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Research Output 1981 2019

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Article
2019
5 Citations (Scopus)

Hyperglycemia and adverse Pregnancy Outcome follow-up study (HAPO FUS): Maternal gestational diabetes mellitus and childhood glucose metabolism

on behalf of the HAPO Follow-up Study Cooperative Research Group*, Mar 1 2019, In : Diabetes care. 42, 3, p. 372-380 9 p.

Research output: Contribution to journalArticle

Gestational Diabetes
Pregnancy Outcome
Hyperglycemia
Mothers
Glucose
6 Citations (Scopus)

Maternal glucose levels during pregnancy and childhood adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study

on behalf of the HAPO Follow-up Study Cooperative Research Group, Apr 1 2019, In : Diabetologia. 62, 4, p. 598-610 13 p.

Research output: Contribution to journalArticle

Adiposity
Pregnancy Outcome
Hyperglycemia
Mothers
Glucose

Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries

for the HAPO Study Cooperative Research Group, Mar 1 2019, In : Diabetologia. 62, 3, p. 473-484 12 p.

Research output: Contribution to journalArticle

Hyperinsulinism
Mothers
Newborn Infant
Pregnancy
C-Peptide
2018
22 Citations (Scopus)

Association of gestational diabetes with maternal disorders of glucose metabolism and childhood adiposity

HAPO Follow-up Study Cooperative Research, Sep 11 2018, In : JAMA - Journal of the American Medical Association. 320, 10, p. 1005-1016 12 p.

Research output: Contribution to journalArticle

Glucose Metabolism Disorders
Gestational Diabetes
Adiposity
Mothers
Odds Ratio
1 Citation (Scopus)

Genetic determinants of glycemic traits and the risk of gestational diabetes mellitus

Powe, C. E., Nodzenski, M., Talbot, O., Allard, C., Briggs, C., Leya, M. V., Perron, P., Bouchard, L., Florez, J. C., Scholtens, D. M., Lowe Jr, W. L. & Hivert, M. F., Dec 1 2018, In : Diabetes. 67, 12, p. 2703-2709 7 p.

Research output: Contribution to journalArticle

Gestational Diabetes
Fasting
Insulin
Type 2 Diabetes Mellitus
Pregnancy
30 Citations (Scopus)

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Early Growth Genetics (EGG) Consortium, Feb 15 2018, In : Human molecular genetics. 27, 4, p. 742-756 15 p., ddx429.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Birth Weight
Mothers
Fetal Development
Single Nucleotide Polymorphism
7 Citations (Scopus)

Maternal and fetal genetic contribution to gestational weight gain

Warrington, N. M., Richmond, R., Fenstra, B., Myhre, R., Gaillard, R., Paternoster, L., Wang, C. A., Beaumont, R. N., Das, S., Murcia, M., Barton, S. J., Espinosa, A., Thiering, E., Atalay, M., Pitkänen, N., Ntalla, I., Jonsson, A. E., Freathy, R., Karhunen, V., Tiesler, C. M. T. & 44 others, Allard, C., Crawford, A., Ring, S. M., Melbye, M., Magnus, P., Rivadeneira, F., Skotte, L., Hansen, T., Marsh, J., Guxens, M., Holloway, J. W., Grallert, H., Jaddoe, V. W. V., Lowe Jr, W. L., Roumeliotaki, T., Hattersley, A. T., Lindi, V., Pahkala, K., Panoutsopoulou, K., Standl, M., Flexeder, C., Bouchard, L., Aagaard Nohr, E., Santa Marina, L., Kogevinas, M., Niinikoski, H., Dedoussis, G., Heinrich, J., Reynolds, R. M., Lakka, T., Zeggini, E., Raitakari, O. T., Chatzi, L., Inskip, H. M., Bustamante, M., Hivert, M. F., Jarvelin, M. R., Sørensen, T. I. A., Pennell, C., Felix, J. F., Jacobsson, B., Geller, F., Evans, D. M. & Lawlor, D. A., Apr 1 2018, In : International Journal of Obesity. 42, 4, p. 775-784 10 p.

Research output: Contribution to journalArticle

Weight Gain
Mothers
Body Mass Index
Genome
Birth Weight
2017
3 Citations (Scopus)

A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women

MEDIA Consortium, Mar 1 2017, In : PloS one. 12, 3, e0172577.

Research output: Contribution to journalArticle

African Americans
Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
8 Citations (Scopus)

Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations

Petry, C. J., Mooslehner, K., Prentice, P., Hayes, M. G., Nodzenski, M., Scholtens, D. M., Hughes, I. A., Acerini, C. L., Ong, K. K., Lowe Jr, W. L. & Dunger, D. B., Sep 1 2017, In : Diabetes and Metabolism. 43, 4, p. 323-331 9 p.

Research output: Contribution to journalArticle

Alleles
Mothers
Glucose
Pregnancy
Single Nucleotide Polymorphism
19 Citations (Scopus)

Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes

Sandler, V., Reisetter, A. C., Bain, J. R., Muehlbauer, M. J., Nodzenski, M., Stevens, R. D., Ilkayeva, O., Lowe, L. P., Metzger, B. E., Newgard, C. B., Scholtens, D. M., Lowe Jr, W. L. & for the HAPO Study Cooperative Research Group, T. HAPO. S. C. R. G., Mar 1 2017, In : Diabetologia. 60, 3, p. 518-530 13 p.

