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Research Output

2019

Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease

Ding, Y., Zhao, J., Zhang, X., Wang, S., Viola, K. L., Chow, F. E., Zhang, Y., Lippa, C., Klein, W. L. & Gong, Y., Nov 1 2019, In : Frontiers in Neurology. 10, 1140.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies

Cline, E. N., Das, A., Bicca, M. A., Mohammad, S. N., Schachner, L. F., Kamel, J. M., DiNunno, N., Weng, A., Paschall, J. D., Bu, R. L., Khan, F. M., Rollins, M. G., Ives, A. N., Shekhawat, G., Nunes-Tavares, N., de Mello, F. G., Compton, P. D., Kelleher, N. L. & Klein, W. L., Mar 2019, In : Journal of neurochemistry. 148, 6, p. 822-836 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers

Xie, Z., Shapiro, L. P., Cahill, M. E., Russell, T. A., Lacor, P. N., Klein, W. L. & Penzes, P., May 2019, In : European Journal of Neuroscience. 49, 9, p. 1091-1101 11 p.

Research output: Contribution to journalArticle

2018

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers

Mendes, N. D., Fernandes, A., Almeida, G. M., Santos, L. E., Selles, M. C., Lyra e Silva, N. M., Machado, C. M., Horta-Júnior, J. A. C., Louzada, P. R., De Felice, F. G., Alves-Leon, S., Marcondes, J., Assirati, J. A., Matias, C. M., Klein, W. L., Garcia-Cairasco, N., Ferreira, S. T., Neder, L. & Sebollela, A., Sep 1 2018, In : Journal of Neuroscience Methods. 307, p. 203-209 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

Yin, J., Zhao, F., Chojnacki, J. E., Fulp, J., Klein, W. L., Zhang, S. & Zhu, X., Mar 1 2018, In : Molecular Neurobiology. 55, 3, p. 1977-1987 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

SMPL synaptic membranes: Nanodisc-mediated synaptic membrane mimetics expand the toolkit for drug discovery and the molecular cell biology of synapses

Lo Bu, R., Clark, J., DiChiara, T., Sligar, S. G. & Klein, W. L., Jan 1 2018, Neuromethods. Humana Press Inc., p. 227-250 24 p. (Neuromethods; vol. 141).

Research output: Chapter in Book/Report/Conference proceedingChapter

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

Cline, E. N., Bicca, M. A., Viola, K. L. & Klein, W. L., Jan 1 2018, In : Journal of Alzheimer's Disease. 64, s1, p. S567-S610

Research output: Contribution to journalReview article

106 Scopus citations

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease

Batista, A. F., Forny-Germano, L., Clarke, J. R., Lyra e Silva, N. M., Brito-Moreira, J., Boehnke, S. E., Winterborn, A., Coe, B. C., Lablans, A., Vital, J. F., Marques, S. A., Martinez, A. M. B., Gralle, M., Holscher, C., Klein, W. L., Houzel, J. C., Ferreira, S. T., Munoz, D. P. & De Felice, F. G., May 2018, In : Journal of Pathology. 245, 1, p. 85-100 16 p.

Research output: Contribution to journalArticle

40 Scopus citations
2017

A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers

Sebollela, A., Cline, E. N., Popova, I. A., Luo, K., Sun, X., Ahn, J., Barcelos, M. A., Bezerra, V. N., Lyra e Silva, N. M., Patel, J., Pinheiro, N. R., Qin, L. A., Kamel, J. M., Weng, A., DiNunno, N., Bebenek, A. M., Velasco, P. T., Viola, K. L., Lacor, P. N., Ferreira, S. T. & 1 others, Klein, W. L., Sep 1 2017, In : Journal of neurochemistry. 142, 6, p. 934-947 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Alzheimer’s toxic amyloid beta oligomers: Unwelcome visitors to the Na/K ATPase alpha3 docking station

di Chiara, T., DiNunno, N., Clark, J., Bu, R. L., Cline, E. N., Rollins, M. G., Gong, Y., Brody, D. L., Sligar, S. G., Velasco, P. T., Viola, K. L. & Klein, W. L., Mar 2017, In : Yale Journal of Biology and Medicine. 90, 1, p. 45-61 17 p.

Research output: Contribution to journalArticle

12 Scopus citations

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons

Seixas da Silva, G. S., Melo, H. M., Lourenco, M. V., Lyra e Silva, N. M., De Carvalho, M. B., Alves-Leon, S. V., De Souza, J. M., Klein, W. L., Da-Silva, W. S., Ferreira, S. T. & De Felice, F. G., May 5 2017, In : Journal of Biological Chemistry. 292, 18, p. 7395-7406 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology

Haure-Mirande, J. V., Audrain, M., Fanutza, T., Kim, S. H., Klein, W. L., Glabe, C., Readhead, B., Dudley, J. T., Blitzer, R. D., Wang, M., Zhang, B., Schadt, E. E., Gandy, S. & Ehrlich, M. E., Nov 1 2017, In : Acta Neuropathologica. 134, 5, p. 769-788 20 p.

