William L Lowe Jr

  • 6489 Citations
1981 …2024

Research output per year

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Research Output

2020

Bayesian estimation of genetic regulatory effects in high-throughput reporter assays

Majoros, W. H., Kim, Y. S., Barrera, A., Li, F., Wang, X., Cunningham, S. J., Johnson, G. D., Guo, C., Lowe, W. L., Scholtens, D. M., Hayes, M. G., Reddy, T. E. & Allen, A. S., Jan 15 2020, In : Bioinformatics (Oxford, England). 36, 2, p. 331-338 8 p.

Research output: Contribution to journalArticle

2019

Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries

HAPO Study Cooperative Research Group, Oct 1 2019, In : The Journal of clinical endocrinology and metabolism. 104, 10, p. 4459-4472 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Gestational Diabetes and Childhood Obesity - Reply

Lowe Jr, W. L., Scholtens, D. M. & Metzger, B. E., Feb 19 2019, In : JAMA - Journal of the American Medical Association. 321, 7, p. 708-709 2 p.

Research output: Contribution to journalLetter

Hyperglycemia and adverse Pregnancy Outcome follow-up study (HAPO FUS): Maternal glycemia and childhood glucose metabolism

the HAPO Follow-up Study Cooperative Research Group, Mar 1 2019, In : Diabetes care. 42, 3, p. 381-392 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Hyperglycemia and adverse Pregnancy Outcome follow-up study (HAPO FUS): Maternal gestational diabetes mellitus and childhood glucose metabolism

on behalf of the HAPO Follow-up Study Cooperative Research Group*, Mar 1 2019, In : Diabetes care. 42, 3, p. 372-380 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Maternal glucose levels during pregnancy and childhood adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study

on behalf of the HAPO Follow-up Study Cooperative Research Group, Apr 1 2019, In : Diabetologia. 62, 4, p. 598-610 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries

for the HAPO Study Cooperative Research Group, Mar 1 2019, In : Diabetologia. 62, 3, p. 473-484 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

Liu, X., Helenius, D., Skotte, L., Beaumont, R. N., Wielscher, M., Geller, F., Juodakis, J., Mahajan, A., Bradfield, J. P., Lin, F. T. J., Vogelezang, S., Bustamante, M., Ahluwalia, T. S., Pitkänen, N., Wang, C. A., Bacelis, J., Borges, M. C., Zhang, G., Bedell, B. A., Rossi, R. M. & 54 others, Skogstrand, K., Peng, S., Thompson, W. K., Appadurai, V., Lawlor, D. A., Kalliala, I., Power, C., McCarthy, M. I., Boyd, H. A., Marazita, M. L., Hakonarson, H., Hayes, M. G., Scholtens, D. M., Rivadeneira, F., Jaddoe, V. W. V., Vinding, R. K., Bisgaard, H., Knight, B. A., Pahkala, K., Raitakari, O., Helgeland, Ø., Johansson, S., Njølstad, P. R., Fadista, J., Schork, A. J., Nudel, R., Miller, D. E., Chen, X., Weirauch, M. T., Mortensen, P. B., Børglum, A. D., Nordentoft, M., Mors, O., Hao, K., Ryckman, K. K., Hougaard, D. M., Kottyan, L. C., Pennell, C. E., Lyytikainen, L. P., Bønnelykke, K., Vrijheid, M., Felix, J. F., Lowe, W. L., Grant, S. F. A., Hyppönen, E., Jacobsson, B., Jarvelin, M. R., Muglia, L. J., Murray, J. C., Freathy, R. M., Werge, T. M., Melbye, M., Buil, A. & Feenstra, B., Dec 1 2019, In : Nature communications. 10, 1, 3927.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Association of gestational diabetes with maternal disorders of glucose metabolism and childhood adiposity

HAPO Follow-up Study Cooperative Research, Sep 11 2018, In : JAMA - Journal of the American Medical Association. 320, 10, p. 1005-1016 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Genetic determinants of glycemic traits and the risk of gestational diabetes mellitus

Powe, C. E., Nodzenski, M., Talbot, O., Allard, C., Briggs, C., Leya, M. V., Perron, P., Bouchard, L., Florez, J. C., Scholtens, D. M., Lowe, W. L. & Hivert, M. F., Dec 1 2018, In : Diabetes. 67, 12, p. 2703-2709 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Early Growth Genetics (EGG) Consortium, Feb 15 2018, In : Human molecular genetics. 27, 4, p. 742-756 15 p., ddx429.