Research output: Contribution to journalArticle

Metabolome
Insulin Resistance
Mothers
Lipids
Adiposity
3 Citations (Scopus)

Genetic determinants of adiponectin regulation revealed by pregnancy

Hivert, M. F., Scholtens, D. M., Allard, C., Nodzenski, M., Bouchard, L., Brisson, D., Lowe, L. P., McDowell, I., Reddy, T., Dastani, Z., Richards, J. B., Hayes, M. G. & Lowe Jr, W. L., May 1 2017, In : Obesity. 25, 5, p. 935-944 10 p.

Research output: Contribution to journalArticle

Adiponectin
Alleles
Pregnancy
Adipocytes
Leptin
16 Citations (Scopus)

Maternal BMI and glycemia impact the fetal metabolome

for the HAPO Study Cooperative Research Group, Jul 1 2017, In : Diabetes care. 40, 7, p. 902-910 9 p.

Research output: Contribution to journalArticle

Metabolome
Fetal Blood
Mothers
Newborn Infant
Metabolomics
13 Citations (Scopus)

Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data

Reisetter, A. C., Muehlbauer, M. J., Bain, J. R., Nodzenski, M., Stevens, R. D., Ilkayeva, O., Metzger, B. E., Newgard, C. B., Lowe Jr, W. L. & Scholtens, D. M., Feb 2 2017, In : BMC Bioinformatics. 18, 1, 84.

Research output: Contribution to journalArticle

Metabolomics
Gas Chromatography
Mass Spectrometry
Mixture Model
Gas chromatography
10 Citations (Scopus)

Targeted metabolomics demonstrates distinct and overlapping maternal metabolites associated with BMI, glucose, and insulin sensitivity during pregnancy across four ancestry groups

for the HAPO Study Cooperative Research Group, Jul 1 2017, In : Diabetes care. 40, 7, p. 911-919 9 p.

Research output: Contribution to journalArticle

Metabolomics
Insulin Resistance
Mothers
Phenotype
Glucose
3 Citations (Scopus)

Transversions have larger regulatory effects than transitions

Guo, C., McDowell, I. C., Nodzenski, M., Scholtens, D. M., Allen, A. S., Lowe Jr, W. L. & Reddy, T. E., May 19 2017, In : BMC Genomics. 18, 1, 1 p., 394.

Research output: Contribution to journalArticle

Transcription Factors
Gene Expression
DNA
DNA-Binding Proteins
Regulator Genes
31 Citations (Scopus)

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

the eMERGE Consortium, the DIAGRAM Consortium, the MuTHER Consortium, SIGMA T2D Consortium, the DIAGRAM Consortium, the MuTHER Consortium, SIGMA T2D Consortium, the MuTHER Consortium, SIGMA T2D Consortium, SIGMA T2D Consortium, MEDIA Consortium, the FIND Consortium, the eMERGE Consortium, the DIAGRAM Consortium, the MuTHER Consortium, SIGMA T2D Consortium, the eMERGE Consortium, the DIAGRAM Consortium, the MuTHER Consortium & SIGMA T2D Consortium, Jun 29 2017, In : Cell. 170, 1, p. 199-212.e20

Research output: Contribution to journalArticle

Medical problems
Type 2 Diabetes Mellitus
Haplotypes
CD147 Antigens
Mexico
2016
9 Citations (Scopus)

Associations between Fetal Imprinted Genes and Maternal Blood Pressure in Pregnancy

Petry, C. J., Sanz Marcos, N., Pimentel, G., Hayes, M. G., Nodzenski, M., Scholtens, D. M., Hughes, I. A., Acerini, C. L., Ong, K. K., Lowe Jr, W. L. & Dunger, D. B., Dec 1 2016, In : Hypertension. 68, 6, p. 1459-1466 8 p.

Research output: Contribution to journalArticle

Mothers
Blood Pressure
Fathers
Pregnancy
Genes
86 Citations (Scopus)

Genetic evidence for causal relationships between maternal obesity-related traits and birth weight

Tyrrell, J., Richmond, R. C., Palmer, T. M., Feenstra, B., Rangarajan, J., Metrustry, S., Cavadino, A., Paternoster, L., Armstrong, L. L., De Silva, N. M. G., Wood, A. R., Horikoshi, M., Geller, F., Myhre, R., Bradfield, J. P., Kreiner-Møller, E., Huikari, I., Painter, J. N., Hottenga, J. J., Allard, C. & 44 others, Berry, D. J., Bouchard, L., Das, S., Evans, D. M., Hakonarson, H., Hayes, M. G., Heikkinen, J., Hofman, A., Knight, B., Lind, P. A., McCarthy, M. I., McMahon, G., Medland, S. E., Melbye, M., Morris, A. P., Nodzenski, M., Reichetzeder, C., Ring, S. M., Sebert, S., Sengpiel, V., Sørensen, T. I. A., Willemsen, G., De Geus, E. J. C., Martin, N. G., Spector, T. D., Power, C., Järvelin, M. R., Bisgaard, H., Grant, S. F. A., Nohr, E. A., Jaddoe, V. W., Jacobsson, B., Murray, J. C., Hocher, B., Hattersley, A. T., Scholtens, D. M., Smith, G. D., Hivert, M. F., Felix, J. F., Hyppönen, E., Lowe, W. L., Frayling, T. M., Lawlor, D. A. & Freathy, R. M., Mar 15 2016, In : JAMA - Journal of the American Medical Association. 315, 11, p. 1129-1140 12 p.

