William M Miller

2019

Characterization of soil profiles and elemental concentrations reveals deposition of heavy metals and phosphorus in a Chicago-area nature preserve, Gensburg Markham Prairie

Hernandez Gonzalez, L. M., Rivera, V. A., Phillips, C. B., Haug, L. A., Hatch, S., Yeager, L. E., Chang, H., Alvarez, J., Gnaedinger, K. J., Miller, W. M. & Packman, A., Jan 1 2019, In : Journal of Soils and Sediments.

Research output: Contribution to journal › Article

prairie

soil profile

heavy metal

phosphorus

ecosystem

2 Citations (Scopus)

Enabling Large-Scale Ex Vivo Production of Megakaryocytes from CD34⁺ Cells Using Gas-Permeable Surfaces

Martinez, A. F. & Miller, W. M., Jul 2019, In : Stem Cells Translational Medicine. 8, 7, p. 658-670 13 p.

Research output: Contribution to journal › Article

Open Access

Megakaryocytes

Gases

Megakaryocyte Progenitor Cells

Blood Platelets

Ploidies

2017

3 Citations (Scopus)

A uniform-shear rate microfluidic bioreactor for real-time study of proplatelet formation and rapidly-released platelets

Martinez, A. F., McMahon, R. D., Horner, M. & Miller, W. M., Nov 1 2017, In : Biotechnology Progress. 33, 6, p. 1614-1629 16 p.

Research output: Contribution to journal › Article

Time and Motion Studies

Microfluidics

Bioreactors

Blood Platelets

Tissue Donors

5 Citations (Scopus)

Essential design considerations for the resazurin reduction assay to noninvasively quantify cell expansion within perfused extracellular matrix scaffolds

Uzarski, J. S., DiVito, M. D., Wertheim, J. A. & Miller, W. M., Jun 1 2017, In : Biomaterials. 129, p. 163-175 13 p.

Research output: Contribution to journal › Article

Scaffolds

Extracellular Matrix

Assays

Cell Count

Tissue

2016

1 Citation (Scopus)

Hoxa10 null animals exhibit reduced platelet biogenesis

Konieczna, I. M., Deluca, T. A., Eklund, E. A. & Miller, W. M., Apr 1 2016, In : British Journal of Haematology. 173, 2, p. 303-313 11 p.

Research output: Contribution to journal › Article

Blood Platelets

Acute Myeloid Leukemia

Stem Cells

Myelopoiesis

Myeloproliferative Disorders

3 Citations (Scopus)

Megakaryocyte polyploidization and proplatelet formation in low-attachment conditions

Schlinker, A. C., Duncan, M. T., DeLuca, T. A., Whitehead, D. C. & Miller, W. M., Jul 15 2016, In : Biochemical Engineering Journal. 111, p. 24-33 10 p.

Research output: Contribution to journal › Article

Megakaryocytes

Platelets

Blood Platelets

Platelet Transfusion

Polyploidy

3 Citations (Scopus)

SIRT1 is a critical regulator of K562 cell growth, survival, and differentiation

Duncan, M. T., DeLuca, T. A., Kuo, H. Y., Yi, M., Mrksich, M. & Miller, W. M., May 15 2016, In : Experimental Cell Research. 344, 1, p. 40-52 13 p.

Research output: Contribution to journal › Article

Sirtuins

K562 Cells

Cell Differentiation

Cell Survival

Autophagy

2015

25 Citations (Scopus)

Dual-Purpose Bioreactors to Monitor Noninvasive Physical and Biochemical Markers of Kidney and Liver Scaffold Recellularization

Uzarski, J. S., Bijonowski, B. M., Wang, B., Ward, H. H., Wandinger-Ness, A., Miller, W. M. & Wertheim, J. A., Oct 1 2015, In : Tissue Engineering - Part C: Methods. 21, 10, p. 1032-1043 12 p.

Research output: Contribution to journal › Article

Bioreactors

Scaffolds (biology)

Scaffolds

Liver

Biomarkers

11 Citations (Scopus)

Epithelial cell repopulation and preparation of rodent extracellular matrix scaffolds for renal tissue development

Uzarski, J. S., Su, J., Xie, Y., Zhang, Z. J., Ward, H. H., Wandinger-Ness, A., Miller, W. M. & Wertheim, J. A., Aug 10 2015, In : Journal of Visualized Experiments. 2015, 102, p. 1-9 9 p., e53271.

Research output: Contribution to journal › Article

Tissue Scaffolds

Scaffolds

Extracellular Matrix

Rodentia

Epithelial Cells

9 Citations (Scopus)

Human megakaryocyte progenitors derived from hematopoietic stem cells of normal individuals are MHC class II-expressing professional APC that enhance Th17 and Th1/Th17 responses

Finkielsztein, A., Schlinker, A. C., Zhang, L., Miller, W. M. & Datta, S. K., Jan 1 2015, In : Immunology Letters. 163, 1, p. 84-95 12 p.