Research output: Contribution to journalArticle

48 Scopus citations

Maternal and fetal genetic contribution to gestational weight gain

Warrington, N. M., Richmond, R., Fenstra, B., Myhre, R., Gaillard, R., Paternoster, L., Wang, C. A., Beaumont, R. N., Das, S., Murcia, M., Barton, S. J., Espinosa, A., Thiering, E., Atalay, M., Pitkänen, N., Ntalla, I., Jonsson, A. E., Freathy, R., Karhunen, V., Tiesler, C. M. T. & 44 others, Allard, C., Crawford, A., Ring, S. M., Melbye, M., Magnus, P., Rivadeneira, F., Skotte, L., Hansen, T., Marsh, J., Guxens, M., Holloway, J. W., Grallert, H., Jaddoe, V. W. V., Lowe, W. L., Roumeliotaki, T., Hattersley, A. T., Lindi, V., Pahkala, K., Panoutsopoulou, K., Standl, M., Flexeder, C., Bouchard, L., Aagaard Nohr, E., Santa Marina, L., Kogevinas, M., Niinikoski, H., Dedoussis, G., Heinrich, J., Reynolds, R. M., Lakka, T., Zeggini, E., Raitakari, O. T., Chatzi, L., Inskip, H. M., Bustamante, M., Hivert, M. F., Jarvelin, M. R., Sørensen, T. I. A., Pennell, C., Felix, J. F., Jacobsson, B., Geller, F., Evans, D. M. & Lawlor, D. A., Apr 1 2018, In : International Journal of Obesity. 42, 4, p. 775-784 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women

MEDIA Consortium, Mar 1 2017, In : PloS one. 12, 3, e0172577.

Research output: Contribution to journalArticle

3 Scopus citations

Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations

Petry, C. J., Mooslehner, K., Prentice, P., Hayes, M. G., Nodzenski, M., Scholtens, D. M., Hughes, I. A., Acerini, C. L., Ong, K. K., Lowe, W. L. & Dunger, D. B., Sep 2017, In : Diabetes and Metabolism. 43, 4, p. 323-331 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes

Sandler, V., Reisetter, A. C., Bain, J. R., Muehlbauer, M. J., Nodzenski, M., Stevens, R. D., Ilkayeva, O., Lowe, L. P., Metzger, B. E., Newgard, C. B., Scholtens, D. M., Lowe, W. L. & for the HAPO Study Cooperative Research Group, T. HAPO. S. C. R. G., Mar 1 2017, In : Diabetologia. 60, 3, p. 518-530 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Genetic determinants of adiponectin regulation revealed by pregnancy

Hivert, M. F., Scholtens, D. M., Allard, C., Nodzenski, M., Bouchard, L., Brisson, D., Lowe, L. P., McDowell, I., Reddy, T., Dastani, Z., Richards, J. B., Hayes, M. G. & Lowe, W. L., May 2017, In : Obesity. 25, 5, p. 935-944 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Maternal BMI and glycemia impact the fetal metabolome

for the HAPO Study Cooperative Research Group, Jul 1 2017, In : Diabetes care. 40, 7, p. 902-910 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data

Reisetter, A. C., Muehlbauer, M. J., Bain, J. R., Nodzenski, M., Stevens, R. D., Ilkayeva, O., Metzger, B. E., Newgard, C. B., Lowe, W. L. & Scholtens, D. M., Feb 2 2017, In : BMC bioinformatics. 18, 1, 84.

