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Research Output

1998

Ammonia inhibits neural cell adhesion molecule polysialylation in chinese hamster ovary and small cell lung cancer cells

Zanghi, J. A., Mendoza, T. P., Knop, R. H. & Miller, W. M., Nov 1 1998, In : Journal of Cellular Physiology. 177, 2, p. 248-263 16 p.

Research output: Contribution to journalArticle

23 Scopus citations

Characterization of hematopoietic cell expansion, oxygen uptake, and glycolysis in a controlled, stirred-tank bioreactor system

Collins, P. C., Nielsen, L. K., Patel, S. D., Papoutsakis, E. T. & Miller, W. M., May 1 1998, In : Biotechnology Progress. 14, 3, p. 466-472 7 p.

Research output: Contribution to journalArticle

58 Scopus citations

Effects of CO2 and osmolality on hybridoma cells: Growth, metabolism and monoclonal antibody production

DeZengotita, V. M., Kimura, R. & Miller, W. M., Dec 1 1998, In : Cytotechnology. 28, 1-3, p. 213-227 15 p.

Research output: Contribution to journalArticle

56 Scopus citations

Elevated pCO2 Inhibits the Polysialylation of the Neural Cell Adhesion Molecule in CHO MT2-1-8 Cell Cultures

Zanghi, J. A., Mendoza, T. P., Knop, R. H. & Miller, W. H., 1998, Proceedings of the 1997 European Society for Animal Cell Technology (ESACT) Meeting. Merten, O. W., Perrin, P. & Griffiths, B. (eds.). Kluwer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Modeling ex vivo hematopoiesis using chemical engineering metaphors

Nielsen, L. K., Papoutsakis, E. T. & Miller, W. M., May 15 1998, In : Chemical Engineering Science. 53, 10, p. 1913-1925 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Oxygen tension alters the effects of cytokines on the megakaryocyte, erythrocyte, and granulocyte lineages

Laluppa, J. A., Papoutsakis, E. T. & Miller, W. M., Aug 8 1998, In : Experimental Hematology. 26, 9, p. 835-843 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

pH is a potent modulator of erythroid differentiation

Mcadams, T. A., Miller, W. M. & Papoutsakis, E. T., Nov 26 1998, In : British Journal of Haematology. 103, 2, p. 317-325 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Population balance model of in vivo neutrophil formation following bone marrow rescue therapy

Nielsen, L. K., Bender, J. G., Miller, W. M. & Papoutsakis, E. T., 1998, In : Cytotechnology. 28, 1-3, p. 157-162 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Quantitative Analysis of Cell Growth, Metabolism, and Product Formation

Miller, W. M. & Reddy, S., 1998, Cell & Tissue Culture: Laboratory Procedures in Biotechnology. Doyle, A. & Griffiths, J. B. (eds.). Chichester, England: John Wiley & Sons, Ltd.

Research output: Chapter in Book/Report/Conference proceedingChapter

Role of nucleotide sugar pools in the inhibition of NCAM polysialylation by ammonia

Zanghi, J. A., Mendoza, T. P., Schmelzer, A. E., Knop, R. H. & Miller, W. M., Nov 1 1998, In : Biotechnology Progress. 14, 6, p. 834-844 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Stirred culture of peripheral and cord blood hematopoietic cells offers advantages over traditional static systems for clinically relevant applications

Collins, P. C., Miller, W. M. & Papoutsakis, E. T., Sep 5 1998, In : Biotechnology and Bioengineering. 59, 5, p. 534-543 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Transport in a grooved perfusion flat-bed bioreactor for cell therapy applications

Horner, M., Miller, W. M., Ottino, J. M. & Papoutsakis, E. T., Sep 1 1998, In : Biotechnology Progress. 14, 5, p. 689-698 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
1999

Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO2 or pH

Zanghi, J. A., Schmelzer, A. E., Mendoza, T. P., Knop, R. H. & Miller, W. M., Oct 20 1999, In : Biotechnology and Bioengineering. 65, 2, p. 182-191 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Ex-vivo expansion of CFU-GM and BFU-E in unselected PBMC cultures with Flt3L is enhanced by autologous plasma

Guo, M., Miller, W. M., Papoutsakis, E. T., Patel, S., James, C., Goolsby, C. & Winter, J. N., Jan 1 1999, In : Cytotherapy. 1, 3, p. 183-194 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations

Hematopoietic Cells for Cellular and Gene Therapy: I. Basic Assay Techniques

Miller, W. M., 1999, Animal Cell Biotechnology: Methods and Protocols (Methods in Molecular Biology Series). Totowa, NJ: Humana Press, p. 211-227

