William L Lowe Jr

  • 6906 Citations
1981 …2020

Research output per year

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Research Output

2013

Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies

Hayes, M. G., Urbanek, M., Hivert, M. F., Armstrong, L. L., Morrison, J., Guo, C., Lowe, L. P., Scheftner, D. A., Pluzhnikov, A., Levine, D. M., McHugh, C. P., Ackerman, C. M., Bouchard, L., Brisson, D., Layden, B. T., Mirel, D., Doheny, K. F., Leya, M. V., Lown-Hecht, R. N., Dyer, A. R. & 4 others, Metzger, B. E., Reddy, T. E., Cox, N. J. & Lowe, W. L., Sep 1 2013, In : Diabetes. 62, 9, p. 3282-3291 10 p.

Research output: Contribution to journalArticle

52 Scopus citations
5 Scopus citations

Porous scaffolds support extrahepatic human islet transplantation, engraftment, and function in mice

Gibly, R. F., Zhang, X., Lowe Jr, W. L. & Shea, L. D., Apr 24 2013, In : Cell transplantation. 22, 5, p. 811-819 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

"Prediction is very hard, especially about the future": New biomarkers for type 2 diabetes?

Lowe Jr, W. L. & Bain, J. R., May 1 2013, In : Diabetes. 62, 5, p. 1384-1385 2 p.

Research output: Contribution to journalComment/debate

12 Scopus citations

Short chain fatty acids and their receptors: New metabolic targets

Layden, B. T., Angueira, A. R., Brodsky, M., Durai, V. & Lowe, W. L., Jan 1 2013, In : Translational Research. 161, 3, p. 131-140 10 p.

Research output: Contribution to journalReview article

124 Scopus citations

The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study

Urbanek, M., Hayes, M. G., Armstrong, L. L., Morrison, J., Lowe, L. P., Badon, S. E., Scheftner, D., Pluzhnikov, A., Levine, D., Laurie, C. C., McHugh, C., Ackerman, C. M., Mirel, D. B., Doheny, K. F., Guo, C., Scholtens, D. M., Dyer, A. R., Metzger, B. E., Reddy, T. E., Cox, N. J. & 1 others, Lowe, W. L., Sep 1 2013, In : Human molecular genetics. 22, 17, p. 3583-3596 14 p., ddt168.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Accumulation of cadmium in insulin-producing β cells

Muayed, M. E., Raja, M. R., Zhang, X., MacRenaris, K. W., Bhatt, S., Chen, X., Urbanek, M., O'Halloran, T. V. & Lowe, W. L., Nov 2012, In : Islets. 4, 6, p. 405-416 12 p.

Research output: Contribution to journalArticle

45 Scopus citations

Detectable clonal mosaicism from birth to old age and its relationship to cancer

Laurie, C. C., Laurie, C. A., Rice, K., Doheny, K. F., Zelnick, L. R., McHugh, C. P., Ling, H., Hetrick, K. N., Pugh, E. W., Amos, C., Wei, Q., Wang, L. E., Lee, J. E., Barnes, K. C., Hansel, N. N., Mathias, R., Daley, D., Beaty, T. H., Scott, A. F., Ruczinski, I. & 53 others, Scharpf, R. B., Bierut, L. J., Hartz, S. M., Landi, M. T., Freedman, N. D., Goldin, L. R., Ginsburg, D., Li, J., Desch, K. C., Strom, S. S., Blot, W. J., Signorello, L. B., Ingles, S. A., Chanock, S. J., Berndt, S. I., Le Marchand, L., Henderson, B. E., Monroe, K. R., Heit, J. A., De Andrade, M., Armasu, S. M., Regnier, C., Lowe, W. L., Hayes, M. G., Marazita, M. L., Feingold, E., Murray, J. C., Melbye, M., Feenstra, B., Kang, J. H., Wiggs, J. L., Jarvik, G. P., McDavid, A. N., Seshan, V. E., Mirel, D. B., Crenshaw, A., Sharopova, N., Wise, A., Shen, J., Crosslin, D. R., Levine, D. M., Zheng, X., Udren, J. I., Bennett, S., Nelson, S. C., Gogarten, S. M., Conomos, M. P., Heagerty, P., Manolio, T., Pasquale, L. R., Haiman, C. A., Caporaso, N. & Weir, B. S., Jun 2012, In : Nature Genetics. 44, 6, p. 642-650 9 p.

