William L Lowe Jr

  • 6263 Citations
1981 …2023
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Research Output 1981 2019

2019

Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries

HAPO Study Cooperative Research Group, Oct 1 2019, In : The Journal of clinical endocrinology and metabolism. 104, 10, p. 4459-4472 14 p.

Research output: Contribution to journalArticle

Metabolomics
C-Peptide
Fetal Blood
Blood
Metabolites

Gestational Diabetes and Childhood Obesity - Reply

Lowe Jr, W. L., Scholtens, D. M. & Metzger, B. E., Feb 19 2019, In : JAMA - Journal of the American Medical Association. 321, 7, p. 708-709 2 p.

Research output: Contribution to journalLetter

Gestational Diabetes
Pediatric Obesity
10 Citations (Scopus)

Hyperglycemia and adverse Pregnancy Outcome follow-up study (HAPO FUS): Maternal gestational diabetes mellitus and childhood glucose metabolism

on behalf of the HAPO Follow-up Study Cooperative Research Group*, Mar 1 2019, In : Diabetes care. 42, 3, p. 372-380 9 p.

Research output: Contribution to journalArticle

Gestational Diabetes
Pregnancy Outcome
Hyperglycemia
Mothers
Glucose
14 Citations (Scopus)

Hyperglycemia and adverse Pregnancy Outcome follow-up study (HAPO FUS): Maternal glycemia and childhood glucose metabolism

the HAPO Follow-up Study Cooperative Research Group, Mar 1 2019, In : Diabetes care. 42, 3, p. 381-392 12 p.

Research output: Contribution to journalArticle

Pregnancy Outcome
Hyperglycemia
Mothers
Glucose
Fasting
7 Citations (Scopus)

Maternal glucose levels during pregnancy and childhood adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study

on behalf of the HAPO Follow-up Study Cooperative Research Group, Apr 1 2019, In : Diabetologia. 62, 4, p. 598-610 13 p.

Research output: Contribution to journalArticle

Adiposity
Pregnancy Outcome
Hyperglycemia
Mothers
Glucose
1 Citation (Scopus)

Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries

for the HAPO Study Cooperative Research Group, Mar 1 2019, In : Diabetologia. 62, 3, p. 473-484 12 p.

Research output: Contribution to journalArticle

Hyperinsulinism
Mothers
Newborn Infant
Pregnancy
C-Peptide

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

Liu, X., Helenius, D., Skotte, L., Beaumont, R. N., Wielscher, M., Geller, F., Juodakis, J., Mahajan, A., Bradfield, J. P., Lin, F. T. J., Vogelezang, S., Bustamante, M., Ahluwalia, T. S., Pitkänen, N., Wang, C. A., Bacelis, J., Borges, M. C., Zhang, G., Bedell, B. A., Rossi, R. M. & 54 others, Skogstrand, K., Peng, S., Thompson, W. K., Appadurai, V., Lawlor, D. A., Kalliala, I., Power, C., McCarthy, M. I., Boyd, H. A., Marazita, M. L., Hakonarson, H., Hayes, M. G., Scholtens, D. M., Rivadeneira, F., Jaddoe, V. W. V., Vinding, R. K., Bisgaard, H., Knight, B. A., Pahkala, K., Raitakari, O., Helgeland, Ø., Johansson, S., Njølstad, P. R., Fadista, J., Schork, A. J., Nudel, R., Miller, D. E., Chen, X., Weirauch, M. T., Mortensen, P. B., Børglum, A. D., Nordentoft, M., Mors, O., Hao, K., Ryckman, K. K., Hougaard, D. M., Kottyan, L. C., Pennell, C. E., Lyytikainen, L. P., Bønnelykke, K., Vrijheid, M., Felix, J. F., Lowe, W. L., Grant, S. F. A., Hyppönen, E., Jacobsson, B., Jarvelin, M. R., Muglia, L. J., Murray, J. C., Freathy, R. M., Werge, T. M., Melbye, M., Buil, A. & Feenstra, B., Dec 1 2019, In : Nature communications. 10, 1, 3927.

Research output: Contribution to journalArticle

Open Access
genome
genes
Genes
Mothers
Genome
2018
34 Citations (Scopus)

Association of gestational diabetes with maternal disorders of glucose metabolism and childhood adiposity

HAPO Follow-up Study Cooperative Research, Sep 11 2018, In : JAMA - Journal of the American Medical Association. 320, 10, p. 1005-1016 12 p.

Research output: Contribution to journalArticle

Glucose Metabolism Disorders
Gestational Diabetes
Adiposity
Mothers
Odds Ratio
1 Citation (Scopus)

Genetic determinants of glycemic traits and the risk of gestational diabetes mellitus

Powe, C. E., Nodzenski, M., Talbot, O., Allard, C., Briggs, C., Leya, M. V., Perron, P., Bouchard, L., Florez, J. C., Scholtens, D. M., Lowe Jr, W. L. & Hivert, M. F., Dec 1 2018, In : Diabetes. 67, 12, p. 2703-2709 7 p.

