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Research Output

1998

Effects of CO2 and osmolality on hybridoma cells: Growth, metabolism and monoclonal antibody production

DeZengotita, V. M., Kimura, R. & Miller, W. M., Dec 1 1998, In : Cytotechnology. 28, 1-3, p. 213-227 15 p.

Research output: Contribution to journalArticle

56 Scopus citations

Elevated pCO2 Inhibits the Polysialylation of the Neural Cell Adhesion Molecule in CHO MT2-1-8 Cell Cultures

Zanghi, J. A., Mendoza, T. P., Knop, R. H. & Miller, W. H., 1998, Proceedings of the 1997 European Society for Animal Cell Technology (ESACT) Meeting. Merten, O. W., Perrin, P. & Griffiths, B. (eds.). Kluwer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Modeling ex vivo hematopoiesis using chemical engineering metaphors

Nielsen, L. K., Papoutsakis, E. T. & Miller, W. M., May 15 1998, In : Chemical Engineering Science. 53, 10, p. 1913-1925 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Oxygen tension alters the effects of cytokines on the megakaryocyte, erythrocyte, and granulocyte lineages

Laluppa, J. A., Papoutsakis, E. T. & Miller, W. M., Aug 8 1998, In : Experimental Hematology. 26, 9, p. 835-843 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

pH is a potent modulator of erythroid differentiation

Mcadams, T. A., Miller, W. M. & Papoutsakis, E. T., Nov 26 1998, In : British Journal of Haematology. 103, 2, p. 317-325 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Population balance model of in vivo neutrophil formation following bone marrow rescue therapy

Nielsen, L. K., Bender, J. G., Miller, W. M. & Papoutsakis, E. T., Dec 1 1998, In : Cytotechnology. 28, 1-3, p. 157-162 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Quantitative Analysis of Cell Growth, Metabolism, and Product Formation

Miller, W. M. & Reddy, S., 1998, Cell & Tissue Culture: Laboratory Procedures in Biotechnology. Doyle, A. & Griffiths, J. B. (eds.). Chichester, England: John Wiley & Sons, Ltd.

Research output: Chapter in Book/Report/Conference proceedingChapter

Role of nucleotide sugar pools in the inhibition of NCAM polysialylation by ammonia

Zanghi, J. A., Mendoza, T. P., Schmelzer, A. E., Knop, R. H. & Miller, W. M., Nov 1 1998, In : Biotechnology Progress. 14, 6, p. 834-844 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Stirred culture of peripheral and cord blood hematopoietic cells offers advantages over traditional static systems for clinically relevant applications

Collins, P. C., Miller, W. M. & Papoutsakis, E. T., Sep 5 1998, In : Biotechnology and Bioengineering. 59, 5, p. 534-543 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Transport in a grooved perfusion flat-bed bioreactor for cell therapy applications

Horner, M., Miller, W. M., Ottino, J. M. & Papoutsakis, E. T., Sep 1 1998, In : Biotechnology Progress. 14, 5, p. 689-698 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
1997

Culture materials affect ex vivo expansion of hematopoietic progenitor cells

Laluppa, J. A., McAdams, T. A., Papoutsakis, E. T. & Miller, W. M., Sep 5 1997, In : Journal of Biomedical Materials Research. 36, 3, p. 347-359 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

Evaluation of cytokines for expansion of the megakaryocyte and granulocyte lineages

Laiuppa, J. A., Papoutsakis, E. T. & Miller, W. M., Jan 1 1997, In : Stem Cells. 15, 3, p. 198-206 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Ex vivo expansion of hematopoietic stem and progenitor cells for transplantation.

LaIuppa, J. A., Papoutsakis, E. T. & Miller, W. M., 1997, In : Cancer treatment and research. 77, p. 159-186 28 p.

Research output: Contribution to journalReview article

5 Scopus citations

Factors affecting megakaryocytic expansion in hematopoietic cultures for transplant therapies

LaIauppa, J. A., Miller, W. M. & Papoutsakis, E. T., 1997, Proceedings of the 1996 European Society for Animal Cell Technology (ESACT) Meeting. Corrondo, J. T., Griffiths, B. & Moreira, J. L. P. (eds.). Kluwer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Glycosylation of CHO-derived recombinant tPA produced under elevated pCO2

Kimura, R. & Miller, W. M., May 1 1997, In : Biotechnology Progress. 13, 3, p. 311-317 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Inverse-signal analysis with PCA

Reddy, V. N., Miller, W. M. & Mavrovouniotis, M. L., Feb 1 1997, In : Chemometrics and Intelligent Laboratory Systems. 36, 1, p. 17-30 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Real-time method for determining the colony-forming cell content of human hematopoietic cell cultures

Collins, P. C., Nielsen, L. K., Wong, C. K., Papoutsakis, E. T. & Miller, W. M., Aug 20 1997, In : Biotechnology and Bioengineering. 55, 4, p. 693-700 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Variations in culture pH affect the cloning efficiency and differentiation of progenitor cells in ex vivo haemopoiesis

Mcadams, T. A., Miller, W. M. & Papoutsakis, E. T., Jan 1 1997, In : British Journal of Haematology. 97, 4, p. 889-895 7 p.