Research output: Chapter in Book/Report/Conference proceedingChapter

Hematopoietic Cells for Cellular and Gene Therapy: II. Expansion Protocols

Miller, W. M., 1999, Animal Cell Biotechnology: Methods and Protocols (Methods in Molecular Biology Series). Totowa, NJ: Humana Press, p. 229-238

Research output: Chapter in Book/Report/Conference proceedingChapter

Hypoxia, Effects on Animal Cells

Miller, W. M., 1999, Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis, and Bioseparation. New York: wiley, p. 1418-1433

Research output: Chapter in Book/Report/Conference proceedingChapter

Initiation, Maintenance, and Quantification of Human Hematopoietic Cell Cultures

Collins, P. C., Patel, S. D. & Miller, W. M., 1999, Methods in Molecular Medicine. Morgan, J. R. & Yarmush, M. L. (eds.). Totowa, NJ: Humana Press, Vol. 18: Tissue Engineeri. p. 271-292

Research output: Chapter in Book/Report/Conference proceedingChapter

Nuclei-size distributions as predictive tools of hematopoietic cell proliferation

Collins, P. C., Patel, S. D., Papoutsakis, E. T. & Miller, W. M., Jan 1 1999, In : Cytotherapy. 1, 2, p. 99-110 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2000

Biotechnology progress: Editorial

Miller, W. M. & Schoenfeld, R. A., Jan 1 2000, In : Biotechnology Progress. 16, 5, 1 p.

Research output: Contribution to journalEditorial

Cell density-dependent proliferation in frequently-fed peripheral blood mononuclear cell cultures

Patel, S. D., Miller, W. M., Winter, J. N. & Papoutsakis, E. T., Jan 1 2000, In : Cytotherapy. 2, 4, p. 267-280 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cell science and protein crystal growth research for the International Space Station

Sigler, P. B., Stein, G. S., Boskey, A. L., Jones, N. D., Kuriyan, J., Miller, W. M., Shuler, M. L. & Wang, B-C., Dec 2000, In : Journal of Cellular Biochemistry. 79, p. 662-671

Research output: Contribution to journalArticle

2 Scopus citations

Clinical-scale production of granulocyte progenitor and post-progenitor cells using daniplestim, leridistim, Progenipoietin, Promegapoietin and autologous plasma

Patel, S. D., Guo, R., Miller, W. M., Papoutsakis, E. T., Minster, N. I., Baum, C. M. & Winter, J. N., Jan 1 2000, In : Cytotherapy. 2, 2, p. 85-94 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Considerations for osmolality measurement under elevated pCO2: Comparison of vapor pressure and freezing point osmometry

Schmelzer, A. E., DeZengotita, V. M. & Miller, W. M., Jan 20 2000, In : Biotechnology and Bioengineering. 67, 2, p. 189-196 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Dynamic model of ex vivo granulocytic kinetics to examine the effects of oxygen tension, pH, and interleukin-3

Hevehan, D. L., Wenning, L. A., Miller, W. M. & Papoutsakis, E. T., Sep 1 2000, In : Experimental Hematology. 28, 9, p. 1016-1028 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Erratum: Clinical-scale production of granulocyte progenitor and post-progenitor cells using daniplestim, leridistim, Progenipoietin, Promegapoietin and autologous plasma (Cytotherapy (2000) 2 (85-94))

Patel, S. D., Guo, R., Miller, W. M., Papoutsakis, E. T., Minister, N. I., Baum, C. M. & Winter, J. N., Dec 1 2000, In : Cytotherapy. 2, 5, 1 p.

Research output: Contribution to journalComment/debate

18 Scopus citations

Oxygen tension influences the differentiation, maturation and apoptosis of human megakaryocytes

Mostafa, S. S., Miller, W. M. & Terry Papoutsakis, E., Dec 1 2000, In : British Journal of Haematology. 111, 3, p. 879-889 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Phosphate feeding improves high-cell-concentration NSO myeloma culture performance for monoclonal antibody production

Dezengotita, V. M., Miller, W. M., Aunins, J. G. & Zhou, W., Sep 5 2000, In : Biotechnology and Bioengineering. 69, 5, p. 566-576 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Physiologically significant effects of pH and oxygen tension on granulopoiesis

Hevehan, D. L., Papoutsakis, E. T. & Miller, W. M., Mar 1 2000, In : Experimental Hematology. 28, 3, p. 267-275 9 p.