Research output: Contribution to journalArticle

16 Scopus citations

Targeted metabolomics demonstrates distinct and overlapping maternal metabolites associated with BMI, glucose, and insulin sensitivity during pregnancy across four ancestry groups

for the HAPO Study Cooperative Research Group, Jul 1 2017, In : Diabetes care. 40, 7, p. 911-919 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Transversions have larger regulatory effects than transitions

Guo, C., McDowell, I. C., Nodzenski, M., Scholtens, D. M., Allen, A. S., Lowe Jr, W. L. & Reddy, T. E., May 19 2017, In : BMC Genomics. 18, 1, 1 p., 394.

Research output: Contribution to journalArticle

5 Scopus citations

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

the eMERGE Consortium, the DIAGRAM Consortium, the MuTHER Consortium, SIGMA T2D Consortium, the DIAGRAM Consortium, the MuTHER Consortium, SIGMA T2D Consortium, the MuTHER Consortium, SIGMA T2D Consortium, SIGMA T2D Consortium, MEDIA Consortium, the FIND Consortium, the eMERGE Consortium, the DIAGRAM Consortium, the MuTHER Consortium, SIGMA T2D Consortium, the eMERGE Consortium, the DIAGRAM Consortium, the MuTHER Consortium & SIGMA T2D Consortium, Jun 29 2017, In : Cell. 170, 1, p. 199-212.e20

Research output: Contribution to journalArticle

49 Scopus citations
2016

Associations between Fetal Imprinted Genes and Maternal Blood Pressure in Pregnancy

Petry, C. J., Sanz Marcos, N., Pimentel, G., Hayes, M. G., Nodzenski, M., Scholtens, D. M., Hughes, I. A., Acerini, C. L., Ong, K. K., Lowe Jr, W. L. & Dunger, D. B., Dec 1 2016, In : Hypertension. 68, 6, p. 1459-1466 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Genetic evidence for causal relationships between maternal obesity-related traits and birth weight

Tyrrell, J., Richmond, R. C., Palmer, T. M., Feenstra, B., Rangarajan, J., Metrustry, S., Cavadino, A., Paternoster, L., Armstrong, L. L., De Silva, N. M. G., Wood, A. R., Horikoshi, M., Geller, F., Myhre, R., Bradfield, J. P., Kreiner-Møller, E., Huikari, I., Painter, J. N., Hottenga, J. J., Allard, C. & 44 others, Berry, D. J., Bouchard, L., Das, S., Evans, D. M., Hakonarson, H., Hayes, M. G., Heikkinen, J., Hofman, A., Knight, B., Lind, P. A., McCarthy, M. I., McMahon, G., Medland, S. E., Melbye, M., Morris, A. P., Nodzenski, M., Reichetzeder, C., Ring, S. M., Sebert, S., Sengpiel, V., Sørensen, T. I. A., Willemsen, G., De Geus, E. J. C., Martin, N. G., Spector, T. D., Power, C., Järvelin, M. R., Bisgaard, H., Grant, S. F. A., Nohr, E. A., Jaddoe, V. W., Jacobsson, B., Murray, J. C., Hocher, B., Hattersley, A. T., Scholtens, D. M., Smith, G. D., Hivert, M. F., Felix, J. F., Hyppönen, E., Lowe, W. L., Frayling, T. M., Lawlor, D. A. & Freathy, R. M., Mar 15 2016, In : JAMA - Journal of the American Medical Association. 315, 11, p. 1129-1140 12 p.

Research output: Contribution to journalArticle

98 Scopus citations

Genetics of Gestational Diabetes Mellitus and Maternal Metabolism

Lowe, W. L., Scholtens, D. M., Sandler, V. & Hayes, M. G., Feb 1 2016, In : Current diabetes reports. 16, 2, p. 1-10 10 p., 15.