Research output: Contribution to journalArticle

Gestational Diabetes
Fasting
Insulin
Type 2 Diabetes Mellitus
Pregnancy
41 Citations (Scopus)

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Early Growth Genetics (EGG) Consortium, Feb 15 2018, In : Human molecular genetics. 27, 4, p. 742-756 15 p., ddx429.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Birth Weight
Mothers
Fetal Development
Single Nucleotide Polymorphism
9 Citations (Scopus)

Maternal and fetal genetic contribution to gestational weight gain

Warrington, N. M., Richmond, R., Fenstra, B., Myhre, R., Gaillard, R., Paternoster, L., Wang, C. A., Beaumont, R. N., Das, S., Murcia, M., Barton, S. J., Espinosa, A., Thiering, E., Atalay, M., Pitkänen, N., Ntalla, I., Jonsson, A. E., Freathy, R., Karhunen, V., Tiesler, C. M. T. & 44 others, Allard, C., Crawford, A., Ring, S. M., Melbye, M., Magnus, P., Rivadeneira, F., Skotte, L., Hansen, T., Marsh, J., Guxens, M., Holloway, J. W., Grallert, H., Jaddoe, V. W. V., Lowe, W. L., Roumeliotaki, T., Hattersley, A. T., Lindi, V., Pahkala, K., Panoutsopoulou, K., Standl, M., Flexeder, C., Bouchard, L., Aagaard Nohr, E., Santa Marina, L., Kogevinas, M., Niinikoski, H., Dedoussis, G., Heinrich, J., Reynolds, R. M., Lakka, T., Zeggini, E., Raitakari, O. T., Chatzi, L., Inskip, H. M., Bustamante, M., Hivert, M. F., Jarvelin, M. R., Sørensen, T. I. A., Pennell, C., Felix, J. F., Jacobsson, B., Geller, F., Evans, D. M. & Lawlor, D. A., Apr 1 2018, In : International Journal of Obesity. 42, 4, p. 775-784 10 p.

Research output: Contribution to journalArticle

Weight Gain
Mothers
Body Mass Index
Genome
Birth Weight
2017
3 Citations (Scopus)

A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women

MEDIA Consortium, Mar 1 2017, In : PloS one. 12, 3, e0172577.

Research output: Contribution to journalArticle

African Americans
Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
9 Citations (Scopus)

Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations

Petry, C. J., Mooslehner, K., Prentice, P., Hayes, M. G., Nodzenski, M., Scholtens, D. M., Hughes, I. A., Acerini, C. L., Ong, K. K., Lowe, W. L. & Dunger, D. B., Sep 2017, In : Diabetes and Metabolism. 43, 4, p. 323-331 9 p.

Research output: Contribution to journalArticle

Alleles
Mothers
Glucose
Pregnancy
Single Nucleotide Polymorphism
25 Citations (Scopus)

Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes

Sandler, V., Reisetter, A. C., Bain, J. R., Muehlbauer, M. J., Nodzenski, M., Stevens, R. D., Ilkayeva, O., Lowe, L. P., Metzger, B. E., Newgard, C. B., Scholtens, D. M., Lowe, W. L. & for the HAPO Study Cooperative Research Group, T. HAPO. S. C. R. G., Mar 1 2017, In : Diabetologia. 60, 3, p. 518-530 13 p.

Research output: Contribution to journalArticle

Metabolome
Insulin Resistance
Mothers
Lipids
Adiposity
3 Citations (Scopus)

Genetic determinants of adiponectin regulation revealed by pregnancy

Hivert, M. F., Scholtens, D. M., Allard, C., Nodzenski, M., Bouchard, L., Brisson, D., Lowe, L. P., McDowell, I., Reddy, T., Dastani, Z., Richards, J. B., Hayes, M. G. & Lowe, W. L., May 2017, In : Obesity. 25, 5, p. 935-944 10 p.

Research output: Contribution to journalArticle

Adiponectin
Alleles
Pregnancy
Adipocytes
Leptin
18 Citations (Scopus)

Maternal BMI and glycemia impact the fetal metabolome

for the HAPO Study Cooperative Research Group, Jul 1 2017, In : Diabetes care. 40, 7, p. 902-910 9 p.

Research output: Contribution to journalArticle

Metabolome
Fetal Blood
Mothers
Newborn Infant
Metabolomics
15 Citations (Scopus)

Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data

Reisetter, A. C., Muehlbauer, M. J., Bain, J. R., Nodzenski, M., Stevens, R. D., Ilkayeva, O., Metzger, B. E., Newgard, C. B., Lowe Jr, W. L. & Scholtens, D. M., Feb 2 2017, In : BMC Bioinformatics. 18, 1, 84.

