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William M Miller

  • 9628 Citations
1985 …2020
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Research Output 1985 2019

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Article
2019

Characterization of soil profiles and elemental concentrations reveals deposition of heavy metals and phosphorus in a Chicago-area nature preserve, Gensburg Markham Prairie

Hernandez Gonzalez, L. M., Rivera, V. A., Phillips, C. B., Haug, L. A., Hatch, S., Yeager, L. E., Chang, H., Alvarez, J., Gnaedinger, K. J., Miller, W. M. & Packman, A., Jan 1 2019, In : Journal of Soils and Sediments.

Research output: Contribution to journal › Article

prairie
soil profile
heavy metal
phosphorus
ecosystem
1 Citation (Scopus)

Enabling Large-Scale Ex Vivo Production of Megakaryocytes from CD34+ Cells Using Gas-Permeable Surfaces

Martinez, A. F. & Miller, W. M., Jul 1 2019, In : Stem Cells Translational Medicine. 8, 7, p. 658-670 13 p.

Research output: Contribution to journal › Article

Open Access
Megakaryocytes
Gases
Megakaryocyte Progenitor Cells
Blood Platelets
Ploidies
2017
2 Citations (Scopus)

A uniform-shear rate microfluidic bioreactor for real-time study of proplatelet formation and rapidly-released platelets

Martinez, A. F., McMahon, R. D., Horner, M. & Miller, W. M., Nov 1 2017, In : Biotechnology Progress. 33, 6, p. 1614-1629 16 p.

Research output: Contribution to journal › Article

Time and Motion Studies
Microfluidics
Bioreactors
Blood Platelets
Tissue Donors
4 Citations (Scopus)

Essential design considerations for the resazurin reduction assay to noninvasively quantify cell expansion within perfused extracellular matrix scaffolds

Uzarski, J. S., DiVito, M. D., Wertheim, J. A. & Miller, W. M., Jun 1 2017, In : Biomaterials. 129, p. 163-175 13 p.

Research output: Contribution to journal › Article

Scaffolds
Extracellular Matrix
Assays
Cell Count
Tissue
2016
1 Citation (Scopus)

Hoxa10 null animals exhibit reduced platelet biogenesis

Konieczna, I. M., Deluca, T. A., Eklund, E. A. & Miller, W. M., Apr 1 2016, In : British Journal of Haematology. 173, 2, p. 303-313 11 p.

Research output: Contribution to journal › Article

Blood Platelets
Acute Myeloid Leukemia
Stem Cells
Myelopoiesis
Myeloproliferative Disorders
3 Citations (Scopus)

Megakaryocyte polyploidization and proplatelet formation in low-attachment conditions

Schlinker, A. C., Duncan, M. T., DeLuca, T. A., Whitehead, D. C. & Miller, W. M., Jul 15 2016, In : Biochemical Engineering Journal. 111, p. 24-33 10 p.

Research output: Contribution to journal › Article

Megakaryocytes
Platelets
Blood Platelets
Platelet Transfusion
Polyploidy
2 Citations (Scopus)

SIRT1 is a critical regulator of K562 cell growth, survival, and differentiation

Duncan, M. T., DeLuca, T. A., Kuo, H. Y., Yi, M., Mrksich, M. & Miller, W. M., May 15 2016, In : Experimental Cell Research. 344, 1, p. 40-52 13 p.

Research output: Contribution to journal › Article

Sirtuins
K562 Cells
Cell Differentiation
Cell Survival
Autophagy
2015
24 Citations (Scopus)

Dual-Purpose Bioreactors to Monitor Noninvasive Physical and Biochemical Markers of Kidney and Liver Scaffold Recellularization

Uzarski, J. S., Bijonowski, B. M., Wang, B., Ward, H. H., Wandinger-Ness, A., Miller, W. M. & Wertheim, J. A., Oct 1 2015, In : Tissue Engineering - Part C: Methods. 21, 10, p. 1032-1043 12 p.