Research output: Contribution to journalReview article

30 Scopus citations

Genome-wide associations for birth weight and correlations with adult disease

Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-Tajes, J., Feenstra, B., Van Zuydam, N. R., Gaulton, K. J., Grarup, N., Bradfield, J. P., Strachan, D. P., Li-Gao, R., Ahluwalia, T. S., Kreiner, E., Rueedi, R., Lyytikaïnen, L. P., Cousminer, D. L., Wu, Y., Thiering, E. & 143 others, Wang, C. A., Have, C. T., Hottenga, J. J., Vilor-Tejedor, N., Joshi, P. K., Boh, E. T. H., Ntalla, I., Pitkänen, N., Mahajan, A., Van Leeuwen, E. M., Joro, R., Lagou, V., Nodzenski, M., Diver, L. A., Zondervan, K. T., Bustamante, M., Marques-Vidal, P., Mercader, J. M., Bennett, A. J., Rahmioglu, N., Nyholt, D. R., Ma, R. C. W., Tam, C. H. T., Tam, W. H., Ganesh, S. K., Van Rooij, F. J. A., Jones, S. E., Loh, P. R., Ruth, K. S., Tuke, M. A., Tyrrell, J., Wood, A. R., Yaghootkar, H., Scholtens, D. M., Paternoster, L., Prokopenko, I., Kovacs, P., Atalay, M., Willems, S. M., Panoutsopoulou, K., Wang, X., Carstensen, L., Geller, F., Schraut, K. E., Murcia, M., Van Beijsterveldt, C. E. M., Willemsen, G., Appel, E. V. R., Fonvig, C. E., Trier, C., Tiesler, C. M. T., Standl, M., Kutalik, Z., Bonàs-Guarch, S., Hougaard, D. M., Sánchez, F., Torrents, D., Waage, J., Hollegaard, M. V., De Haan, H. G., Rosendaal, F. R., Medina-Gomez, C., Ring, S. M., Hemani, G., McMahon, G., Robertson, N. R., Groves, C. J., Langenberg, C., Luan, JA., Scott, R. A., Zhao, J. H., Mentch, F. D., MacKenzie, S. M., Reynolds, R. M., Lowe Jr, W. L., Tönjes, A., Stumvoll, M., Lindi, V., Lakka, T. A., Van Duijn, C. M., Kiess, W., Körner, A., Sørensen, T. I. A., Niinikoski, H., Pahkala, K., Raitakari, O. T., Zeggini, E., Dedoussis, G. V., Teo, Y. Y., Saw, S. M., Melbye, M., Campbell, H., Wilson, J. F., Vrijheid, M., De Geus, E. J. C. N., Boomsma, D. I., Kadarmideen, H. N., Holm, J. C., Hansen, T., Sebert, S., Hattersley, A. T., Beilin, L. J., Newnham, J. P., Pennell, C. E., Heinrich, J., Adair, L. S., Borja, J. B., Mohlke, K. L., Eriksson, J. G., Widén, E., Kähönen, M., Viikari, J. S., Lehtimäki, T., Vollenweider, P., Bønnelykke, K., Bisgaard, H., Mook-Kanamori, D. O., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Pisinger, C., Pedersen, O., Power, C., Hyppönen, E., Wareham, N. J., Hakonarson, H., Davies, E., Walker, B. R., Jaddoe, V. W. V., Järvelin, M. R., Grant, S. F. A., Vaag, A. A., Lawlor, D. A., Frayling, T. M., Smith, G. D., Morris, A. P., Ong, K. K., Felix, J. F., Timpson, N. J., Perry, J. R. B., Evans, D. M., McCarthy, M. I. & Freathy, R. M., Jan 1 2016, In : Nature. 538, 7624, p. 248-252 5 p.

Research output: Contribution to journalArticle

141 Scopus citations

HKDC1 Is a novel hexokinase involved in Whole-Body glucose use

Ludvik, A. E., Pusec, C. M., Priyadarshini, M., Angueira, A. R., Guo, C., Lo, A., Hershenhouse, K. S., Yang, G. Y., Ding, X., Reddy, T. E., Lowe, W. L. & Layden, B. T., Sep 2016, In : Endocrinology. 157, 9, p. 3452-3461 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Metabolic networks and metabolites underlie associations between maternal glucose during pregnancy and newborn size at birth

Scholtens, D. M., Bain, J. R., Reisetter, A. C., Muehlbauer, M. J., Nodzenski, M., Stevens, R. D., Ilkayeva, O., Lowe, L. P., Metzger, B. E., Newgard, C. B. & Lowe, W. L., Jul 1 2016, In : Diabetes. 65, 7, p. 2039-2050 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