Research output: Contribution to journalArticle

300 Scopus citations

Ethnic variation in allele distribution of the androgen receptor (AR) (CAG) n repeat

Ackerman, C. M., Lowe, L. P., Lee, H., Hayes, M. G., Dyer, A. R., Metzger, B. E., Lowe, W. L. & Urbanek, M., Mar 1 2012, In : Journal of Andrology. 33, 2, p. 210-215 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5- CHRNA3-CHRNB4) interacts with maternal selfreported smoking status during pregnancy to influence birth weight

Tyrrell, J., Huikari, V., Christie, J. T., Cavadino, A., Bakker, R., Brion, M. J. A., Geller, F., Paternoster, L., Myhre, R., Potter, C., Johnson, P. C. D., Ebrahim, S., Feenstra, B., Hartikainen, A. L., Hattersley, A. T., Hofman, A., Kaakinen, M., Lowe, L. P., Magnus, P., McConnachie, A. & 23 others, Melbye, M., Ng, J. W. Y., Nohr, E. A., Power, C., Ring, S. M., Sebert, S. P., Sengpiel, V., Taal, H. R., Watt, G. C. M., Sattar, N., Relton, C. L., Jacobsson, B., Frayling, T. M., Sørensen, T. I. A., Murray, J. C., Lawlor, D. A., Pennell, C. E., Jaddoe, V. W. V., Hypponen, E., Lowe, W. L., Jarvelin, M. R., Smith, G. D. & Freathy, R. M., Dec 2012, In : Human molecular genetics. 21, 24, p. 5344-5358 15 p., dds372.

Research output: Contribution to journalArticle

42 Scopus citations

Negative association of acetate with visceral adipose tissue and insulin levels

Layden, B. T., Yalamanchi, S. K., Wolever, T. M. S., Dunaif, A. & Lowe, W. L., Jan 1 2012, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 5, p. 49-55 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy

Urbanek, M., Hayes, M. G., Lee, H., Freathy, R. M., Lowe, L. P., Ackerman, C., Jafari, N., Dyer, A. R., Cox, N. J., Dunger, D. B., Hattersley, A. T., Metzger, B. E. & Lowe, W. L., Mar 30 2012, In : PloS one. 7, 3, e32958.

Research output: Contribution to journalArticle

19 Scopus citations

Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study

Kho, A. N., Hayes, M. G., Rasmussen-Torvik, L., Pacheco, J. A., Thompson, W. K., Armstrong, L. L., Denny, J. C., Peissig, P. L., Miller, A. W., Wei, W. Q., Bielinski, S. J., Chute, C. G., Leibson, C. L., Jarvik, G. P., Crosslin, D. R., Carlson, C. S., Newton, K. M., Wolf, W. A., Chisholm, R. L. & Lowe, W. L., Mar 1 2012, In : Journal of the American Medical Informatics Association. 19, 2, p. 212-218 7 p.

Research output: Contribution to journalArticle

162 Scopus citations
2011

Advancing islet transplantation: From engraftment to the immune response

Gibly, R. F., Graham, J. G., Luo, X., Lowe, W. L., Hering, B. J. & Shea, L. D., Oct 1 2011, In : Diabetologia. 54, 10, p. 2494-2505 12 p.

Research output: Contribution to journalReview article

74 Scopus citations

Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine models

Gibly, R. F., Zhang, X., Graham, M. L., Hering, B. J., Kaufman, D. B., Lowe Jr, W. L. & Shea, L. D., Dec 1 2011, In : Biomaterials. 32, 36, p. 9677-9684 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Gene-environment interplay in common complex diseases: Forging an integrative model-Recommendations from an NIH workshop

Bookman, E. B., McAllister, K., Gillanders, E., Wanke, K., Balshaw, D., Rutter, J., Reedy, J., Shaughnessy, D., Agurs-Collins, T., Paltoo, D., Atienza, A., Bierut, L., Kraft, P., Fallin, M. D., Perera, F., Turkheimer, E., Boardman, J., Marazita, M. L., Rappaport, S. M., Boerwinkle, E. & 13 others, Suomi, S. J., Caporaso, N. E., Hertz-Picciotto, I., Jacobson, K. C., Lowe Jr, W. L., Goldman, L. R., Duggal, P., Gunnar, M. R., Manolio, T. A., Green, E. D., Olster, D. H., Birnbaum, L. S. & Gunnar, M. R., 2011, In : Genetic Epidemiology. 35, 4, p. 217-225 9 p.

Research output: Contribution to journalArticle

71 Scopus citations

Genome partitioning of genetic variation for complex traits using common SNPs

Yang, J., Manolio, T. A., Pasquale, L. R., Boerwinkle, E., Caporaso, N., Cunningham, J. M., De Andrade, M., Feenstra, B., Feingold, E., Hayes, M. G., Hill, W. G., Landi, M. T., Alonso, A., Lettre, G., Lin, P., Ling, H., Lowe, W., Mathias, R. A., Melbye, M., Pugh, E. & 4 others, Cornelis, M. C., Weir, B. S., Goddard, M. E. & Visscher, P. M., Jun 2011, In : Nature Genetics. 43, 6, p. 519-525 7 p.

