William L Lowe Jr

  • 6415 Citations
1981 …2023
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Research Output 1981 2020

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310 Citations (Scopus)

Abnormal glucose metabolism and pancreatic cancer mortality

Gapstur, S. M., Gann, P. H., Lowe, W., Liu, K., Colangelo, L. & Dyer, A., May 17 2000, In : Journal of the American Medical Association. 283, 19, p. 2552-2558 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Glucose
Mortality
Body Mass Index
Uric Acid
43 Citations (Scopus)

Accumulation of cadmium in insulin-producing β cells

El Muayed, M., Raja, M. R., Zhang, X., Macrenaris, K. W., Bhatt, S., Chen, X., Urbanek, M., O'Halloran, T. V. & Lowe Jr, W. L., Nov 1 2012, In : Islets. 4, 6, p. 405-416 12 p.

Research output: Contribution to journalArticle

Cadmium
Insulin
Oxidative Stress
Cadmium Chloride
Type 2 Diabetes Mellitus
60 Citations (Scopus)

Activation of members of the mitogen-activated protein kinase family by glucose in endothelial cells

Liu, W., Schoenkerman, A. & Lowe Jr, W. L., Oct 1 2000, In : American Journal of Physiology. 279, 4 PART 1

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Endothelial Cells
Glucose
Raffinose
Fructose
57 Citations (Scopus)

Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic β-cell death

Wenli, L. I. U., Chin-Chance, C., Eun-Jig, L. E. E. & Lowe Jr, W. L., Oct 1 2002, In : Endocrinology. 143, 10, p. 3802-3812 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Insulin-Like Growth Factor I
Cell Death
Cyclic AMP Response Element-Binding Protein
Phosphorylation
25 Citations (Scopus)

Activation of protein kinase-C differentially regulates insulin-like growth factor-I and basic fibroblast growth factor messenger RNA levels

Lowe, W. L., Yorek, M. A., Karpen, C. W., Teasdale, R. M., Hovis, J. G., Albrecht, B. & Prokopiou, C., May 1 1992, In : Molecular Endocrinology. 6, 5, p. 741-752 12 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Insulin-Like Growth Factor I
Protein Kinase C
Messenger RNA
Acetates
37 Citations (Scopus)

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic β-cell function

El Muayed, M., Billings, L. K., Raja, M. R., Zhang, X., Park, P. J., Newman, M. V., Kaufman, D. B., O'Halloran, T. V. & Lowe, W. L., Aug 1 2010, In : Journal of Endocrinology. 206, 2, p. 159-169 11 p.

Research output: Contribution to journalArticle

Down-Regulation
Cytokines
Interleukin-1
Insulin
Messenger RNA
47 Citations (Scopus)

A novel common variant in DCST2 is associated with length in early life and height in adulthood

van der Valk, R. J. P., Kreiner-Møller, E., Kooijman, M. N., Guxens, M., Stergiakouli, E., Sääf, A., Bradfield, J. P., Geller, F., Geoffrey Hayes, M., Cousminer, D. L., Körner, A., Thiering, E., Curtin, J. A., Myhre, R., Huikari, V., Joro, R., Kerkhof, M., Warrington, N. M., Pitkänen, N., Ntalla, I. & 33 others, Horikoshi, M., Veijola, R., Freathy, R. M., Teo, Y. Y., Barton, S. J., Evans, D. M., Kemp, J. P., Pourcain, B. S., Ring, S. M., Smith, G. D., Bergström, A., Kull, I., Hakonarson, H., Mentch, F. D., Bisgaard, H., Chawes, B., Stokholm, J., Waage, J., Eriksen, P., Sevelsted, A., Melbye, M., van Duijn, C. M., Medina-Gomez, C., Hofman, A., de Jongste, J. C., Rob Taal, H., Uitterlinden, A. G., Armstrong, L. L., Eriksson, J., Lowe, W. L., Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium, Genetic Investigation of ANthropometric Traits (GIANT) Consortium & for the Early Growth Genetics (EGG) Consortium, Feb 15 2015, In : Human molecular genetics. 24, 4, p. 1155-1168 14 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Parturition
Genome
Cell Fusion
Genome-Wide Association Study
3 Citations (Scopus)

A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women

MEDIA Consortium, Mar 1 2017, In : PloS one. 12, 3, e0172577.