Research output: Contribution to journal › Article

Megakaryocyte Progenitor Cells

Hematopoietic Stem Cells

Extramedullary Hematopoiesis

Blood Platelets

T-Lymphocytes

88 Citations (Scopus)

Optimization and critical evaluation of decellularization strategies to develop renal extracellular matrix scaffolds as biological templates for organ engineering and transplantation

Caralt, M., Uzarski, J. S., Iacob, S., Obergfell, K. P., Berg, N., Bijonowski, B. M., Kiefer, K. M., Ward, H. H., Wandinger-Ness, A., Miller, W. M., Zhang, Z. J., Abecassis, M. M. & Wertheim, J. A., Jan 1 2015, In : American Journal of Transplantation. 15, 1, p. 64-75 12 p.

Research output: Contribution to journal › Article

Organ Transplantation

Extracellular Matrix

Kidney

Sodium Dodecyl Sulfate

Rodentia

16 Citations (Scopus)

Separation of in-vitro-derived megakaryocytes and platelets using spinning-membrane filtration

Schlinker, A. C., Radwanski, K., Wegener, C., Min, K. & Miller, W. M., Apr 1 2015, In : Biotechnology and Bioengineering. 112, 4, p. 788-800 13 p.

Research output: Contribution to journal › Article

Megakaryocytes

Platelets

Blood Platelets

Membranes

In Vitro Techniques

2014

6 Citations (Scopus)

Dynamic transcription factor activity profiles reveal key regulatory interactions during megakaryocytic and erythroid differentiation

Duncan, M. T., Shin, S., Wu, J. J., Mays, Z., Weng, S., Bagheri, N., Miller, W. M. & Shea, L. D., Jan 1 2014, In : Biotechnology and Bioengineering. 111, 10, p. 2082-2094 13 p.

Research output: Contribution to journal › Article

Transcription factors

Transcription Factors

Niacinamide

Cells

GATA Transcription Factors

2013

5 Citations (Scopus)

Administration of nicotinamide does not increase platelet levels in mice

Konieczna, I. M., Panuganti, S., DeLuca, T. A., Papoutsakis, E. T., Eklund, E. A. & Miller, W. M., Mar 1 2013, In : Blood Cells, Molecules, and Diseases. 50, 3, p. 171-176 6 p.

Research output: Contribution to journal › Article

Niacinamide

Blood Platelets

Megakaryocytes

Bone Marrow Cells

Transfusion Medicine

13 Citations (Scopus)

Synergistic effect of hydrogen peroxide on polyploidization during the megakaryocytic differentiation of K562 leukemia cells by PMA

Ojima, Y., Duncan, M. T., Nurhayati, R. W., Taya, M. & Miller, W. M., Aug 15 2013, In : Experimental Cell Research. 319, 14, p. 2205-2215 11 p.

Research output: Contribution to journal › Article

K562 Cells

Hydrogen Peroxide

Leukemia

Acetates

Reactive Oxygen Species

34 Citations (Scopus)

Three-stage Ex vivo expansion of high-ploidy megakaryocytic cells: Toward large-scale platelet production

Panuganti, S., Schlinker, A. C., Lindholm, P. F., Papoutsakis, E. T. & Miller, W. M., Apr 1 2013, In : Tissue Engineering - Part A. 19, 7-8, p. 998-1014 17 p.

Research output: Contribution to journal › Article

Ploidies

Hematopoietic Stem Cells

Platelets

Blood Platelets

Interleukin-3

2012

18 Citations (Scopus)

Energy, Water and Fish: Biodiversity Impacts of Energy-Sector Water Demand in the United States Depend on Efficiency and Policy Measures

McDonald, R. I., Olden, J. D., Opperman, J. J., Miller, W. M., Fargione, J., Revenga, C., Higgins, J. V. & Powell, J., Nov 21 2012, In : PloS one. 7, 11, e50219.

Research output: Contribution to journal › Article

Biodiversity

Fish

biodiversity

Water

energy

15 Citations (Scopus)

Proposed megakaryocytic regulon of p53: The genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation

Apostolidis, P. A., Lindsey, S., Miller, W. M. & Papoutsakis, E. T., Jun 1 2012, In : Physiological genomics. 44, 12, p. 638-650 13 p.

