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Personal profile

Education/Academic qualification

Molecular Biology, PhD, University of California at Los Angeles

… → 1973

Biology, BS, Massachusetts Institute of Technology

… → 1968

Fingerprint Dive into the research topics where William L Klein is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 18 Similar Profiles
Alzheimer Disease Medicine & Life Sciences
Amyloid Medicine & Life Sciences
Oligomers Chemical Compounds
Neurons Medicine & Life Sciences
Muscarinic Receptors Medicine & Life Sciences
Synapses Medicine & Life Sciences
Brain Medicine & Life Sciences
Retina Medicine & Life Sciences

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Grants 2001 2024

Amyloid
Alzheimer Disease
Post Translational Protein Processing
Peptides
Data Mining
Amyloid
Alzheimer Disease
Post Translational Protein Processing
Peptides
Data Mining
Amyloid
Retina
Ganglia
Neuronal Plasticity
Poisons
Alzheimer Disease
Cholesterol
Rabbits
Type 2 Diabetes Mellitus
Hypercholesterolemia
Molecular Probes
Nanoparticles
Alzheimer Disease
Investigational Drugs
Dementia

Research Output 1972 2019

1 Citation (Scopus)

A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies

Cline, E. N., Das, A., Bicca, M. A., Mohammad, S. N., Schachner, L. F., Kamel, J. M., DiNunno, N., Weng, A., Paschall, J. D., Bu, R. L., Khan, F. M., Rollins, M. G., Ives, A. N., Shekhawat, G. S., Nunes-Tavares, N., de Mello, F. G., Compton, P. D., Kelleher, N. L. & Klein, W. L., Mar 1 2019, In : Journal of neurochemistry. 148, 6, p. 822-836 15 p.

Research output: Contribution to journalArticle

Pathology
Oligomers
Amyloid
Crosslinking
Alzheimer Disease

Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers

Xie, Z., Shapiro, L. P., Cahill, M. E., Russell, T. A., Lacor, P. N., Klein, W. L. & Penzes, P., May 1 2019, In : European Journal of Neuroscience. 49, 9, p. 1091-1101 11 p.

Research output: Contribution to journalArticle

Dendritic Spines
Amyloid
Alzheimer Disease
Ligands
Synapses
4 Citations (Scopus)

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers

Mendes, N. D., Fernandes, A., Almeida, G. M., Santos, L. E., Selles, M. C., Lyra e Silva, N. M., Machado, C. M., Horta-Júnior, J. A. C., Louzada, P. R., De Felice, F. G., Alves-Leon, S., Marcondes, J., Assirati, J. A., Matias, C. M., Klein, W. L., Garcia-Cairasco, N., Ferreira, S. T., Neder, L. & Sebollela, A., Sep 1 2018, In : Journal of Neuroscience Methods. 307, p. 203-209 7 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Brain
Cell Survival
Neurodegenerative Diseases
Neurotransmitter Agents
29 Citations (Scopus)

NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

Yin, J., Zhao, F., Chojnacki, J. E., Fulp, J., Klein, W. L., Zhang, S. & Zhu, X., Mar 1 2018, In : Molecular Neurobiology. 55, 3, p. 1977-1987 11 p.

Research output: Contribution to journalArticle

Inflammasomes
Amyloid
Alzheimer Disease
Pathology
Synaptophysin

SMPL synaptic membranes: Nanodisc-mediated synaptic membrane mimetics expand the toolkit for drug discovery and the molecular cell biology of synapses

Lo Bu, R., Clark, J., DiChiara, T., Sligar, S. G. & Klein, W. L., Jan 1 2018, Neuromethods. Humana Press Inc, p. 227-250 24 p. (Neuromethods; vol. 141).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cytology
Synaptic Membranes
Molecular biology
Drug Discovery
Synapses