Research output: Contribution to journalArticle

Metabolomics
Gas Chromatography
Mass Spectrometry
Mixture Model
Gas chromatography
11 Citations (Scopus)

Targeted metabolomics demonstrates distinct and overlapping maternal metabolites associated with BMI, glucose, and insulin sensitivity during pregnancy across four ancestry groups

for the HAPO Study Cooperative Research Group, Jul 1 2017, In : Diabetes care. 40, 7, p. 911-919 9 p.

Research output: Contribution to journalArticle

Metabolomics
Insulin Resistance
Mothers
Phenotype
Glucose
4 Citations (Scopus)

Transversions have larger regulatory effects than transitions

Guo, C., McDowell, I. C., Nodzenski, M., Scholtens, D. M., Allen, A. S., Lowe Jr, W. L. & Reddy, T. E., May 19 2017, In : BMC Genomics. 18, 1, 1 p., 394.

Research output: Contribution to journalArticle

Transcription Factors
Gene Expression
DNA
DNA-Binding Proteins
Regulator Genes
37 Citations (Scopus)

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

the eMERGE Consortium, the DIAGRAM Consortium, the MuTHER Consortium, SIGMA T2D Consortium, the DIAGRAM Consortium, the MuTHER Consortium, SIGMA T2D Consortium, the MuTHER Consortium, SIGMA T2D Consortium, SIGMA T2D Consortium, MEDIA Consortium, the FIND Consortium, the eMERGE Consortium, the DIAGRAM Consortium, the MuTHER Consortium, SIGMA T2D Consortium, the eMERGE Consortium, the DIAGRAM Consortium, the MuTHER Consortium & SIGMA T2D Consortium, Jun 29 2017, In : Cell. 170, 1, p. 199-212.e20

Research output: Contribution to journalArticle

Medical problems
Type 2 Diabetes Mellitus
Haplotypes
CD147 Antigens
Mexico
2016
9 Citations (Scopus)

Associations between Fetal Imprinted Genes and Maternal Blood Pressure in Pregnancy

Petry, C. J., Sanz Marcos, N., Pimentel, G., Hayes, M. G., Nodzenski, M., Scholtens, D. M., Hughes, I. A., Acerini, C. L., Ong, K. K., Lowe Jr, W. L. & Dunger, D. B., Dec 1 2016, In : Hypertension. 68, 6, p. 1459-1466 8 p.

Research output: Contribution to journalArticle

Mothers
Blood Pressure
Fathers
Pregnancy
Genes
93 Citations (Scopus)

Genetic evidence for causal relationships between maternal obesity-related traits and birth weight

Tyrrell, J., Richmond, R. C., Palmer, T. M., Feenstra, B., Rangarajan, J., Metrustry, S., Cavadino, A., Paternoster, L., Armstrong, L. L., De Silva, N. M. G., Wood, A. R., Horikoshi, M., Geller, F., Myhre, R., Bradfield, J. P., Kreiner-Møller, E., Huikari, I., Painter, J. N., Hottenga, J. J., Allard, C. & 44 others, Berry, D. J., Bouchard, L., Das, S., Evans, D. M., Hakonarson, H., Hayes, M. G., Heikkinen, J., Hofman, A., Knight, B., Lind, P. A., McCarthy, M. I., McMahon, G., Medland, S. E., Melbye, M., Morris, A. P., Nodzenski, M., Reichetzeder, C., Ring, S. M., Sebert, S., Sengpiel, V., Sørensen, T. I. A., Willemsen, G., De Geus, E. J. C., Martin, N. G., Spector, T. D., Power, C., Järvelin, M. R., Bisgaard, H., Grant, S. F. A., Nohr, E. A., Jaddoe, V. W., Jacobsson, B., Murray, J. C., Hocher, B., Hattersley, A. T., Scholtens, D. M., Smith, G. D., Hivert, M. F., Felix, J. F., Hyppönen, E., Lowe, W. L., Frayling, T. M., Lawlor, D. A. & Freathy, R. M., Mar 15 2016, In : JAMA - Journal of the American Medical Association. 315, 11, p. 1129-1140 12 p.

Research output: Contribution to journalArticle

Birth Weight
Obesity
Mothers
Blood Pressure
Body Mass Index
28 Citations (Scopus)

Genetics of Gestational Diabetes Mellitus and Maternal Metabolism

Lowe, W. L., Scholtens, D. M., Sandler, V. & Hayes, M. G., Feb 1 2016, In : Current diabetes reports. 16, 2, p. 1-10 10 p., 15.