Research output: Contribution to journal › Article

Bioreactors
Scaffolds (biology)
Scaffolds
Liver
Biomarkers
11 Citations (Scopus)

Epithelial cell repopulation and preparation of rodent extracellular matrix scaffolds for renal tissue development

Uzarski, J. S., Su, J., Xie, Y., Zhang, Z. J., Ward, H. H., Wandinger-Ness, A., Miller, W. M. & Wertheim, J. A., Aug 10 2015, In : Journal of Visualized Experiments. 2015, 102, p. 1-9 9 p., e53271.

Research output: Contribution to journal › Article

Tissue Scaffolds
Scaffolds
Extracellular Matrix
Rodentia
Epithelial Cells
7 Citations (Scopus)

Human megakaryocyte progenitors derived from hematopoietic stem cells of normal individuals are MHC class II-expressing professional APC that enhance Th17 and Th1/Th17 responses

Finkielsztein, A., Schlinker, A. C., Zhang, L., Miller, W. M. & Datta, S. K., Jan 1 2015, In : Immunology Letters. 163, 1, p. 84-95 12 p.

Research output: Contribution to journal › Article

Megakaryocyte Progenitor Cells
Hematopoietic Stem Cells
Extramedullary Hematopoiesis
Blood Platelets
T-Lymphocytes
83 Citations (Scopus)

Optimization and critical evaluation of decellularization strategies to develop renal extracellular matrix scaffolds as biological templates for organ engineering and transplantation

Caralt, M., Uzarski, J. S., Iacob, S., Obergfell, K. P., Berg, N., Bijonowski, B. M., Kiefer, K. M., Ward, H. H., Wandinger-Ness, A., Miller, W. M., Zhang, Z. J., Abecassis, M. M. & Wertheim, J. A., Jan 1 2015, In : American Journal of Transplantation. 15, 1, p. 64-75 12 p.

Research output: Contribution to journal › Article

Organ Transplantation
Extracellular Matrix
Kidney
Sodium Dodecyl Sulfate
Rodentia
13 Citations (Scopus)

Separation of in-vitro-derived megakaryocytes and platelets using spinning-membrane filtration

Schlinker, A. C., Radwanski, K., Wegener, C., Min, K. & Miller, W. M., Apr 1 2015, In : Biotechnology and Bioengineering. 112, 4, p. 788-800 13 p.

Research output: Contribution to journal › Article

Megakaryocytes
Platelets
Blood Platelets
Membranes
In Vitro Techniques
2014
6 Citations (Scopus)

Dynamic transcription factor activity profiles reveal key regulatory interactions during megakaryocytic and erythroid differentiation

Duncan, M. T., Shin, S., Wu, J. J., Mays, Z., Weng, S., Bagheri, N., Miller, W. M. & Shea, L. D., Jan 1 2014, In : Biotechnology and Bioengineering. 111, 10, p. 2082-2094 13 p.

Research output: Contribution to journal › Article

Transcription factors
Transcription Factors
Niacinamide
Cells
GATA Transcription Factors
2013
5 Citations (Scopus)

Administration of nicotinamide does not increase platelet levels in mice

Konieczna, I. M., Panuganti, S., DeLuca, T. A., Papoutsakis, E. T., Eklund, E. A. & Miller, W. M., Mar 1 2013, In : Blood Cells, Molecules, and Diseases. 50, 3, p. 171-176 6 p.

Research output: Contribution to journal › Article

Niacinamide
Blood Platelets
Megakaryocytes
Bone Marrow Cells
Transfusion Medicine
13 Citations (Scopus)

Synergistic effect of hydrogen peroxide on polyploidization during the megakaryocytic differentiation of K562 leukemia cells by PMA

Ojima, Y., Duncan, M. T., Nurhayati, R. W., Taya, M. & Miller, W. M., Aug 15 2013, In : Experimental Cell Research. 319, 14, p. 2205-2215 11 p.