Research output: Contribution to journalArticle

African Americans
Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
112 Citations (Scopus)

Anti-inflammatory peptide-functionalized hydrogels for insulin-secreting cell encapsulation

Su, J., Hu, B. H., Lowe, W. L., Kaufman, D. B. & Messersmith, P. B., Jan 1 2010, In : Biomaterials. 31, 2, p. 308-314 7 p.

Research output: Contribution to journalArticle

Hydrogels
Insulin
Insulin-Secreting Cells
Encapsulation
Peptides
41 Citations (Scopus)

Association of gestational diabetes with maternal disorders of glucose metabolism and childhood adiposity

HAPO Follow-up Study Cooperative Research, Sep 11 2018, In : JAMA - Journal of the American Medical Association. 320, 10, p. 1005-1016 12 p.

Research output: Contribution to journalArticle

Glucose Metabolism Disorders
Gestational Diabetes
Adiposity
Mothers
Odds Ratio
9 Citations (Scopus)

Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations

Petry, C. J., Mooslehner, K., Prentice, P., Hayes, M. G., Nodzenski, M., Scholtens, D. M., Hughes, I. A., Acerini, C. L., Ong, K. K., Lowe, W. L. & Dunger, D. B., Sep 2017, In : Diabetes and Metabolism. 43, 4, p. 323-331 9 p.

Research output: Contribution to journalArticle

Alleles
Mothers
Glucose
Pregnancy
Single Nucleotide Polymorphism
9 Citations (Scopus)

Associations between Fetal Imprinted Genes and Maternal Blood Pressure in Pregnancy

Petry, C. J., Sanz Marcos, N., Pimentel, G., Hayes, M. G., Nodzenski, M., Scholtens, D. M., Hughes, I. A., Acerini, C. L., Ong, K. K., Lowe Jr, W. L. & Dunger, D. B., Dec 1 2016, In : Hypertension. 68, 6, p. 1459-1466 8 p.

Research output: Contribution to journalArticle

Mothers
Blood Pressure
Fathers
Pregnancy
Genes
26 Citations (Scopus)

Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes

Sandler, V., Reisetter, A. C., Bain, J. R., Muehlbauer, M. J., Nodzenski, M., Stevens, R. D., Ilkayeva, O., Lowe, L. P., Metzger, B. E., Newgard, C. B., Scholtens, D. M., Lowe, W. L. & for the HAPO Study Cooperative Research Group, T. HAPO. S. C. R. G., Mar 1 2017, In : Diabetologia. 60, 3, p. 518-530 13 p.

Research output: Contribution to journalArticle

Metabolome
Insulin Resistance
Mothers
Lipids
Adiposity

Bayesian estimation of genetic regulatory effects in high-throughput reporter assays

Majoros, W. H., Kim, Y. S., Barrera, A., Li, F., Wang, X., Cunningham, S. J., Johnson, G. D., Guo, C., Lowe, W. L., Scholtens, D. M., Hayes, M. G., Reddy, T. E. & Allen, A. S., Jan 15 2020, In : Bioinformatics (Oxford, England). 36, 2, p. 331-338 8 p.

Research output: Contribution to journalArticle

Bayesian Estimation
High Throughput
Assays
Throughput
Experimental design
17 Citations (Scopus)

Characterization of a rat insulin-like growth factor I gene promoter

Lowe, W. L. & Teasdale, R. M., Dec 15 1992, In : Biochemical and Biophysical Research Communications. 189, 2, p. 972-978 7 p.

Research output: Contribution to journalArticle

5' Flanking Region
Insulin-Like Growth Factor I
Rats
Exons
Genes
45 Citations (Scopus)