SLC30A8: A complex road from association to function

Flannick, J. & Lowe, W. L., Jan 1 2016, The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation. Springer International Publishing, p. 379-401 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin

Liu, C. T., Raghavan, S., Maruthur, N., Kabagambe, E. K., Hong, J., Ng, M. C. Y., Hivert, M. F., Lu, Y., An, P., Bentley, A. R., Drolet, A. M., Gaulton, K. J., Guo, X., Armstrong, L. L., Irvin, M. R., Li, M., Lipovich, L., Rybin, D. V., Taylor, K. D., Agyemang, C. & 95 others, Palmer, N. D., Cade, B. E., Chen, W. M., Dauriz, M., Delaney, J. A. C., Edwards, T. L., Evans, D. S., Evans, M. K., Lange, L. A., Leong, A., Liu, J., Liu, Y., Nayak, U., Patel, S. R., Porneala, B. C., Rasmussen-Torvik, L. J., Snijder, M. B., Stallings, S. C., Tanaka, T., Yanek, L. R., Zhao, W., Becker, D. M., Bielak, L. F., Biggs, M. L., Bottinger, E. P., Bowden, D. W., Chen, G., Correa, A., Couper, D. J., Crawford, D. C., Cushman, M., Eicher, J. D., Fornage, M., Franceschini, N., Fu, Y. P., Goodarzi, M. O., Gottesman, O., Hara, K., Harris, T. B., Jensen, R. A., Johnson, A. D., Jhun, M. A., Karter, A. J., Keller, M. F., Kho, A. N., Kizer, J. R., Krauss, R. M., Langefeld, C. D., Li, X., Liang, J., Liu, S., Lowe, W. L., Mosley, T. H., North, K. E., Pacheco, J. A., Peyser, P. A., Patrick, A. L., Rice, K. M., Selvin, E., Sims, M., Smith, J. A., Tajuddin, S. M., Vaidya, D., Wren, M. P., Yao, J., Zhu, X., Ziegler, J. T., Zmuda, J. M., Zonderman, A. B., Zwinderman, A. H., Adeyemo, A., Boerwinkle, E., Ferrucci, L., Hayes, M. G., Kardia, S. L. R., Miljkovic, I., Pankow, J. S., Rotimi, C. N., Sale, M. M., Wagenknecht, L. E., Arnett, D. K., Chen, Y. D. I., Nalls, M. A., Province, M. A., Kao, W. H. L., Siscovick, D. S., Psaty, B. M., Wilson, J. G., Loos, R. J. F., Dupuis, J., Rich, S. S., Florez, J. C., Rotter, J. I., Morris, A. P. & Meigs, J. B., Jul 7 2016, In : American journal of human genetics. 99, 1, p. 56-75 20 p.

Research output: Contribution to journalArticle

28 Scopus citations
2015

A novel common variant in DCST2 is associated with length in early life and height in adulthood

van der Valk, R. J. P., Kreiner-Møller, E., Kooijman, M. N., Guxens, M., Stergiakouli, E., Sääf, A., Bradfield, J. P., Geller, F., Geoffrey Hayes, M., Cousminer, D. L., Körner, A., Thiering, E., Curtin, J. A., Myhre, R., Huikari, V., Joro, R., Kerkhof, M., Warrington, N. M., Pitkänen, N., Ntalla, I. & 33 others, Horikoshi, M., Veijola, R., Freathy, R. M., Teo, Y. Y., Barton, S. J., Evans, D. M., Kemp, J. P., Pourcain, B. S., Ring, S. M., Smith, G. D., Bergström, A., Kull, I., Hakonarson, H., Mentch, F. D., Bisgaard, H., Chawes, B., Stokholm, J., Waage, J., Eriksen, P., Sevelsted, A., Melbye, M., van Duijn, C. M., Medina-Gomez, C., Hofman, A., de Jongste, J. C., Rob Taal, H., Uitterlinden, A. G., Armstrong, L. L., Eriksson, J., Lowe, W. L., Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium, Genetic Investigation of ANthropometric Traits (GIANT) Consortium & for the Early Growth Genetics (EGG) Consortium, Feb 15 2015, In : Human molecular genetics. 24, 4, p. 1155-1168 14 p.