Research output: Contribution to journal › Article

K562 Cells
Hydrogen Peroxide
Leukemia
Acetates
Reactive Oxygen Species
33 Citations (Scopus)

Three-stage Ex vivo expansion of high-ploidy megakaryocytic cells: Toward large-scale platelet production

Panuganti, S., Schlinker, A. C., Lindholm, P. F., Papoutsakis, E. T. & Miller, W. M., Apr 1 2013, In : Tissue Engineering - Part A. 19, 7-8, p. 998-1014 17 p.

Research output: Contribution to journal › Article

Ploidies
Hematopoietic Stem Cells
Platelets
Blood Platelets
Interleukin-3
2012
18 Citations (Scopus)

Energy, Water and Fish: Biodiversity Impacts of Energy-Sector Water Demand in the United States Depend on Efficiency and Policy Measures

McDonald, R. I., Olden, J. D., Opperman, J. J., Miller, W. M., Fargione, J., Revenga, C., Higgins, J. V. & Powell, J., Nov 21 2012, In : PLoS One. 7, 11, e50219.

Research output: Contribution to journal › Article

Biodiversity
Fish
biodiversity
Water
energy
14 Citations (Scopus)

Proposed megakaryocytic regulon of p53: The genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation

Apostolidis, P. A., Lindsey, S., Miller, W. M. & Papoutsakis, E. T., Jun 1 2012, In : Physiological Genomics. 44, 12, p. 638-650 13 p.

Research output: Contribution to journal › Article

Regulon
p53 Genes
Cell Cycle Checkpoints
Apoptosis
Megakaryocytes
18 Citations (Scopus)

Role of tumor suppressor p53 in megakaryopoiesis and platelet function

Apostolidis, P. A., Woulfe, D. S., Chavez, M., Miller, W. M. & Papoutsakis, E. T., Jan 1 2012, In : Experimental Hematology. 40, 2, p. 131-142.e4

Research output: Contribution to journal › Article

Megakaryocytes
Ploidies
Thrombopoietin
Blood Platelets
Bone Marrow
2010
10 Citations (Scopus)

Bone marrow niche-inspired, multiphase expansion of megakaryocytic progenitors with high polyploidization potential

Panuganti, S., Papoutsakis, E. T. & Miller, W. M., Jan 1 2010, In : Cytotherapy. 12, 6, p. 767-782 16 p.

Research output: Contribution to journal › Article

Hematopoietic Stem Cells
Ploidies
Bone Marrow
Niacinamide
Interleukin-3
2009
12 Citations (Scopus)

Cholesterol supplementation during production increases the infectivity of retroviral and lentiviral vectors pseudotyped with the vesicular stomatitis virus glycoprotein (VSV-G)

Chen, Y., Ott, C. J., Townsend, K., Subbaiah, P., Aiyar, A. & Miller, W. M., May 15 2009, In : Biochemical Engineering Journal. 44, 2-3, p. 199-207 9 p.

Research output: Contribution to journal › Article

Vesicular Stomatitis
Glycoproteins
Cholesterol
Viruses
Cell membranes
17 Citations (Scopus)

Effects of supported lipid monolayer fluidity on the adhesion of hematopoietic progenitor cell lines to fibronectin-derived peptide ligands for α5β1 and α4β1 integrins

Garcia, A. S., Dellatore, S. M., Messersmith, P. B. & Miller, W. M., Mar 3 2009, In : Langmuir. 25, 5, p. 2994-3002 9 p.

Research output: Contribution to journal › Article

Fluidity
Fibronectins
cultured cells
Integrins
Lipids
175 Citations (Scopus)

Energy sprawl or energy efficiency: Climate policy impacts on natural habitat for the United States of America

McDonald, R. I., Fargione, J., Kiesecker, J., Miller, W. M. & Powell, J., Aug 26 2009, In : PloS one. 4, 8, e6802.