Characterization of large structural genetic mosaicism in human autosomes

Machiela, M. J., Zhou, W., Sampson, J. N., Dean, M. C., Jacobs, K. B., Black, A., Brinton, L. A., Chang, I. S., Chen, C., Chen, C., Chen, K., Cook, L. S., Crous Bou, M., De Vivo, I., Doherty, J., Friedenreich, C. M., Gaudet, M. M., Haiman, C. A., Hankinson, S. E., Hartge, P. & 179 others, Henderson, B. E., Hong, Y. C., Hosgood, H. D., Hsiung, C. A., Hu, W., Hunter, D. J., Jessop, L., Kim, H. N., Kim, Y. H., Kim, Y. T., Klein, R., Kraft, P., Lan, Q., Lin, D., Liu, J., Le Marchand, L., Liang, X., Lissowska, J., Lu, L., Magliocco, A. M., Matsuo, K., Olson, S. H., Orlow, I., Park, J. Y., Pooler, L., Prescott, J., Rastogi, R., Risch, H. A., Schumacher, F., Seow, A., Setiawan, V. W., Shen, H., Sheng, X., Shin, M. H., Shu, X. O., Vanden Berg, D., Wang, J. C., Wentzensen, N., Wong, M. P., Wu, C., Wu, T., Wu, Y. L., Xia, L., Yang, H. P., Yang, P. C., Zheng, W., Zhou, B., Abnet, C. C., Albanes, D., Aldrich, M. C., Amos, C., Amundadottir, L. T., Berndt, S. I., Blot, W. J., Bock, C. H., Bracci, P. M., Burdett, L., Buring, J. E., Butler, M. A., Carreón, T., Chatterjee, N., Chung, C. C., Cook, M. B., Cullen, M., Davis, F. G., Ding, T., Duell, E. J., Epstein, C. G., Fan, J. H., Figueroa, J. D., Fraumeni, J. F., Freedman, N. D., Fuchs, C. S., Gao, Y. T., Gapstur, S. M., Patiño-Garcia, A., Garcia-Closas, M., Gaziano, J. M., Giles, G. G., Gillanders, E. M., Giovannucci, E. L., Goldin, L., Goldstein, A. M., Greene, M. H., Hallmans, G., Harris, C. C., Henriksson, R., Holly, E. A., Hoover, R. N., Hu, N., Hutchinson, A., Jenab, M., Johansen, C., Khaw, K. T., Koh, W. P., Kolonel, L. N., Kooperberg, C., Krogh, V., Kurtz, R. C., Lacroix, A., Landgren, A., Landi, M. T., Li, D., Liao, L. M., Malats, N., McGlynn, K. A., McNeill, L. H., McWilliams, R. R., Melin, B. S., Mirabello, L., Peplonska, B., Peters, U., Petersen, G. M., Prokunina-Olsson, L., Purdue, M., Qiao, Y. L., Rabe, K. G., Rajaraman, P., Real, F. X., Riboli, E., Rodríguez-Santiago, B., Rothman, N., Ruder, A. M., Savage, S. A., Schwartz, A. G., Schwartz, K. L., Sesso, H. D., Severi, G., Silverman, D. T., Spitz, M. R., Stevens, V. L., Stolzenberg-Solomon, R., Stram, D., Tang, Z. Z., Taylor, P. R., Teras, L. R., Tobias, G. S., Viswanathan, K., Wacholder, S., Wang, Z., Weinstein, S. J., Wheeler, W., White, E., Wiencke, J. K., Wolpin, B. M., Wu, X., Wunder, J. S., Yu, K., Zanetti, K. A., Zeleniuch-Jacquotte, A., Ziegler, R. G., De Andrade, M., Barnes, K. C., Beaty, T. H., Bierut, L. J., Desch, K. C., Doheny, K. F., Feenstra, B., Ginsburg, D., Heit, J. A., Kang, J. H., Laurie, C. A., Li, J. Z., Lowe, W. L., Marazita, M. L., Melbye, M., Mirel, D. B., Murray, J. C., Nelson, S. C., Pasquale, L. R., Rice, K., Wiggs, J. L., Wise, A., Tucker, M., Pérez-Jurado, L. A., Laurie, C. C., Caporaso, N. E., Yeager, M. & Chanock, S. J., Mar 5 2015, In : American Journal of Human Genetics. 96, 3, p. 487-497 11 p.

Research output: Contribution to journalArticle

Mosaicism
Genome-Wide Association Study
Meta-Analysis
Genome
Population
12 Citations (Scopus)

Characterization of the altered oligosaccharide composition of the insulin receptor on neural-derived cells

Ota, A., Shemer, J., Pruss, R. M., Lowe, W. L. & LeRoith, D., Mar 8 1988, In : Brain research. 443, 1-2, p. 1-11 11 p.

Research output: Contribution to journalArticle

Insulin Receptor
Oligosaccharides
Insulin
Membranes
Neuroblastoma
32 Citations (Scopus)

Collagen IV-modified scaffolds improve islet survival and function and reduce time to euglycemia

Yap, W. T., Salvay, D. M., Silliman, M. A., Zhang, X., Bannon, Z. G., Kaufman, D. B., Lowe, W. L. & Shea, L. D., Jan 1 2013, In : Tissue Engineering - Part A. 19, 21-22, p. 2361-2372 12 p.

Research output: Contribution to journalArticle

Scaffolds (biology)
Collagen
Scaffolds
Islets of Langerhans Transplantation
Insulin
27 Citations (Scopus)

Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1

Guo, C., Ludvik, A. E., Arlotto, M. E., Hayes, M. G., Armstrong, L. L., Scholtens, D. M., Brown, C. D., Newgard, C. B., Becker, T. C., Layden, B. T., Lowe, W. L. & Reddy, T. E., Feb 4 2015, In : Nature communications. 6, 6069.

Research output: Contribution to journalArticle

hexokinase
hyperglycemia
Hexokinase
glucose
Hyperglycemia
1 Citation (Scopus)

Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries

HAPO Study Cooperative Research Group, Oct 1 2019, In : The Journal of clinical endocrinology and metabolism. 104, 10, p. 4459-4472 14 p.

Research output: Contribution to journalArticle

Metabolomics
C-Peptide
Fetal Blood
Blood
Metabolites
286 Citations (Scopus)

Detectable clonal mosaicism from birth to old age and its relationship to cancer

Laurie, C. C., Laurie, C. A., Rice, K., Doheny, K. F., Zelnick, L. R., McHugh, C. P., Ling, H., Hetrick, K. N., Pugh, E. W., Amos, C., Wei, Q., Wang, L. E., Lee, J. E., Barnes, K. C., Hansel, N. N., Mathias, R., Daley, D., Beaty, T. H., Scott, A. F., Ruczinski, I. & 53 others, Scharpf, R. B., Bierut, L. J., Hartz, S. M., Landi, M. T., Freedman, N. D., Goldin, L. R., Ginsburg, D., Li, J., Desch, K. C., Strom, S. S., Blot, W. J., Signorello, L. B., Ingles, S. A., Chanock, S. J., Berndt, S. I., Le Marchand, L., Henderson, B. E., Monroe, K. R., Heit, J. A., De Andrade, M., Armasu, S. M., Regnier, C., Lowe, W. L., Hayes, M. G., Marazita, M. L., Feingold, E., Murray, J. C., Melbye, M., Feenstra, B., Kang, J. H., Wiggs, J. L., Jarvik, G. P., McDavid, A. N., Seshan, V. E., Mirel, D. B., Crenshaw, A., Sharopova, N., Wise, A., Shen, J., Crosslin, D. R., Levine, D. M., Zheng, X., Udren, J. I., Bennett, S., Nelson, S. C., Gogarten, S. M., Conomos, M. P., Heagerty, P., Manolio, T., Pasquale, L. R., Haiman, C. A., Caporaso, N. & Weir, B. S., Jun 1 2012, In : Nature Genetics. 44, 6, p. 642-650 9 p.

Research output: Contribution to journalArticle

Mosaicism
Parturition
Neoplasms
Chromosome Duplication
Uniparental Disomy
41 Citations (Scopus)

Developmental regulation of insulin-like growth factor-I and growth hormone receptor gene expression

Shoba, L., An, M. R., Frank, S. J. & Lowe, W. L., Jun 25 1999, In : Molecular and Cellular Endocrinology. 152, 1-2, p. 125-136 12 p.

Research output: Contribution to journalArticle

Somatotropin Receptors
Insulin-Like Growth Factor I
Gene expression
Gene Expression
Messenger RNA
63 Citations (Scopus)

Developmental regulation of rat brain/hep G2 glucose transporter gene expression

Werner, H., Adamo, M., Lowe, W. L., Roberts, C. T. & LeRoith, D., Feb 1989, In : Molecular Endocrinology. 3, 2, p. 273-279 7 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Gene Expression
Brain
Messenger RNA
Ribonucleases
53 Citations (Scopus)

Developmental regulation of somatostatin gene expression in the brain is region specific

Lowe, W. L., Schaffner, A. E., Roberts, C. T. & Leroith, D., Feb 1987, In : Molecular Endocrinology. 1, 2, p. 181-187 7 p.

Research output: Contribution to journalArticle

Developmental Gene Expression Regulation
Somatostatin
Stomach
Messenger RNA
Brain
98 Citations (Scopus)

Development of brain insulin receptors: Structural and functional studies of insulin receptors from whole brain and primary cell cultures

Lowe, W. L., Boyd, F. T., Clarke, D. W., Raizada, M. K., Hart, C. & Leroith, D., Jan 1 1986, In : Endocrinology. 119, 1, p. 25-35 11 p.

Research output: Contribution to journalArticle

Primary Cell Culture
Insulin Receptor
Brain
Neuroglia
Liver
298 Citations (Scopus)

Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I.

Lowe, W. L., Roberts, C. T., Lasky, S. R. & LeRoith, D., Jan 1 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 24, p. 8946-8950 5 p.

Research output: Contribution to journalArticle

5' Untranslated Regions
Insulin-Like Growth Factor I
Growth Hormone
Messenger RNA
Liver
199 Citations (Scopus)
Insulin-Like Growth Factor I
RNA
Messenger RNA
Liver
Alternative Splicing
4 Citations (Scopus)

Editorial: Once is not enough--promiscuity begets diversity among the insulin-like growth factor binding proteins

Lowe Jr, W. L., Jan 1 1994, In : Endocrinology. 135, 5, p. 1719-1721 3 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Proteins
Growth Inhibitors
Signal Transduction
Carrier Proteins
17 Citations (Scopus)

Effect of TNF-α on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells

Yorek, M. A., Dunlap, J. A., Thomas, M. J., Cammarata, P. R., Zhou, C. & Lowe, W. L., Jan 1 1998, In : American Journal of Physiology - Cell Physiology. 274, 1 43-1

Research output: Contribution to journalArticle

Inositol
Cultured Cells
Endothelial Cells
Tumor Necrosis Factor-alpha
Messenger RNA
70 Citations (Scopus)

Endothelial cells express insulin-like growth factor-binding proteins 2 to 6

Moser, D. R., Lowe, W. L., Dake, B. L., Booth, B. A., Boes, M., Clemmons, D. R. & Bar, R. S., Nov 1 1992, In : Molecular Endocrinology. 6, 11, p. 1805-1814 10 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
Endothelial Cells
Insulin-Like Growth Factor Binding Proteins
Pulmonary Artery
Microvessels
22 Citations (Scopus)

Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds

Hlavaty, K. A., Gibly, R. F., Zhang, X., Rives, C. B., Graham, J. G., Lowe, W. L., Luo, X. & Shea, L. D., Jul 2014, In : American Journal of Transplantation. 14, 7, p. 1523-1532 10 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Transplantation
Somatomedins
Transplants
Proteins
43 Citations (Scopus)
Fibroblast Growth Factor 2
Mitogen-Activated Protein Kinases
Human Activities
Estrogens
Endothelial Cells
42 Citations (Scopus)

Ethnic variation in allele distribution of the androgen receptor (AR) (CAG) n repeat

Ackerman, C. M., Lowe, L. P., Lee, H., Hayes, M. G., Dyer, A. R., Metzger, B. E., Lowe, W. L. & Urbanek, M., Mar 1 2012, In : Journal of Andrology. 33, 2, p. 210-215 6 p.

Research output: Contribution to journalArticle

Androgen Receptors
Alleles
Mothers
Hispanic Americans
Ethnic Groups
10 Citations (Scopus)

Expression and stability of insulin-like growth factor-I (IGF-I) mRNA splicing variants in the GH3 rat pituitary cell line

Lowe, W. L., Adamo, M., LeRoith, D. & Roberts, C. T., Aug 15 1989, In : Biochemical and Biophysical Research Communications. 162, 3, p. 1174-1179 6 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Rats
Cells
Cell Line
Messenger RNA
24 Citations (Scopus)

Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells

Zilberstein, M., Chou, J. Y., Lowe, W. L., Orr, Z. S., Roberts, C. T., Leroith, D. & Catt, K. J., Sep 1989, In : Molecular Endocrinology. 3, 9, p. 1488-1497 10 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Granulosa Cells
Insulin-Like Growth Factor I
Ovary
Messenger RNA
92 Citations (Scopus)

Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation

Salvay, D. M., Rives, C. B., Zhang, X., Chen, F., Kaufman, D. B., Lowe Jr, W. L. & Shea, L. D., May 27 2008, In : Transplantation. 85, 10, p. 1456-1464 9 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Extracellular Matrix Proteins
Transplants
Collagen
Fibronectins
40 Citations (Scopus)

Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine models

Gibly, R. F., Zhang, X., Graham, M. L., Hering, B. J., Kaufman, D. B., Lowe Jr, W. L. & Shea, L. D., Dec 1 2011, In : Biomaterials. 32, 36, p. 9677-9684 8 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Scaffolds
Polymers
Swine
Transplantation
70 Citations (Scopus)

Gene-environment interplay in common complex diseases: Forging an integrative model-Recommendations from an NIH workshop

Bookman, E. B., McAllister, K., Gillanders, E., Wanke, K., Balshaw, D., Rutter, J., Reedy, J., Shaughnessy, D., Agurs-Collins, T., Paltoo, D., Atienza, A., Bierut, L., Kraft, P., Fallin, M. D., Perera, F., Turkheimer, E., Boardman, J., Marazita, M. L., Rappaport, S. M., Boerwinkle, E. & 13 others, Suomi, S. J., Caporaso, N. E., Hertz-Picciotto, I., Jacobson, K. C., Lowe Jr, W. L., Goldman, L. R., Duggal, P., Gunnar, M. R., Manolio, T. A., Green, E. D., Olster, D. H., Birnbaum, L. S. & Gunnar, M. R., Apr 6 2011, In : Genetic Epidemiology. 35, 4, p. 217-225 9 p.

Research output: Contribution to journalArticle

Gene-Environment Interaction
Education
Disease Attributes
Genes
Information Dissemination
48 Citations (Scopus)

Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis

Chung, W. K., Luke, A., Cooper, R. S., Rotini, C., Vidal-Puig, A., Rosenbaum, M., Chua, M., Solanes, G., Zheng, M., Zhao, L., LeDuc, C., Eisberg, A., Chu, F., Murphy, E., Schreier, M., Aronne, L., Caprio, S., Kahle, B., Gordon, D., Leal, S. M. & 9 others, Goldsmith, R., Andreu, A. L., Bruno, C., DiMauro, S., Heo, M., Lowe, W. L., Lowell, B. B., Allison, D. B. & Leibel, R. L., Sep 11 1999, In : Diabetes. 48, 9, p. 1890-1895 6 p.

Research output: Contribution to journalArticle

Homeostasis
Mutation
RNA Isoforms
Quadriceps Muscle
Body Composition
3 Citations (Scopus)

Genetic determinants of adiponectin regulation revealed by pregnancy

Hivert, M. F., Scholtens, D. M., Allard, C., Nodzenski, M., Bouchard, L., Brisson, D., Lowe, L. P., McDowell, I., Reddy, T., Dastani, Z., Richards, J. B., Hayes, M. G. & Lowe, W. L., May 2017, In : Obesity. 25, 5, p. 935-944 10 p.

Research output: Contribution to journalArticle

Adiponectin
Alleles
Pregnancy
Adipocytes
Leptin
2 Citations (Scopus)

Genetic determinants of glycemic traits and the risk of gestational diabetes mellitus

Powe, C. E., Nodzenski, M., Talbot, O., Allard, C., Briggs, C., Leya, M. V., Perron, P., Bouchard, L., Florez, J. C., Scholtens, D. M., Lowe, W. L. & Hivert, M. F., Dec 1 2018, In : Diabetes. 67, 12, p. 2703-2709 7 p.

Research output: Contribution to journalArticle

Gestational Diabetes
Fasting
Insulin
Type 2 Diabetes Mellitus
Pregnancy
97 Citations (Scopus)

Genetic evidence for causal relationships between maternal obesity-related traits and birth weight

Tyrrell, J., Richmond, R. C., Palmer, T. M., Feenstra, B., Rangarajan, J., Metrustry, S., Cavadino, A., Paternoster, L., Armstrong, L. L., De Silva, N. M. G., Wood, A. R., Horikoshi, M., Geller, F., Myhre, R., Bradfield, J. P., Kreiner-Møller, E., Huikari, I., Painter, J. N., Hottenga, J. J., Allard, C. & 44 others, Berry, D. J., Bouchard, L., Das, S., Evans, D. M., Hakonarson, H., Hayes, M. G., Heikkinen, J., Hofman, A., Knight, B., Lind, P. A., McCarthy, M. I., McMahon, G., Medland, S. E., Melbye, M., Morris, A. P., Nodzenski, M., Reichetzeder, C., Ring, S. M., Sebert, S., Sengpiel, V., Sørensen, T. I. A., Willemsen, G., De Geus, E. J. C., Martin, N. G., Spector, T. D., Power, C., Järvelin, M. R., Bisgaard, H., Grant, S. F. A., Nohr, E. A., Jaddoe, V. W., Jacobsson, B., Murray, J. C., Hocher, B., Hattersley, A. T., Scholtens, D. M., Smith, G. D., Hivert, M. F., Felix, J. F., Hyppönen, E., Lowe, W. L., Frayling, T. M., Lawlor, D. A. & Freathy, R. M., Mar 15 2016, In : JAMA - Journal of the American Medical Association. 315, 11, p. 1129-1140 12 p.