Research output: Contribution to journalArticle

45 Scopus citations
1996

Comparison of whole serum-deprived media for ex vivo expansion of hematopoietic progenitor cells from cord blood and mobilized peripheral blood mononuclear cells

Sandstrom, C. E., Collins, P. C., Mcadams, T. A., Bender, J. G., Papoutsakis, E. T. & Miller, W. M., Oct 1996, In : Journal of Hematotherapy and Stem Cell Research. 5, 5, p. 461-473 13 p.

Research output: Contribution to journalReview article

16 Scopus citations
51 Scopus citations

Effects of elevated pCO2 and/or osmolality on the growth and recombinant tPA production of CHO cells

Kimura, R. & Miller, W. M., Oct 5 1996, In : Biotechnology and Bioengineering. 52, 1, p. 152-160 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Ex vivo culture systems for hematopoietic cells

Collins, P. C., Papoutsakis, E. T. & Miller, W. M., Apr 1996, In : Current Opinion in Biotechnology. 7, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Hematopoietic cell culture therapies (Part I): Cell culture considerations

McAdams, T. A., Miller, W. M. & Papoutsakis, E. T., Sep 1996, In : Trends in biotechnology. 14, 9, p. 341-349 9 p.

Research output: Contribution to journalReview article

41 Scopus citations

Hematopoietic cell culture therapies (Part II): Clinical aspects and applications

McAdams, T. A., Winter, J. N., Miller, W. M. & Papoutsakis, E. T., Oct 1996, In : Trends in biotechnology. 14, 10, p. 388-396 9 p.

Research output: Contribution to journalReview article

33 Scopus citations
25 Scopus citations
1995

Effects of CD34+ cell selection and perfusion on ex vivo expansion of peripheral blood mononuclear cells

Sandstrom, C. E., Bender, J. G., Papoutsakis, E. T. & Miller, W. M., Jan 1 1995, In : Blood. 86, 3, p. 958-970 13 p.

Research output: Contribution to journalArticle

69 Scopus citations

Ex vivo expansion of primitive hematopoietic cells for cellular therapies: An overview

McAdams, T. A., Sandstrom, C. E., Miller, W. M., Bender, J. G. & Papoutsakis, E. T., Jan 1 1995, In : Cytotechnology. 18, 1-2, p. 133-146 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

First-order toxicity assays for eye irritation using cell lines: Parameters that affect in Vitro evaluation

Pasternak, A. S. & Miller, W. M., May 1 1995, In : Toxicological Sciences. 25, 2, p. 253-263 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

First-Order Toxicity Assays for Eye Irritation Using Cell Lines: Parameters That Affect in Vitro Evaluation

Pasternak, A. S. & Miller, W. M., May 1 1995, In : Fundamental and Applied Toxicology. 25, 2, p. 253-263 11 p.

Research output: Contribution to journalArticle

Loss of fatty acid Δ6 desaturating ability in human mammary epithelial cells that express an activated c-Ha-ras oncogene

Grammatikos, S. I., Harvey, M. J., Subbaiah, P. V., Victor, T. A. & Miller, W. M., Jan 1 1995, In : International Journal of Oncology. 6, 5, p. 1039-1046 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
1994

Bioreactors for expansion of hematopoetic progenitor cells

Miller, W. M., Koller, M. R., Sandstrom, C. E., Papoutsakis, E. T. & Bender, J. G., Nov 17 1994, In : Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 22, 5

Research output: Contribution to journalArticle

Discrimination of fluorinated uridine metabolites in N‐417 small cell lung cancer cell extracts via 19F‐ and 31P‐NMR

Pederson, N. V., Zanghi, J. A., Miller, W. M. & Knop, R. H., Jan 1 1994, In : Magnetic resonance in medicine. 31, 2, p. 224-228 5 p.

Research output: Contribution to journalLetter

7 Scopus citations

Diverse effects of essential (n-6 and n-3) fatty acids on cultured cells

Grammatikos, S. I., Subbaiah, P. V., Victor, T. A. & Miller, W. M., Feb 1 1994, In : Cytotechnology. 15, 1-3, p. 31-50 20 p.

Research output: Contribution to journalArticle

32 Scopus citations

Diversity in the ability of cultured cells to elongate and desaturate essential (n-6 and n-3) fatty acids

Grammatikos, S. I., Subbaiah, P. V., Victor, T. A. & Miller, W. M., Jan 1 1994, In : Annals of the New York Academy of Sciences. 745, p. 92-105 14 p.