Research output: Contribution to journal › Article

energy efficiency
Climate
Ecosystem
Energy efficiency
environmental markets
27 Citations (Scopus)

Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD+ levels and SIRT inhibition

Giammona, L. M., Panuganti, S., Kemper, J. M., Apostolidis, P. A., Lindsey, S., Papoutsakis, E. T. & Miller, W. M., Jan 1 2009, In : Experimental Hematology. 37, 11

Research output: Contribution to journal › Article

Niacinamide
NAD
Ploidies
Acetylation
Blood Cells
2008
20 Citations (Scopus)

Gene Ontology-driven transcriptional analysis of CD34+ cell-initiated megakaryocytic cultures identifies new transcriptional regulators of megakaryopoiesis

Fuhrken, P. G., Chen, C., Apostolidis, P. A., Wang, M., Miller, W. M. & Papoutsakis, E. T., Apr 22 2008, In : Physiological Genomics. 33, 2, p. 159-169 11 p.

Research output: Contribution to journal › Article

Gene Ontology
Transcription Factors
Megakaryocytes
Hematopoietic Stem Cells
GATA1 Transcription Factor
26 Citations (Scopus)

Tumor suppressor protein p53 regulates megakaryocytic polyploidization and apoptosis

Fuhrken, P. G., Apostolidis, P. A., Lindsey, S., Miller, W. M. & Papoutsakis, E. T., Jun 6 2008, In : Journal of Biological Chemistry. 283, 23, p. 15589-15600 12 p.

Research output: Contribution to journal › Article

Tumor Suppressor Protein p53
Apoptosis
Ploidies
Acetates
Cells
2007
16 Citations (Scopus)

A systems-biology analysis of isogenic megakaryocytic and granulocytic cultures identifies new molecular components of megakaryocytic apoptosis

Chen, C., Fuhrken, P. G., Huang, L. T., Apostolidis, P., Wang, M., Paredes, C. J., Miller, W. M. & Papoutsakis, E. T., Oct 22 2007, In : BMC Genomics. 8, 384.

Research output: Contribution to journal › Article

Systems Biology
Apoptosis
Genes
Hematopoietic Stem Cells
MAP Kinase Kinase Kinase 5
37 Citations (Scopus)

Comparative, genome-scale transcriptional analysis of CHRF-288-11 and primary human megakaryocytic cell cultures provides novel insights into lineage-specific differentiation

Fuhrken, P. G., Chen, C., Miller, W. M. & Papoutsakis, E. T., Jan 1 2007, In : Experimental Hematology. 35, 3

Research output: Contribution to journal › Article

Cell Culture Techniques
Genome
Genes
Phorbol Esters
Up-Regulation
3 Citations (Scopus)

Gene expression analysis illuminates the transcriptional programs underlying the functional activity of ex vivo-expanded granulocytes

Huang, L. T., Paredes, C. J., Papoutsakis, E. T. & Miller, W. M., Sep 19 2007, In : Physiological Genomics. 31, 1, p. 114-125 12 p.

Research output: Contribution to journal › Article

Granulocytes
Gene Expression
Respiratory Burst
Fc Receptors
Phagocytosis
4855 Citations (Scopus)

Mussel-inspired surface chemistry for multifunctional coatings

Lee, H., Dellatore, S. M., Miller, W. M. & Messersmith, P. B., Oct 19 2007, In : Science. 318, 5849, p. 426-430 5 p.

Research output: Contribution to journal › Article

Bivalvia
Dopamine
Polymers
Metals
Semiconductors
53 Citations (Scopus)

Proteome analysis of antibody-producing CHO cell lines with different metabolic profiles

Pascoe, D. E., Arnott, D., Papoutsakis, E. T., Miller, W. M. & Andersen, D. C., Oct 1 2007, In : Biotechnology and Bioengineering. 98, 2, p. 391-410 20 p.

Research output: Contribution to journal › Article

Antibody-Producing Cells
Metabolome
CHO Cells
Proteome
Antibodies
36 Citations (Scopus)

Surface presentation of bioactive ligands in a nonadhesive background using DOPA-tethered biotinylated poly(ethylene glycol)

Gunawan, R. C., King, J. A., Lee, B. P., Messersmith, P. B. & Miller, W. M., Oct 9 2007, In : Langmuir. 23, 21, p. 10635-10643 9 p.

Research output: Contribution to journal › Article

activity (biology)
Polyethylene glycols
glycols
biotin
ethylene
2006
57 Citations (Scopus)

Nicotinamide (vitamin B3) increases the polyploidisation and proplatelet formation of cultured primary human megakaryocytes

Giammona, L. M., Fuhrken, P. G., Papoutsakis, E. T. & Miller, W. M., Nov 1 2006, In : British Journal of Haematology. 135, 4, p. 554-566 13 p.

Research output: Contribution to journal › Article

Megakaryocytes
Niacinamide
Ploidies
Thrombopoietin
DNA
2005
1 Citation (Scopus)

Effects of NHE1 expression level on CHO cell responses to environmental stress

Abston, L. R. & Miller, W. M., Mar 1 2005, In : Biotechnology Progress. 21, 2, p. 562-567 6 p.

Research output: Contribution to journal › Article

CHO Cells
Sodium-Hydrogen Antiporter
Lactic Acid
Ammonia
Growth
5 Citations (Scopus)

Transduction efficiency of pantropic retroviral vectors is controlled by the envelope plasmid to vector plasmid ratio

Chen, Y., Miller, W. M. & Aiyar, A., Jan 1 2005, In : Biotechnology Progress. 21, 1, p. 274-282 9 p.

Research output: Contribution to journal › Article

Viral Envelope Proteins
Plasmids
Product Packaging
Fibroblasts
Diploidy
2004
41 Citations (Scopus)

Actin Re-Distribution in Response to Hydrogen Peroxide in Airway Epithelial Cells

Boardman, K. C., Aryal, A. M., Miller, W. M. & Waters, C. M., Apr 1 2004, In : Journal of Cellular Physiology. 199, 1, p. 57-66 10 p.

Research output: Contribution to journal › Article

Hydrogen Peroxide
Actins
Epithelial Cells
Cytoskeleton
Actin Cytoskeleton
34 Citations (Scopus)

Lipopeptides incorporated into supported phospholipid monolayers have high specific activity at low incorporation levels

Jensen, T. W., Hu, B. H., Delatore, S. M., Garcia, A. S., Messersmith, P. B. & Miller, W. M., Nov 24 2004, In : Journal of the American Chemical Society. 126, 46, p. 15223-15230 8 p.

Research output: Contribution to journal › Article

Lipopeptides
Cell adhesion
Phospholipids
Cell Adhesion Molecules
Monolayers
2003
4 Citations (Scopus)

Small increases in pH enhance retroviral vector transduction efficiency of NIH-3T3 cells

Jensen, T. W., Chen, Y. & Miller, W. M., Jan 1 2003, In : Biotechnology Progress. 19, 1, p. 216-223 8 p.

Research output: Contribution to journal › Article

NIH 3T3 Cells
Protamines
Hexadimethrine Bromide
Moloney murine leukemia virus
Serum
2002
71 Citations (Scopus)

Characterization of hybridoma cell responses to elevated pCO2 and osmolality: Intracellular pH, cell size, apoptosis, and metabolism

DeZengotita, V. M., Schmelzer, A. E. & Miller, W. M., Feb 15 2002, In : Biotechnology and Bioengineering. 77, 4, p. 369-380 12 p.

Research output: Contribution to journal › Article

Hybridomas
Cell death
Cell Size
Metabolism
Osmolar Concentration
28 Citations (Scopus)

Continuous exposure of airway epithelial cells to hydrogen peroxide: Protection by KGF

Chapman, K. E., Waters, C. M. & Miller, W. M., Jun 13 2002, In : Journal of Cellular Physiology. 192, 1, p. 71-80 10 p.

Research output: Contribution to journal › Article

Fibroblast Growth Factor 7
Acoustic impedance
Electric Impedance
Hydrogen Peroxide
Epithelial Cells
44 Citations (Scopus)

Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation

Hevehan, D. L., Miller, W. M. & Papoutsakis, E. T., Mar 1 2002, In : Blood. 99, 5, p. 1627-1637 11 p.

Research output: Contribution to journal › Article

STAT Transcription Factors
STAT3 Transcription Factor
Phosphorylation
Proteins
Protein Isoforms
15 Citations (Scopus)

Effects of osmoprotectant compounds on NCAM polysialylation under hyperosmotic stress and elevated pCO2

Schmelzer, A. E. & Miller, W. M., Feb 15 2002, In : Biotechnology and Bioengineering. 77, 4, p. 359-368 10 p.

Research output: Contribution to journal › Article

Neural Cell Adhesion Molecules
Betaine
Betaines
Amino acids
Cell adhesion
45 Citations (Scopus)

Higher pH promotes megakaryocytic maturation and apoptosis

Yang, H., Miller, W. M. & Papoutsakis, E. T., Jan 1 2002, In : Stem Cells. 20, 4, p. 320-328 9 p.

Research output: Contribution to journal › Article

Apoptosis
Ploidies
Bone Marrow
Proton-Motive Force
Serum-Free Culture Media
45 Citations (Scopus)

Hyperosmotic stress and elevated pCO2 alter monoclonal antibody charge distribution and monosaccharide content

Schmelzer, A. E. & Miller, W. M., Apr 22 2002, In : Biotechnology Progress. 18, 2, p. 346-353 8 p.

Research output: Contribution to journal › Article

Monosaccharides
osmolality
monosaccharides
Osmolar Concentration
monoclonal antibodies
37 Citations (Scopus)

Selected amino acids protect hybridoma and CHO cells from elevated carbon dioxide and osmolality

DeZengotita, V. M., Abston, L. R., Schmelzer, A. E., Shaw, S. & Miller, W. M., Jun 30 2002, In : Biotechnology and Bioengineering. 78, 7, p. 741-752 12 p.

Research output: Contribution to journal › Article

CHO Cells
Hybridomas
Carbon Dioxide
Osmolar Concentration
Amino acids
2001
4 Citations (Scopus)

Model-based estimation of myeloid hematopoietic progenitor cells in ex vivo cultures for cell and gene therapies

Yang, H., Papoutsakis, E. T. & Miller, W. M., Jan 7 2001, In : Biotechnology and Bioengineering. 72, 2, p. 144-155 12 p.

Research output: Contribution to journal › Article

Myeloid Progenitor Cells
Gene therapy
Cell- and Tissue-Based Therapy
Hematopoietic Stem Cells
Genetic Therapy
175 Citations (Scopus)

Modeling pO2 distributions in the bone marrow hematopoietic compartment. I. Krogh's model

Chow, D. C., Wenning, L. A., Miller, W. M. & Papoutsakis, E. T., Jan 1 2001, In : Biophysical Journal. 81, 2, p. 675-684 10 p.

Research output: Contribution to journal › Article

Bone Marrow
Hematopoietic Stem Cells
Stem Cells
Adipocytes
Bone Marrow Cells
210 Citations (Scopus)

Modeling pO2 distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models

Chow, D. C., Wenning, L. A., Miller, W. M. & Papoutsakis, E. T., Jan 1 2001, In : Biophysical Journal. 81, 2, p. 685-696 12 p.

Research output: Contribution to journal › Article

Bone Marrow
Oxygen
Erythroid Cells
Megakaryocytes
Cell Lineage
41 Citations (Scopus)

Oxygen tension modulates the expression of cytokine receptors, transcription factors, and lineage-specific markers in cultured human megakaryocytes

Mostafa, S. S., Papoutsakis, E. T. & Miller, W. M., Jul 12 2001, In : Experimental Hematology. 29, 7, p. 873-883 11 p.

Research output: Contribution to journal › Article

Cytokine Receptors
Megakaryocytes
GATA Transcription Factors
N-Methylaspartate
Transcription Factors
2000
2 Citations (Scopus)

Cell density-dependent proliferation in frequently-fed peripheral blood mononuclear cell cultures

Patel, S. D., Miller, W. M., Winter, J. N. & Papoutsakis, E. T., Jan 1 2000, In : Cytotherapy. 2, 4, p. 267-280 14 p.

Research output: Contribution to journal › Article

Blood Cells
Cell Culture Techniques
Cell Count
Granulocyte Precursor Cells
Lactic Acid