Research output: Contribution to journalArticle

67 Scopus citations
46 Scopus citations

Trans-epithelial electrical resistance in bronchial epithelial cells: effects of continuous H2O2 exposure and KGF

Chapman, K., Miller, W. M. & Waters, C., Dec 1 2000, In : Annals of Biomedical Engineering. 28, SUPPL. 1

Research output: Contribution to journalArticle

2001

Model-based estimation of myeloid hematopoietic progenitor cells in ex vivo cultures for cell and gene therapies

Yang, H., Papoutsakis, E. T. & Miller, W. M., Jan 7 2001, In : Biotechnology and Bioengineering. 72, 2, p. 144-155 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Modeling pO2 distributions in the bone marrow hematopoietic compartment. I. Krogh's model

Chow, D. C., Wenning, L. A., Miller, W. M. & Papoutsakis, E. T., Jan 1 2001, In : Biophysical Journal. 81, 2, p. 675-684 10 p.

Research output: Contribution to journalArticle

185 Scopus citations

Modeling pO2 distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models

Chow, D. C., Wenning, L. A., Miller, W. M. & Papoutsakis, E. T., Jan 1 2001, In : Biophysical Journal. 81, 2, p. 685-696 12 p.

Research output: Contribution to journalArticle

223 Scopus citations

Oxygen tension modulates the expression of cytokine receptors, transcription factors, and lineage-specific markers in cultured human megakaryocytes

Mostafa, S. S., Papoutsakis, E. T. & Miller, W. M., Jul 12 2001, In : Experimental Hematology. 29, 7, p. 873-883 11 p.

Research output: Contribution to journalArticle

43 Scopus citations
2002

A systems biology approach to hematopoietic stem-cell differentiation

Papoutsakis, E. T., Huang, L. T., Yang, H. & Miller, W. M., Jan 1 2002, In : Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 1, 1 p.

Research output: Contribution to journalConference article

Characterization of hybridoma cell responses to elevated pCO2 and osmolality: Intracellular pH, cell size, apoptosis, and metabolism

DeZengotita, V. M., Schmelzer, A. E. & Miller, W. M., Feb 15 2002, In : Biotechnology and Bioengineering. 77, 4, p. 369-380 12 p.

Research output: Contribution to journalArticle

72 Scopus citations

Continuous exposure of airway epithelial cells to hydrogen peroxide: Protection by KGF

Chapman, K. E., Waters, C. M. & Miller, W. M., Jun 13 2002, In : Journal of Cellular Physiology. 192, 1, p. 71-80 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation

Hevehan, D. L., Miller, W. M. & Papoutsakis, E. T., Mar 1 2002, In : Blood. 99, 5, p. 1627-1637 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

Effects of osmoprotectant compounds on NCAM polysialylation under hyperosmotic stress and elevated pCO2

Schmelzer, A. E. & Miller, W. M., Feb 15 2002, In : Biotechnology and Bioengineering. 77, 4, p. 359-368 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Environmental Effects of Cell Physiology and Metabolism: Response to Elevated pCO2

Schmelzer, A. E., deZengotita, V. M. & Miller, W. M., 2002, Proceedings of the 17th European Society for Animal Cell Technology (ESACT) Meeting. Lindner-Olsson, E., Chatzissavidou, N. & Lüllau, E. (eds.). Kluwer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Higher pH promotes megakaryocytic maturation and apoptosis

Yang, H., Miller, W. M. & Papoutsakis, E. T., Jan 1 2002, In : Stem Cells. 20, 4, p. 320-328 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Hyperosmotic stress and elevated pCO2 alter monoclonal antibody charge distribution and monosaccharide content

Schmelzer, A. E. & Miller, W. M., Apr 22 2002, In : Biotechnology Progress. 18, 2, p. 346-353 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Selected amino acids protect hybridoma and CHO cells from elevated carbon dioxide and osmolality

DeZengotita, V. M., Abston, L. R., Schmelzer, A. E., Shaw, S. & Miller, W. M., Jun 30 2002, In : Biotechnology and Bioengineering. 78, 7, p. 741-752 12 p.

Research output: Contribution to journalArticle

38 Scopus citations
2003

Small increases in pH enhance retroviral vector transduction efficiency of NIH-3T3 cells

Jensen, T. W., Chen, Y. & Miller, W. M., Jan 1 2003, In : Biotechnology Progress. 19, 1, p. 216-223 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2004

Actin Re-Distribution in Response to Hydrogen Peroxide in Airway Epithelial Cells

Boardman, K. C., Aryal, A. M., Miller, W. M. & Waters, C. M., Apr 1 2004, In : Journal of Cellular Physiology. 199, 1, p. 57-66 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

DNA-array based transcriptional analysis elucidates granulocytic differentiation of human stem cells

Huang, L. T., Miller, W. M. & Papoutsakis, E. T., Dec 1 2004. 1 p.

Research output: Contribution to conferencePaper