Research output: Contribution to journalReview article

Surrogate Mothers
Gestational Diabetes
Genes
Genome-Wide Association Study
Mothers
128 Citations (Scopus)

Genome-wide associations for birth weight and correlations with adult disease

Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-Tajes, J., Feenstra, B., Van Zuydam, N. R., Gaulton, K. J., Grarup, N., Bradfield, J. P., Strachan, D. P., Li-Gao, R., Ahluwalia, T. S., Kreiner, E., Rueedi, R., Lyytikaïnen, L. P., Cousminer, D. L., Wu, Y., Thiering, E. & 143 others, Wang, C. A., Have, C. T., Hottenga, J. J., Vilor-Tejedor, N., Joshi, P. K., Boh, E. T. H., Ntalla, I., Pitkänen, N., Mahajan, A., Van Leeuwen, E. M., Joro, R., Lagou, V., Nodzenski, M., Diver, L. A., Zondervan, K. T., Bustamante, M., Marques-Vidal, P., Mercader, J. M., Bennett, A. J., Rahmioglu, N., Nyholt, D. R., Ma, R. C. W., Tam, C. H. T., Tam, W. H., Ganesh, S. K., Van Rooij, F. J. A., Jones, S. E., Loh, P. R., Ruth, K. S., Tuke, M. A., Tyrrell, J., Wood, A. R., Yaghootkar, H., Scholtens, D. M., Paternoster, L., Prokopenko, I., Kovacs, P., Atalay, M., Willems, S. M., Panoutsopoulou, K., Wang, X., Carstensen, L., Geller, F., Schraut, K. E., Murcia, M., Van Beijsterveldt, C. E. M., Willemsen, G., Appel, E. V. R., Fonvig, C. E., Trier, C., Tiesler, C. M. T., Standl, M., Kutalik, Z., Bonàs-Guarch, S., Hougaard, D. M., Sánchez, F., Torrents, D., Waage, J., Hollegaard, M. V., De Haan, H. G., Rosendaal, F. R., Medina-Gomez, C., Ring, S. M., Hemani, G., McMahon, G., Robertson, N. R., Groves, C. J., Langenberg, C., Luan, JA., Scott, R. A., Zhao, J. H., Mentch, F. D., MacKenzie, S. M., Reynolds, R. M., Lowe Jr, W. L., Tönjes, A., Stumvoll, M., Lindi, V., Lakka, T. A., Van Duijn, C. M., Kiess, W., Körner, A., Sørensen, T. I. A., Niinikoski, H., Pahkala, K., Raitakari, O. T., Zeggini, E., Dedoussis, G. V., Teo, Y. Y., Saw, S. M., Melbye, M., Campbell, H., Wilson, J. F., Vrijheid, M., De Geus, E. J. C. N., Boomsma, D. I., Kadarmideen, H. N., Holm, J. C., Hansen, T., Sebert, S., Hattersley, A. T., Beilin, L. J., Newnham, J. P., Pennell, C. E., Heinrich, J., Adair, L. S., Borja, J. B., Mohlke, K. L., Eriksson, J. G., Widén, E., Kähönen, M., Viikari, J. S., Lehtimäki, T., Vollenweider, P., Bønnelykke, K., Bisgaard, H., Mook-Kanamori, D. O., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Pisinger, C., Pedersen, O., Power, C., Hyppönen, E., Wareham, N. J., Hakonarson, H., Davies, E., Walker, B. R., Jaddoe, V. W. V., Järvelin, M. R., Grant, S. F. A., Vaag, A. A., Lawlor, D. A., Frayling, T. M., Smith, G. D., Morris, A. P., Ong, K. K., Felix, J. F., Timpson, N. J., Perry, J. R. B., Evans, D. M., McCarthy, M. I. & Freathy, R. M., Jan 1 2016, In : Nature. 538, 7624, p. 248-252 5 p.

Research output: Contribution to journalArticle

Birth Weight
Genome
Type 2 Diabetes Mellitus
Blood Pressure
Chromatin Assembly and Disassembly
9 Citations (Scopus)

HKDC1 Is a novel hexokinase involved in Whole-Body glucose use

Ludvik, A. E., Pusec, C. M., Priyadarshini, M., Angueira, A. R., Guo, C., Lo, A., Hershenhouse, K. S., Yang, G. Y., Ding, X., Reddy, T. E., Lowe, W. L. & Layden, B. T., Sep 2016, In : Endocrinology. 157, 9, p. 3452-3461 10 p.

Research output: Contribution to journalArticle

Hexokinase
Glucose
Homeostasis
Glucose Tolerance Test
Pregnancy
22 Citations (Scopus)

Metabolic networks and metabolites underlie associations between maternal glucose during pregnancy and newborn size at birth

Scholtens, D. M., Bain, J. R., Reisetter, A. C., Muehlbauer, M. J., Nodzenski, M., Stevens, R. D., Ilkayeva, O., Lowe, L. P., Metzger, B. E., Newgard, C. B. & Lowe Jr, W. L., Jul 1 2016, In : Diabetes. 65, 7, p. 2039-2050 12 p.

