William L Lowe Jr

  • 6607 Citations
1981 …2024

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Research Output

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Article
2012

Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study

Kho, A. N., Hayes, M. G., Rasmussen-Torvik, L., Pacheco, J. A., Thompson, W. K., Armstrong, L. L., Denny, J. C., Peissig, P. L., Miller, A. W., Wei, W. Q., Bielinski, S. J., Chute, C. G., Leibson, C. L., Jarvik, G. P., Crosslin, D. R., Carlson, C. S., Newton, K. M., Wolf, W. A., Chisholm, R. L. & Lowe, W. L., Mar 1 2012, In : Journal of the American Medical Informatics Association. 19, 2, p. 212-218 7 p.

Research output: Contribution to journalArticle

157 Scopus citations
2011

Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine models

Gibly, R. F., Zhang, X., Graham, M. L., Hering, B. J., Kaufman, D. B., Lowe Jr, W. L. & Shea, L. D., Dec 1 2011, In : Biomaterials. 32, 36, p. 9677-9684 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Gene-environment interplay in common complex diseases: Forging an integrative model-Recommendations from an NIH workshop

Bookman, E. B., McAllister, K., Gillanders, E., Wanke, K., Balshaw, D., Rutter, J., Reedy, J., Shaughnessy, D., Agurs-Collins, T., Paltoo, D., Atienza, A., Bierut, L., Kraft, P., Fallin, M. D., Perera, F., Turkheimer, E., Boardman, J., Marazita, M. L., Rappaport, S. M., Boerwinkle, E. & 13 others, Suomi, S. J., Caporaso, N. E., Hertz-Picciotto, I., Jacobson, K. C., Lowe Jr, W. L., Goldman, L. R., Duggal, P., Gunnar, M. R., Manolio, T. A., Green, E. D., Olster, D. H., Birnbaum, L. S. & Gunnar, M. R., Apr 6 2011, In : Genetic Epidemiology. 35, 4, p. 217-225 9 p.

Research output: Contribution to journalArticle

71 Scopus citations

Genome partitioning of genetic variation for complex traits using common SNPs

Yang, J., Manolio, T. A., Pasquale, L. R., Boerwinkle, E., Caporaso, N., Cunningham, J. M., De Andrade, M., Feenstra, B., Feingold, E., Hayes, M. G., Hill, W. G., Landi, M. T., Alonso, A., Lettre, G., Lin, P., Ling, H., Lowe, W., Mathias, R. A., Melbye, M., Pugh, E. & 4 others, Cornelis, M. C., Weir, B. S., Goddard, M. E. & Visscher, P. M., Jun 2011, In : Nature Genetics. 43, 6, p. 519-525 7 p.

Research output: Contribution to journalArticle

522 Scopus citations

Phenotype harmonization and cross-study collaboration in GWAS consortia: The GENEVA experience

Bennett, S. N., Caporaso, N., Fitzpatrick, A. L., Agrawal, A., Barnes, K., Boyd, H. A., Cornelis, M. C., Hansel, N. N., Heiss, G., Heit, J. A., Kang, J. H., Kittner, S. J., Kraft, P., Lowe, W., Marazita, M. L., Monroe, K. R., Pasquale, L. R., Ramos, E. M., van Dam, R. M., Udren, J. & 1 others, Williams, K., Apr 1 2011, In : Genetic Epidemiology. 35, 3, p. 159-173 15 p.

Research output: Contribution to journalArticle

33 Scopus citations
2010

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic β-cell function

El Muayed, M., Billings, L. K., Raja, M. R., Zhang, X., Park, P. J., Newman, M. V., Kaufman, D. B., O'Halloran, T. V. & Lowe, W. L., Aug 1 2010, In : Journal of Endocrinology. 206, 2, p. 159-169 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Anti-inflammatory peptide-functionalized hydrogels for insulin-secreting cell encapsulation

Su, J., Hu, B. H., Lowe, W. L., Kaufman, D. B. & Messersmith, P. B., Jan 1 2010, In : Biomaterials. 31, 2, p. 308-314 7 p.

