Grants per year
Personal profile
Research Interests
My clinical domain is breast cancer management. My clinical research interest focuses on the development of novel therapies for the treatment of breast cancer. Clinical trials focusing on precision medicine for defining the right therapy, for the right patient at the right time is our goal. To that end, molecular interogation of breast tumors are leading to novel trial design that will hopefully translate into better outcomes for our patients. In conjuction with the developmental therapeutics program, novel agents are being incorporated into clinical trials for patients with both early and late stage disease.
Certifications and Licenses
| Internal Medicine | |
| Medical Oncology |
Training Experience
| 1986 | Residency, Michael Reese Medical Center |
| 1990 | Fellowship, University of Chicago Hospitals |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, University of Illinois at Chicago
… → 1982
Research interests keywords
- Breast Cancer
- Chemotherapy
- Clinical Research
- Drug Discovery
- Drugs (clinical pharmacology)
- Genomic Medicine/Personalized Medicine
- Medical Education
Fingerprint
Dive into the research topics where William J Gradishar is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Prot #GS-US-592-6173 (ASCENT-04): A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician’s Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic
ICON Clinical Research Limited, Gilead Sciences, Inc
1/31/23 → 1/31/26
Project: Research project
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Prot #GS-US-592-6238: A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Previously Untreated, Locally Advanced, Inoperable or Metastatic Triple-Negative Breast Cancer Whose Tumors Do N
ICON Clinical Research Limited, Gilead Sciences, Inc
1/30/23 → 1/30/26
Project: Research project
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Prot #ML43171: A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Giredestrant Plus Everolimus Compared with Exemestane Plus Everolimus in Patients with Estrogen Receptor (ER)-Positive, HER2-Negative, Locally Adva
INC Research, LLC, Genentech, Inc
11/16/22 → 8/31/26
Project: Research project
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Advances in the Management of Metastatic Breast Cancer
Gradishar, W. J., May 2023, In: JNCCN Journal of the National Comprehensive Cancer Network. 21, 55Research output: Contribution to journal › Article › peer-review
Open Access -
A multi-site trial of an electronic health integrated physical activity promotion intervention in breast and endometrial cancers survivors: MyActivity study protocol
Cadmus-Bertram, L., Solk, P., Agnew, M., Starikovsky, J., Schmidt, C., Morelli, W. A., Hodgson, V., Freeman, H., Muller, L., Mishory, A., Naxi, S., Carden, L., Tevaarwerk, A. J., Wolter, M., Barber, E., Spencer, R., Sesto, M. E., Gradishar, W., Gangnon, R., Spring, B., & 2 others, Jul 2023, In: Contemporary Clinical Trials. 130, 107187.Research output: Contribution to journal › Article › peer-review
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A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2-positive) cancer with leptomeningeal metastases: Safety, efficacy, and cerebrospinal fluid pharmacokinetics
Kumthekar, P. U., Avram, M. J., Lassman, A. B., Lin, N. U., Lee, E., Grimm, S. A., Schwartz, M., Bell Burdett, K. L., Lukas, R. V., Dixit, K., Perron, I., Zhang, H., Gradishar, W. J., Pentsova, E. I., Jeyapalan, S., Groves, M. D., Melisko, M. & Raizer, J. J., Mar 14 2023, In: Neuro-oncology. 25, 3, p. 557-565 9 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
A Phase II Single-arm Study of Palbociclib in Patients With HER2-positive Breast Cancer With Brain Metastases and Analysis of ctDNA in Patients With Active Brain Metastases
Shah, A. N., Santa-Maria, C. A., Mukhija, D., Shah, N., Kang, A. K., Kumthekar, P., Burdett, K., Chandra, S., Chang, J., Tsarwhas, D., Woodman, J., Jovanovic, B., Gerratana, L., Gradishar, W. & Cristofanilli, M., Apr 2023, In: Clinical breast cancer. 23, 3, p. 324-329 6 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib (Nature Communications, (2023), 14, 1, (4444), 10.1038/s41467-023-40061-y)
Coombes, R. C., Howell, S., Lord, S. R., Kenny, L., Mansi, J., Mitri, Z., Palmieri, C., Chap, L. I., Richards, P., Gradishar, W., Sardesai, S., Melear, J., O’Shaughnessy, J., Ward, P., Chalasani, P., Arkenau, T., Baird, R. D., Jeselsohn, R., Ali, S., Clack, G., & 3 others, Dec 2023, In: Nature communications. 14, 1, 4741.Research output: Contribution to journal › Comment/debate › peer-review
Open Access
Datasets
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Association of a novel circulating tumor DNA next-generating sequencing platform with circulating tumor cells (CTCs) and CTC clusters in metastatic breast cancer
Davis, A. A. (Creator), Zhang, Q. (Creator), Gerratana, L. (Creator), Shah, A. N. (Creator), Zhan, Y. (Contributor), Qiang, W. (Contributor), Finkelman, B. S. (Creator), Flaum, L. E. (Creator), Behdad, A. (Creator), Gradishar, W. J. (Creator), Platanias, L. C. (Creator), Cristofanilli, M. (Creator) & Cristofanilli, M. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4770416.v1, https://springernature.figshare.com/collections/Association_of_a_novel_circulating_tumor_DNA_next-generating_sequencing_platform_with_circulating_tumor_cells_CTCs_and_CTC_clusters_in_metastatic_breast_cancer/4770416/1
Dataset