Research output: Contribution to journalArticle

Birth Weight
Obesity
Mothers
Blood Pressure
Body Mass Index
10 Citations (Scopus)

Genetic risk score for prediction of newborn adiposity and large-for-gestational-age birth

Chawla, R., Badon, S. E., Rangarajan, J., Reisetter, A. C., Armstrong, L. L., Lowe, L. P., Urbanek, M., Metzger, B. E., Hayes, M. G., Scholtens, D. M. & Lowe, W. L., Nov 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 11, p. E2377-E2386

Research output: Contribution to journalArticle

Adiposity
Polymorphism
Gestational Age
Single Nucleotide Polymorphism
Nucleotides
42 Citations (Scopus)

Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5- CHRNA3-CHRNB4) interacts with maternal selfreported smoking status during pregnancy to influence birth weight

Tyrrell, J., Huikari, V., Christie, J. T., Cavadino, A., Bakker, R., Brion, M. J. A., Geller, F., Paternoster, L., Myhre, R., Potter, C., Johnson, P. C. D., Ebrahim, S., Feenstra, B., Hartikainen, A. L., Hattersley, A. T., Hofman, A., Kaakinen, M., Lowe, L. P., Magnus, P., McConnachie, A. & 23 others, Melbye, M., Ng, J. W. Y., Nohr, E. A., Power, C., Ring, S. M., Sebert, S. P., Sengpiel, V., Taal, H. R., Watt, G. C. M., Sattar, N., Relton, C. L., Jacobsson, B., Frayling, T. M., Sørensen, T. I. A., Murray, J. C., Lawlor, D. A., Pennell, C. E., Jaddoe, V. W. V., Hypponen, E., Lowe, W. L., Jarvelin, M. R., Smith, G. D. & Freathy, R. M., Dec 1 2012, In : Human molecular genetics. 21, 24, p. 5344-5358 15 p., dds372.

Research output: Contribution to journalArticle

Nicotinic Receptors
Multigene Family
Birth Weight
Smoking
Mothers
504 Citations (Scopus)

Genome partitioning of genetic variation for complex traits using common SNPs

Yang, J., Manolio, T. A., Pasquale, L. R., Boerwinkle, E., Caporaso, N., Cunningham, J. M., De Andrade, M., Feenstra, B., Feingold, E., Hayes, M. G., Hill, W. G., Landi, M. T., Alonso, A., Lettre, G., Lin, P., Ling, H., Lowe, W., Mathias, R. A., Melbye, M., Pugh, E. & 4 others, Cornelis, M. C., Weir, B. S., Goddard, M. E. & Visscher, P. M., Jan 1 2011, In : Nature Genetics. 43, 6, p. 519-525 7 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Genome
Body Mass Index
von Willebrand Factor
Multifactorial Inheritance
137 Citations (Scopus)

Genome-wide associations for birth weight and correlations with adult disease

Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-Tajes, J., Feenstra, B., Van Zuydam, N. R., Gaulton, K. J., Grarup, N., Bradfield, J. P., Strachan, D. P., Li-Gao, R., Ahluwalia, T. S., Kreiner, E., Rueedi, R., Lyytikaïnen, L. P., Cousminer, D. L., Wu, Y., Thiering, E. & 143 others, Wang, C. A., Have, C. T., Hottenga, J. J., Vilor-Tejedor, N., Joshi, P. K., Boh, E. T. H., Ntalla, I., Pitkänen, N., Mahajan, A., Van Leeuwen, E. M., Joro, R., Lagou, V., Nodzenski, M., Diver, L. A., Zondervan, K. T., Bustamante, M., Marques-Vidal, P., Mercader, J. M., Bennett, A. J., Rahmioglu, N., Nyholt, D. R., Ma, R. C. W., Tam, C. H. T., Tam, W. H., Ganesh, S. K., Van Rooij, F. J. A., Jones, S. E., Loh, P. R., Ruth, K. S., Tuke, M. A., Tyrrell, J., Wood, A. R., Yaghootkar, H., Scholtens, D. M., Paternoster, L., Prokopenko, I., Kovacs, P., Atalay, M., Willems, S. M., Panoutsopoulou, K., Wang, X., Carstensen, L., Geller, F., Schraut, K. E., Murcia, M., Van Beijsterveldt, C. E. M., Willemsen, G., Appel, E. V. R., Fonvig, C. E., Trier, C., Tiesler, C. M. T., Standl, M., Kutalik, Z., Bonàs-Guarch, S., Hougaard, D. M., Sánchez, F., Torrents, D., Waage, J., Hollegaard, M. V., De Haan, H. G., Rosendaal, F. R., Medina-Gomez, C., Ring, S. M., Hemani, G., McMahon, G., Robertson, N. R., Groves, C. J., Langenberg, C., Luan, JA., Scott, R. A., Zhao, J. H., Mentch, F. D., MacKenzie, S. M., Reynolds, R. M., Lowe Jr, W. L., Tönjes, A., Stumvoll, M., Lindi, V., Lakka, T. A., Van Duijn, C. M., Kiess, W., Körner, A., Sørensen, T. I. A., Niinikoski, H., Pahkala, K., Raitakari, O. T., Zeggini, E., Dedoussis, G. V., Teo, Y. Y., Saw, S. M., Melbye, M., Campbell, H., Wilson, J. F., Vrijheid, M., De Geus, E. J. C. N., Boomsma, D. I., Kadarmideen, H. N., Holm, J. C., Hansen, T., Sebert, S., Hattersley, A. T., Beilin, L. J., Newnham, J. P., Pennell, C. E., Heinrich, J., Adair, L. S., Borja, J. B., Mohlke, K. L., Eriksson, J. G., Widén, E., Kähönen, M., Viikari, J. S., Lehtimäki, T., Vollenweider, P., Bønnelykke, K., Bisgaard, H., Mook-Kanamori, D. O., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Pisinger, C., Pedersen, O., Power, C., Hyppönen, E., Wareham, N. J., Hakonarson, H., Davies, E., Walker, B. R., Jaddoe, V. W. V., Järvelin, M. R., Grant, S. F. A., Vaag, A. A., Lawlor, D. A., Frayling, T. M., Smith, G. D., Morris, A. P., Ong, K. K., Felix, J. F., Timpson, N. J., Perry, J. R. B., Evans, D. M., McCarthy, M. I. & Freathy, R. M., Jan 1 2016, In : Nature. 538, 7624, p. 248-252 5 p.

Research output: Contribution to journalArticle

Birth Weight
Genome
Type 2 Diabetes Mellitus
Blood Pressure
Chromatin Assembly and Disassembly
45 Citations (Scopus)

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Early Growth Genetics (EGG) Consortium, Feb 15 2018, In : Human molecular genetics. 27, 4, p. 742-756 15 p., ddx429.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Birth Weight
Mothers
Fetal Development
Single Nucleotide Polymorphism
25 Citations (Scopus)

G protein coupled receptors in embryonic stem cells: A role for Gs-alpha signaling

Layden, B. T., Newman, M., Chen, F., Fisher, A. & Lowe, W. L., Feb 8 2010, In : PloS one. 5, 2, e9105.

Research output: Contribution to journalArticle

embryonic stem cells
Embryonic Stem Cells
G-Protein-Coupled Receptors
Stem cells
Cell proliferation
21 Citations (Scopus)

Growth factor-induced transcription via the serum response element is inhibited by cyclic adenosine 3',5'-monophosphate in MCF-7 breast cancer cells

Lowe, W. L., Fu, R. & Banko, M., Jan 1 1997, In : Endocrinology. 138, 6, p. 2219-2226 8 p.

Research output: Contribution to journalArticle

Serum Response Element
Cyclic AMP
Intercellular Signaling Peptides and Proteins
Insulin-Like Growth Factor I
Epidermal Growth Factor
35 Citations (Scopus)

Growth hormone-mediated regulation of insulin-like growth factor I promoter activity in C6 glioma cells

Benbassat, C., Shoba, L. N. N., Newman, M., Adamo, M. L., Frank, S. J. & Lowe, W. L., Jan 1 1999, In : Endocrinology. 140, 7, p. 3073-3081 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Glioma
Growth Hormone
Luciferases
Genes