Research output: Contribution to journal › Article

Regulon

p53 Genes

Cell Cycle Checkpoints

Apoptosis

Megakaryocytes

19 Citations (Scopus)

Role of tumor suppressor p53 in megakaryopoiesis and platelet function

Apostolidis, P. A., Woulfe, D. S., Chavez, M., Miller, W. M. & Papoutsakis, E. T., Jan 1 2012, In : Experimental Hematology. 40, 2, p. 131-142.e4

Research output: Contribution to journal › Article

Megakaryocytes

Ploidies

Thrombopoietin

Blood Platelets

Bone Marrow

2010

10 Citations (Scopus)

Bone marrow niche-inspired, multiphase expansion of megakaryocytic progenitors with high polyploidization potential

Panuganti, S., Papoutsakis, E. T. & Miller, W. M., Jan 1 2010, In : Cytotherapy. 12, 6, p. 767-782 16 p.

Research output: Contribution to journal › Article

Hematopoietic Stem Cells

Ploidies

Bone Marrow

Niacinamide

Interleukin-3

2009

12 Citations (Scopus)

Cholesterol supplementation during production increases the infectivity of retroviral and lentiviral vectors pseudotyped with the vesicular stomatitis virus glycoprotein (VSV-G)

Chen, Y., Ott, C. J., Townsend, K., Subbaiah, P., Aiyar, A. & Miller, W. M., May 15 2009, In : Biochemical Engineering Journal. 44, 2-3, p. 199-207 9 p.

Research output: Contribution to journal › Article

Vesicular Stomatitis

Glycoproteins

Cholesterol

Viruses

Cell membranes

17 Citations (Scopus)

Effects of supported lipid monolayer fluidity on the adhesion of hematopoietic progenitor cell lines to fibronectin-derived peptide ligands for α5β1 and α4β1 integrins

Garcia, A. S., Dellatore, S. M., Messersmith, P. B. & Miller, W. M., Mar 3 2009, In : Langmuir. 25, 5, p. 2994-3002 9 p.

Research output: Contribution to journal › Article

Fluidity

Fibronectins

cultured cells

Integrins

Lipids

184 Citations (Scopus)

Energy sprawl or energy efficiency: Climate policy impacts on natural habitat for the United States of America

McDonald, R. I., Fargione, J., Kiesecker, J., Miller, W. M. & Powell, J., Aug 26 2009, In : PloS one. 4, 8, e6802.

Research output: Contribution to journal › Article

energy efficiency

Climate

Ecosystem

Energy efficiency

environmental markets

29 Citations (Scopus)

Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD⁺ levels and SIRT inhibition

Giammona, L. M., Panuganti, S., Kemper, J. M., Apostolidis, P. A., Lindsey, S., Papoutsakis, E. T. & Miller, W. M., Jan 1 2009, In : Experimental Hematology. 37, 11

Research output: Contribution to journal › Article

Niacinamide

NAD

Ploidies

Acetylation

Blood Cells

2008

21 Citations (Scopus)

Gene Ontology-driven transcriptional analysis of CD34⁺ cell-initiated megakaryocytic cultures identifies new transcriptional regulators of megakaryopoiesis

Fuhrken, P. G., Chen, C., Apostolidis, P. A., Wang, M., Miller, W. M. & Papoutsakis, E. T., Apr 22 2008, In : Physiological Genomics. 33, 2, p. 159-169 11 p.

Research output: Contribution to journal › Article

Gene Ontology

Transcription Factors

Megakaryocytes

Hematopoietic Stem Cells

GATA1 Transcription Factor

28 Citations (Scopus)

Tumor suppressor protein p53 regulates megakaryocytic polyploidization and apoptosis

Fuhrken, P. G., Apostolidis, P. A., Lindsey, S., Miller, W. M. & Papoutsakis, E. T., Jun 6 2008, In : Journal of Biological Chemistry. 283, 23, p. 15589-15600 12 p.

Research output: Contribution to journal › Article

Tumor Suppressor Protein p53

Apoptosis

Ploidies

Acetates

Cells

2007

16 Citations (Scopus)

A systems-biology analysis of isogenic megakaryocytic and granulocytic cultures identifies new molecular components of megakaryocytic apoptosis

Chen, C., Fuhrken, P. G., Huang, L. T., Apostolidis, P., Wang, M., Paredes, C. J., Miller, W. M. & Papoutsakis, E. T., Oct 22 2007, In : BMC Genomics. 8, 384.

Research output: Contribution to journal › Article

Systems Biology

Apoptosis

Genes

Hematopoietic Stem Cells

MAP Kinase Kinase Kinase 5

37 Citations (Scopus)

Comparative, genome-scale transcriptional analysis of CHRF-288-11 and primary human megakaryocytic cell cultures provides novel insights into lineage-specific differentiation

Fuhrken, P. G., Chen, C., Miller, W. M. & Papoutsakis, E. T., Jan 1 2007, In : Experimental Hematology. 35, 3

Research output: Contribution to journal › Article

Cell Culture Techniques

Genome

Genes

Phorbol Esters

Up-Regulation

3 Citations (Scopus)

Gene expression analysis illuminates the transcriptional programs underlying the functional activity of ex vivo-expanded granulocytes

Huang, L. T., Paredes, C. J., Papoutsakis, E. T. & Miller, W. M., Sep 19 2007, In : Physiological genomics. 31, 1, p. 114-125 12 p.

