William L Lowe Jr

  • 6394 Citations
1981 …2023
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Research Output 1981 2019

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2011
40 Citations (Scopus)

Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine models

Gibly, R. F., Zhang, X., Graham, M. L., Hering, B. J., Kaufman, D. B., Lowe Jr, W. L. & Shea, L. D., Dec 1 2011, In : Biomaterials. 32, 36, p. 9677-9684 8 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Scaffolds
Polymers
Swine
Transplantation
70 Citations (Scopus)

Gene-environment interplay in common complex diseases: Forging an integrative model-Recommendations from an NIH workshop

Bookman, E. B., McAllister, K., Gillanders, E., Wanke, K., Balshaw, D., Rutter, J., Reedy, J., Shaughnessy, D., Agurs-Collins, T., Paltoo, D., Atienza, A., Bierut, L., Kraft, P., Fallin, M. D., Perera, F., Turkheimer, E., Boardman, J., Marazita, M. L., Rappaport, S. M., Boerwinkle, E. & 13 others, Suomi, S. J., Caporaso, N. E., Hertz-Picciotto, I., Jacobson, K. C., Lowe Jr, W. L., Goldman, L. R., Duggal, P., Gunnar, M. R., Manolio, T. A., Green, E. D., Olster, D. H., Birnbaum, L. S. & Gunnar, M. R., Apr 6 2011, In : Genetic Epidemiology. 35, 4, p. 217-225 9 p.

Research output: Contribution to journalArticle

Gene-Environment Interaction
Education
Disease Attributes
Genes
Information Dissemination
504 Citations (Scopus)

Genome partitioning of genetic variation for complex traits using common SNPs

Yang, J., Manolio, T. A., Pasquale, L. R., Boerwinkle, E., Caporaso, N., Cunningham, J. M., De Andrade, M., Feenstra, B., Feingold, E., Hayes, M. G., Hill, W. G., Landi, M. T., Alonso, A., Lettre, G., Lin, P., Ling, H., Lowe, W., Mathias, R. A., Melbye, M., Pugh, E. & 4 others, Cornelis, M. C., Weir, B. S., Goddard, M. E. & Visscher, P. M., Jan 1 2011, In : Nature Genetics. 43, 6, p. 519-525 7 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Genome
Body Mass Index
von Willebrand Factor
Multifactorial Inheritance
32 Citations (Scopus)

Phenotype harmonization and cross-study collaboration in GWAS consortia: The GENEVA experience

Bennett, S. N., Caporaso, N., Fitzpatrick, A. L., Agrawal, A., Barnes, K., Boyd, H. A., Cornelis, M. C., Hansel, N. N., Heiss, G., Heit, J. A., Kang, J. H., Kittner, S. J., Kraft, P., Lowe, W., Marazita, M. L., Monroe, K. R., Pasquale, L. R., Ramos, E. M., van Dam, R. M., Udren, J. & 1 others, Williams, K., Apr 1 2011, In : Genetic Epidemiology. 35, 3, p. 159-173 15 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Phenotype
Genes
Information Dissemination
Gene-Environment Interaction
2010
37 Citations (Scopus)

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic β-cell function

El Muayed, M., Billings, L. K., Raja, M. R., Zhang, X., Park, P. J., Newman, M. V., Kaufman, D. B., O'Halloran, T. V. & Lowe, W. L., Aug 1 2010, In : Journal of Endocrinology. 206, 2, p. 159-169 11 p.

Research output: Contribution to journalArticle

Down-Regulation
Cytokines
Interleukin-1
Insulin
Messenger RNA
111 Citations (Scopus)

Anti-inflammatory peptide-functionalized hydrogels for insulin-secreting cell encapsulation

Su, J., Hu, B. H., Lowe, W. L., Kaufman, D. B. & Messersmith, P. B., Jan 1 2010, In : Biomaterials. 31, 2, p. 308-314 7 p.

Research output: Contribution to journalArticle

Hydrogels
Insulin
Insulin-Secreting Cells
Encapsulation
Peptides
25 Citations (Scopus)

G protein coupled receptors in embryonic stem cells: A role for Gs-alpha signaling

Layden, B. T., Newman, M., Chen, F., Fisher, A. & Lowe, W. L., Feb 8 2010, In : PloS one. 5, 2, e9105.

Research output: Contribution to journalArticle

embryonic stem cells
Embryonic Stem Cells
G-Protein-Coupled Receptors
Stem cells
Cell proliferation
64 Citations (Scopus)
Gestational Diabetes
Pregnancy Outcome
Hyperglycemia
Fasting
Mothers
88 Citations (Scopus)
Pregnancy Outcome
Hyperglycemia
Outcome Assessment (Health Care)
Glucose
Pregnancy
31 Citations (Scopus)

Regulation of pancreatic islet gene expression in mouse islets by pregnancy

Layden, B. T., Durai, V., Newman, M. V., Marinelarena, A. M., Ahn, C. W., Feng, G., Lin, S., Zhang, X., Kaufman, D. B., Jafari, N., Sørensen, G. L. & Lowe, W. L., Dec 1 2010, In : Journal of Endocrinology. 207, 3, p. 265-279 15 p.

Research output: Contribution to journalArticle

Islets of Langerhans
Gene Expression
Pregnancy
Pulmonary Surfactant-Associated Protein D
RNA
9 Citations (Scopus)

The role of the polycystic ovary syndrome susceptibility locus D19S884 allele 8 in maternal glycemia and fetal size

Ackerman, C. M., Lowe, L. P., Lee, H., Chen, F., Hughes, E., Cholod, P., Dyer, A. R., Hayes, M. G., Metzger, B. E., Lowe, W. L. & Urbanek, M., Jul 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 7, p. 3242-3250 9 p.

Research output: Contribution to journalArticle

Polycystic Ovary Syndrome
C-Peptide
Alleles
Mothers
Glucose
2009
30 Citations (Scopus)

Layered PLG scaffolds for in vivo plasmid delivery

Rives, C. B., Rieux, A. D., Zelivyanskaya, M., Stock, S. R., Lowe, W. L. & Shea, L. D., Jan 1 2009, In : Biomaterials. 30, 3, p. 394-401 8 p.

Research output: Contribution to journalArticle

Scaffolds
Plasmids
Tissue Scaffolds
Scaffolds (biology)
Cell Transplantation
17 Citations (Scopus)

The association between pulse wave velocity and metabolic syndrome and adiponectin in patients with impaired fasting glucose: Cardiovascular risks and adiponectin in IFG

Nam, J. S., Park, J. S., Cho, M. H., Jee, S. H., Lee, H. S., Ahn, C. W., Lowe Jr, W. L. & Kim, K. R., May 1 2009, In : Diabetes Research and Clinical Practice. 84, 2, p. 145-151 7 p.

Research output: Contribution to journalArticle

Pulse Wave Analysis
Adiponectin
Fasting
Glucose
Waist Circumference
2008
92 Citations (Scopus)

Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation

Salvay, D. M., Rives, C. B., Zhang, X., Chen, F., Kaufman, D. B., Lowe Jr, W. L. & Shea, L. D., May 27 2008, In : Transplantation. 85, 10, p. 1456-1464 9 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Extracellular Matrix Proteins
Transplants
Collagen
Fibronectins
11 Citations (Scopus)

Rapamycin inhibits growth factor-induced cell cycle regulation in pancreatic β cells

Aronovitz, A., Josefson, J., Fisher, A., Newman, M., Hughes, E., Chen, F., Moons, D. S., Kiyokawa, H. & Lowe, W. L., Dec 2008, In : Journal of Investigative Medicine. 56, 8, p. 985-996 12 p.

Research output: Contribution to journalArticle

Sirolimus
Insulin-Like Growth Factor I
Intercellular Signaling Peptides and Proteins
Cell Cycle
Cells
2006
93 Citations (Scopus)

Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation

Blomeier, H., Zhang, X., Rives, C., Brissova, M., Hughes, E., Baker, M., Powers, A. C., Kaufman, D. B., Shea, L. D. & Lowe, W. L., Aug 1 2006, In : Transplantation. 82, 4, p. 452-459 8 p.

Research output: Contribution to journalArticle

Islets of Langerhans Transplantation
Polymers
Transplantation
Glucose Tolerance Test
Liver Transplantation
11 Citations (Scopus)

Role of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expression

Chin-Chance, C. V. T., Newman, M. V., Aronovitz, A., Blomeier, H., Kruger, J., Lee, E. J. & Lowe Jr, W. L., Jan 1 2006, In : Journal of Investigative Medicine. 54, 3, p. 132-142 11 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Gene expression
Insulin
Cytokines
Gene Expression
2002
57 Citations (Scopus)

Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic β-cell death

Wenli, L. I. U., Chin-Chance, C., Eun-Jig, L. E. E. & Lowe Jr, W. L., Oct 1 2002, In : Endocrinology. 143, 10, p. 3802-3812 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Insulin-Like Growth Factor I
Cell Death
Cyclic AMP Response Element-Binding Protein
Phosphorylation
2001
84 Citations (Scopus)

Heritability of obesity-related traits among Nigerians, Jamaicans and US black people

Luke, A., Guo, X., Adeyemo, A. A., Wilks, R., Forrester, T., Lowe Jr, W. L., Comuzzie, A. G., Martin, L. J., Zhu, X., Rotimi, C. N. & Cooper, R. S., Jul 4 2001, In : International Journal of Obesity. 25, 7, p. 1034-1041 8 p.

Research output: Contribution to journalArticle

Jamaica
Nigeria
Obesity
Fats
Population
29 Citations (Scopus)

LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes

Shoba, L. N. N., Newman, M., Liu, W. & Lowe, W. L., Jan 1 2001, In : Endocrinology. 142, 9, p. 3980-3986 7 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Insulin-Like Growth Factor I
Hepatocytes
Phosphatidylinositol 3-Kinases
63 Citations (Scopus)
Phosphatidylinositol 3-Kinase
Mitogen-Activated Protein Kinases
Insulin-Like Growth Factor I
Endothelial Cells
Cell Movement
11 Citations (Scopus)

The β3-adrenergic receptor gene and obesity in a population sample of African Americans

Lowe, W. L., Rotimi, C. N., Luke, A., Guo, X., Zhu, X., Comuzzie, A. G., Schuh, T. S., Halbach, S., Kotlar, T. J. & Cooper, R. S., Feb 20 2001, In : International Journal of Obesity. 25, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

African Americans
Adrenergic Receptors
Obesity
Population
Genes
2000
310 Citations (Scopus)

Abnormal glucose metabolism and pancreatic cancer mortality

Gapstur, S. M., Gann, P. H., Lowe, W., Liu, K., Colangelo, L. & Dyer, A., May 17 2000, In : Journal of the American Medical Association. 283, 19, p. 2552-2558 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Glucose
Mortality
Body Mass Index
Uric Acid
60 Citations (Scopus)

Activation of members of the mitogen-activated protein kinase family by glucose in endothelial cells

Liu, W., Schoenkerman, A. & Lowe Jr, W. L., Oct 1 2000, In : American Journal of Physiology. 279, 4 PART 1

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Endothelial Cells
Glucose
Raffinose
Fructose
29 Citations (Scopus)

Insulin-like growth factor I activates c-Jun N-terminal kinase in MCF-7 breast cancer cells

Monno, S., Newman, M. V., Cook, M. & Lowe, J., Jan 1 2000, In : Endocrinology. 141, 2, p. 544-550 7 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Insulin-Like Growth Factor I
Breast Neoplasms
Phosphatidylinositol 3-Kinase
Mitogen-Activated Protein Kinase 3
23 Citations (Scopus)

Lack of association between the - 308 polymorphism of the tumor necrosis factor-α gene and the insulin resistance syndrome

Da Silva, B., Gapstur, S. M., Achenbach, Y. H., Schuh, T. S., Kotlar, T. J., Liu, K. & Lowe Jr, W. L., Jan 1 2000, In : Journal of Investigative Medicine. 48, 4, p. 236-244 9 p.

Research output: Contribution to journalArticle

Polymorphism
Insulin Resistance
Tumor Necrosis Factor-alpha
Genes
Alleles
11 Citations (Scopus)

Normalization of hyperosmotic-induced inositol uptake by renal and endothelial cells is regulated by NF-κB

Yorek, M. A., Dunlap, J. A., Liu, W. & Lowe, W. L., Jun 22 2000, In : American Journal of Physiology - Cell Physiology. 278, 5 47-5

Research output: Contribution to journalArticle

Inositol
Endothelial Cells
Kidney
Messenger RNA
Dactinomycin
3 Citations (Scopus)
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Inositol
Adipocytes
Aorta
Endothelial Cells
1999
41 Citations (Scopus)

Developmental regulation of insulin-like growth factor-I and growth hormone receptor gene expression

Shoba, L., An, M. R., Frank, S. J. & Lowe, W. L., Jun 25 1999, In : Molecular and Cellular Endocrinology. 152, 1-2, p. 125-136 12 p.

Research output: Contribution to journalArticle

Somatotropin Receptors
Insulin-Like Growth Factor I
Gene expression
Gene Expression
Messenger RNA
48 Citations (Scopus)

Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis

Chung, W. K., Luke, A., Cooper, R. S., Rotini, C., Vidal-Puig, A., Rosenbaum, M., Chua, M., Solanes, G., Zheng, M., Zhao, L., LeDuc, C., Eisberg, A., Chu, F., Murphy, E., Schreier, M., Aronne, L., Caprio, S., Kahle, B., Gordon, D., Leal, S. M. & 9 others, Goldsmith, R., Andreu, A. L., Bruno, C., DiMauro, S., Heo, M., Lowe, W. L., Lowell, B. B., Allison, D. B. & Leibel, R. L., Sep 11 1999, In : Diabetes. 48, 9, p. 1890-1895 6 p.

Research output: Contribution to journalArticle

Homeostasis
Mutation
RNA Isoforms
Quadriceps Muscle
Body Composition
35 Citations (Scopus)

Growth hormone-mediated regulation of insulin-like growth factor I promoter activity in C6 glioma cells

Benbassat, C., Shoba, L. N. N., Newman, M., Adamo, M. L., Frank, S. J. & Lowe, W. L., Jan 1 1999, In : Endocrinology. 140, 7, p. 3073-3081 9 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Glioma
Growth Hormone
Luciferases
Genes
5 Citations (Scopus)

Osmotic regulation of the Na+/myo-inositol cotransporter and postinduction normalization

Yorek, M. A., Dunlap, J. A. & Lowe, W. L., Jan 1 1999, In : Kidney international. 55, 1, p. 215-224 10 p.

Research output: Contribution to journalArticle

Inositol
Messenger RNA
Extremities
Kidney
Dactinomycin
7 Citations (Scopus)

The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis

Chung, W. K., Luke, A., Cooper, R. S., Rotini, C., Vidal-Puig, A., Rosenbaum, M., Gordon, D., Leal, S. M., Caprio, S., Goldsmith, R., Andreu, A. L., Bruno, C., DiMauro, S., Heo, M., Lowe, W. L., Lowell, B. B., Allison, D. B. & Leibel, R. L., Jun 1 1999, In : International Journal of Obesity. 23, p. S49-S50

Research output: Contribution to journalArticle

Protein Isoforms
Homeostasis
Amino Acid Sequence Homology
Mutation
Rodentia
92 Citations (Scopus)

The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans

Rotimi, C. N., Comuzzie, A. G., Lowe, W. L., Luke, A., Blangero, J. & Cooper, R. S., Jan 1 1999, In : Diabetes. 48, 3, p. 643-644 2 p.

Research output: Contribution to journalArticle

Heritable Quantitative Trait
Genetic Linkage
Chromosomes, Human, Pair 2
Chromosome Mapping
Quantitative Trait Loci
1998
17 Citations (Scopus)

Effect of TNF-α on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells

Yorek, M. A., Dunlap, J. A., Thomas, M. J., Cammarata, P. R., Zhou, C. & Lowe, W. L., Jan 1 1998, In : American Journal of Physiology - Cell Physiology. 274, 1 43-1

Research output: Contribution to journalArticle

Inositol
Cultured Cells
Endothelial Cells
Tumor Necrosis Factor-alpha
Messenger RNA
43 Citations (Scopus)
Fibroblast Growth Factor 2
Mitogen-Activated Protein Kinases
Human Activities
Estrogens
Endothelial Cells
7 Citations (Scopus)
Symporters
Inositol
Adipocytes
Tumor Necrosis Factor-alpha
Messenger RNA
1997
21 Citations (Scopus)

Growth factor-induced transcription via the serum response element is inhibited by cyclic adenosine 3',5'-monophosphate in MCF-7 breast cancer cells

Lowe, W. L., Fu, R. & Banko, M., Jan 1 1997, In : Endocrinology. 138, 6, p. 2219-2226 8 p.

Research output: Contribution to journalArticle

Serum Response Element
Cyclic AMP
Intercellular Signaling Peptides and Proteins
Insulin-Like Growth Factor I
Epidermal Growth Factor
1996
24 Citations (Scopus)

Localization and regulation of renal Na+/myo-inositol cotransporter in diabetic rats

Wiese, T. J., Matsushita, K., Lowe, W. L., Stokes, J. B. & Yorek, M. A., Jan 1 1996, In : Kidney international. 50, 4, p. 1202-1211 10 p.

Research output: Contribution to journalArticle

Inositol
Kidney
Sodium
Messenger RNA
Loop of Henle
49 Citations (Scopus)

Osmotic regulation of Na-myo-inositol cotransporter mRNA level and activity in endothelial and neural cells

Wiese, T. J., Dunlap, J. A., Conner, C. E., Grzybowski, J. A., Lowe, W. L. & Yorek, M. A., Apr 1 1996, In : American Journal of Physiology - Cell Physiology. 270, 4 39-4, p. C990-C997

Research output: Contribution to journalArticle

Inositol
Endothelial Cells
Messenger RNA
Sodium
Osmolar Concentration
1995
30 Citations (Scopus)

Regulation of growth factor mRNA levels in the eyes of diabetic rats

Lowe, W. L., Florkiewicz, R. Z., Yorek, M. A., Spanheimer, R. G. & Albrecht, B. N., Jan 1 1995, In : Metabolism. 44, 8, p. 1038-1045 8 p.

Research output: Contribution to journalArticle

Intercellular Signaling Peptides and Proteins
Messenger RNA
Insulin-Like Growth Factor I
Retina
Insulin
24 Citations (Scopus)
Insulin-Like Growth Factor I
Rats
Exons
Protein Binding
Genes
1994
4 Citations (Scopus)

Editorial: Once is not enough--promiscuity begets diversity among the insulin-like growth factor binding proteins

Lowe Jr, W. L., Jan 1 1994, In : Endocrinology. 135, 5, p. 1719-1721 3 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Proteins
Growth Inhibitors
Signal Transduction
Carrier Proteins
1993
14 Citations (Scopus)

Intracellular calcium regulates insulin-like growth factor-i messenger ribonucleic acid levels

Hovis, J. G., Meyer, T., Teasdale, R. M., Albrecht, B. N., Yorek, M. A. & Lowe, W. L., Jan 1 1993, In : Endocrinology. 132, 5, p. 1931-1938 8 p.

Research output: Contribution to journalArticle

Thapsigargin
Somatomedins
Calcimycin
Insulin-Like Growth Factor I
RNA
7 Citations (Scopus)
Fibroblast Growth Factor 2
Insulin-Like Growth Factor I
Protein Kinase C
RNA
Ligands
1992
25 Citations (Scopus)

Activation of protein kinase-C differentially regulates insulin-like growth factor-I and basic fibroblast growth factor messenger RNA levels

Lowe, W. L., Yorek, M. A., Karpen, C. W., Teasdale, R. M., Hovis, J. G., Albrecht, B. & Prokopiou, C., May 1 1992, In : Molecular Endocrinology. 6, 5, p. 741-752 12 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Insulin-Like Growth Factor I
Protein Kinase C
Messenger RNA
Acetates
17 Citations (Scopus)

Characterization of a rat insulin-like growth factor I gene promoter

Lowe, W. L. & Teasdale, R. M., Dec 15 1992, In : Biochemical and Biophysical Research Communications. 189, 2, p. 972-978 7 p.

Research output: Contribution to journalArticle

5' Flanking Region
Insulin-Like Growth Factor I
Rats
Exons
Genes
70 Citations (Scopus)

Endothelial cells express insulin-like growth factor-binding proteins 2 to 6

Moser, D. R., Lowe, W. L., Dake, B. L., Booth, B. A., Boes, M., Clemmons, D. R. & Bar, R. S., Nov 1 1992, In : Molecular Endocrinology. 6, 11, p. 1805-1814 10 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 2
Endothelial Cells
Insulin-Like Growth Factor Binding Proteins
Pulmonary Artery
Microvessels
52 Citations (Scopus)

Regulation of insulin-like growth factor i production in rat c6 glioma cells: Possible role as an autocrine/paracrine growth factor

Lowe, W. L., Meyer, T., Karpen, C. W. & Lorentzen, L. R., Jan 1 1992, In : Endocrinology. 130, 5, p. 2683-2691 9 p.

Research output: Contribution to journalArticle

Somatomedins
Glioma
Intercellular Signaling Peptides and Proteins
Tretinoin
Dexamethasone
34 Citations (Scopus)

Tissue-specific regulation of basic fibroblast growth factor mRNA levels by diabetes

Karpen, C. W., Spanheimer, R. G., Randolph, A. L. & Lowe, W. L., Jan 1 1992, In : Diabetes. 41, 2, p. 222-226 5 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Messenger RNA
Diabetic Angiopathies
Streptozocin
Intercellular Signaling Peptides and Proteins