Research output: Contribution to journalArticle

24 Scopus citations

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers

Pitt, J., Wilcox, K. C., Tortelli, V., Diniz, L. P., Oliveira, M. S., Dobbins, C., Yu, X. W., Nandamuri, S., Gomes, F. C. A., DiNunno, N., Viola, K. L., De Felice, F. G., Ferreira, S. T. & Klein, W. L., Oct 1 2017, In : Molecular biology of the cell. 28, 20, p. 2623-2636 14 p.

Research output: Contribution to journalArticle

26 Scopus citations
2016

A study of Aβ oligomers in the temporal cortex and cerebellum of patients with neuropathologically confirmed Alzheimer's disease compared to aged controls

Savioz, A., Giannakopoulos, P., Herrmann, F. R., Klein, W. L., Kövari, E., Bouras, C. & Giacobini, E., Sep 1 2016, In : Neurodegenerative Diseases. 16, 5-6, p. 398-406 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Effective anti-Alzheimer Ab therapy involves depletion of specific Ab oligomer subtypes

Knight, E. M., Kim, S. H., Kottwitz, J. C., Hatami, A., Albay, R., Suzuki, A., Lublin, A., Alberini, C. M., Klein, W. L., Szabo, P., Relkin, N. R., Ehrlich, M., Glabe, C. G., Gandy, S. & Steele, J. W., Jan 1 2016, In : Neurology: Neuroimmunology and NeuroInflammation. 3, 3, e237.

Research output: Contribution to journalArticle

28 Scopus citations

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

Lauritzen, I., Pardossi-Piquard, R., Bourgeois, A., Pagnotta, S., Biferi, M. G., Barkats, M., Lacor, P., Klein, W., Bauer, C. & Checler, F., Aug 1 2016, In : Acta Neuropathologica. 132, 2, p. 257-276 20 p.

Research output: Contribution to journalArticle

52 Scopus citations

Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers

Umeda, T., Ono, K., Sakai, A., Yamashita, M., Mizuguchi, M., Klein, W. L., Yamada, M., Mori, H. & Tomiyama, T., May 1 2016, In : Brain. 139, 5, p. 1568-1586 19 p.

Research output: Contribution to journalArticle

40 Scopus citations

Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1

Knight, E. M., Ruiz, H. H., Kim, S. H., Harte, J. C., Hsieh, W., Glabe, C., Klein, W. L., Attie, A. D., Buettner, C., Ehrlich, M. E. & Gandy, S., Feb 25 2016, In : Acta Neuropathologica Communications. 4, 1 p.

Research output: Contribution to journalArticle

13 Scopus citations
2015

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

Clarke, J. R., Lyra e Silva, N. M., Figueiredo, C. P., Frozza, R. L., Ledo, J. H., Beckman, D., Katashima, C. K., Razolli, D., Carvalho, B. M., Frazão, R., Silveira, M. A., Ribeiro, F. C., Bomfim, T. R., Neves, F. S., Klein, W. L., Medeiros, R., Laferla, F. M., Carvalheira, J. B., Saad, M. J., Munoz, D. P. & 3 others, Velloso, L. A., Ferreira, S. T. & De Felice, F. G., Feb 1 2015, In : EMBO Molecular Medicine. 7, 2, p. 190-210 21 p.

Research output: Contribution to journalArticle

105 Scopus citations

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

Viola, K. L. & Klein, W. L., Jan 24 2015, In : Acta Neuropathologica. 129, 2, p. 183-206 24 p.

Research output: Contribution to journalReview article

234 Scopus citations

Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APPE693Q mice through reduction of ganglioside-bound Aβ

Knight, E. M., Williams, H. N., Stevens, A. C., Kim, S. H., Kottwitz, J. C., Morant, A. D., Steele, J. W., Klein, W. L., Yanagisawa, K., Boyd, R. E., Lockhart, D. J., Sjoberg, E. R., Ehrlich, M. E., Wustman, B. A. & Gandy, S., Feb 5 2015, In : Molecular Psychiatry. 20, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Nanoscale synaptic membrane mimetic allows unbiased high throughput screen that targets binding sites for Alzheimer's-associated Aβ oligomers

Wilcox, K. C., Marunde, M. R., Das, A., Velasco, P. T., Kuhns, B. D., Marty, M. T., Jiang, H., Luan, C. H., Sligar, S. G. & Klein, W. L., Apr 1 2015, In : PLoS One. 10, 4, e0125263.