Research output: Contribution to journalArticle

Birth Weight
Obesity
Mothers
Blood Pressure
Body Mass Index
110 Citations (Scopus)

Genome-wide associations for birth weight and correlations with adult disease

Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-Tajes, J., Feenstra, B., Van Zuydam, N. R., Gaulton, K. J., Grarup, N., Bradfield, J. P., Strachan, D. P., Li-Gao, R., Ahluwalia, T. S., Kreiner, E., Rueedi, R., Lyytikaïnen, L. P., Cousminer, D. L., Wu, Y., Thiering, E. & 143 others, Wang, C. A., Have, C. T., Hottenga, J. J., Vilor-Tejedor, N., Joshi, P. K., Boh, E. T. H., Ntalla, I., Pitkänen, N., Mahajan, A., Van Leeuwen, E. M., Joro, R., Lagou, V., Nodzenski, M., Diver, L. A., Zondervan, K. T., Bustamante, M., Marques-Vidal, P., Mercader, J. M., Bennett, A. J., Rahmioglu, N., Nyholt, D. R., Ma, R. C. W., Tam, C. H. T., Tam, W. H., Ganesh, S. K., Van Rooij, F. J. A., Jones, S. E., Loh, P. R., Ruth, K. S., Tuke, M. A., Tyrrell, J., Wood, A. R., Yaghootkar, H., Scholtens, D. M., Paternoster, L., Prokopenko, I., Kovacs, P., Atalay, M., Willems, S. M., Panoutsopoulou, K., Wang, X., Carstensen, L., Geller, F., Schraut, K. E., Murcia, M., Van Beijsterveldt, C. E. M., Willemsen, G., Appel, E. V. R., Fonvig, C. E., Trier, C., Tiesler, C. M. T., Standl, M., Kutalik, Z., Bonàs-Guarch, S., Hougaard, D. M., Sánchez, F., Torrents, D., Waage, J., Hollegaard, M. V., De Haan, H. G., Rosendaal, F. R., Medina-Gomez, C., Ring, S. M., Hemani, G., McMahon, G., Robertson, N. R., Groves, C. J., Langenberg, C., Luan, JA., Scott, R. A., Zhao, J. H., Mentch, F. D., MacKenzie, S. M., Reynolds, R. M., Lowe Jr, W. L., Tönjes, A., Stumvoll, M., Lindi, V., Lakka, T. A., Van Duijn, C. M., Kiess, W., Körner, A., Sørensen, T. I. A., Niinikoski, H., Pahkala, K., Raitakari, O. T., Zeggini, E., Dedoussis, G. V., Teo, Y. Y., Saw, S. M., Melbye, M., Campbell, H., Wilson, J. F., Vrijheid, M., De Geus, E. J. C. N., Boomsma, D. I., Kadarmideen, H. N., Holm, J. C., Hansen, T., Sebert, S., Hattersley, A. T., Beilin, L. J., Newnham, J. P., Pennell, C. E., Heinrich, J., Adair, L. S., Borja, J. B., Mohlke, K. L., Eriksson, J. G., Widén, E., Kähönen, M., Viikari, J. S., Lehtimäki, T., Vollenweider, P., Bønnelykke, K., Bisgaard, H., Mook-Kanamori, D. O., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Pisinger, C., Pedersen, O., Power, C., Hyppönen, E., Wareham, N. J., Hakonarson, H., Davies, E., Walker, B. R., Jaddoe, V. W. V., Järvelin, M. R., Grant, S. F. A., Vaag, A. A., Lawlor, D. A., Frayling, T. M., Smith, G. D., Morris, A. P., Ong, K. K., Felix, J. F., Timpson, N. J., Perry, J. R. B., Evans, D. M., McCarthy, M. I. & Freathy, R. M., Jan 1 2016, In : Nature. 538, 7624, p. 248-252 5 p.

Research output: Contribution to journalArticle

Birth Weight
Genome
Type 2 Diabetes Mellitus
Blood Pressure
Chromatin Assembly and Disassembly
9 Citations (Scopus)

HKDC1 Is a novel hexokinase involved in Whole-Body glucose use

Ludvik, A. E., Pusec, C. M., Priyadarshini, M., Angueira, A. R., Guo, C., Lo, A., Hershenhouse, K. S., Yang, G-Y., Ding, X., Reddy, T. E., Lowe Jr, W. L. & Layden, B. T., Sep 1 2016, In : Endocrinology. 157, 9, p. 3452-3461 10 p.

Research output: Contribution to journalArticle

Hexokinase
Glucose
Homeostasis
Glucose Tolerance Test
Pregnancy
19 Citations (Scopus)

Metabolic networks and metabolites underlie associations between maternal glucose during pregnancy and newborn size at birth

Scholtens, D. M., Bain, J. R., Reisetter, A. C., Muehlbauer, M. J., Nodzenski, M., Stevens, R. D., Ilkayeva, O., Lowe, L. P., Metzger, B. E., Newgard, C. B. & Lowe Jr, W. L., Jul 1 2016, In : Diabetes. 65, 7, p. 2039-2050 12 p.

