William J Gradishar

  • 11444 Citations
1988 …2022
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Personal profile

Research Interests

My clinical domain is breast cancer management. My clinical research interest focuses on the development of novel therapies for the treatment of breast cancer. Clinical trials focusing on precision medicine for defining the right therapy, for the right patient at the right time is our goal. To that end, molecular interogation of breast tumors are leading to novel trial design that will hopefully translate into better outcomes for our patients. In conjuction with the developmental therapeutics program, novel agents are being incorporated into clinical trials for patients with both early and late stage disease.

Certifications and Licenses

Medical Oncology
Internal Medicine

Training Experience

1986Residency, Michael Reese Medical Center
1990Fellowship, University of Chicago Hospitals

Education/Academic qualification

MD, University of Illinois - Chicago

… → 1982


  • Breast Cancer
  • Chemotherapy
  • Clinical Research
  • Drug Discovery
  • Drugs (clinical pharmacology)
  • Genomic Medicine/Personalized Medicine
  • Medical Education

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Grants 1999 2022

Patient Care
Patient Care Planning
Patient-Centered Care
Patient Rights

Research Output 1988 2019

Breast cancer, version 3.2018 featured updates to the NCCN guidelines

Goetz, M. P., Gradishar, W. J., Anderson, B. O., Abraham, J., Aft, R., Allison, K. H., Blair, S. L., Burstein, H. J., Dang, C., Elias, A. D., Farrar, W. B., Giordano, S. H., Goldstein, L. J., Isakoff, S. J., Lyons, J., Kelly Marcom, P., Mayer, I. A., Moran, M. S., Mortimer, J., O’Regan, R. M. & 13 othersPatel, S. A., Pierce, L. J., Reed, E. C., Rugo, H. S., Sitapati, A., Smith, K. L., Smith, M. L., Soliman, H., Telli, M. L., Ward, J. H., Young, J. S., Shead, D. A. & Kumar, R., Feb 1 2019, In : JNCCN Journal of the National Comprehensive Cancer Network. 17, 2, p. 118-126 9 p.

Research output: Contribution to journalArticle

Open Access
Adjuvant Chemotherapy
Breast Neoplasms
Colorectal Neoplasms
Diagnostic Services
Patient Rights

Prognostic role of serum thymidine kinase 1 activity in patients with hormone receptor–positive metastatic breast cancer: Analysis of the randomised phase III Evaluation of Faslodex versus Exemestane Clinical Trial (EFECT)

McCartney, A., Biagioni, C., Schiavon, G., Bergqvist, M., Mattsson, K., Migliaccio, I., Benelli, M., Romagnoli, D., Bonechi, M., Boccalini, G., Pestrin, M., Galardi, F., De Luca, F., Biganzoli, L., Piccart, M., Gradishar, W. J., Chia, S., Di Leo, A. & Malorni, L., Jun 1 2019, In : European Journal of Cancer. 114, p. 55-66 12 p.

Research output: Contribution to journalArticle

Clinical Trials
Breast Neoplasms
Breast Neoplasms
Gene Expression
Progesterone Receptors
Adjuvant Chemotherapy

Adjuvant Anthracyclines in Breast Cancer: What Is Their Role?

Shah, A. N. & Gradishar, W. J., Aug 17 2018, In : The oncologist.

Research output: Contribution to journalReview article

Breast Neoplasms
Lymph Nodes