Research output: Contribution to journalArticle

49 Scopus citations

Characterization of large structural genetic mosaicism in human autosomes

Machiela, M. J., Zhou, W., Sampson, J. N., Dean, M. C., Jacobs, K. B., Black, A., Brinton, L. A., Chang, I. S., Chen, C., Chen, C., Chen, K., Cook, L. S., Crous Bou, M., De Vivo, I., Doherty, J., Friedenreich, C. M., Gaudet, M. M., Haiman, C. A., Hankinson, S. E., Hartge, P. & 179 others, Henderson, B. E., Hong, Y. C., Hosgood, H. D., Hsiung, C. A., Hu, W., Hunter, D. J., Jessop, L., Kim, H. N., Kim, Y. H., Kim, Y. T., Klein, R., Kraft, P., Lan, Q., Lin, D., Liu, J., Le Marchand, L., Liang, X., Lissowska, J., Lu, L., Magliocco, A. M., Matsuo, K., Olson, S. H., Orlow, I., Park, J. Y., Pooler, L., Prescott, J., Rastogi, R., Risch, H. A., Schumacher, F., Seow, A., Setiawan, V. W., Shen, H., Sheng, X., Shin, M. H., Shu, X. O., Vanden Berg, D., Wang, J. C., Wentzensen, N., Wong, M. P., Wu, C., Wu, T., Wu, Y. L., Xia, L., Yang, H. P., Yang, P. C., Zheng, W., Zhou, B., Abnet, C. C., Albanes, D., Aldrich, M. C., Amos, C., Amundadottir, L. T., Berndt, S. I., Blot, W. J., Bock, C. H., Bracci, P. M., Burdett, L., Buring, J. E., Butler, M. A., Carreón, T., Chatterjee, N., Chung, C. C., Cook, M. B., Cullen, M., Davis, F. G., Ding, T., Duell, E. J., Epstein, C. G., Fan, J. H., Figueroa, J. D., Fraumeni, J. F., Freedman, N. D., Fuchs, C. S., Gao, Y. T., Gapstur, S. M., Patiño-Garcia, A., Garcia-Closas, M., Gaziano, J. M., Giles, G. G., Gillanders, E. M., Giovannucci, E. L., Goldin, L., Goldstein, A. M., Greene, M. H., Hallmans, G., Harris, C. C., Henriksson, R., Holly, E. A., Hoover, R. N., Hu, N., Hutchinson, A., Jenab, M., Johansen, C., Khaw, K. T., Koh, W. P., Kolonel, L. N., Kooperberg, C., Krogh, V., Kurtz, R. C., Lacroix, A., Landgren, A., Landi, M. T., Li, D., Liao, L. M., Malats, N., McGlynn, K. A., McNeill, L. H., McWilliams, R. R., Melin, B. S., Mirabello, L., Peplonska, B., Peters, U., Petersen, G. M., Prokunina-Olsson, L., Purdue, M., Qiao, Y. L., Rabe, K. G., Rajaraman, P., Real, F. X., Riboli, E., Rodríguez-Santiago, B., Rothman, N., Ruder, A. M., Savage, S. A., Schwartz, A. G., Schwartz, K. L., Sesso, H. D., Severi, G., Silverman, D. T., Spitz, M. R., Stevens, V. L., Stolzenberg-Solomon, R., Stram, D., Tang, Z. Z., Taylor, P. R., Teras, L. R., Tobias, G. S., Viswanathan, K., Wacholder, S., Wang, Z., Weinstein, S. J., Wheeler, W., White, E., Wiencke, J. K., Wolpin, B. M., Wu, X., Wunder, J. S., Yu, K., Zanetti, K. A., Zeleniuch-Jacquotte, A., Ziegler, R. G., De Andrade, M., Barnes, K. C., Beaty, T. H., Bierut, L. J., Desch, K. C., Doheny, K. F., Feenstra, B., Ginsburg, D., Heit, J. A., Kang, J. H., Laurie, C. A., Li, J. Z., Lowe, W. L., Marazita, M. L., Melbye, M., Mirel, D. B., Murray, J. C., Nelson, S. C., Pasquale, L. R., Rice, K., Wiggs, J. L., Wise, A., Tucker, M., Pérez-Jurado, L. A., Laurie, C. C., Caporaso, N. E., Yeager, M. & Chanock, S. J., Mar 5 2015, In : American journal of human genetics. 96, 3, p. 487-497 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1

