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William J Gradishar

  • 12659 Citations
1988 …2023

Research output per year

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Personal profile

Research Interests

My clinical domain is breast cancer management. My clinical research interest focuses on the development of novel therapies for the treatment of breast cancer. Clinical trials focusing on precision medicine for defining the right therapy, for the right patient at the right time is our goal. To that end, molecular interogation of breast tumors are leading to novel trial design that will hopefully translate into better outcomes for our patients. In conjuction with the developmental therapeutics program, novel agents are being incorporated into clinical trials for patients with both early and late stage disease.

Certifications and Licenses

Internal Medicine
Medical Oncology

Training Experience

1986Residency, Michael Reese Medical Center
1990Fellowship, University of Chicago Hospitals

Education/Academic qualification

MD, University of Illinois at Chicago

… → 1982

Research interests

  • Breast Cancer
  • Chemotherapy
  • Clinical Research
  • Drug Discovery
  • Drugs (clinical pharmacology)
  • Genomic Medicine/Personalized Medicine
  • Medical Education

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Grants

57148711: Assessing Treatment Patterns of CDK 4/6 Inhibitor Utilization in HR+/HER2- Metastatic Breast within Northwestern Medicine and Addressing Opportunities for Improvement

Gradishar, W. J.

Pfizer Inc.

12/16/19 → 3/31/21

Project: Research project

Prot #U31402-A-J101: Phase 1/2, Multicenter, Open-label, Multiple Dose First-In-Human Study of U3-1402, in Subjects with HER3 Positive Metastatic Breast Cancer

Gradishar, W. J.

Quintiles, Inc., Daiichi Sankyo, Inc.

3/13/19 → 3/13/22

Project: Research project

Technology-Supported Physical Activity Intervention for Metastatic Breast Cancer Survivors:Fit2ThriveMB

Phillips, S. M., Gradishar, W. J., Lee, J. & Spring, B.

National Cancer Institute

3/1/19 → 2/28/21

Project: Research project

    • Coleman 4R Patient Care Sequences for Cancer and Supportive Care

    Garcia, S. F. & Gradishar, W. J.

    Coleman Foundation, Inc.

    10/1/18 → 9/30/21

    Project: Research project

    • Prot #MCLA-128-CL02: Phase 2 Study of MCLA-128-based Combinations in Metastatic Breast Cancer (MBC): MCLA-128/Trastuzumab/Chemotherapy in HER2-Positive MBC and MCLA-128/Endocrine Therapy in Estrogen Receptor Positive and Low HER2 Expression MBC

    Gradishar, W. J.

    SCRI Development Innovations, LLC, Merus N.V.

    8/7/18 → 8/7/21

    Project: Research project

    Research Output

    Evaluation of the 12-Gene Molecular Score and the 21-Gene Recurrence Score as Predictors of Response to Neo-adjuvant Chemotherapy in Estrogen Receptor-Positive, HER2-Negative Breast Cancer

    Soliman, H., Wagner, S., Flake, D. D., Robson, M., Schwartzberg, L., Sharma, P., Magliocco, A., Kronenwett, R., Lancaster, J. M., Lanchbury, J. S., Gutin, A. & Gradishar, W., Mar 1 2020, In : Annals of surgical oncology. 27, 3, p. 765-771 7 p.

    Research output: Contribution to journal › Article

    Open Access

    • Performance of a novel Next Generation Sequencing circulating tumor DNA (ctDNA) platform for the evaluation of samples from patients with metastatic breast cancer (MBC)

    Gerratana, L., Zhang, Q., Shah, A. N., Davis, A. A., Zhang, Y., Wehbe, F., Qiang, W., Flaum, L., Finkelman, B. S., Gradishar, W. J., Platanias, L. C., Behdad, A. & Cristofanilli, M., Jan 2020, In : Critical Reviews in Oncology/Hematology. 145, 102856.

    Research output: Contribution to journal › Review article

    Open Access

    • Phase II study of pembrolizumab and capecitabine for triple negative and hormone receptor-positive, HER2-negative endocrine-refractory metastatic breast cancer

    Shah, A. N., Flaum, L., Helenowski, I., Santa-Maria, C. A., Jain, S., Rademaker, A., Nelson, V., Tsarwhas, D., Cristofanilli, M. & Gradishar, W., Feb 13 2020, In : Journal for immunotherapy of cancer. 8, 1, e000173.

    Research output: Contribution to journal › Article

    Open Access

    • Recommendations for prioritization, treatment, and triage of breast cancer patients during the COVID-19 pandemic. the COVID-19 pandemic breast cancer consortium

    Dietz, J. R., Moran, M. S., Isakoff, S. J., Kurtzman, S. H., Willey, S. C., Burstein, H. J., Bleicher, R. J., Lyons, J. A., Sarantou, T., Baron, P. L., Stevens, R. E., Boolbol, S. K., Anderson, B. O., Shulman, L. N., Gradishar, W. J., Monticciolo, D. L., Plecha, D. M., Nelson, H. & Yao, K. A., Jan 1 2020, (Accepted/In press) In : Breast Cancer Research and Treatment. 181, 3, p. 487-497 11 p.

    Research output: Contribution to journal › Editorial

    Open Access

    • Selective progesterone receptor modulators in early-stage breast cancer: A randomized, placebo-controlled phase II window-of-opportunity trial using telapristone acetate

    Lee, O., Sullivan, M. E., Xu, Y., Rogers, C., Muzzio, M., Helenowski, I., Shidfar, A., Zeng, Z., Singhal, H., Jovanovic, B., Hansen, N., Bethke, K. P., Gann, P. H., Gradishar, W., Kim, J. J., Clare, S. E. & Khan, S. A., Jan 1 2020, In : Clinical Cancer Research. 26, 1, p. 25-34 10 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations