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Research Output

Maturation and death in terminal megakaryocytic differentiation: Phenotypic and DNA-microarray characterization

Fuhrken, P. G., Chen, C., Giammona, L. M., Miller, W. M. & Papoutsakis, E. T., Dec 1 2004. 1 p.

Research output: Contribution to conferencePaper

25 Scopus citations

Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD+ levels and SIRT inhibition

Giammona, L. M., Panuganti, S., Kemper, J. M., Apostolidis, P. A., Lindsey, S., Papoutsakis, E. T. & Miller, W. M., Nov 2009, In : Experimental Hematology. 37, 11, p. 1340-1352.e3

Research output: Contribution to journalArticle

31 Scopus citations

Megakaryocyte development illuminated by transcriptional analysis

Fuhrken, P. G., Chen, C., Miller, W. M. & Papoutsakis, E. T., Dec 1 2005, 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings. 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Megakaryocyte polyploidization and proplatelet formation in low-attachment conditions

Schlinker, A. C., Duncan, M. T., DeLuca, T. A., Whitehead, D. C. & Miller, W. M., Jul 15 2016, In : Biochemical Engineering Journal. 111, p. 24-33 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mimicking stem cell niches to increase stem cell expansion

Dellatore, S. M., Garcia, A. S. & Miller, W. M., Oct 1 2008, In : Current Opinion in Biotechnology. 19, 5, p. 534-540 7 p.

Research output: Contribution to journalReview article

169 Scopus citations

Model-based estimation of myeloid hematopoietic progenitor cells in ex vivo cultures for cell and gene therapies

Yang, H., Papoutsakis, E. T. & Miller, W. M., Jan 7 2001, In : Biotechnology and Bioengineering. 72, 2, p. 144-155 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Modeling ex vivo hematopoiesis using chemical engineering metaphors

Nielsen, L. K., Papoutsakis, E. T. & Miller, W. M., May 15 1998, In : Chemical Engineering Science. 53, 10, p. 1913-1925 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Modeling pO2 distributions in the bone marrow hematopoietic compartment. I. Krogh's model

Chow, D. C., Wenning, L. A., Miller, W. M. & Papoutsakis, E. T., Jan 1 2001, In : Biophysical Journal. 81, 2, p. 675-684 10 p.

Research output: Contribution to journalArticle

186 Scopus citations

Modeling pO2 distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models

Chow, D. C., Wenning, L. A., Miller, W. M. & Papoutsakis, E. T., Jan 1 2001, In : Biophysical Journal. 81, 2, p. 685-696 12 p.

Research output: Contribution to journalArticle

223 Scopus citations
13 Scopus citations

Mussel-inspired biofunctional coatings that can be applied to any material surface

Lee, H., Dellatore, S. M., Miller, W. M. & Messersmith, P. B., Dec 1 2008, 8th World Biomaterials Congress 2008. 1 p. (8th World Biomaterials Congress 2008; vol. 4).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mussel-inspired surface chemistry for multifunctional coatings

Lee, H., Dellatore, S. M., Miller, W. M. & Messersmith, P. B., Oct 19 2007, In : Science. 318, 5849, p. 426-430 5 p.

Research output: Contribution to journalArticle

5762 Scopus citations

n-3 and n-6 fatty acid processing and growth effects in neoplastic and non-cancerous human mammary epithelial cell lines

Grammatikos, S. I., Subbaiah, P. V., Victor, T. A. & Miller, W. M., Aug 1994, In : British Journal of Cancer. 70, 2, p. 219-227 9 p.

Research output: Contribution to journalArticle

127 Scopus citations

Nicotinamide (vitamin B3) increases the polyploidisation and proplatelet formation of cultured primary human megakaryocytes

Giammona, L. M., Fuhrken, P. G., Papoutsakis, E. T. & Miller, W. M., Nov 1 2006, In : British Journal of Haematology. 135, 4, p. 554-566 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

Nicotinamide increases the megakaryocytic maturation of human hematopoietic stem cells primarily due to sirtuin inhibition

Panuganti, S., Papoutsakis, E. T. & Miller, W. M., Dec 1 2008, AIChE100 - 2008 AIChE Annual Meeting, Conference Proceedings. (AIChE Annual Meeting, Conference Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nuclei-size distributions as predictive tools of hematopoietic cell proliferation

Collins, P. C., Patel, S. D., Papoutsakis, E. T. & Miller, W. M., Jan 1 1999, In : Cytotherapy. 1, 2, p. 99-110 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Optimization and critical evaluation of decellularization strategies to develop renal extracellular matrix scaffolds as biological templates for organ engineering and transplantation

Caralt, M., Uzarski, J. S., Iacob, S., Obergfell, K. P., Berg, N., Bijonowski, B. M., Kiefer, K. M., Ward, H. H., Wandinger-Ness, A., Miller, W. M., Zhang, Z. J., Abecassis, M. M. & Wertheim, J. A., Jan 1 2015, In : American Journal of Transplantation. 15, 1, p. 64-75 12 p.

Research output: Contribution to journalArticle

109 Scopus citations

Oxygen tension alters the effects of cytokines on the megakaryocyte, erythrocyte, and granulocyte lineages

Laluppa, J. A., Papoutsakis, E. T. & Miller, W. M., Aug 8 1998, In : Experimental Hematology. 26, 9, p. 835-843 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Oxygen tension influences the differentiation, maturation and apoptosis of human megakaryocytes

Mostafa, S. S., Miller, W. M. & Terry Papoutsakis, E., Dec 1 2000, In : British Journal of Haematology. 111, 3, p. 879-889 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Oxygen tension modulates the expression of cytokine receptors, transcription factors, and lineage-specific markers in cultured human megakaryocytes

Mostafa, S. S., Papoutsakis, E. T. & Miller, W. M., Jul 12 2001, In : Experimental Hematology. 29, 7, p. 873-883 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

pH is a potent modulator of erythroid differentiation

Mcadams, T. A., Miller, W. M. & Papoutsakis, E. T., Nov 26 1998, In : British Journal of Haematology. 103, 2, p. 317-325 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Phosphate feeding improves high-cell-concentration NSO myeloma culture performance for monoclonal antibody production

Dezengotita, V. M., Miller, W. M., Aunins, J. G. & Zhou, W., Sep 5 2000, In : Biotechnology and Bioengineering. 69, 5, p. 566-576 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Physiologically significant effects of pH and oxygen tension on granulopoiesis

Hevehan, D. L., Papoutsakis, E. T. & Miller, W. M., Mar 1 2000, In : Experimental Hematology. 28, 3, p. 267-275 9 p.

Research output: Contribution to journalArticle

67 Scopus citations

Polymer biocompatibility-effect on hybridoma growth and metabolism

Miller, W. M., Lin, A. A., Wilke, C. R. & Blanch, H. W., Jul 1 1986, In : Biotechnology Letters. 8, 7, p. 463-468 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Population balance model of in vivo neutrophil formation following bone marrow rescue therapy

Nielsen, L. K., Bender, J. G., Miller, W. M. & Papoutsakis, E. T., 1998, In : Cytotechnology. 28, 1-3, p. 157-162 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Production of tPA in recombinant CHO cells under oxygen‐limited conditions

Lin, A. A., Kimura, R. & Miller, W. M., Jul 1993, In : Biotechnology and Bioengineering. 42, 3, p. 339-350 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Profiling deacetylase activities in cell lysates with peptide arrays and SAMDI mass spectrometry

Kuo, H. Y., Deluca, T. A., Miller, W. M. & Mrksich, M., Nov 19 2013, In : Analytical Chemistry. 85, 22, p. 10635-10642 8 p.

Research output: Contribution to journalReview article

28 Scopus citations

Proposed megakaryocytic regulon of p53: The genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation

Apostolidis, P. A., Lindsey, S., Miller, W. M. & Papoutsakis, E. T., Jun 1 2012, In : Physiological genomics. 44, 12, p. 638-650 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Proteome analysis of antibody-producing CHO cell lines with different metabolic profiles

Pascoe, D. E., Arnott, D., Papoutsakis, E. T., Miller, W. M. & Andersen, D. C., Oct 1 2007, In : Biotechnology and Bioengineering. 98, 2, p. 391-410 20 p.

Research output: Contribution to journalArticle

55 Scopus citations

Quantitative Analysis of Cell Growth, Metabolism, and Product Formation

Miller, W. M., 1993, Cell & Tissue Culture: Laboratory Procedures. Chichester, England: John Wiley & Sons, Ltd., p. 8B1.1-26

Research output: Chapter in Book/Report/Conference proceedingChapter

Quantitative Analysis of Cell Growth, Metabolism, and Product Formation

Miller, W. M. & Reddy, S., 1998, Cell & Tissue Culture: Laboratory Procedures in Biotechnology. Doyle, A. & Griffiths, J. B. (eds.). Chichester, England: John Wiley & Sons, Ltd.

Research output: Chapter in Book/Report/Conference proceedingChapter

Real-time method for determining the colony-forming cell content of human hematopoietic cell cultures

Collins, P. C., Nielsen, L. K., Wong, C. K., Papoutsakis, E. T. & Miller, W. M., Aug 20 1997, In : Biotechnology and Bioengineering. 55, 4, p. 693-700 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Reduced oxygen tension increases hematopoiesis in long-term culture of human stem and progenitor cells from cord blood and bone marrow

Koller, M. R., Bender, J. G., Miller, W. M. & Papoutsakis, E. T., Jan 1 1992, In : Experimental Hematology. 20, 2, p. 264-270 7 p.

Research output: Contribution to journalArticle

80 Scopus citations

Regulation of animal cell metabolism in bioreactors.

Miller, W. M. & Blanch, H. W., 1991, In : Biotechnology (Reading, Mass.). 17, p. 119-161 43 p.

Research output: Contribution to journalReview article

21 Scopus citations

Role of lysine deacetylases in megakaryocyte differentiation

DeLuca, T., Kuo, H. Y., Konieczna, I., Mrksich, M. & Miller, W. M., Jan 1 2013, Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future. AIChE, p. 188-189 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Role of nucleotide sugar pools in the inhibition of NCAM polysialylation by ammonia

Zanghi, J. A., Mendoza, T. P., Schmelzer, A. E., Knop, R. H. & Miller, W. M., Nov 1 1998, In : Biotechnology Progress. 14, 6, p. 834-844 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Role of tumor suppressor p53 in megakaryopoiesis and platelet function

Apostolidis, P. A., Woulfe, D. S., Chavez, M., Miller, W. M. & Papoutsakis, E. T., Feb 2012, In : Experimental Hematology. 40, 2, p. 131-142.e4

Research output: Contribution to journalArticle

22 Scopus citations

Selected amino acids protect hybridoma and CHO cells from elevated carbon dioxide and osmolality

DeZengotita, V. M., Abston, L. R., Schmelzer, A. E., Shaw, S. & Miller, W. M., Jun 30 2002, In : Biotechnology and Bioengineering. 78, 7, p. 741-752 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Separation of in-vitro-derived megakaryocytes and platelets using spinning-membrane filtration

Schlinker, A. C., Radwanski, K., Wegener, C., Min, K. & Miller, W. M., Apr 1 2015, In : Biotechnology and Bioengineering. 112, 4, p. 788-800 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Serum‐free media for cultures of primitive and mature hematopoietic cells

Sandstrom, C. E., Miller, W. M. & Papoutsakis, E. T., Apr 5 1994, In : Biotechnology and Bioengineering. 43, 8, p. 706-733 28 p.

Research output: Contribution to journalReview article

29 Scopus citations

SIRT1 is a critical regulator of K562 cell growth, survival, and differentiation

Duncan, M. T., DeLuca, T. A., Kuo, H. Y., Yi, M., Mrksich, M. & Miller, W. M., May 15 2016, In : Experimental Cell Research. 344, 1, p. 40-52 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Small increases in pH enhance retroviral vector transduction efficiency of NIH-3T3 cells

Jensen, T. W., Chen, Y. & Miller, W. M., Jan 1 2003, In : Biotechnology Progress. 19, 1, p. 216-223 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Soil hydrology drives ecological niche differentiation in a native prairie microbiome

Griffin, J. S., Haug, L. A., Rivera, V. A., Hernandez Gonzalez, L. M., Kelly, J. J., Miller, W. M., Wells, G. F. & Packman, A. I., Feb 1 2020, In : FEMS microbiology ecology. 96, 1, fiz163.

Research output: Contribution to journalArticle

1 Scopus citations

Stirred culture of peripheral and cord blood hematopoietic cells offers advantages over traditional static systems for clinically relevant applications

Collins, P. C., Miller, W. M. & Papoutsakis, E. T., Sep 5 1998, In : Biotechnology and Bioengineering. 59, 5, p. 534-543 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Surface presentation of bioactive ligands in a nonadhesive background using DOPA-tethered biotinylated poly(ethylene glycol)

Gunawan, R. C., King, J. A., Lee, B. P., Messersmith, P. B. & Miller, W. M., Oct 9 2007, In : Langmuir. 23, 21, p. 10635-10643 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Synergistic effect of hydrogen peroxide on polyploidization during the megakaryocytic differentiation of K562 leukemia cells by PMA

Ojima, Y., Duncan, M. T., Nurhayati, R. W., Taya, M. & Miller, W. M., Aug 15 2013, In : Experimental Cell Research. 319, 14, p. 2205-2215 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
47 Scopus citations

The transient responses of hybridoma cells to nutrient additions in continuous culture: II. Glutamine pulse and step changes

Miller, W. M., Wilke, C. R. & Blanch, H. W., Jan 1 1989, In : Biotechnology and Bioengineering. 33, 4, p. 487-499 13 p.

Research output: Contribution to journalArticle

75 Scopus citations

Three-stage Ex vivo expansion of high-ploidy megakaryocytic cells: Toward large-scale platelet production

Panuganti, S., Schlinker, A. C., Lindholm, P. F., Papoutsakis, E. T. & Miller, W. M., Apr 1 2013, In : Tissue Engineering - Part A. 19, 7-8, p. 998-1014 17 p.

Research output: Contribution to journalArticle

38 Scopus citations