William L Lowe Jr

  • 6415 Citations
1981 …2023
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Research Output 1981 2019

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1981
53 Citations (Scopus)

Vitamin D and pregnancy: The maternal-fetal metabolism of vitamin D

Gray, T. K., Lowe Jr, W. L. & Lester, G. E., Jan 1 1981, In : Endocrine reviews. 2, 3, p. 264-274 11 p.

Research output: Contribution to journalArticle

25-Hydroxyvitamin D 2
Maternal-Fetal Exchange
Ergocalciferols
Biological Models
Vitamin D Deficiency
1986
98 Citations (Scopus)

Development of brain insulin receptors: Structural and functional studies of insulin receptors from whole brain and primary cell cultures

Lowe, W. L., Boyd, F. T., Clarke, D. W., Raizada, M. K., Hart, C. & Leroith, D., Jan 1 1986, In : Endocrinology. 119, 1, p. 25-35 11 p.

Research output: Contribution to journalArticle

Primary Cell Culture
Insulin Receptor
Brain
Neuroglia
Liver
33 Citations (Scopus)

Insulin receptor of human cerebral gliomas. Structure and function

Grunberger, G., Lowe, W. L., McElduff, A. & Glick, R. P., Jan 1 1986, In : Journal of Clinical Investigation. 77, 3, p. 997-1005 9 p.

Research output: Contribution to journalArticle

Glioma
Insulin Receptor
Insulin
Neuroglia
Brain
34 Citations (Scopus)

Insulin receptors from guinea pig liver and brain:structural and functional studies

Lowe, W. & Leroith, D., Jan 1 1986, In : Endocrinology. 118, 4, p. 1669-1677 9 p.

Research output: Contribution to journalArticle

Insulin Receptor
Guinea Pigs
Liver
Brain
Insulin
19 Citations (Scopus)

Tyrosine kinase activity of brain insulin and IGF-1 receptors

Lowe, W. L. & LeRoith, D., Jan 29 1986, In : Biochemical and Biophysical Research Communications. 134, 2, p. 532-538 7 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Protein-Tyrosine Kinases
Brain
Insulin
Liver
1987
53 Citations (Scopus)

Developmental regulation of somatostatin gene expression in the brain is region specific

Lowe, W. L., Schaffner, A. E., Roberts, C. T. & Leroith, D., Feb 1987, In : Molecular Endocrinology. 1, 2, p. 181-187 7 p.

Research output: Contribution to journalArticle

Developmental Gene Expression Regulation
Somatostatin
Stomach
Messenger RNA
Brain
298 Citations (Scopus)

Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.

Lowe, W. L., Roberts, C. T., Lasky, S. R. & LeRoith, D., Jan 1 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 24, p. 8946-8950 5 p.

Research output: Contribution to journalArticle

5' Untranslated Regions
Insulin-Like Growth Factor I
Growth Hormone
Messenger RNA
Liver
242 Citations (Scopus)
Molecular Cloning
Insulin-Like Growth Factor I
Growth Hormone
RNA
Complementary DNA
62 Citations (Scopus)

Rat IGF-I cDNA's contain multiple 5′-untranslated regions

Roberts, C. T., Lasky, S. R., Lowe, W. L. & LeRoith, D., Aug 14 1987, In : Biochemical and Biophysical Research Communications. 146, 3, p. 1154-1159 6 p.

Research output: Contribution to journalArticle

5' Untranslated Regions
Insulin-Like Growth Factor I
Rats
Complementary DNA
3' Untranslated Regions
1988
12 Citations (Scopus)

Characterization of the altered oligosaccharide composition of the insulin receptor on neural-derived cells

Ota, A., Shemer, J., Pruss, R. M., Lowe, W. L. & LeRoith, D., Mar 8 1988, In : Brain research. 443, 1-2, p. 1-11 11 p.

Research output: Contribution to journalArticle

Insulin Receptor
Oligosaccharides
Insulin
Membranes
Neuroblastoma
199 Citations (Scopus)
Insulin-Like Growth Factor I
RNA
Messenger RNA
Liver
Alternative Splicing
1989
63 Citations (Scopus)

Developmental regulation of rat brain/hep G2 glucose transporter gene expression

Werner, H., Adamo, M., Lowe, W. L., Roberts, C. T. & LeRoith, D., Feb 1989, In : Molecular Endocrinology. 3, 2, p. 273-279 7 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Gene Expression
Brain
Messenger RNA
Ribonucleases
10 Citations (Scopus)

Expression and stability of insulin-like growth factor-I (IGF-I) mRNA splicing variants in the GH3 rat pituitary cell line

Lowe, W. L., Adamo, M., LeRoith, D. & Roberts, C. T., Aug 15 1989, In : Biochemical and Biophysical Research Communications. 162, 3, p. 1174-1179 6 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Rats
Cells
Cell Line
Messenger RNA
24 Citations (Scopus)

Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells

Zilberstein, M., Chou, J. Y., Lowe, W. L., Orr, Z. S., Roberts, C. T., Leroith, D. & Catt, K. J., Sep 1989, In : Molecular Endocrinology. 3, 9, p. 1488-1497 10 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Granulosa Cells
Insulin-Like Growth Factor I
Ovary
Messenger RNA
50 Citations (Scopus)

Insulin-like growth factor-II in nonislet cell tumors associated with hypoglycemia: Increased levels of messenger ribonucleic acid

Lowe, W. L., Roberts, C. T., Leroith, D., Rojeski, M. T., Merimee, T. J., Fui, S. T., Keen, H., Arnold, D., Mersey, J., Gluzman, S., Spratt, D., Eastman, R. C. & Roth, J., Jan 1 1989, In : Journal of Clinical Endocrinology and Metabolism. 69, 6, p. 1153-1159 7 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor II
Hypoglycemia
Tumors
RNA
Neoplasms
116 Citations (Scopus)

Insulin-like growth factor i messenger ribonucleic acids with alternative 5'-untranslated regions are differentially expressed during development of the rat

Adamo, M., Lowe, W. L., Leroith, D. & Roberts, C. T., Jan 1 1989, In : Endocrinology. 124, 6, p. 2737-2744 8 p.

Research output: Contribution to journalArticle

5' Untranslated Regions
Somatomedins
Insulin-Like Growth Factor I
RNA
Messenger RNA
194 Citations (Scopus)

Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding

Lowe, W. L., Adamo, M., Werner, H., Roberts, C. T. & LeRoith, D., Jan 1 1989, In : Journal of Clinical Investigation. 84, 2, p. 619-626 8 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Insulin-Like Growth Factor I
Fasting
Gene Expression
Messenger RNA
1990
27 Citations (Scopus)

Regulation of insulin-like growth factor i messenger ribonucleic acid levels by serum in cultured rat fibroblasts

Lowe, W. L., Kummer, M., Karpen, C. W. & Dong Wu, X., Jan 1 1990, In : Endocrinology. 127, 6, p. 2854-2861 8 p.

Research output: Contribution to journalArticle

Somatomedins
Fibroblasts
RNA
Insulin-Like Growth Factor I
Serum
1991
120 Citations (Scopus)

Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain

Bach, M. A., Shen-Orr, Z., Lowe, W. L., Roberts, C. T. & Leroith, D., Apr 1991, In : Molecular Brain Research. 10, 1, p. 43-48 6 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Messenger RNA
Brain
IGF Type 1 Receptor
Gene Expression
1992
25 Citations (Scopus)

Activation of protein kinase-C differentially regulates insulin-like growth factor-I and basic fibroblast growth factor messenger RNA levels

Lowe, W. L., Yorek, M. A., Karpen, C. W., Teasdale, R. M., Hovis, J. G., Albrecht, B. & Prokopiou, C., May 1 1992, In : Molecular Endocrinology. 6, 5, p. 741-752 12 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Insulin-Like Growth Factor I
Protein Kinase C
Messenger RNA
Acetates
17 Citations (Scopus)

Characterization of a rat insulin-like growth factor I gene promoter

Lowe, W. L. & Teasdale, R. M., Dec 15 1992, In : Biochemical and Biophysical Research Communications. 189, 2, p. 972-978 7 p.

Research output: Contribution to journalArticle

5' Flanking Region
Insulin-Like Growth Factor I
Rats
Exons
Genes
70 Citations (Scopus)

Endothelial cells express insulin-like growth factor-binding proteins 2 to 6

Moser, D. R., Lowe, W. L., Dake, B. L., Booth, B. A., Boes, M., Clemmons, D. R. & Bar, R. S., Nov 1 1992, In : Molecular Endocrinology. 6, 11, p. 1805-1814 10 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
Endothelial Cells
Insulin-Like Growth Factor Binding Proteins
Pulmonary Artery
Microvessels
52 Citations (Scopus)

Regulation of insulin-like growth factor i production in rat c6 glioma cells: Possible role as an autocrine/paracrine growth factor

Lowe, W. L., Meyer, T., Karpen, C. W. & Lorentzen, L. R., Jan 1 1992, In : Endocrinology. 130, 5, p. 2683-2691 9 p.

Research output: Contribution to journalArticle

Somatomedins
Glioma
Intercellular Signaling Peptides and Proteins
Tretinoin
Dexamethasone
34 Citations (Scopus)

Tissue-specific regulation of basic fibroblast growth factor mRNA levels by diabetes

Karpen, C. W., Spanheimer, R. G., Randolph, A. L. & Lowe, W. L., Jan 1 1992, In : Diabetes. 41, 2, p. 222-226 5 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Messenger RNA
Diabetic Angiopathies
Streptozocin
Intercellular Signaling Peptides and Proteins
1993
14 Citations (Scopus)

Intracellular calcium regulates insulin-like growth factor-i messenger ribonucleic acid levels

Hovis, J. G., Meyer, T., Teasdale, R. M., Albrecht, B. N., Yorek, M. A. & Lowe, W. L., Jan 1 1993, In : Endocrinology. 132, 5, p. 1931-1938 8 p.

Research output: Contribution to journalArticle

Thapsigargin
Somatomedins
Calcimycin
Insulin-Like Growth Factor I
RNA
7 Citations (Scopus)
Fibroblast Growth Factor 2
Insulin-Like Growth Factor I
Protein Kinase C
RNA
Ligands
1994
4 Citations (Scopus)

Editorial: Once is not enough--promiscuity begets diversity among the insulin-like growth factor binding proteins

Lowe Jr, W. L., Jan 1 1994, In : Endocrinology. 135, 5, p. 1719-1721 3 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Proteins
Growth Inhibitors
Signal Transduction
Carrier Proteins
1995
30 Citations (Scopus)

Regulation of growth factor mRNA levels in the eyes of diabetic rats

Lowe, W. L., Florkiewicz, R. Z., Yorek, M. A., Spanheimer, R. G. & Albrecht, B. N., Jan 1 1995, In : Metabolism. 44, 8, p. 1038-1045 8 p.

Research output: Contribution to journalArticle

Intercellular Signaling Peptides and Proteins
Messenger RNA
Insulin-Like Growth Factor I
Retina
Insulin
24 Citations (Scopus)
Insulin-Like Growth Factor I
Rats
Exons
Protein Binding
Genes
1996
24 Citations (Scopus)

Localization and regulation of renal Na+/myo-inositol cotransporter in diabetic rats

Wiese, T. J., Matsushita, K., Lowe, W. L., Stokes, J. B. & Yorek, M. A., Jan 1 1996, In : Kidney international. 50, 4, p. 1202-1211 10 p.

Research output: Contribution to journalArticle

Inositol
Kidney
Sodium
Messenger RNA
Loop of Henle
49 Citations (Scopus)

Osmotic regulation of Na-myo-inositol cotransporter mRNA level and activity in endothelial and neural cells

Wiese, T. J., Dunlap, J. A., Conner, C. E., Grzybowski, J. A., Lowe, W. L. & Yorek, M. A., Apr 1 1996, In : American Journal of Physiology - Cell Physiology. 270, 4 39-4, p. C990-C997

Research output: Contribution to journalArticle

Inositol
Endothelial Cells
Messenger RNA
Sodium
Osmolar Concentration
1997
21 Citations (Scopus)

Growth factor-induced transcription via the serum response element is inhibited by cyclic adenosine 3',5'-monophosphate in MCF-7 breast cancer cells

Lowe, W. L., Fu, R. & Banko, M., Jan 1 1997, In : Endocrinology. 138, 6, p. 2219-2226 8 p.

Research output: Contribution to journalArticle

Serum Response Element
Cyclic AMP
Intercellular Signaling Peptides and Proteins
Insulin-Like Growth Factor I
Epidermal Growth Factor
1998
17 Citations (Scopus)

Effect of TNF-α on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells

Yorek, M. A., Dunlap, J. A., Thomas, M. J., Cammarata, P. R., Zhou, C. & Lowe, W. L., Jan 1 1998, In : American Journal of Physiology - Cell Physiology. 274, 1 43-1

Research output: Contribution to journalArticle

Inositol
Cultured Cells
Endothelial Cells
Tumor Necrosis Factor-alpha
Messenger RNA
43 Citations (Scopus)
Fibroblast Growth Factor 2
Mitogen-Activated Protein Kinases
Human Activities
Estrogens
Endothelial Cells
7 Citations (Scopus)
Symporters
Inositol
Adipocytes
Tumor Necrosis Factor-alpha
Messenger RNA
1999
41 Citations (Scopus)

Developmental regulation of insulin-like growth factor-I and growth hormone receptor gene expression

Shoba, L., An, M. R., Frank, S. J. & Lowe, W. L., Jun 25 1999, In : Molecular and Cellular Endocrinology. 152, 1-2, p. 125-136 12 p.

Research output: Contribution to journalArticle

Somatotropin Receptors
Insulin-Like Growth Factor I
Gene expression
Gene Expression
Messenger RNA
48 Citations (Scopus)

Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis

Chung, W. K., Luke, A., Cooper, R. S., Rotini, C., Vidal-Puig, A., Rosenbaum, M., Chua, M., Solanes, G., Zheng, M., Zhao, L., LeDuc, C., Eisberg, A., Chu, F., Murphy, E., Schreier, M., Aronne, L., Caprio, S., Kahle, B., Gordon, D., Leal, S. M. & 9 others, Goldsmith, R., Andreu, A. L., Bruno, C., DiMauro, S., Heo, M., Lowe, W. L., Lowell, B. B., Allison, D. B. & Leibel, R. L., Sep 11 1999, In : Diabetes. 48, 9, p. 1890-1895 6 p.

Research output: Contribution to journalArticle

Homeostasis
Mutation
RNA Isoforms
Quadriceps Muscle
Body Composition
35 Citations (Scopus)

Growth hormone-mediated regulation of insulin-like growth factor I promoter activity in C6 glioma cells

Benbassat, C., Shoba, L. N. N., Newman, M., Adamo, M. L., Frank, S. J. & Lowe, W. L., Jan 1 1999, In : Endocrinology. 140, 7, p. 3073-3081 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Glioma
Growth Hormone
Luciferases
Genes
5 Citations (Scopus)

Osmotic regulation of the Na+/myo-inositol cotransporter and postinduction normalization

Yorek, M. A., Dunlap, J. A. & Lowe, W. L., Jan 1 1999, In : Kidney international. 55, 1, p. 215-224 10 p.

Research output: Contribution to journalArticle

Inositol
Messenger RNA
Extremities
Kidney
Dactinomycin
7 Citations (Scopus)

The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

Chung, W. K., Luke, A., Cooper, R. S., Rotini, C., Vidal-Puig, A., Rosenbaum, M., Gordon, D., Leal, S. M., Caprio, S., Goldsmith, R., Andreu, A. L., Bruno, C., DiMauro, S., Heo, M., Lowe, W. L., Lowell, B. B., Allison, D. B. & Leibel, R. L., Jun 1 1999, In : International Journal of Obesity. 23, p. S49-S50

Research output: Contribution to journalArticle

Protein Isoforms
Homeostasis
Amino Acid Sequence Homology
Mutation
Rodentia
92 Citations (Scopus)

The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans

Rotimi, C. N., Comuzzie, A. G., Lowe, W. L., Luke, A., Blangero, J. & Cooper, R. S., Jan 1 1999, In : Diabetes. 48, 3, p. 643-644 2 p.

Research output: Contribution to journalArticle

Heritable Quantitative Trait
Genetic Linkage
Chromosomes, Human, Pair 2
Chromosome Mapping
Quantitative Trait Loci
2000
310 Citations (Scopus)

Abnormal glucose metabolism and pancreatic cancer mortality

Gapstur, S. M., Gann, P. H., Lowe, W., Liu, K., Colangelo, L. & Dyer, A., May 17 2000, In : Journal of the American Medical Association. 283, 19, p. 2552-2558 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Glucose
Mortality
Body Mass Index
Uric Acid
60 Citations (Scopus)

Activation of members of the mitogen-activated protein kinase family by glucose in endothelial cells

Liu, W., Schoenkerman, A. & Lowe Jr, W. L., Oct 1 2000, In : American Journal of Physiology. 279, 4 PART 1

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Endothelial Cells
Glucose
Raffinose
Fructose
29 Citations (Scopus)

Insulin-like growth factor I activates c-Jun N-terminal kinase in MCF-7 breast cancer cells

Monno, S., Newman, M. V., Cook, M. & Lowe, J., Jan 1 2000, In : Endocrinology. 141, 2, p. 544-550 7 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Insulin-Like Growth Factor I
Breast Neoplasms
Phosphatidylinositol 3-Kinase
Mitogen-Activated Protein Kinase 3
23 Citations (Scopus)

Lack of association between the - 308 polymorphism of the tumor necrosis factor-α gene and the insulin resistance syndrome

Da Silva, B., Gapstur, S. M., Achenbach, Y. H., Schuh, T. S., Kotlar, T. J., Liu, K. & Lowe Jr, W. L., Jan 1 2000, In : Journal of Investigative Medicine. 48, 4, p. 236-244 9 p.

Research output: Contribution to journalArticle

Polymorphism
Insulin Resistance
Tumor Necrosis Factor-alpha
Genes
Alleles
11 Citations (Scopus)

Normalization of hyperosmotic-induced inositol uptake by renal and endothelial cells is regulated by NF-κB

Yorek, M. A., Dunlap, J. A., Liu, W. & Lowe, W. L., Jun 22 2000, In : American Journal of Physiology - Cell Physiology. 278, 5 47-5

Research output: Contribution to journalArticle

Inositol
Endothelial Cells
Kidney
Messenger RNA
Dactinomycin
3 Citations (Scopus)
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Inositol
Adipocytes
Aorta
Endothelial Cells
2001
84 Citations (Scopus)

Heritability of obesity-related traits among Nigerians, Jamaicans and US black people

Luke, A., Guo, X., Adeyemo, A. A., Wilks, R., Forrester, T., Lowe Jr, W. L., Comuzzie, A. G., Martin, L. J., Zhu, X., Rotimi, C. N. & Cooper, R. S., Jul 4 2001, In : International Journal of Obesity. 25, 7, p. 1034-1041 8 p.

Research output: Contribution to journalArticle

Jamaica
Nigeria
Obesity
Fats
Population
29 Citations (Scopus)

LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes

Shoba, L. N. N., Newman, M., Liu, W. & Lowe, W. L., Jan 1 2001, In : Endocrinology. 142, 9, p. 3980-3986 7 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Insulin-Like Growth Factor I
Hepatocytes
Phosphatidylinositol 3-Kinases
63 Citations (Scopus)
Phosphatidylinositol 3-Kinase
Mitogen-Activated Protein Kinases
Insulin-Like Growth Factor I
Endothelial Cells
Cell Movement