Research output: Contribution to journalArticle

22 Scopus citations
36 Scopus citations

n-3 and n-6 fatty acid processing and growth effects in neoplastic and non-cancerous human mammary epithelial cell lines

Grammatikos, S. I., Subbaiah, P. V., Victor, T. A. & Miller, W. M., Aug 1994, In : British Journal of Cancer. 70, 2, p. 219-227 9 p.

Research output: Contribution to journalArticle

127 Scopus citations

Serum‐free media for cultures of primitive and mature hematopoietic cells

Sandstrom, C. E., Miller, W. M. & Papoutsakis, E. T., Apr 5 1994, In : Biotechnology and Bioengineering. 43, 8, p. 706-733 28 p.

Research output: Contribution to journalReview article

29 Scopus citations
1993

Expansion of primitive human hematopoietic progenitors in a perfusion bioreactor system with IL-3, IL-6, and stem cell factor

Koller, M. R., Bender, J. G., Miller, W. M. & Papoutsakis, E. T., Mar 1993, In : Bio/Technology. 11, 3, p. 358-363 6 p.

Research output: Contribution to journalArticle

82 Scopus citations

Ex Vivo Expansion of Hematopoietic Stem and Progenitor Cells

Miller, W. M. & Papoutsakis, E. T., 1993, In : Journal of the Robert H. Lurie Cancer Center of Northwestern University. 3, p. 78-84

Research output: Contribution to journalArticle

111 Scopus citations

Production of tPA in recombinant CHO cells under oxygen‐limited conditions

Lin, A. A., Kimura, R. & Miller, W. M., Jul 1993, In : Biotechnology and Bioengineering. 42, 3, p. 339-350 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Quantitative Analysis of Cell Growth, Metabolism, and Product Formation

Miller, W. M., 1993, Cell & Tissue Culture: Laboratory Procedures. Chichester, England: John Wiley & Sons, Ltd., p. 8B1.1-26

Research output: Chapter in Book/Report/Conference proceedingChapter

1992

Beneficial Effects of Reduced Oxygen Tension and Perfusion in Long‐Term Hematopoietic Cultures

KOLLER, MANFRED. R., BENDER, JAMES. G., PAPOUTSAKIS, E. TERRY. & Miller, W. M., Jan 1 1992, In : Annals of the New York Academy of Sciences. 665, 1, p. 105-116 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

CHO cell responses to low oxygen: Regulation of oxygen consumption and sensitization to oxidative stress

Lin, A. A. & Miller, W. M., Aug 5 1992, In : Biotechnology and Bioengineering. 40, 4, p. 505-516 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Determination of antibody content in live versus dead hybridoma cells: Analysis of antibody production in osmotically stressed cultures

Reddy, S., Bauer, K. D. & Miller, W. M., Jan 1 1992, In : Biotechnology and Bioengineering. 40, 8, p. 947-964 18 p.

Research output: Contribution to journalArticle

35 Scopus citations

Effects of synergistic cytokine combinations, low oxygen, and irradiated stroma on the expansion of human cord blood progenitors

Koller, M. R., Bender, J. G., Papoutsakis, E. T. & Miller, W. M., Jan 1 1992, In : Blood. 80, 2, p. 403-411 9 p.

Research output: Contribution to journalArticle

73 Scopus citations

Hybridoma antibody content and production rate in continuous culture: Effect of dilution rate

Reddy, S. & Miller, W. M., Nov 1 1992, In : Biotechnology Letters. 14, 11, p. 1007-1012 6 p.

Research output: Contribution to journalArticle

3 Scopus citations
13 Scopus citations

Reduced oxygen tension increases hematopoiesis in long-term culture of human stem and progenitor cells from cord blood and bone marrow

Koller, M. R., Bender, J. G., Miller, W. M. & Papoutsakis, E. T., Jan 1 1992, In : Experimental Hematology. 20, 2, p. 264-270 7 p.

Research output: Contribution to journalArticle

79 Scopus citations

UDP-AT-Acetylhexosamine Modulation by Glucosamine and Uridine in NCI N-417 Variant Small Cell Lung Cancer Cells: 31P Nuclear Magnetic Resonance Results

Pederson, N. V., Knop, R. H. & Miller, W. M., Jul 1992, In : Cancer Research. 52, 13, p. 3782-3786 5 p.

Research output: Contribution to journalArticle

15 Scopus citations
1991

A rapid method for counting cell nuclei using a particle sizer/counter

Lin, A. A., Nguyen, T. & Miller, W. M., Mar 1 1991, In : Biotechnology Techniques. 5, 2, p. 153-156 4 p.

Research output: Contribution to journalArticle

25 Scopus citations