Research output: Contribution to journalArticle

113 Scopus citations

G protein coupled receptors in embryonic stem cells: A role for Gs-alpha signaling

Layden, B. T., Newman, M., Chen, F., Fisher, A. & Lowe, W. L., Feb 8 2010, In : PloS one. 5, 2, e9105.

Research output: Contribution to journalArticle

25 Scopus citations
64 Scopus citations
89 Scopus citations

Regulation of pancreatic islet gene expression in mouse islets by pregnancy

Layden, B. T., Durai, V., Newman, M. V., Marinelarena, A. M., Ahn, C. W., Feng, G., Lin, S., Zhang, X., Kaufman, D. B., Jafari, N., Sørensen, G. L. & Lowe, W. L., Dec 1 2010, In : Journal of Endocrinology. 207, 3, p. 265-279 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

The role of the polycystic ovary syndrome susceptibility locus D19S884 allele 8 in maternal glycemia and fetal size

Ackerman, C. M., Lowe, L. P., Lee, H., Chen, F., Hughes, E., Cholod, P., Dyer, A. R., Hayes, M. G., Metzger, B. E., Lowe, W. L. & Urbanek, M., Jul 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 7, p. 3242-3250 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2009

Layered PLG scaffolds for in vivo plasmid delivery

Rives, C. B., Rieux, A. D., Zelivyanskaya, M., Stock, S. R., Lowe, W. L. & Shea, L. D., Jan 1 2009, In : Biomaterials. 30, 3, p. 394-401 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

The association between pulse wave velocity and metabolic syndrome and adiponectin in patients with impaired fasting glucose: Cardiovascular risks and adiponectin in IFG

Nam, J. S., Park, J. S., Cho, M. H., Jee, S. H., Lee, H. S., Ahn, C. W., Lowe Jr, W. L. & Kim, K. R., May 1 2009, In : Diabetes Research and Clinical Practice. 84, 2, p. 145-151 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation

Salvay, D. M., Rives, C. B., Zhang, X., Chen, F., Kaufman, D. B., Lowe Jr, W. L. & Shea, L. D., May 27 2008, In : Transplantation. 85, 10, p. 1456-1464 9 p.

Research output: Contribution to journalArticle

94 Scopus citations

Rapamycin inhibits growth factor-induced cell cycle regulation in pancreatic β cells

Aronovitz, A., Josefson, J., Fisher, A., Newman, M., Hughes, E., Chen, F., Moons, D. S., Kiyokawa, H. & Lowe, W. L., Dec 2008, In : Journal of Investigative Medicine. 56, 8, p. 985-996 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2006

Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation

Blomeier, H., Zhang, X., Rives, C., Brissova, M., Hughes, E., Baker, M., Powers, A. C., Kaufman, D. B., Shea, L. D. & Lowe, W. L., Aug 1 2006, In : Transplantation. 82, 4, p. 452-459 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Role of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expression

Chin-Chance, C. V. T., Newman, M. V., Aronovitz, A., Blomeier, H., Kruger, J., Lee, E. J. & Lowe Jr, W. L., Jan 1 2006, In : Journal of Investigative Medicine. 54, 3, p. 132-142 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2002

Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic β-cell death

Wenli, L. I. U., Chin-Chance, C., Eun-Jig, L. E. E. & Lowe Jr, W. L., Oct 1 2002, In : Endocrinology. 143, 10, p. 3802-3812 11 p.

Research output: Contribution to journalArticle

57 Scopus citations
2001

Heritability of obesity-related traits among Nigerians, Jamaicans and US black people

Luke, A., Guo, X., Adeyemo, A. A., Wilks, R., Forrester, T., Lowe, W., Comuzzie, A. G., Martin, L. J., Zhu, X., Rotimi, C. N. & Cooper, R. S., Jul 4 2001, In : International Journal of Obesity. 25, 7, p. 1034-1041 8 p.

Research output: Contribution to journalArticle

86 Scopus citations

LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes

Shoba, L. N. N., Newman, M., Liu, W. & Lowe, W. L., Jan 1 2001, In : Endocrinology. 142, 9, p. 3980-3986 7 p.

Research output: Contribution to journalArticle

29 Scopus citations
63 Scopus citations

The β3-adrenergic receptor gene and obesity in a population sample of African Americans

Lowe, W. L., Rotimi, C. N., Luke, A., Guo, X., Zhu, X., Comuzzie, A. G., Schuh, T. S., Halbach, S., Kotlar, T. J. & Cooper, R. S., Feb 20 2001, In : International Journal of Obesity. 25, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
2000

Abnormal glucose metabolism and pancreatic cancer mortality

Gapstur, S. M., Gann, P. H., Lowe, W., Liu, K., Colangelo, L. & Dyer, A., May 17 2000, In : Journal of the American Medical Association. 283, 19, p. 2552-2558 7 p.

Research output: Contribution to journalArticle

315 Scopus citations

Activation of members of the mitogen-activated protein kinase family by glucose in endothelial cells

Liu, W., Schoenkerman, A. & Lowe Jr, W. L., Oct 1 2000, In : American Journal of Physiology. 279, 4 PART 1

Research output: Contribution to journalArticle

59 Scopus citations

Insulin-like growth factor I activates c-Jun N-terminal kinase in MCF-7 breast cancer cells

Monno, S., Newman, M. V., Cook, M. & Lowe, J., Jan 1 2000, In : Endocrinology. 141, 2, p. 544-550 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Lack of association between the - 308 polymorphism of the tumor necrosis factor-α gene and the insulin resistance syndrome

Da Silva, B., Gapstur, S. M., Achenbach, Y. H., Schuh, T. S., Kotlar, T. J., Liu, K. & Lowe Jr, W. L., Jan 1 2000, In : Journal of Investigative Medicine. 48, 4, p. 236-244 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Normalization of hyperosmotic-induced inositol uptake by renal and endothelial cells is regulated by NF-κB

Yorek, M. A., Dunlap, J. A., Liu, W. & Lowe, W. L., Jun 22 2000, In : American Journal of Physiology - Cell Physiology. 278, 5 47-5

Research output: Contribution to journalArticle

11 Scopus citations
3 Scopus citations
1999

Developmental regulation of insulin-like growth factor-I and growth hormone receptor gene expression

Shoba, L., An, M. R., Frank, S. J. & Lowe, W. L., Jun 25 1999, In : Molecular and Cellular Endocrinology. 152, 1-2, p. 125-136 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis

Chung, W. K., Luke, A., Cooper, R. S., Rotini, C., Vidal-Puig, A., Rosenbaum, M., Chua, M., Solanes, G., Zheng, M., Zhao, L., LeDuc, C., Eisberg, A., Chu, F., Murphy, E., Schreier, M., Aronne, L., Caprio, S., Kahle, B., Gordon, D., Leal, S. M. & 9 others, Goldsmith, R., Andreu, A. L., Bruno, C., DiMauro, S., Heo, M., Lowe, W. L., Lowell, B. B., Allison, D. B. & Leibel, R. L., Sep 11 1999, In : Diabetes. 48, 9, p. 1890-1895 6 p.

Research output: Contribution to journalArticle

48 Scopus citations

Growth hormone-mediated regulation of insulin-like growth factor I promoter activity in C6 glioma cells

Benbassat, C., Shoba, L. N. N., Newman, M., Adamo, M. L., Frank, S. J. & Lowe, W. L., Jan 1 1999, In : Endocrinology. 140, 7, p. 3073-3081 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Osmotic regulation of the Na+/myo-inositol cotransporter and postinduction normalization

Yorek, M. A., Dunlap, J. A. & Lowe, W. L., Jan 1 1999, In : Kidney international. 55, 1, p. 215-224 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

Chung, W. K., Luke, A., Cooper, R. S., Rotini, C., Vidal-Puig, A., Rosenbaum, M., Gordon, D., Leal, S. M., Caprio, S., Goldsmith, R., Andreu, A. L., Bruno, C., DiMauro, S., Heo, M., Lowe, W. L., Lowell, B. B., Allison, D. B. & Leibel, R. L., Jun 1 1999, In : International Journal of Obesity. 23, p. S49-S50

Research output: Contribution to journalArticle

7 Scopus citations

The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans

Rotimi, C. N., Comuzzie, A. G., Lowe, W. L., Luke, A., Blangero, J. & Cooper, R. S., Jan 1 1999, In : Diabetes. 48, 3, p. 643-644 2 p.

Research output: Contribution to journalArticle

92 Scopus citations
1998

Effect of TNF-α on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells

Yorek, M. A., Dunlap, J. A., Thomas, M. J., Cammarata, P. R., Zhou, C. & Lowe, W. L., Jan 1 1998, In : American Journal of Physiology - Cell Physiology. 274, 1 43-1

Research output: Contribution to journalArticle

18 Scopus citations
43 Scopus citations
7 Scopus citations
1997

Growth factor-induced transcription via the serum response element is inhibited by cyclic adenosine 3',5'-monophosphate in MCF-7 breast cancer cells

Lowe, W. L., Fu, R. & Banko, M., Jan 1 1997, In : Endocrinology. 138, 6, p. 2219-2226 8 p.

Research output: Contribution to journalArticle

21 Scopus citations
1996

Localization and regulation of renal Na+/myo-inositol cotransporter in diabetic rats

Wiese, T. J., Matsushita, K., Lowe, W. L., Stokes, J. B. & Yorek, M. A., Jan 1 1996, In : Kidney international. 50, 4, p. 1202-1211 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Osmotic regulation of Na-myo-inositol cotransporter mRNA level and activity in endothelial and neural cells

Wiese, T. J., Dunlap, J. A., Conner, C. E., Grzybowski, J. A., Lowe, W. L. & Yorek, M. A., Apr 1 1996, In : American Journal of Physiology - Cell Physiology. 270, 4 39-4, p. C990-C997

Research output: Contribution to journalArticle

49 Scopus citations
1995

Regulation of growth factor mRNA levels in the eyes of diabetic rats

Lowe, W. L., Florkiewicz, R. Z., Yorek, M. A., Spanheimer, R. G. & Albrecht, B. N., Aug 1995, In : Metabolism. 44, 8, p. 1038-1045 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
24 Scopus citations
1994

Editorial: Once is not enough--promiscuity begets diversity among the insulin-like growth factor binding proteins

Lowe Jr, W. L., Jan 1 1994, In : Endocrinology. 135, 5, p. 1719-1721 3 p.

Research output: Contribution to journalArticle

4 Scopus citations
1993

Intracellular calcium regulates insulin-like growth factor-i messenger ribonucleic acid levels

Hovis, J. G., Meyer, T., Teasdale, R. M., Albrecht, B. N., Yorek, M. A. & Lowe, W. L., Jan 1 1993, In : Endocrinology. 132, 5, p. 1931-1938 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
7 Scopus citations
1992

Activation of protein kinase-C differentially regulates insulin-like growth factor-I and basic fibroblast growth factor messenger RNA levels

Lowe, W. L., Yorek, M. A., Karpen, C. W., Teasdale, R. M., Hovis, J. G., Albrecht, B. & Prokopiou, C., May 1 1992, In : Molecular Endocrinology. 6, 5, p. 741-752 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Characterization of a rat insulin-like growth factor I gene promoter

Lowe, W. L. & Teasdale, R. M., Dec 15 1992, In : Biochemical and Biophysical Research Communications. 189, 2, p. 972-978 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Endothelial cells express insulin-like growth factor-binding proteins 2 to 6

Moser, D. R., Lowe, W. L., Dake, B. L., Booth, B. A., Boes, M., Clemmons, D. R. & Bar, R. S., Nov 1 1992, In : Molecular Endocrinology. 6, 11, p. 1805-1814 10 p.

Research output: Contribution to journalArticle

70 Scopus citations

Regulation of insulin-like growth factor i production in rat c6 glioma cells: Possible role as an autocrine/paracrine growth factor

Lowe, W. L., Meyer, T., Karpen, C. W. & Lorentzen, L. R., May 1992, In : Endocrinology. 130, 5, p. 2683-2691 9 p.

Research output: Contribution to journalArticle

52 Scopus citations