Research output: Contribution to journalArticle

Metabolic Networks and Pathways
Mothers
Parturition
Glucose
Pregnancy

SLC30A8: A complex road from association to function

Flannick, J. & Lowe Jr, W. L., Jan 1 2016, The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation. Springer International Publishing, p. 379-401 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Medical problems
Type 2 Diabetes Mellitus
Genes
Genome-Wide Association Study
Secretory Vesicles
26 Citations (Scopus)

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin

Liu, C. T., Raghavan, S., Maruthur, N., Kabagambe, E. K., Hong, J., Ng, M. C. Y., Hivert, M. F., Lu, Y., An, P., Bentley, A. R., Drolet, A. M., Gaulton, K. J., Guo, X., Armstrong, L. L., Irvin, M. R., Li, M., Lipovich, L., Rybin, D. V., Taylor, K. D., Agyemang, C. & 95 others, Palmer, N. D., Cade, B. E., Chen, W. M., Dauriz, M., Delaney, J. A. C., Edwards, T. L., Evans, D. S., Evans, M. K., Lange, L. A., Leong, A., Liu, J., Liu, Y., Nayak, U., Patel, S. R., Porneala, B. C., Rasmussen-Torvik, L. J., Snijder, M. B., Stallings, S. C., Tanaka, T., Yanek, L. R., Zhao, W., Becker, D. M., Bielak, L. F., Biggs, M. L., Bottinger, E. P., Bowden, D. W., Chen, G., Correa, A., Couper, D. J., Crawford, D. C., Cushman, M., Eicher, J. D., Fornage, M., Franceschini, N., Fu, Y. P., Goodarzi, M. O., Gottesman, O., Hara, K., Harris, T. B., Jensen, R. A., Johnson, A. D., Jhun, M. A., Karter, A. J., Keller, M. F., Kho, A. N., Kizer, J. R., Krauss, R. M., Langefeld, C. D., Li, X., Liang, J., Liu, S., Lowe, W. L., Mosley, T. H., North, K. E., Pacheco, J. A., Peyser, P. A., Patrick, A. L., Rice, K. M., Selvin, E., Sims, M., Smith, J. A., Tajuddin, S. M., Vaidya, D., Wren, M. P., Yao, J., Zhu, X., Ziegler, J. T., Zmuda, J. M., Zonderman, A. B., Zwinderman, A. H., Adeyemo, A., Boerwinkle, E., Ferrucci, L., Hayes, M. G., Kardia, S. L. R., Miljkovic, I., Pankow, J. S., Rotimi, C. N., Sale, M. M., Wagenknecht, L. E., Arnett, D. K., Chen, Y. D. I., Nalls, M. A., Province, M. A., Kao, W. H. L., Siscovick, D. S., Psaty, B. M., Wilson, J. G., Loos, R. J. F., Dupuis, J., Rich, S. S., Florez, J. C., Rotter, J. I., Morris, A. P. & Meigs, J. B., Jul 7 2016, In : American Journal of Human Genetics. 99, 1, p. 56-75 20 p.

Research output: Contribution to journalArticle

Meta-Analysis
Fasting
Insulin
Glucose
Type 2 Diabetes Mellitus
2015
46 Citations (Scopus)

A novel common variant in DCST2 is associated with length in early life and height in adulthood

van der Valk, R. J. P., Kreiner-Møller, E., Kooijman, M. N., Guxens, M., Stergiakouli, E., Sääf, A., Bradfield, J. P., Geller, F., Geoffrey Hayes, M., Cousminer, D. L., Körner, A., Thiering, E., Curtin, J. A., Myhre, R., Huikari, V., Joro, R., Kerkhof, M., Warrington, N. M., Pitkänen, N., Ntalla, I. & 33 others, Horikoshi, M., Veijola, R., Freathy, R. M., Teo, Y. Y., Barton, S. J., Evans, D. M., Kemp, J. P., Pourcain, B. S., Ring, S. M., Smith, G. D., Bergström, A., Kull, I., Hakonarson, H., Mentch, F. D., Bisgaard, H., Chawes, B., Stokholm, J., Waage, J., Eriksen, P., Sevelsted, A., Melbye, M., van Duijn, C. M., Medina-Gomez, C., Hofman, A., de Jongste, J. C., Rob Taal, H., Uitterlinden, A. G., Armstrong, L. L., Eriksson, J., Lowe, W. L., Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium, Genetic Investigation of ANthropometric Traits (GIANT) Consortium & for the Early Growth Genetics (EGG) Consortium, Feb 15 2015, In : Human molecular genetics. 24, 4, p. 1155-1168 14 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Parturition
Genome
Cell Fusion
Genome-Wide Association Study
42 Citations (Scopus)