Research output: Contribution to journalArticle

532 Scopus citations

Phenotype harmonization and cross-study collaboration in GWAS consortia: The GENEVA experience

Bennett, S. N., Caporaso, N., Fitzpatrick, A. L., Agrawal, A., Barnes, K., Boyd, H. A., Cornelis, M. C., Hansel, N. N., Heiss, G., Heit, J. A., Kang, J. H., Kittner, S. J., Kraft, P., Lowe, W., Marazita, M. L., Monroe, K. R., Pasquale, L. R., Ramos, E. M., van Dam, R. M., Udren, J. & 1 others, Williams, K., Apr 1 2011, In : Genetic Epidemiology. 35, 3, p. 159-173 15 p.

Research output: Contribution to journalArticle

33 Scopus citations

The beta and alpha cell-specific Znt8-knockout mouse model: New mechanistic insights?

El Muayed, M. & Lowe, W. L., Jan 1 2011, In : Diabetologia. 54, 1, p. 207-208 2 p.

Research output: Contribution to journalLetter

2010

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic β-cell function

El Muayed, M., Billings, L. K., Raja, M. R., Zhang, X., Park, P. J., Newman, M. V., Kaufman, D. B., O'Halloran, T. V. & Lowe, W. L., Aug 1 2010, In : Journal of Endocrinology. 206, 2, p. 159-169 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic β-cell function (Journal of Endocrinology (2010) 206 (159-169))

Muayed, M. E., Billings, L. K., Raja, M. R., Zhang, X., Park, P. J., Newman, M. V., Kaufman, D. B., O'Halloran, T. V. & Lowe, W. L., Sep 1 2010, In : Journal of Endocrinology. 206, 3, 1 p.

Research output: Contribution to journalComment/debate

Anti-inflammatory peptide-functionalized hydrogels for insulin-secreting cell encapsulation

Su, J., Hu, B. H., Lowe, W. L., Kaufman, D. B. & Messersmith, P. B., Jan 1 2010, In : Biomaterials. 31, 2, p. 308-314 7 p.

Research output: Contribution to journalArticle

118 Scopus citations

G protein coupled receptors in embryonic stem cells: A role for Gs-alpha signaling

Layden, B. T., Newman, M., Chen, F., Fisher, A. & Lowe, W. L., Feb 8 2010, In : PloS one. 5, 2, e9105.

Research output: Contribution to journalArticle

25 Scopus citations
64 Scopus citations
90 Scopus citations

Regulation of pancreatic islet gene expression in mouse islets by pregnancy

Layden, B. T., Durai, V., Newman, M. V., Marinelarena, A. M., Ahn, C. W., Feng, G., Lin, S., Zhang, X., Kaufman, D. B., Jafari, N., Sørensen, G. L. & Lowe, W. L., Dec 1 2010, In : Journal of Endocrinology. 207, 3, p. 265-279 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

The role of the polycystic ovary syndrome susceptibility locus D19S884 allele 8 in maternal glycemia and fetal size

Ackerman, C. M., Lowe, L. P., Lee, H., Chen, F., Hughes, E., Cholod, P., Dyer, A. R., Hayes, M. G., Metzger, B. E., Lowe, W. L. & Urbanek, M., Jul 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 7, p. 3242-3250 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2009

Layered PLG scaffolds for in vivo plasmid delivery

Rives, C. B., Rieux, A. D., Zelivyanskaya, M., Stock, S. R., Lowe, W. L. & Shea, L. D., Jan 1 2009, In : Biomaterials. 30, 3, p. 394-401 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

The association between pulse wave velocity and metabolic syndrome and adiponectin in patients with impaired fasting glucose: Cardiovascular risks and adiponectin in IFG

Nam, J. S., Park, J. S., Cho, M. H., Jee, S. H., Lee, H. S., Ahn, C. W., Lowe Jr, W. L. & Kim, K. R., May 1 2009, In : Diabetes Research and Clinical Practice. 84, 2, p. 145-151 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation

Salvay, D. M., Rives, C. B., Zhang, X., Chen, F., Kaufman, D. B., Lowe Jr, W. L. & Shea, L. D., May 27 2008, In : Transplantation. 85, 10, p. 1456-1464 9 p.

