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William J Gradishar

  • 11444 Citations
1988 …2022
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Personal profile

Research Interests

My clinical domain is breast cancer management. My clinical research interest focuses on the development of novel therapies for the treatment of breast cancer. Clinical trials focusing on precision medicine for defining the right therapy, for the right patient at the right time is our goal. To that end, molecular interogation of breast tumors are leading to novel trial design that will hopefully translate into better outcomes for our patients. In conjuction with the developmental therapeutics program, novel agents are being incorporated into clinical trials for patients with both early and late stage disease.

Certifications and Licenses

Medical Oncology
Internal Medicine

Training Experience

1986Residency, Michael Reese Medical Center
1990Fellowship, University of Chicago Hospitals

Education/Academic qualification

MD, University of Illinois - Chicago

… → 1982

Keywords

  • Breast Cancer
  • Chemotherapy
  • Clinical Research
  • Drug Discovery
  • Drugs (clinical pharmacology)
  • Genomic Medicine/Personalized Medicine
  • Medical Education

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 1999 2022

Prot #U31402-A-J101: Phase 1/2, Multicenter, Open-label, Multiple Dose First-In-Human Study of U3-1402, in Subjects with HER3 Positive Metastatic Breast Cancer

Gradishar, W. J.

Quintiles, Inc., Daiichi Sankyo, Inc.

3/13/19 → 3/13/22

Project: Research project

Coleman 4R Patient Care Sequences for Cancer and Supportive Care

Garcia, S. F. & Gradishar, W. J.

Coleman Foundation, Inc.

10/1/18 → 9/30/21

Project: Research project

Patient Care
Neoplasms
Patient Care Planning
Patient-Centered Care
Patient Rights

Prot #MCLA-128-CL02: Phase 2 Study of MCLA-128-based Combinations in Metastatic Breast Cancer (MBC): MCLA-128/Trastuzumab/Chemotherapy in HER2-Positive MBC and MCLA-128/Endocrine Therapy in Estrogen Receptor Positive and Low HER2 Expression MBC

Gradishar, W. J.

SCRI Development Innovations, LLC, Merus N.V.

8/7/18 → 8/7/21

Project: Research project

Prot #NU UC18B01: Phase Ib/II Open-Label Single Arm Study to Evaluate Safety and Efficacy of Tucatinib in Combination with Letrozole and Palbociclib in Subjects with Hormone Receptor Positive and HER2-Positive Metastatic Breast Cancer

Gradishar, W. J.

Criterium, Inc., Pfizer Inc.

5/29/18 → 5/29/21

Project: Research project

Prot #CO40016: A Double-Blind, Placebo-Controlled, Randomized Phase III Study Of Ipatasertib In Combination With Paclitaxel As A Treatment For Patients With Pik3ca/Akt1/Pten-Altered, Locally Advanced Or Metastatic, Triple-Negative Breast Cancer Or Hormone

Gradishar, W. J.

Syneos Health, Inc., Genentech, Inc.

4/19/18 → 4/19/21

Project: Research project

Research Output 1988 2019

Breast cancer, version 3.2018 featured updates to the NCCN guidelines

Goetz, M. P., Gradishar, W. J., Anderson, B. O., Abraham, J., Aft, R., Allison, K. H., Blair, S. L., Burstein, H. J., Dang, C., Elias, A. D., Farrar, W. B., Giordano, S. H., Goldstein, L. J., Isakoff, S. J., Lyons, J., Kelly Marcom, P., Mayer, I. A., Moran, M. S., Mortimer, J., O’Regan, R. M. & 13 othersPatel, S. A., Pierce, L. J., Reed, E. C., Rugo, H. S., Sitapati, A., Smith, K. L., Smith, M. L., Soliman, H., Telli, M. L., Ward, J. H., Young, J. S., Shead, D. A. & Kumar, R., Feb 1 2019, In : JNCCN Journal of the National Comprehensive Cancer Network. 17, 2, p. 118-126 9 p.

Research output: Contribution to journal › Article

Open Access
Adjuvant Chemotherapy
Hormones
Guidelines
Breast Neoplasms
Therapeutics

Innovating Cancer Care Delivery: the Example of the 4R Oncology Model for Colorectal Cancer Patients

Trosman, J., Weldon, C., Kircher, S. M., Gradishar, W. J. & Benson III, A. B., Feb 1 2019, In : Current treatment options in oncology. 20, 2, 11.

Research output: Contribution to journal › Review article

Colorectal Neoplasms
Neoplasms
Research
Diagnostic Services
Patient Rights

Prognostic role of serum thymidine kinase 1 activity in patients with hormone receptor–positive metastatic breast cancer: Analysis of the randomised phase III Evaluation of Faslodex versus Exemestane Clinical Trial (EFECT)

McCartney, A., Biagioni, C., Schiavon, G., Bergqvist, M., Mattsson, K., Migliaccio, I., Benelli, M., Romagnoli, D., Bonechi, M., Boccalini, G., Pestrin, M., Galardi, F., De Luca, F., Biganzoli, L., Piccart, M., Gradishar, W. J., Chia, S., Di Leo, A. & Malorni, L., Jun 1 2019, In : European Journal of Cancer. 114, p. 55-66 12 p.

Research output: Contribution to journal › Article

exemestane
Clinical Trials
Hormones
Breast Neoplasms
Serum

Relationship of pathological features and a 21 gene expression assay in younger versus older women with node-negative endocrine receptor-positive breast cancer

Mutonga, M., Speedy, S., Rademaker, A. W., Liu, D., Uthe, R., Jain, S., Gradishar, W. J., Flaum, L. E. & Santa-Maria, C. A., Jan 1 2019, In : Breast Cancer Research and Treatment.

Research output: Contribution to journal › Article

Breast Neoplasms
Gene Expression
Recurrence
Progesterone Receptors
Adjuvant Chemotherapy

Adjuvant Anthracyclines in Breast Cancer: What Is Their Role?

Shah, A. N. & Gradishar, W. J., Aug 17 2018, In : The oncologist.

Research output: Contribution to journal › Review article

Anthracyclines
Breast Neoplasms
Cyclophosphamide
Therapeutics
Lymph Nodes