Research output: Contribution to journalArticle

19 Scopus citations

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease

Baker-Nigh, A., Vahedi, S., Davis, E. G., Weintraub, S., Bigio, E. H., Klein, W. L. & Geula, C., Jun 1 2015, In : Brain. 138, 6, p. 1722-1737 16 p.

Research output: Contribution to journalArticle

82 Scopus citations

Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease

Viola, K. L., Sbarboro, J., Sureka, R., De, M., Bicca, M. A., Wang, J., Vasavada, S., Satpathy, S., Wu, S., Joshi, H., Velasco, P. T., Macrenaris, K. W., Waters, E. A., Lu, C., Phan, J., Lacor, P., Prasad, P., Dravid, V. P. & Klein, W. L., Jan 1 2015, In : Nature nanotechnology. 10, 1, p. 91-98 8 p.

Research output: Contribution to journalArticle

88 Scopus citations
2014

Accumulation of intraneuronal amyloid-β is common in normal brain

Blair, J. A., Siedlak, S. L., Wolfram, J. A., Nunomura, A., Castellani, R. J., Ferreira, S. T., Klein, W. L., Wang, Y., Casadesus, G., Smith, M. A., Perry, G., Zhu, X. & Lee, H. G., Jan 1 2014, In : Current Alzheimer Research. 11, 4, p. 317-324 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Alzheimer’s disease-like pathology induced by amyloid-β oligomers in nonhuman primates

Forny-Germano, L., Lyra E Silva, N. M., Batista, A. F., Brito-Moreira, J., Gralle, M., Boehnke, S. E., Coe, B. C., Lablans, A., Marques, S. A., Martinez, A. M. B., Klein, W. L., Houzel, J. C., Ferreira, S. T., Munoz, D. P. & De Felice, F. G., Oct 8 2014, In : Journal of Neuroscience. 34, 41, p. 13629-13643 15 p.

Research output: Contribution to journalArticle

92 Scopus citations

Anti-ADDL Antibodies and Uses Thereof

Klein, W., Aug 14 2014

Research output: Patent

Anti-ADDL Antibodies and Uses Thereof

Klein, W., Dec 3 2014, Patent No. JP 5634975

Research output: Patent

Elucidating molecular mass and shape of a neurotoxic aβ oligomer

Sebollela, A., Mustata, G. M., Luo, K., Velasco, P. T., Viola, K. L., Cline, E. N., Shekhawat, G. S., Wilcox, K. C., Dravid, V. P. & Klein, W. L., Dec 17 2014, In : ACS Chemical Neuroscience. 5, 12, p. 1238-1245 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: A multidimensional study

Iulita, M. F., Allard, S., Richter, L., Munter, L. M., Ducatenzeiler, A., Weise, C., DoCarmo, S., Klein, W. L., Multhaup, G. & Cuello, A. C., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 61.

Research output: Contribution to journalArticle

47 Scopus citations

Modulation of amyloid-β aggregation by histidine-coordinating cobalt(III) schiff base complexes

Heffern, M. C., Velasco, P. T., Matosziuk, L. M., Coomes, J. L., Karras, C., Ratner, M. A., Klein, W. L., Eckermann, A. L. & Meade, T. J., Jul 21 2014, In : ChemBioChem. 15, 11, p. 1584-1589 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
2013

Brain transit and ameliorative effects of intranasally delivered anti-amyloid-β oligomer antibody in 5XFAD mice

Xiao, C., Davis, F. J., Chauhan, B. C., Viola, K. L., Lacor, P. N., Velasco, P. T., Klein, W. L. & Chauhan, N. B., Jan 1 2013, In : Journal of Alzheimer's Disease. 35, 4, p. 777-788 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Disruption of neocortical histone H3 homeostasis by soluble Aβ: Implications for Alzheimer's disease

Lithner, C. U., Lacor, P. N., Zhao, W. Q., Mustafiz, T., Klein, W. L., Sweatt, J. D. & Hernandez, C. M., Sep 1 2013, In : Neurobiology of Aging. 34, 9, p. 2081-2090 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease

Kam, T. I., Song, S., Gwon, Y., Park, H., Yan, J. J., Im, I., Choi, J. W., Choi, T. Y., Kim, J., Song, D. K., Takai, T., Kim, Y. C., Kim, K. S., Choi, S. Y., Choi, S., Klein, W. L., Yuan, J. & Jung, Y. K., Jul 1 2013, In : Journal of Clinical Investigation. 123, 7, p. 2791-2802 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Memantine rescues transient cognitive impairment caused by high-molecular-weight Aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers

Figueiredo, C. P., Clarke, J. R., Ledo, J. H., Ribeiro, F. C., Costa, C. V., Melo, H. M., Mota-Sales, A. P., Saraiva, L. M., Klein, W. L., Sebollela, A., De Felice, F. G. & Ferreira, S. T., Jun 7 2013, In : Journal of Neuroscience. 33, 23, p. 9626-9634 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

Kondo, T., Asai, M., Tsukita, K., Kutoku, Y., Ohsawa, Y., Sunada, Y., Imamura, K., Egawa, N., Yahata, N., Okita, K., Takahashi, K., Asaka, I., Aoi, T., Watanabe, A., Watanabe, K., Kadoya, C., Nakano, R., Watanabe, D., Maruyama, K., Hori, O. & 23 others, Hibino, S., Choshi, T., Nakahata, T., Hioki, H., Kaneko, T., Naitoh, M., Yoshikawa, K., Yamawaki, S., Suzuki, S., Hata, R., Ueno, S. I., Seki, T., Kobayashi, K., Toda, T., Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S. & Inoue, H., Apr 4 2013, In : Cell Stem Cell. 12, 4, p. 487-496 10 p.

Research output: Contribution to journalArticle

426 Scopus citations

Nanodisc-solubilized membrane protein library reflects the membrane proteome

Marty, M. T., Wilcox, K. C., Klein, W. L. & Sligar, S. G., Feb 12 2013, In : Analytical and Bioanalytical Chemistry. 405, 12, p. 4009-4016 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols

Pitt, J., Thorner, M., Brautigan, D., Larner, J. & Klein, W. L., Jan 1 2013, In : FASEB Journal. 27, 1, p. 199-207 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Synaptotoxic amyloid-β oligomers: A molecular basis for the cause, diagnosis, and treatment of alzheimer's disease?

Klein, W. L., Feb 15 2013, Alzheimer's Disease: Advances for a New Century. IOS Press, p. 49-65 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

109 Scopus citations

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys

Lourenco, M. V., Clarke, J. R., Frozza, R. L., Bomfim, T. R., Forny-Germano, L., Batista, A. F., Sathler, L. B., Brito-Moreira, J., Amaral, O. B., Silva, C. A., Freitas-Correa, L., Espírito-Santo, S., Campello-Costa, P., Houzel, J. C., Klein, W. L., Holscher, C., Carvalheira, J. B., Silva, A. M., Velloso, L. A., Munoz, D. P. & 2 others, Ferreira, S. T. & De Felice, F. G., Dec 3 2013, In : Cell Metabolism. 18, 6, p. 831-843 13 p.

Research output: Contribution to journalArticle

177 Scopus citations

Amyloid Beta Protein (Globular Assembly and Uses Thereof)

Klein, W., May 1 2012, Patent No. CA 2,279,555

Research output: Patent

Amyloid-β and tau pathology of Alzheimer's disease induced by diabetes in a RABBIT animal model

Bitel, C. L., Kasinathan, C., Kaswala, R. H., Klein, W. L. & Frederikse, P. H., 2012, In : Journal of Alzheimer's Disease. 32, 2, p. 291-305 15 p.

Research output: Contribution to journalArticle

52 Scopus citations

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers

Bomfim, T. R., Forny-Germano, L., Sathler, L. B., Brito-Moreira, J., Houzel, J. C., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., Holscher, C., Arnold, S. E., Talbot, K., Klein, W. L., Munoz, D. P., Ferreira, S. T. & De Felice, F. G., Apr 2 2012, In : Journal of Clinical Investigation. 122, 4, p. 1339-1353 15 p.

Research output: Contribution to journalArticle

458 Scopus citations

Anti-ADDL Antibodies and Uses Thereof

Klein, W., Oct 18 2012

Research output: Patent

Anti-ADDL Antibodies and Uses Thereof

Klein, W., Mar 27 2012, Patent No. IN 251624

Research output: Patent

Anti-ADDL Antibodies and Uses Thereof

Klein, W., Jul 5 2012, Patent No. 8383113

Research output: Patent

Aβ oligomers-induced toxicity is attenuated in cells cultured with Nβactiv4™ medium

Zhou, Y. & Klein, W. L., Nov 1 2012, In : Neurotoxicity Research. 22, 4, p. 335-344 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Biological targeting and activity of pre-fibrillar Aβ assemblies

Wilcox, K. C., Pitt, J., Sebollela, A., Martirosova, H., Lacor, P. N. & Klein, W. L., Mar 1 2012, Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases. Springer Netherlands, Vol. 9789400727748. p. 103-133 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations