William L Lowe Jr

  • 6632 Citations
1981 …2024

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1981

Vitamin D and pregnancy: The maternal-fetal metabolism of vitamin D

Gray, T. K., Lowe Jr, W. L. & Lester, G. E., Jan 1 1981, In : Endocrine reviews. 2, 3, p. 264-274 11 p.

Research output: Contribution to journalArticle

54 Scopus citations
1986

Development of brain insulin receptors: Structural and functional studies of insulin receptors from whole brain and primary cell cultures

Lowe, W. L., Boyd, F. T., Clarke, D. W., Raizada, M. K., Hart, C. & Leroith, D., Jan 1 1986, In : Endocrinology. 119, 1, p. 25-35 11 p.

Research output: Contribution to journalArticle

99 Scopus citations

Insulin receptor of human cerebral gliomas. Structure and function

Grunberger, G., Lowe, W. L., McElduff, A. & Glick, R. P., Jan 1 1986, In : Journal of Clinical Investigation. 77, 3, p. 997-1005 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Insulin receptors from guinea pig liver and brain:structural and functional studies

Lowe, W. & Leroith, D., Jan 1 1986, In : Endocrinology. 118, 4, p. 1669-1677 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Tyrosine kinase activity of brain insulin and IGF-1 receptors

Lowe, W. L. & LeRoith, D., Jan 29 1986, In : Biochemical and Biophysical Research Communications. 134, 2, p. 532-538 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
1987

Developmental regulation of somatostatin gene expression in the brain is region specific

Lowe, W. L., Schaffner, A. E., Roberts, C. T. & Leroith, D., Feb 1987, In : Molecular Endocrinology. 1, 2, p. 181-187 7 p.

Research output: Contribution to journalArticle

54 Scopus citations

Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.

Lowe, W. L., Roberts, C. T., Lasky, S. R. & LeRoith, D., Jan 1 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 24, p. 8946-8950 5 p.

Research output: Contribution to journalArticle

298 Scopus citations
243 Scopus citations

Rat IGF-I cDNA's contain multiple 5′-untranslated regions

Roberts, C. T., Lasky, S. R., Lowe, W. L. & LeRoith, D., Aug 14 1987, In : Biochemical and Biophysical Research Communications. 146, 3, p. 1154-1159 6 p.

Research output: Contribution to journalArticle

62 Scopus citations
1988

Characterization of the altered oligosaccharide composition of the insulin receptor on neural-derived cells

Ota, A., Shemer, J., Pruss, R. M., Lowe, W. L. & LeRoith, D., Mar 8 1988, In : Brain research. 443, 1-2, p. 1-11 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
199 Scopus citations
1989

Developmental regulation of rat brain/hep G2 glucose transporter gene expression

Werner, H., Adamo, M., Lowe, W. L., Roberts, C. T. & LeRoith, D., Feb 1989, In : Molecular Endocrinology. 3, 2, p. 273-279 7 p.

Research output: Contribution to journalArticle

63 Scopus citations

Expression and stability of insulin-like growth factor-I (IGF-I) mRNA splicing variants in the GH3 rat pituitary cell line

Lowe, W. L., Adamo, M., LeRoith, D. & Roberts, C. T., Aug 15 1989, In : Biochemical and Biophysical Research Communications. 162, 3, p. 1174-1179 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells

Zilberstein, M., Chou, J. Y., Lowe, W. L., Orr, Z. S., Roberts, C. T., Leroith, D. & Catt, K. J., Sep 1989, In : Molecular Endocrinology. 3, 9, p. 1488-1497 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Insulin-like growth factor-II in nonislet cell tumors associated with hypoglycemia: Increased levels of messenger ribonucleic acid

Lowe, W. L., Roberts, C. T., Leroith, D., Rojeski, M. T., Merimee, T. J., Fui, S. T., Keen, H., Arnold, D., Mersey, J., Gluzman, S., Spratt, D., Eastman, R. C. & Roth, J., Jan 1 1989, In : Journal of Clinical Endocrinology and Metabolism. 69, 6, p. 1153-1159 7 p.

Research output: Contribution to journalArticle

51 Scopus citations

Insulin-like growth factor i messenger ribonucleic acids with alternative 5'-untranslated regions are differentially expressed during development of the rat

Adamo, M., Lowe, W. L., Leroith, D. & Roberts, C. T., Jan 1 1989, In : Endocrinology. 124, 6, p. 2737-2744 8 p.

Research output: Contribution to journalArticle

116 Scopus citations

Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding

Lowe, W. L., Adamo, M., Werner, H., Roberts, C. T. & LeRoith, D., Jan 1 1989, In : Journal of Clinical Investigation. 84, 2, p. 619-626 8 p.

Research output: Contribution to journalArticle

195 Scopus citations
1990

Regulation of insulin-like growth factor i messenger ribonucleic acid levels by serum in cultured rat fibroblasts

Lowe, W. L., Kummer, M., Karpen, C. W. & Dong Wu, X., Dec 1990, In : Endocrinology. 127, 6, p. 2854-2861 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
1991

Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain

Bach, M. A., Shen-Orr, Z., Lowe, W. L., Roberts, C. T. & Leroith, D., Apr 1991, In : Molecular Brain Research. 10, 1, p. 43-48 6 p.

Research output: Contribution to journalArticle

121 Scopus citations
1992

Activation of protein kinase-C differentially regulates insulin-like growth factor-I and basic fibroblast growth factor messenger RNA levels

Lowe, W. L., Yorek, M. A., Karpen, C. W., Teasdale, R. M., Hovis, J. G., Albrecht, B. & Prokopiou, C., May 1 1992, In : Molecular Endocrinology. 6, 5, p. 741-752 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Characterization of a rat insulin-like growth factor I gene promoter

Lowe, W. L. & Teasdale, R. M., Dec 15 1992, In : Biochemical and Biophysical Research Communications. 189, 2, p. 972-978 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Endothelial cells express insulin-like growth factor-binding proteins 2 to 6

Moser, D. R., Lowe, W. L., Dake, B. L., Booth, B. A., Boes, M., Clemmons, D. R. & Bar, R. S., Nov 1 1992, In : Molecular Endocrinology. 6, 11, p. 1805-1814 10 p.

Research output: Contribution to journalArticle

70 Scopus citations

Regulation of insulin-like growth factor i production in rat c6 glioma cells: Possible role as an autocrine/paracrine growth factor

Lowe, W. L., Meyer, T., Karpen, C. W. & Lorentzen, L. R., May 1992, In : Endocrinology. 130, 5, p. 2683-2691 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Tissue-specific regulation of basic fibroblast growth factor mRNA levels by diabetes

Karpen, C. W., Spanheimer, R. G., Randolph, A. L. & Lowe, W. L., Jan 1 1992, In : Diabetes. 41, 2, p. 222-226 5 p.

Research output: Contribution to journalArticle

34 Scopus citations
1993

Intracellular calcium regulates insulin-like growth factor-i messenger ribonucleic acid levels

Hovis, J. G., Meyer, T., Teasdale, R. M., Albrecht, B. N., Yorek, M. A. & Lowe, W. L., Jan 1 1993, In : Endocrinology. 132, 5, p. 1931-1938 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
7 Scopus citations
1994

Editorial: Once is not enough--promiscuity begets diversity among the insulin-like growth factor binding proteins

Lowe Jr, W. L., Jan 1 1994, In : Endocrinology. 135, 5, p. 1719-1721 3 p.

Research output: Contribution to journalArticle

4 Scopus citations
1995

Regulation of growth factor mRNA levels in the eyes of diabetic rats

Lowe, W. L., Florkiewicz, R. Z., Yorek, M. A., Spanheimer, R. G. & Albrecht, B. N., Aug 1995, In : Metabolism. 44, 8, p. 1038-1045 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
24 Scopus citations
1996

Localization and regulation of renal Na+/myo-inositol cotransporter in diabetic rats

Wiese, T. J., Matsushita, K., Lowe, W. L., Stokes, J. B. & Yorek, M. A., Jan 1 1996, In : Kidney international. 50, 4, p. 1202-1211 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Osmotic regulation of Na-myo-inositol cotransporter mRNA level and activity in endothelial and neural cells

Wiese, T. J., Dunlap, J. A., Conner, C. E., Grzybowski, J. A., Lowe, W. L. & Yorek, M. A., Apr 1 1996, In : American Journal of Physiology - Cell Physiology. 270, 4 39-4, p. C990-C997

Research output: Contribution to journalArticle

49 Scopus citations
1997

Growth factor-induced transcription via the serum response element is inhibited by cyclic adenosine 3',5'-monophosphate in MCF-7 breast cancer cells

Lowe, W. L., Fu, R. & Banko, M., Jan 1 1997, In : Endocrinology. 138, 6, p. 2219-2226 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
1998

Effect of TNF-α on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells

Yorek, M. A., Dunlap, J. A., Thomas, M. J., Cammarata, P. R., Zhou, C. & Lowe, W. L., Jan 1 1998, In : American Journal of Physiology - Cell Physiology. 274, 1 43-1

Research output: Contribution to journalArticle

18 Scopus citations
43 Scopus citations
7 Scopus citations
1999

Developmental regulation of insulin-like growth factor-I and growth hormone receptor gene expression

Shoba, L., An, M. R., Frank, S. J. & Lowe, W. L., Jun 25 1999, In : Molecular and Cellular Endocrinology. 152, 1-2, p. 125-136 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis

Chung, W. K., Luke, A., Cooper, R. S., Rotini, C., Vidal-Puig, A., Rosenbaum, M., Chua, M., Solanes, G., Zheng, M., Zhao, L., LeDuc, C., Eisberg, A., Chu, F., Murphy, E., Schreier, M., Aronne, L., Caprio, S., Kahle, B., Gordon, D., Leal, S. M. & 9 others, Goldsmith, R., Andreu, A. L., Bruno, C., DiMauro, S., Heo, M., Lowe, W. L., Lowell, B. B., Allison, D. B. & Leibel, R. L., Sep 11 1999, In : Diabetes. 48, 9, p. 1890-1895 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Growth hormone-mediated regulation of insulin-like growth factor I promoter activity in C6 glioma cells

Benbassat, C., Shoba, L. N. N., Newman, M., Adamo, M. L., Frank, S. J. & Lowe, W. L., Jan 1 1999, In : Endocrinology. 140, 7, p. 3073-3081 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Osmotic regulation of the Na+/myo-inositol cotransporter and postinduction normalization

Yorek, M. A., Dunlap, J. A. & Lowe, W. L., Jan 1 1999, In : Kidney international. 55, 1, p. 215-224 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

Chung, W. K., Luke, A., Cooper, R. S., Rotini, C., Vidal-Puig, A., Rosenbaum, M., Gordon, D., Leal, S. M., Caprio, S., Goldsmith, R., Andreu, A. L., Bruno, C., DiMauro, S., Heo, M., Lowe, W. L., Lowell, B. B., Allison, D. B. & Leibel, R. L., Jun 1 1999, In : International Journal of Obesity. 23, p. S49-S50

Research output: Contribution to journalArticle

7 Scopus citations

The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans

Rotimi, C. N., Comuzzie, A. G., Lowe, W. L., Luke, A., Blangero, J. & Cooper, R. S., Jan 1 1999, In : Diabetes. 48, 3, p. 643-644 2 p.

Research output: Contribution to journalArticle

92 Scopus citations
2000

Abnormal glucose metabolism and pancreatic cancer mortality

Gapstur, S. M., Gann, P. H., Lowe, W., Liu, K., Colangelo, L. & Dyer, A., May 17 2000, In : Journal of the American Medical Association. 283, 19, p. 2552-2558 7 p.

Research output: Contribution to journalArticle

318 Scopus citations

Activation of members of the mitogen-activated protein kinase family by glucose in endothelial cells

Liu, W., Schoenkerman, A. & Lowe Jr, W. L., Oct 1 2000, In : American Journal of Physiology. 279, 4 PART 1

Research output: Contribution to journalArticle

59 Scopus citations

Insulin-like growth factor I activates c-Jun N-terminal kinase in MCF-7 breast cancer cells

Monno, S., Newman, M. V., Cook, M. & Lowe, J., Jan 1 2000, In : Endocrinology. 141, 2, p. 544-550 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Lack of association between the - 308 polymorphism of the tumor necrosis factor-α gene and the insulin resistance syndrome

Da Silva, B., Gapstur, S. M., Achenbach, Y. H., Schuh, T. S., Kotlar, T. J., Liu, K. & Lowe Jr, W. L., Jan 1 2000, In : Journal of Investigative Medicine. 48, 4, p. 236-244 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Normalization of hyperosmotic-induced inositol uptake by renal and endothelial cells is regulated by NF-κB

Yorek, M. A., Dunlap, J. A., Liu, W. & Lowe, W. L., Jun 22 2000, In : American Journal of Physiology - Cell Physiology. 278, 5 47-5

Research output: Contribution to journalArticle

11 Scopus citations
3 Scopus citations
2001

Heritability of obesity-related traits among Nigerians, Jamaicans and US black people

Luke, A., Guo, X., Adeyemo, A. A., Wilks, R., Forrester, T., Lowe, W., Comuzzie, A. G., Martin, L. J., Zhu, X., Rotimi, C. N. & Cooper, R. S., Jul 4 2001, In : International Journal of Obesity. 25, 7, p. 1034-1041 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes

Shoba, L. N. N., Newman, M., Liu, W. & Lowe, W. L., Jan 1 2001, In : Endocrinology. 142, 9, p. 3980-3986 7 p.

Research output: Contribution to journalArticle

29 Scopus citations
63 Scopus citations