Open-Label Multicenter Phase 2 Study (ELCIN)
Gradishar, W. J. (PD/PI)
Worldwide Clinical Trials, Inc., Stemline Therapeutics, Inc.
12/6/24 → 12/6/27
Project: Research project
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Targeting alpha B-Crystallin in Basal-like Breast Cancer 2024-2025
Gradishar, W. J. (PD/PI)
University of Wisconsin-Madison, Breast Cancer Research Foundation
10/1/24 → 9/30/25
Project: Research project
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Acceptability of the Fit2ThriveMB mHealth physical activity promotion intervention in women with metastatic breast cancer
Starikovsky, J., Solk, P., Desai, R., Reading, J. M., Hasanaj, K., Wang, S. D., Carden, L. B., Wolter, M., Hickey, B., Lee, J., Song, J., Freeman, H., Alexander, J., Spring, B., Gradishar, W. & Phillips, S. M., Jan 2025, In: Supportive Care in Cancer. 33, 1, 72.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Accuracy and Reproducibility of ChatGPT Responses to Breast Cancer Tumor Board Patients
Liao, N., Li, C., Gradishar, W. J., Klimberg, V. S., Roshal, J. A., Yuan, T., Agarwala, S. S., Valero, V. K., Swain, S. M., Margenthaler, J. A., Rubio, I. T., Hurvitz, S. A., Geyer, C. E., Lin, N. U., Rugo, H. S., Zhang, G., Liu, N. & Balch, C. M., Jun 1 2025, In: JCO Clinical Cancer Informatics. 9, e2500001.Research output: Contribution to journal › Article › peer-review
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Circulation tumor cell isolation and enrichment technologies
Zhang, Y., Scholten, D., Qiang, W., Platanias, L. C., Gradishar, W. J., Kelley, S. O. & Liu, H., Jan 2025, Circulating Tumor Cells, From Biotech Innovation to Clinical Utility - Part B. Elsevier Inc, p. 119-149 31 p. (International Review of Cell and Molecular Biology; vol. 392).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Correction to: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib (Nature Communications, (2023), 14, 1, (4444), 10.1038/s41467-023-40061-y)
Coombes, R. C., Howell, S., Lord, S. R., Kenny, L., Mansi, J., Mitri, Z., Palmieri, C., Chap, L. I., Richards, P., Gradishar, W., Sardesai, S., Melear, J., O’Shaughnessy, J., Ward, P., Chalasani, P., Arkenau, T., Baird, R. D., Jeselsohn, R., Ali, S. & Clack, G. & 3 others, , Dec 2025, In: Nature communications. 16, 1, 2242.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Effective Strategies for the Prevention and Mitigation of Phosphatidylinositol-3-Kinase Inhibitor-Associated Hyperglycemia: Optimizing Patient Care
Moore, H. N., Goncalves, M. D., Johnston, A. M., Mayer, E. L., Rugo, H. S., Gradishar, W. J., Zylla, D. M. & Bergenstal, R. M., Jan 2025, In: Clinical breast cancer. 25, 1, p. 1-11 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations
Datasets
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Association of a novel circulating tumor DNA next-generating sequencing platform with circulating tumor cells (CTCs) and CTC clusters in metastatic breast cancer
Davis, A. A. (Creator), Zhang, Q. (Creator), Gerratana, L. (Creator), Shah, A. N. (Creator), Zhan, Y. (Creator), Qiang, W. (Creator), Finkelman, B. S. (Creator), Flaum, L. (Creator), Behdad, A. (Creator), Gradishar, W. J. (Creator), Platanias, L. C. (Creator) & Cristofanilli, M. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4770416, https://springernature.figshare.com/collections/Association_of_a_novel_circulating_tumor_DNA_next-generating_sequencing_platform_with_circulating_tumor_cells_CTCs_and_CTC_clusters_in_metastatic_breast_cancer/4770416
Dataset