Guo, C., Ludvik, A. E., Arlotto, M. E., Hayes, M. G., Armstrong, L. L., Scholtens, D. M., Brown, C. D., Newgard, C. B., Becker, T. C., Layden, B. T., Lowe, W. L. & Reddy, T. E., Feb 4 2015, In : Nature communications. 6, 6069.

Research output: Contribution to journalArticle

28 Scopus citations

Genomic approaches for understanding the genetics of complex disease

Lowe Jr, W. L. & Reddy, T. E., Oct 1 2015, In : Genome Research. 25, 10, p. 1432-1441 10 p.

Research output: Contribution to journalReview article

33 Scopus citations

Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort

Vockley, C. M., Guo, C., Majoros, W. H., Nodzenski, M., Scholtens, D. M., Hayes, M. G., Lowe, W. L. & Reddy, T. E., Aug 1 2015, In : Genome Research. 25, 8, p. 1206-1214 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

New insights into gestational glucose metabolism: Lessons learned from 21st century approaches

Angueira, A. R., Ludvik, A. E., Reddy, T. E., Wicksteed, B., Lowe, W. L. & Layden, B. T., Feb 1 2015, In : Diabetes. 64, 2, p. 327-334 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis

Fuller, M., Priyadarshini, M., Gibbons, S. M., Angueira, A. R., Brodsky, M., Geoffrey Hayes, M., Kovatcheva-Datchary, P., Bäckhed, F., Gilbert, J. A., Lowe, W. L. & Layden, B. T., Jan 1 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 309, 10, p. 840-851 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2014

Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds

Hlavaty, K. A., Gibly, R. F., Zhang, X., Rives, C. B., Graham, J. G., Lowe, W. L., Luo, X. & Shea, L. D., Jul 2014, In : American Journal of Transplantation. 14, 7, p. 1523-1532 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Genetic risk score for prediction of newborn adiposity and large-for-gestational-age birth

Chawla, R., Badon, S. E., Rangarajan, J., Reisetter, A. C., Armstrong, L. L., Lowe, L. P., Urbanek, M., Metzger, B. E., Hayes, M. G., Scholtens, D. M. & Lowe, W. L., Nov 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 11, p. E2377-E2386

Research output: Contribution to journalArticle

10 Scopus citations

Genetics, genomics and metabolomics: New insights into maternal metabolism during pregnancy

Lowe Jr, W. L. & Karban, J., Mar 1 2014, In : Diabetic Medicine. 31, 3, p. 254-262 9 p.

Research output: Contribution to journalReview article

29 Scopus citations

Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk

Quilter, C. R., Cooper, W. N., Cliffe, K. M., Skinner, B. M., Prentice, P. M., Nelson, L., Bauer, J., Ong, K. K., Constância, M., Lowe, W. L., Affara, N. A. & Dunger, D. B., Nov 1 2014, In : FASEB Journal. 28, 11, p. 4868-4879 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

Ng, M. C. Y., Shriner, D., Chen, B. H., Li, J., Chen, W. M., Guo, X., Liu, J., Bielinski, S. J., Yanek, L. R., Nalls, M. A., Comeau, M. E., Rasmussen-Torvik, L. J., Jensen, R. A., Evans, D. S., Sun, Y. V., An, P., Patel, S. R., Lu, Y., Long, J., Armstrong, L. L. & 32 others, Wagenknecht, L., Yang, L., Snively, B. M., Palmer, N. D., Mudgal, P., Langefeld, C. D., Keene, K. L., Freedman, B. I., Mychaleckyj, J. C., Nayak, U., Raffel, L. J., Goodarzi, M. O., Chen, Y. D. I., Taylor, H. A., Correa, A., Sims, M., Couper, D., Pankow, J. S., Boerwinkle, E., Adeyemo, A., Doumatey, A., Hayes, M. G., Starren, J., Chisholm, R. L., Greenland, P., Kho, A. N., Lowe, W. L., Smith, M. E., Thompson, W. K., Cornelis, M., The MAGIC investigators & The GIANT consortium, Aug 7 2014, In : PLoS genetics. 10, 8, e1004517.