Research output: Contribution to journalArticle

94 Scopus citations

Rapamycin inhibits growth factor-induced cell cycle regulation in pancreatic β cells

Aronovitz, A., Josefson, J., Fisher, A., Newman, M., Hughes, E., Chen, F., Moons, D. S., Kiyokawa, H. & Lowe, W. L., Dec 2008, In : Journal of Investigative Medicine. 56, 8, p. 985-996 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2006

Diabetes mellitus

Lowe Jr, W. L., Dec 1 2006, Principles of Molecular Medicine. Humana Press, p. 308-318 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation

Blomeier, H., Zhang, X., Rives, C., Brissova, M., Hughes, E., Baker, M., Powers, A. C., Kaufman, D. B., Shea, L. D. & Lowe, W. L., Aug 1 2006, In : Transplantation. 82, 4, p. 452-459 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Role of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expression

Chin-Chance, C. V. T., Newman, M. V., Aronovitz, A., Blomeier, H., Kruger, J., Lee, E. J. & Lowe Jr, W. L., Jan 1 2006, In : Journal of Investigative Medicine. 54, 3, p. 132-142 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2005

Growth factors

Leroith, D. & Lowe Jr, W. L., Dec 1 2005, Endocrinology: Basic and Clinical Principles: Second Edition. Humana Press, p. 85-91 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2003

Clinical islet transplantation

Kaufman, D. B. & Lowe, W. L., Aug 2003, In : Current diabetes reports. 3, 4, p. 344-350 7 p.

Research output: Contribution to journalReview article

13 Scopus citations

"The matrix unloaded": Implications for cytokine signaling in islets?

Lowe, W. L., Oct 1 2003, In : Endocrinology. 144, 10, p. 4262-4263 2 p.

Research output: Contribution to journalShort survey

2 Scopus citations
2002

Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic β-cell death

Wenli, L. I. U., Chin-Chance, C., Eun-Jig, L. E. E. & Lowe, W. L., Oct 1 2002, In : Endocrinology. 143, 10, p. 3802-3812 11 p.

Research output: Contribution to journalArticle

57 Scopus citations
2001

Genetics of Diabetes Mellitus

Lowe Jr, W. L., 2001, Boston: Kluwer Academic Publishers.

Research output: Book/ReportBook

Heritability of obesity-related traits among Nigerians, Jamaicans and US black people

Luke, A., Guo, X., Adeyemo, A. A., Wilks, R., Forrester, T., Lowe, W., Comuzzie, A. G., Martin, L. J., Zhu, X., Rotimi, C. N. & Cooper, R. S., Jul 4 2001, In : International Journal of Obesity. 25, 7, p. 1034-1041 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes

Shoba, L. N. N., Newman, M., Liu, W. & Lowe, W. L., Jan 1 2001, In : Endocrinology. 142, 9, p. 3980-3986 7 p.

Research output: Contribution to journalArticle

29 Scopus citations
64 Scopus citations

The β3-adrenergic receptor gene and obesity in a population sample of African Americans

Lowe, W. L., Rotimi, C. N., Luke, A., Guo, X., Zhu, X., Comuzzie, A. G., Schuh, T. S., Halbach, S., Kotlar, T. J. & Cooper, R. S., Feb 20 2001, In : International Journal of Obesity. 25, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
2000

Abnormal glucose metabolism and pancreatic cancer mortality

Gapstur, S. M., Gann, P. H., Lowe, W., Liu, K., Colangelo, L. & Dyer, A., May 17 2000, In : Journal of the American Medical Association. 283, 19, p. 2552-2558 7 p.

Research output: Contribution to journalArticle

319 Scopus citations

Activation of members of the mitogen-activated protein kinase family by glucose in endothelial cells

Liu, W., Schoenkerman, A. & Lowe Jr, W. L., Oct 1 2000, In : American Journal of Physiology. 279, 4 PART 1, p. E782-E790

Research output: Contribution to journalArticle

59 Scopus citations

Insulin-like growth factor I activates c-Jun N-terminal kinase in MCF-7 breast cancer cells

Monno, S., Newman, M. V., Cook, M. & Lowe, J., Jan 1 2000, In : Endocrinology. 141, 2, p. 544-550 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Lack of association between the - 308 polymorphism of the tumor necrosis factor-α gene and the insulin resistance syndrome

Da Silva, B., Gapstur, S. M., Achenbach, Y. H., Schuh, T. S., Kotlar, T. J., Liu, K. & Lowe Jr, W. L., Jan 1 2000, In : Journal of Investigative Medicine. 48, 4, p. 236-244 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Normalization of hyperosmotic-induced inositol uptake by renal and endothelial cells is regulated by NF-κB

Yorek, M. A., Dunlap, J. A., Liu, W. & Lowe, W. L., 2000, In : American Journal of Physiology - Cell Physiology. 278, 5 47-5, p. C1011-C1018

Research output: Contribution to journalArticle

11 Scopus citations
3 Scopus citations
1999

Developmental regulation of insulin-like growth factor-I and growth hormone receptor gene expression

Shoba, L., An, M. R., Frank, S. J. & Lowe, W. L., Jun 25 1999, In : Molecular and Cellular Endocrinology. 152, 1-2, p. 125-136 12 p.

Research output: Contribution to journalArticle

41 Scopus citations