Characterization of large structural genetic mosaicism in human autosomes

Machiela, M. J., Zhou, W., Sampson, J. N., Dean, M. C., Jacobs, K. B., Black, A., Brinton, L. A., Chang, I. S., Chen, C., Chen, C., Chen, K., Cook, L. S., Crous Bou, M., De Vivo, I., Doherty, J., Friedenreich, C. M., Gaudet, M. M., Haiman, C. A., Hankinson, S. E., Hartge, P. & 179 others, Henderson, B. E., Hong, Y. C., Hosgood, H. D., Hsiung, C. A., Hu, W., Hunter, D. J., Jessop, L., Kim, H. N., Kim, Y. H., Kim, Y. T., Klein, R., Kraft, P., Lan, Q., Lin, D., Liu, J., Le Marchand, L., Liang, X., Lissowska, J., Lu, L., Magliocco, A. M., Matsuo, K., Olson, S. H., Orlow, I., Park, J. Y., Pooler, L., Prescott, J., Rastogi, R., Risch, H. A., Schumacher, F., Seow, A., Setiawan, V. W., Shen, H., Sheng, X., Shin, M. H., Shu, X. O., Vanden Berg, D., Wang, J. C., Wentzensen, N., Wong, M. P., Wu, C., Wu, T., Wu, Y. L., Xia, L., Yang, H. P., Yang, P. C., Zheng, W., Zhou, B., Abnet, C. C., Albanes, D., Aldrich, M. C., Amos, C., Amundadottir, L. T., Berndt, S. I., Blot, W. J., Bock, C. H., Bracci, P. M., Burdett, L., Buring, J. E., Butler, M. A., Carreón, T., Chatterjee, N., Chung, C. C., Cook, M. B., Cullen, M., Davis, F. G., Ding, T., Duell, E. J., Epstein, C. G., Fan, J. H., Figueroa, J. D., Fraumeni, J. F., Freedman, N. D., Fuchs, C. S., Gao, Y. T., Gapstur, S. M., Patiño-Garcia, A., Garcia-Closas, M., Gaziano, J. M., Giles, G. G., Gillanders, E. M., Giovannucci, E. L., Goldin, L., Goldstein, A. M., Greene, M. H., Hallmans, G., Harris, C. C., Henriksson, R., Holly, E. A., Hoover, R. N., Hu, N., Hutchinson, A., Jenab, M., Johansen, C., Khaw, K. T., Koh, W. P., Kolonel, L. N., Kooperberg, C., Krogh, V., Kurtz, R. C., Lacroix, A., Landgren, A., Landi, M. T., Li, D., Liao, L. M., Malats, N., McGlynn, K. A., McNeill, L. H., McWilliams, R. R., Melin, B. S., Mirabello, L., Peplonska, B., Peters, U., Petersen, G. M., Prokunina-Olsson, L., Purdue, M., Qiao, Y. L., Rabe, K. G., Rajaraman, P., Real, F. X., Riboli, E., Rodríguez-Santiago, B., Rothman, N., Ruder, A. M., Savage, S. A., Schwartz, A. G., Schwartz, K. L., Sesso, H. D., Severi, G., Silverman, D. T., Spitz, M. R., Stevens, V. L., Stolzenberg-Solomon, R., Stram, D., Tang, Z. Z., Taylor, P. R., Teras, L. R., Tobias, G. S., Viswanathan, K., Wacholder, S., Wang, Z., Weinstein, S. J., Wheeler, W., White, E., Wiencke, J. K., Wolpin, B. M., Wu, X., Wunder, J. S., Yu, K., Zanetti, K. A., Zeleniuch-Jacquotte, A., Ziegler, R. G., De Andrade, M., Barnes, K. C., Beaty, T. H., Bierut, L. J., Desch, K. C., Doheny, K. F., Feenstra, B., Ginsburg, D., Heit, J. A., Kang, J. H., Laurie, C. A., Li, J. Z., Lowe, W. L., Marazita, M. L., Melbye, M., Mirel, D. B., Murray, J. C., Nelson, S. C., Pasquale, L. R., Rice, K., Wiggs, J. L., Wise, A., Tucker, M., Pérez-Jurado, L. A., Laurie, C. C., Caporaso, N. E., Yeager, M. & Chanock, S. J., Mar 5 2015, In : American Journal of Human Genetics. 96, 3, p. 487-497 11 p.

Research output: Contribution to journalArticle

Mosaicism
Genome-Wide Association Study
Meta-Analysis
Genome
Population
25 Citations (Scopus)

Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1

Guo, C., Ludvik, A. E., Arlotto, M. E., Hayes, M. G., Armstrong, L. L., Scholtens, D. M., Brown, C. D., Newgard, C. B., Becker, T. C., Layden, B. T., Lowe, W. L. & Reddy, T. E., Feb 4 2015, In : Nature communications. 6, 6069.

Research output: Contribution to journalArticle

hexokinase
hyperglycemia
Hexokinase
glucose
Hyperglycemia
30 Citations (Scopus)

Genomic approaches for understanding the genetics of complex disease

Lowe Jr, W. L. & Reddy, T. E., Oct 1 2015, In : Genome Research. 25, 10, p. 1432-1441 10 p.

Research output: Contribution to journalReview article

Inborn Genetic Diseases
Phenotype
Genetic Association Studies
Human Genome
Haplotypes
36 Citations (Scopus)

Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort

Vockley, C. M., Guo, C., Majoros, W. H., Nodzenski, M., Scholtens, D. M., Hayes, M. G., Lowe, W. L. & Reddy, T. E., Aug 1 2015, In : Genome Research. 25, 8, p. 1206-1214 9 p.

Research output: Contribution to journalArticle

Haplotypes
Quantitative Trait Loci
Linkage Disequilibrium
Reporter Genes
Phenotype
40 Citations (Scopus)

New insights into gestational glucose metabolism: Lessons learned from 21st century approaches

Angueira, A. R., Ludvik, A. E., Reddy, T. E., Wicksteed, B., Lowe Jr, W. L. & Layden, B. T., Feb 1 2015, In : Diabetes. 64, 2, p. 327-334 8 p.

Research output: Contribution to journalArticle

Gestational Diabetes
Glucose
Pregnancy
Type 2 Diabetes Mellitus
Metabolomics
16 Citations (Scopus)

The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis

Fuller, M., Priyadarshini, M., Gibbons, S. M., Angueira, A. R., Brodsky, M., Geoffrey Hayes, M., Kovatcheva-Datchary, P., Bäckhed, F., Gilbert, J. A., Lowe, W. L. & Layden, B. T., Jan 1 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 309, 10, p. 840-851 12 p.

Research output: Contribution to journalArticle

Volatile Fatty Acids
Nonesterified Fatty Acids
Homeostasis
Glucose
Pregnancy
2014
22 Citations (Scopus)

Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds

Hlavaty, K. A., Gibly, R. F., Zhang, X., Rives, C. B., Graham, J. G., Lowe, W. L., Luo, X. & Shea, L. D., Jan 1 2014, In : American Journal of Transplantation. 14, 7, p. 1523-1532 10 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Transplantation
Somatomedins
Transplants
Proteins
10 Citations (Scopus)

Genetic risk score for prediction of newborn adiposity and large-for-gestational-age birth

Chawla, R., Badon, S. E., Rangarajan, J., Reisetter, A. C., Armstrong, L. L., Lowe, L. P., Urbanek, M., Metzger, B. E., Hayes, M. G., Scholtens, D. M. & Lowe, W. L., Nov 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 11, p. E2377-E2386

Research output: Contribution to journalArticle

Adiposity
Polymorphism
Gestational Age
Single Nucleotide Polymorphism
Nucleotides
28 Citations (Scopus)

Genetics, genomics and metabolomics: New insights into maternal metabolism during pregnancy

Lowe Jr, W. L. & Karban, J., Mar 1 2014, In : Diabetic Medicine. 31, 3, p. 254-262 9 p.

Research output: Contribution to journalReview article

Metabolomics
Genomics
Mothers
Pregnancy
Type 2 Diabetes Mellitus
43 Citations (Scopus)

Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk

Quilter, C. R., Cooper, W. N., Cliffe, K. M., Skinner, B. M., Prentice, P. M., Nelson, L. D., Bauer, J., Ong, K. K., Constância, M., Lowe Jr, W. L., Affara, N. A. & Dunger, D. B., Nov 1 2014, In : FASEB Journal. 28, 11, p. 4868-4879 12 p.

Research output: Contribution to journalArticle

Methylation
Gestational Diabetes
Medical problems
Type 2 Diabetes Mellitus
Genes
94 Citations (Scopus)

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

Ng, M. C. Y., Shriner, D., Chen, B. H., Li, J., Chen, W. M., Guo, X., Liu, J., Bielinski, S. J., Yanek, L. R., Nalls, M. A., Comeau, M. E., Rasmussen-Torvik, L. J., Jensen, R. A., Evans, D. S., Sun, Y. V., An, P., Patel, S. R., Lu, Y., Long, J., Armstrong, L. L. & 32 others, Wagenknecht, L., Yang, L., Snively, B. M., Palmer, N. D., Mudgal, P., Langefeld, C. D., Keene, K. L., Freedman, B. I., Mychaleckyj, J. C., Nayak, U., Raffel, L. J., Goodarzi, M. O., Chen, Y. D. I., Taylor, H. A., Correa, A., Sims, M., Couper, D., Pankow, J. S., Boerwinkle, E., Adeyemo, A., Doumatey, A., Hayes, M. G., Starren, J., Chisholm, R. L., Greenland, P., Kho, A. N., Lowe, W. L., Smith, M. E., Thompson, W. K., Cornelis, M., The MAGIC investigators & The GIANT consortium, Aug 7 2014, In : PLoS genetics. 10, 8, e1004517.

Research output: Contribution to journalArticle

diabetes
African American
Genome-Wide Association Study
meta-analysis
African Americans
53 Citations (Scopus)

Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy

Scholtens, D. M., Muehlbauer, M. J., Daya, N. R., Stevens, R. D., Dyer, A. R., Lowe, L. P., Metzger, B. E., Newgard, C. B., Bain, J. R. & Lowe Jr, W. L., Jan 1 2014, In : Diabetes Care. 37, 1, p. 158-166 9 p.

Research output: Contribution to journalArticle

Metabolomics
Fasting
Glucose
Pregnancy
Amino Acids
11 Citations (Scopus)

Metabomxtr: An R package for mixture-model analysis of non-targeted metabolomics data

Nodzenski, M., Muehlbauer, M. J., Bain, J. R., Reisetter, A. C., Lowe Jr, W. L. & Scholtens, D. M., Jan 1 2014, In : Bioinformatics. 30, 22, p. 3287-3288 2 p.

Research output: Contribution to journalArticle

Metabolomics
Model Analysis
Metabolites
Mixture Model
Software

The chromosome 3q25 locus associated with fetal adiposity is not associated with childhood adiposity

Chawla, R., McCance, D. R., McKenna, S., Young, I. S., Patterson, C. C., Rangarajan, J., Reisetter, A. C., Armstrong, L. L., Lowe, L. P., Metzger, B. E., Hayes, M. G., Scholtens, D. M. & Lowe, W. L., Jan 1 2014, In : Nutrition and Diabetes. 4, 9, e138.

Research output: Contribution to journalArticle

Adiposity
Chromosomes
Newborn Infant
Genome-Wide Association Study
Parturition
2013
31 Citations (Scopus)

Collagen IV-modified scaffolds improve islet survival and function and reduce time to euglycemia

Yap, W. T., Salvay, D. M., Silliman, M. A., Zhang, X., Bannon, Z. G., Kaufman, D. B., Lowe Jr, W. L. & Shea, L. D., Jan 1 2013, In : Tissue Engineering - Part A. 19, 21-22, p. 2361-2372 12 p.

Research output: Contribution to journalArticle

Scaffolds (biology)
Collagen
Scaffolds
Islets of Langerhans Transplantation
Insulin
1 Citation (Scopus)

Erratum: Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies (Diabetes (2013) 62 (3282-3291))

Hayes, M. G., Urbanek, M., Hivert, M. F., Armstrong, L. L., Morrison, J., Guo, C., Lowe, L. P., Scheftner, D. A., Pluzhnikov, A., Levine, D. M., McHugh, C. P., Ackerman, C. M., Bouchard, L., Brisson, D., Layden, B. T., Mirel, D., Doheny, K. F., Leya, M. V., Lown-Hecht, R. N., Dyer, A. R. & 4 others, Metzger, B. E., Reddy, T. E., Cox, N. J. & Lowe, W. L., Oct 1 2013, In : Diabetes. 62, 10, 1 p.

Research output: Contribution to journalComment/debate

Genome-Wide Association Study
Pregnancy
Genes
44 Citations (Scopus)

Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies

Hayes, M. G., Urbanek, M., Hivert, M. F., Armstrong, L. L., Morrison, J., Guo, C., Lowe, L. P., Scheftner, D. A., Pluzhnikov, A., Levine, D. M., McHugh, C. P., Ackerman, C. M., Bouchard, L., Brisson, D., Layden, B. T., Mirel, D., Doheny, K. F., Leya, M. V., Lown-Hecht, R. N., Dyer, A. R. & 4 others, Metzger, B. E., Reddy, T. E., Cox, N. J. & Lowe, W. L., Sep 1 2013, In : Diabetes. 62, 9, p. 3282-3291 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Mothers
Pregnancy
Glucose
Genes
5 Citations (Scopus)
C-Peptide
Pregnancy Outcome
Hyperglycemia
Testosterone
Mothers
16 Citations (Scopus)

Porous scaffolds support extrahepatic human islet transplantation, engraftment, and function in mice

Gibly, R. F., Zhang, X., Lowe Jr, W. L. & Shea, L. D., Apr 24 2013, In : Cell transplantation. 22, 5, p. 811-819 9 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Scaffolds
Grafts
Transplants
Medical problems
12 Citations (Scopus)

"Prediction is very hard, especially about the future": New biomarkers for type 2 diabetes?

Lowe Jr, W. L. & Bain, J. R., May 1 2013, In : Diabetes. 62, 5, p. 1384-1385 2 p.

Research output: Contribution to journalComment/debate

Glucose Metabolism Disorders
Hydroxybutyrates
Phosphatidylcholines
Type 2 Diabetes Mellitus
Insulin Resistance
104 Citations (Scopus)

Short chain fatty acids and their receptors: New metabolic targets

Layden, B. T., Angueira, A. R., Brodsky, M., Durai, V. & Lowe, W. L., Jan 1 2013, In : Translational Research. 161, 3, p. 131-140 10 p.

Research output: Contribution to journalReview article

Volatile Fatty Acids
Metabolism
Carboxylic Acids
Tail
Salvaging