Research output: Contribution to journalArticle

103 Scopus citations

Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy

Scholtens, D. M., Muehlbauer, M. J., Daya, N. R., Stevens, R. D., Dyer, A. R., Lowe, L. P., Metzger, B. E., Newgard, C. B., Bain, J. R. & Lowe Jr, W. L., Jan 1 2014, In : Diabetes Care. 37, 1, p. 158-166 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Metabomxtr: An R package for mixture-model analysis of non-targeted metabolomics data

Nodzenski, M., Muehlbauer, M. J., Bain, J. R., Reisetter, A. C., Lowe Jr, W. L. & Scholtens, D. M., Feb 27 2014, In : Bioinformatics. 30, 22, p. 3287-3288 2 p.

Research output: Contribution to journalArticle

12 Scopus citations

The chromosome 3q25 locus associated with fetal adiposity is not associated with childhood adiposity

Chawla, R., McCance, D. R., McKenna, S., Young, I. S., Patterson, C. C., Rangarajan, J., Reisetter, A. C., Armstrong, L. L., Lowe, L. P., Metzger, B. E., Hayes, M. G., Scholtens, D. M. & Lowe, W. L., Jan 1 2014, In : Nutrition and Diabetes. 4, 9, e138.

Research output: Contribution to journalArticle

2013

Collagen IV-modified scaffolds improve islet survival and function and reduce time to euglycemia

Yap, W. T., Salvay, D. M., Silliman, M. A., Zhang, X., Bannon, Z. G., Kaufman, D. B., Lowe, W. L. & Shea, L. D., Jan 1 2013, In : Tissue Engineering - Part A. 19, 21-22, p. 2361-2372 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

Erratum: Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies (Diabetes (2013) 62 (3282-3291))

Hayes, M. G., Urbanek, M., Hivert, M. F., Armstrong, L. L., Morrison, J., Guo, C., Lowe, L. P., Scheftner, D. A., Pluzhnikov, A., Levine, D. M., McHugh, C. P., Ackerman, C. M., Bouchard, L., Brisson, D., Layden, B. T., Mirel, D., Doheny, K. F., Leya, M. V., Lown-Hecht, R. N., Dyer, A. R. & 4 others, Metzger, B. E., Reddy, T. E., Cox, N. J. & Lowe, W. L., Oct 1 2013, In : Diabetes. 62, 10, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies

Hayes, M. G., Urbanek, M., Hivert, M. F., Armstrong, L. L., Morrison, J., Guo, C., Lowe, L. P., Scheftner, D. A., Pluzhnikov, A., Levine, D. M., McHugh, C. P., Ackerman, C. M., Bouchard, L., Brisson, D., Layden, B. T., Mirel, D., Doheny, K. F., Leya, M. V., Lown-Hecht, R. N., Dyer, A. R. & 4 others, Metzger, B. E., Reddy, T. E., Cox, N. J. & Lowe, W. L., Sep 1 2013, In : Diabetes. 62, 9, p. 3282-3291 10 p.

Research output: Contribution to journalArticle

48 Scopus citations
5 Scopus citations

Porous scaffolds support extrahepatic human islet transplantation, engraftment, and function in mice

Gibly, R. F., Zhang, X., Lowe Jr, W. L. & Shea, L. D., Apr 24 2013, In : Cell transplantation. 22, 5, p. 811-819 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

"Prediction is very hard, especially about the future": New biomarkers for type 2 diabetes?

Lowe Jr, W. L. & Bain, J. R., May 1 2013, In : Diabetes. 62, 5, p. 1384-1385 2 p.

Research output: Contribution to journalComment/debate

12 Scopus citations