Research output: Contribution to journalArticle

Metabolic Networks and Pathways
Mothers
Parturition
Glucose
Pregnancy
25 Citations (Scopus)

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin

Liu, C. T., Raghavan, S., Maruthur, N., Kabagambe, E. K., Hong, J., Ng, M. C. Y., Hivert, M. F., Lu, Y., An, P., Bentley, A. R., Drolet, A. M., Gaulton, K. J., Guo, X., Armstrong, L. L., Irvin, M. R., Li, M., Lipovich, L., Rybin, D. V., Taylor, K. D., Agyemang, C. & 95 others, Palmer, N. D., Cade, B. E., Chen, W. M., Dauriz, M., Delaney, J. A. C., Edwards, T. L., Evans, D. S., Evans, M. K., Lange, L. A., Leong, A., Liu, J., Liu, Y., Nayak, U., Patel, S. R., Porneala, B. C., Rasmussen-Torvik, L. J., Snijder, M. B., Stallings, S. C., Tanaka, T., Yanek, L. R., Zhao, W., Becker, D. M., Bielak, L. F., Biggs, M. L., Bottinger, E. P., Bowden, D. W., Chen, G., Correa, A., Couper, D. J., Crawford, D. C., Cushman, M., Eicher, J. D., Fornage, M., Franceschini, N., Fu, Y. P., Goodarzi, M. O., Gottesman, O., Hara, K., Harris, T. B., Jensen, R. A., Johnson, A. D., Jhun, M. A., Karter, A. J., Keller, M. F., Kho, A. N., Kizer, J. R., Krauss, R. M., Langefeld, C. D., Li, X., Liang, J., Liu, S., Lowe, W. L., Mosley, T. H., North, K. E., Pacheco, J. A., Peyser, P. A., Patrick, A. L., Rice, K. M., Selvin, E., Sims, M., Smith, J. A., Tajuddin, S. M., Vaidya, D., Wren, M. P., Yao, J., Zhu, X., Ziegler, J. T., Zmuda, J. M., Zonderman, A. B., Zwinderman, A. H., Adeyemo, A., Boerwinkle, E., Ferrucci, L., Hayes, M. G., Kardia, S. L. R., Miljkovic, I., Pankow, J. S., Rotimi, C. N., Sale, M. M., Wagenknecht, L. E., Arnett, D. K., Chen, Y. D. I., Nalls, M. A., Province, M. A., Kao, W. H. L., Siscovick, D. S., Psaty, B. M., Wilson, J. G., Loos, R. J. F., Dupuis, J., Rich, S. S., Florez, J. C., Rotter, J. I., Morris, A. P. & Meigs, J. B., Jul 7 2016, In : American Journal of Human Genetics. 99, 1, p. 56-75 20 p.

Research output: Contribution to journalArticle

Meta-Analysis
Fasting
Insulin
Glucose
Type 2 Diabetes Mellitus
2015
41 Citations (Scopus)

A novel common variant in DCST2 is associated with length in early life and height in adulthood

van der Valk, R. J. P., Kreiner-Møller, E., Kooijman, M. N., Guxens, M., Stergiakouli, E., Sääf, A., Bradfield, J. P., Geller, F., Geoffrey Hayes, M., Cousminer, D. L., Körner, A., Thiering, E., Curtin, J. A., Myhre, R., Huikari, V., Joro, R., Kerkhof, M., Warrington, N. M., Pitkänen, N., Ntalla, I. & 33 others, Horikoshi, M., Veijola, R., Freathy, R. M., Teo, Y. Y., Barton, S. J., Evans, D. M., Kemp, J. P., Pourcain, B. S., Ring, S. M., Smith, G. D., Bergström, A., Kull, I., Hakonarson, H., Mentch, F. D., Bisgaard, H., Chawes, B., Stokholm, J., Waage, J., Eriksen, P., Sevelsted, A., Melbye, M., van Duijn, C. M., Medina-Gomez, C., Hofman, A., de Jongste, J. C., Rob Taal, H., Uitterlinden, A. G., Armstrong, L. L., Eriksson, J., Lowe, W. L., Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium, Genetic Investigation of ANthropometric Traits (GIANT) Consortium & for the Early Growth Genetics (EGG) Consortium, Feb 15 2015, In : Human molecular genetics. 24, 4, p. 1155-1168 14 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Parturition
Genome
Cell Fusion
Genome-Wide Association Study
36 Citations (Scopus)

Characterization of large structural genetic mosaicism in human autosomes

Machiela, M. J., Zhou, W., Sampson, J. N., Dean, M. C., Jacobs, K. B., Black, A., Brinton, L. A., Chang, I. S., Chen, C., Chen, C., Chen, K., Cook, L. S., Crous Bou, M., De Vivo, I., Doherty, J., Friedenreich, C. M., Gaudet, M. M., Haiman, C. A., Hankinson, S. E., Hartge, P. & 179 others, Henderson, B. E., Hong, Y. C., Hosgood, H. D., Hsiung, C. A., Hu, W., Hunter, D. J., Jessop, L., Kim, H. N., Kim, Y. H., Kim, Y. T., Klein, R., Kraft, P., Lan, Q., Lin, D., Liu, J., Le Marchand, L., Liang, X., Lissowska, J., Lu, L., Magliocco, A. M., Matsuo, K., Olson, S. H., Orlow, I., Park, J. Y., Pooler, L., Prescott, J., Rastogi, R., Risch, H. A., Schumacher, F., Seow, A., Setiawan, V. W., Shen, H., Sheng, X., Shin, M. H., Shu, X. O., Vanden Berg, D., Wang, J. C., Wentzensen, N., Wong, M. P., Wu, C., Wu, T., Wu, Y. L., Xia, L., Yang, H. P., Yang, P. C., Zheng, W., Zhou, B., Abnet, C. C., Albanes, D., Aldrich, M. C., Amos, C., Amundadottir, L. T., Berndt, S. I., Blot, W. J., Bock, C. H., Bracci, P. M., Burdett, L., Buring, J. E., Butler, M. A., Carreón, T., Chatterjee, N., Chung, C. C., Cook, M. B., Cullen, M., Davis, F. G., Ding, T., Duell, E. J., Epstein, C. G., Fan, J. H., Figueroa, J. D., Fraumeni, J. F., Freedman, N. D., Fuchs, C. S., Gao, Y. T., Gapstur, S. M., Patiño-Garcia, A., Garcia-Closas, M., Gaziano, J. M., Giles, G. G., Gillanders, E. M., Giovannucci, E. L., Goldin, L., Goldstein, A. M., Greene, M. H., Hallmans, G., Harris, C. C., Henriksson, R., Holly, E. A., Hoover, R. N., Hu, N., Hutchinson, A., Jenab, M., Johansen, C., Khaw, K. T., Koh, W. P., Kolonel, L. N., Kooperberg, C., Krogh, V., Kurtz, R. C., Lacroix, A., Landgren, A., Landi, M. T., Li, D., Liao, L. M., Malats, N., McGlynn, K. A., McNeill, L. H., McWilliams, R. R., Melin, B. S., Mirabello, L., Peplonska, B., Peters, U., Petersen, G. M., Prokunina-Olsson, L., Purdue, M., Qiao, Y. L., Rabe, K. G., Rajaraman, P., Real, F. X., Riboli, E., Rodríguez-Santiago, B., Rothman, N., Ruder, A. M., Savage, S. A., Schwartz, A. G., Schwartz, K. L., Sesso, H. D., Severi, G., Silverman, D. T., Spitz, M. R., Stevens, V. L., Stolzenberg-Solomon, R., Stram, D., Tang, Z. Z., Taylor, P. R., Teras, L. R., Tobias, G. S., Viswanathan, K., Wacholder, S., Wang, Z., Weinstein, S. J., Wheeler, W., White, E., Wiencke, J. K., Wolpin, B. M., Wu, X., Wunder, J. S., Yu, K., Zanetti, K. A., Zeleniuch-Jacquotte, A., Ziegler, R. G., De Andrade, M., Barnes, K. C., Beaty, T. H., Bierut, L. J., Desch, K. C., Doheny, K. F., Feenstra, B., Ginsburg, D., Heit, J. A., Kang, J. H., Laurie, C. A., Li, J. Z., Lowe Jr, W. L., Marazita, M. L., Melbye, M., Mirel, D. B., Murray, J. C., Nelson, S. C., Pasquale, L. R., Rice, K., Wiggs, J. L., Wise, A., Tucker, M., Pérez-Jurado, L. A., Laurie, C. C., Caporaso, N. E., Yeager, M. & Chanock, S. J., Mar 5 2015, In : American Journal of Human Genetics. 96, 3, p. 487-497 11 p.

Research output: Contribution to journalArticle

Mosaicism
Genome-Wide Association Study
Meta-Analysis
Genome
Population
25 Citations (Scopus)

Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1

Guo, C., Ludvik, A. E., Arlotto, M. E., Hayes, M. G., Armstrong, L. L., Scholtens, D. M., Brown, C. D., Newgard, C. B., Becker, T. C., Layden, B. T., Lowe, W. L. & Reddy, T. E., Feb 4 2015, In : Nature communications. 6, 6069.

Research output: Contribution to journalArticle

hexokinase
hyperglycemia
Hexokinase
glucose
Hyperglycemia
36 Citations (Scopus)

Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort

Vockley, C. M., Guo, C., Majoros, W. H., Nodzenski, M., Scholtens, D. M., Hayes, M. G., Lowe, W. L. & Reddy, T. E., Aug 1 2015, In : Genome Research. 25, 8, p. 1206-1214 9 p.

Research output: Contribution to journalArticle

Haplotypes
Quantitative Trait Loci
Linkage Disequilibrium
Reporter Genes
Phenotype
39 Citations (Scopus)

New insights into gestational glucose metabolism: Lessons learned from 21st century approaches

Angueira, A. R., Ludvik, A. E., Reddy, T. E., Wicksteed, B., Lowe Jr, W. L. & Layden, B. T., Feb 1 2015, In : Diabetes. 64, 2, p. 327-334 8 p.

Research output: Contribution to journalArticle

Gestational Diabetes
Glucose
Pregnancy
Type 2 Diabetes Mellitus
Metabolomics
16 Citations (Scopus)

The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis

Fuller, M., Priyadarshini, M., Gibbons, S. M., Angueira, A. R., Brodsky, M., Geoffrey Hayes, M., Kovatcheva-Datchary, P., Bäckhed, F., Gilbert, J. A., Lowe, W. L. & Layden, B. T., Jan 1 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 309, 10, p. 840-851 12 p.

Research output: Contribution to journalArticle

Volatile Fatty Acids
Nonesterified Fatty Acids
Homeostasis
Glucose
Pregnancy
2014
22 Citations (Scopus)

Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds

Hlavaty, K. A., Gibly, R. F., Zhang, X., Rives, C. B., Graham, J. G., Lowe, W. L., Luo, X. & Shea, L. D., Jan 1 2014, In : American Journal of Transplantation. 14, 7, p. 1523-1532 10 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Transplantation
Somatomedins
Transplants
Proteins
10 Citations (Scopus)

Genetic risk score for prediction of newborn adiposity and large-for-gestational-age birth

Chawla, R., Badon, S. E., Rangarajan, J., Reisetter, A. C., Armstrong, L. L., Lowe, L. P., Urbanek, M., Metzger, B. E., Hayes, M. G., Scholtens, D. M. & Lowe, W. L., Nov 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 11, p. E2377-E2386

Research output: Contribution to journalArticle

Adiposity
Polymorphism
Gestational Age
Single Nucleotide Polymorphism
Nucleotides
41 Citations (Scopus)

Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk

Quilter, C. R., Cooper, W. N., Cliffe, K. M., Skinner, B. M., Prentice, P. M., Nelson, L. D., Bauer, J., Ong, K. K., Constância, M., Lowe Jr, W. L., Affara, N. A. & Dunger, D. B., Nov 1 2014, In : FASEB Journal. 28, 11, p. 4868-4879 12 p.

Research output: Contribution to journalArticle

Methylation
Gestational Diabetes
Medical problems
Type 2 Diabetes Mellitus
Genes
91 Citations (Scopus)

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

Ng, M. C. Y., Shriner, D., Chen, B. H., Li, J., Chen, W. M., Guo, X., Liu, J., Bielinski, S. J., Yanek, L. R., Nalls, M. A., Comeau, M. E., Rasmussen-Torvik, L. J., Jensen, R. A., Evans, D. S., Sun, Y. V., An, P., Patel, S. R., Lu, Y., Long, J., Armstrong, L. L. & 32 others, Wagenknecht, L., Yang, L., Snively, B. M., Palmer, N. D., Mudgal, P., Langefeld, C. D., Keene, K. L., Freedman, B. I., Mychaleckyj, J. C., Nayak, U., Raffel, L. J., Goodarzi, M. O., Chen, Y. D. I., Taylor, H. A., Correa, A., Sims, M., Couper, D., Pankow, J. S., Boerwinkle, E., Adeyemo, A., Doumatey, A., Hayes, M. G., Starren, J., Chisholm, R. L., Greenland, P., Kho, A. N., Lowe, W. L., Smith, M. E., Thompson, W. K., Cornelis, M., The MAGIC investigators & The GIANT consortium, Aug 7 2014, In : PLoS genetics. 10, 8, e1004517.

Research output: Contribution to journalArticle

diabetes
African American
Genome-Wide Association Study
meta-analysis
African Americans
51 Citations (Scopus)

Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy

Scholtens, D. M., Muehlbauer, M. J., Daya, N. R., Stevens, R. D., Dyer, A. R., Lowe, L. P., Metzger, B. E., Newgard, C. B., Bain, J. R. & Lowe Jr, W. L., Jan 1 2014, In : Diabetes Care. 37, 1, p. 158-166 9 p.

Research output: Contribution to journalArticle

Metabolomics
Fasting
Glucose
Pregnancy
Amino Acids
10 Citations (Scopus)

Metabomxtr: An R package for mixture-model analysis of non-targeted metabolomics data

Nodzenski, M., Muehlbauer, M. J., Bain, J. R., Reisetter, A. C., Lowe Jr, W. L. & Scholtens, D. M., Jan 1 2014, In : Bioinformatics. 30, 22, p. 3287-3288 2 p.

Research output: Contribution to journalArticle

Metabolomics
Model Analysis
Metabolites
Mixture Model
Software

The chromosome 3q25 locus associated with fetal adiposity is not associated with childhood adiposity

Chawla, R., McCance, D. R., McKenna, S., Young, I. S., Patterson, C. C., Rangarajan, J., Reisetter, A. C., Armstrong, L. L., Lowe, L. P., Metzger, B. E., Hayes, M. G., Scholtens, D. M. & Lowe, W. L., Jan 1 2014, In : Nutrition and Diabetes. 4, 9, e138.

Research output: Contribution to journalArticle

Adiposity
Chromosomes
Newborn Infant
Genome-Wide Association Study
Parturition
2013
30 Citations (Scopus)

Collagen IV-modified scaffolds improve islet survival and function and reduce time to euglycemia

Yap, W. T., Salvay, D. M., Silliman, M. A., Zhang, X., Bannon, Z. G., Kaufman, D. B., Lowe Jr, W. L. & Shea, L. D., Jan 1 2013, In : Tissue Engineering - Part A. 19, 21-22, p. 2361-2372 12 p.

Research output: Contribution to journalArticle

Scaffolds (biology)
Collagen
Scaffolds
Islets of Langerhans Transplantation
Insulin
41 Citations (Scopus)

Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies

Hayes, M. G., Urbanek, M., Hivert, M. F., Armstrong, L. L., Morrison, J., Guo, C., Lowe, L. P., Scheftner, D. A., Pluzhnikov, A., Levine, D. M., McHugh, C. P., Ackerman, C. M., Bouchard, L., Brisson, D., Layden, B. T., Mirel, D., Doheny, K. F., Leya, M. V., Lown-Hecht, R. N., Dyer, A. R. & 4 others, Metzger, B. E., Reddy, T. E., Cox, N. J. & Lowe, W. L., Sep 1 2013, In : Diabetes. 62, 9, p. 3282-3291 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Mothers
Pregnancy
Glucose
Genes
5 Citations (Scopus)
C-Peptide
Pregnancy Outcome
Hyperglycemia
Testosterone
Mothers
16 Citations (Scopus)

Porous scaffolds support extrahepatic human islet transplantation, engraftment, and function in mice

Gibly, R. F., Zhang, X., Lowe Jr, W. L. & Shea, L. D., Apr 24 2013, In : Cell transplantation. 22, 5, p. 811-819 9 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Scaffolds
Grafts
Transplants
Medical problems
21 Citations (Scopus)

The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study

Urbanek, M., Hayes, M. G., Armstrong, L. L., Morrison, J., Lowe, L. P., Badon, S. E., Scheftner, D., Pluzhnikov, A., Levine, D., Laurie, C. C., McHugh, C., Ackerman, C. M., Mirel, D. B., Doheny, K. F., Guo, C., Scholtens, D. M., Dyer, A. R., Metzger, B. E., Reddy, T. E., Cox, N. J. & 1 others, Lowe, W. L., Sep 1 2013, In : Human molecular genetics. 22, 17, p. 3583-3596 14 p., ddt168.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Adiposity
Chromosomes
Newborn Infant
Glucose Tolerance Test
2012
35 Citations (Scopus)

Accumulation of cadmium in insulin-producing β cells

El Muayed, M., Raja, M. R., Zhang, X., Macrenaris, K. W., Bhatt, S., Chen, X., Urbanek, M., O'Halloran, T. V. & Lowe Jr, W. L., Nov 1 2012, In : Islets. 4, 6, p. 405-416 12 p.

Research output: Contribution to journalArticle

Cadmium
Insulin
Oxidative Stress
Cadmium Chloride
Type 2 Diabetes Mellitus
261 Citations (Scopus)

Detectable clonal mosaicism from birth to old age and its relationship to cancer

Laurie, C. C., Laurie, C. A., Rice, K., Doheny, K. F., Zelnick, L. R., McHugh, C. P., Ling, H., Hetrick, K. N., Pugh, E. W., Amos, C., Wei, Q., Wang, L. E., Lee, J. E., Barnes, K. C., Hansel, N. N., Mathias, R., Daley, D., Beaty, T. H., Scott, A. F., Ruczinski, I. & 53 others, Scharpf, R. B., Bierut, L. J., Hartz, S. M., Landi, M. T., Freedman, N. D., Goldin, L. R., Ginsburg, D., Li, J., Desch, K. C., Strom, S. S., Blot, W. J., Signorello, L. B., Ingles, S. A., Chanock, S. J., Berndt, S. I., Le Marchand, L., Henderson, B. E., Monroe, K. R., Heit, J. A., De Andrade, M., Armasu, S. M., Regnier, C., Lowe, W. L., Hayes, M. G., Marazita, M. L., Feingold, E., Murray, J. C., Melbye, M., Feenstra, B., Kang, J. H., Wiggs, J. L., Jarvik, G. P., McDavid, A. N., Seshan, V. E., Mirel, D. B., Crenshaw, A., Sharopova, N., Wise, A., Shen, J., Crosslin, D. R., Levine, D. M., Zheng, X., Udren, J. I., Bennett, S., Nelson, S. C., Gogarten, S. M., Conomos, M. P., Heagerty, P., Manolio, T., Pasquale, L. R., Haiman, C. A., Caporaso, N. & Weir, B. S., Jun 1 2012, In : Nature Genetics. 44, 6, p. 642-650 9 p.

Research output: Contribution to journalArticle

Mosaicism
Parturition
Neoplasms
Chromosome Duplication
Uniparental Disomy
41 Citations (Scopus)

Ethnic variation in allele distribution of the androgen receptor (AR) (CAG) n repeat

Ackerman, C. M., Lowe, L. P., Lee, H., Hayes, M. G., Dyer, A. R., Metzger, B. E., Lowe, W. L. & Urbanek, M., Mar 1 2012, In : Journal of Andrology. 33, 2, p. 210-215 6 p.

Research output: Contribution to journalArticle

Androgen Receptors
Alleles
Mothers
Hispanic Americans
Ethnic Groups
40 Citations (Scopus)

Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5- CHRNA3-CHRNB4) interacts with maternal selfreported smoking status during pregnancy to influence birth weight

Tyrrell, J., Huikari, V., Christie, J. T., Cavadino, A., Bakker, R., Brion, M. J. A., Geller, F., Paternoster, L., Myhre, R., Potter, C., Johnson, P. C. D., Ebrahim, S., Feenstra, B., Hartikainen, A. L., Hattersley, A. T., Hofman, A., Kaakinen, M., Lowe, L. P., Magnus, P., McConnachie, A. & 23 others, Melbye, M., Ng, J. W. Y., Nohr, E. A., Power, C., Ring, S. M., Sebert, S. P., Sengpiel, V., Taal, H. R., Watt, G. C. M., Sattar, N., Relton, C. L., Jacobsson, B., Frayling, T. M., Sørensen, T. I. A., Murray, J. C., Lawlor, D. A., Pennell, C. E., Jaddoe, V. W. V., Hypponen, E., Lowe Jr, W. L., Jarvelin, M. R., Smith, G. D. & Freathy, R. M., Dec 1 2012, In : Human molecular genetics. 21, 24, p. 5344-5358 15 p., dds372.

Research output: Contribution to journalArticle

Nicotinic Receptors
Multigene Family
Birth Weight
Smoking
Mothers
17 Citations (Scopus)

Negative association of acetate with visceral adipose tissue and insulin levels

Layden, B. T., Yalamanchi, S. K., Wolever, T. M. S., Dunaif, A. & Lowe, W. L., Jan 1 2012, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 5, p. 49-55 7 p.

Research output: Contribution to journalArticle

Intra-Abdominal Fat
Volatile Fatty Acids
Acetates
Insulin
Insulin Resistance
17 Citations (Scopus)

The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy

Urbanek, M., Hayes, M. G., Lee, H., Freathy, R. M., Lowe, L. P., Ackerman, C., Jafari, N., Dyer, A. R., Cox, N. J., Dunger, D. B., Hattersley, A. T., Metzger, B. E. & Lowe, W. L., Mar 30 2012, In : PloS one. 7, 3, e32958.

Research output: Contribution to journalArticle

Alleles
Mothers
pregnancy
alleles
Phenotype
149 Citations (Scopus)

Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study

Kho, A. N., Hayes, M. G., Rasmussen-Torvik, L., Pacheco, J. A., Thompson, W. K., Armstrong, L. L., Denny, J. C., Peissig, P. L., Miller, A. W., Wei, W. Q., Bielinski, S. J., Chute, C. G., Leibson, C. L., Jarvik, G. P., Crosslin, D. R., Carlson, C. S., Newton, K. M., Wolf, W. A., Chisholm, R. L. & Lowe, W. L., Mar 1 2012, In : Journal of the American Medical Informatics Association. 19, 2, p. 212-218 7 p.

Research output: Contribution to journalArticle

Electronic Health Records
Genome-Wide Association Study
Type 2 Diabetes Mellitus
Clinical Laboratory Techniques
Genetic Association Studies
2011
39 Citations (Scopus)

Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine models

Gibly, R. F., Zhang, X., Graham, M. L., Hering, B. J., Kaufman, D. B., Lowe Jr, W. L. & Shea, L. D., Dec 1 2011, In : Biomaterials. 32, 36, p. 9677-9684 8 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Scaffolds
Polymers
Swine
Transplantation
68 Citations (Scopus)

Gene-environment interplay in common complex diseases: Forging an integrative model-Recommendations from an NIH workshop

Bookman, E. B., McAllister, K., Gillanders, E., Wanke, K., Balshaw, D., Rutter, J., Reedy, J., Shaughnessy, D., Agurs-Collins, T., Paltoo, D., Atienza, A., Bierut, L., Kraft, P., Fallin, M. D., Perera, F., Turkheimer, E., Boardman, J., Marazita, M. L., Rappaport, S. M., Boerwinkle, E. & 13 others, Suomi, S. J., Caporaso, N. E., Hertz-Picciotto, I., Jacobson, K. C., Lowe Jr, W. L., Goldman, L. R., Duggal, P., Gunnar, M. R., Manolio, T. A., Green, E. D., Olster, D. H., Birnbaum, L. S. & Gunnar, M. R., Apr 6 2011, In : Genetic Epidemiology. 35, 4, p. 217-225 9 p.

Research output: Contribution to journalArticle

Gene-Environment Interaction
Education
Disease Attributes
Genes
Information Dissemination
486 Citations (Scopus)

Genome partitioning of genetic variation for complex traits using common SNPs

Yang, J., Manolio, T. A., Pasquale, L. R., Boerwinkle, E., Caporaso, N., Cunningham, J. M., De Andrade, M., Feenstra, B., Feingold, E., Hayes, M. G., Hill, W. G., Landi, M. T., Alonso, A., Lettre, G., Lin, P., Ling, H., Lowe, W., Mathias, R. A., Melbye, M., Pugh, E. & 4 others, Cornelis, M. C., Weir, B. S., Goddard, M. E. & Visscher, P. M., Jun 1 2011, In : Nature Genetics. 43, 6, p. 519-525 7 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Genome
Body Mass Index
von Willebrand Factor
Multifactorial Inheritance