Research output: Contribution to journal › Article

Granulocytes

Gene Expression

Respiratory Burst

Fc Receptors

Phagocytosis

5143 Citations (Scopus)

Mussel-inspired surface chemistry for multifunctional coatings

Lee, H., Dellatore, S. M., Miller, W. M. & Messersmith, P. B., Oct 19 2007, In : Science. 318, 5849, p. 426-430 5 p.

Research output: Contribution to journal › Article

Bivalvia

Dopamine

Polymers

Metals

Semiconductors

54 Citations (Scopus)

Proteome analysis of antibody-producing CHO cell lines with different metabolic profiles

Pascoe, D. E., Arnott, D., Papoutsakis, E. T., Miller, W. M. & Andersen, D. C., Oct 1 2007, In : Biotechnology and Bioengineering. 98, 2, p. 391-410 20 p.

Research output: Contribution to journal › Article

Antibody-Producing Cells

Metabolome

CHO Cells

Proteome

Antibodies

36 Citations (Scopus)

Surface presentation of bioactive ligands in a nonadhesive background using DOPA-tethered biotinylated poly(ethylene glycol)

Gunawan, R. C., King, J. A., Lee, B. P., Messersmith, P. B. & Miller, W. M., Oct 9 2007, In : Langmuir. 23, 21, p. 10635-10643 9 p.

Research output: Contribution to journal › Article

activity (biology)

Polyethylene glycols

glycols

biotin

ethylene

2006

57 Citations (Scopus)

Nicotinamide (vitamin B3) increases the polyploidisation and proplatelet formation of cultured primary human megakaryocytes

Giammona, L. M., Fuhrken, P. G., Papoutsakis, E. T. & Miller, W. M., Nov 1 2006, In : British Journal of Haematology. 135, 4, p. 554-566 13 p.

Research output: Contribution to journal › Article

Megakaryocytes

Niacinamide

Ploidies

Thrombopoietin

DNA

2005

1 Citation (Scopus)

Effects of NHE1 expression level on CHO cell responses to environmental stress

Abston, L. R. & Miller, W. M., Mar 1 2005, In : Biotechnology Progress. 21, 2, p. 562-567 6 p.

Research output: Contribution to journal › Article

CHO Cells

Sodium-Hydrogen Antiporter

Lactic Acid

Ammonia

Growth

5 Citations (Scopus)

Transduction efficiency of pantropic retroviral vectors is controlled by the envelope plasmid to vector plasmid ratio

Chen, Y., Miller, W. M. & Aiyar, A., Jan 1 2005, In : Biotechnology Progress. 21, 1, p. 274-282 9 p.

Research output: Contribution to journal › Article

Viral Envelope Proteins

Plasmids

Product Packaging

Fibroblasts

Diploidy

2004

42 Citations (Scopus)

Actin Re-Distribution in Response to Hydrogen Peroxide in Airway Epithelial Cells

Boardman, K. C., Aryal, A. M., Miller, W. M. & Waters, C. M., Apr 1 2004, In : Journal of Cellular Physiology. 199, 1, p. 57-66 10 p.

Research output: Contribution to journal › Article

Hydrogen Peroxide

Actins

Epithelial Cells

Cytoskeleton

Actin Cytoskeleton

34 Citations (Scopus)

Lipopeptides incorporated into supported phospholipid monolayers have high specific activity at low incorporation levels

Jensen, T. W., Hu, B. H., Delatore, S. M., Garcia, A. S., Messersmith, P. B. & Miller, W. M., Nov 24 2004, In : Journal of the American Chemical Society. 126, 46, p. 15223-15230 8 p.

Research output: Contribution to journal › Article

Lipopeptides

Cell adhesion

Phospholipids

Cell Adhesion Molecules

Monolayers

2003

5 Citations (Scopus)

Small increases in pH enhance retroviral vector transduction efficiency of NIH-3T3 cells

Jensen, T. W., Chen, Y. & Miller, W. M., Jan 1 2003, In : Biotechnology Progress. 19, 1, p. 216-223 8 p.

Research output: Contribution to journal › Article

NIH 3T3 Cells

Protamines

Hexadimethrine Bromide

Moloney murine leukemia virus

Serum

2002

71 Citations (Scopus)

Characterization of hybridoma cell responses to elevated pCO₂ and osmolality: Intracellular pH, cell size, apoptosis, and metabolism

DeZengotita, V. M., Schmelzer, A. E. & Miller, W. M., Feb 15 2002, In : Biotechnology and Bioengineering. 77, 4, p. 369-380 12 p.

Research output: Contribution to journal › Article

Hybridomas

Cell death

Cell Size

Metabolism

Osmolar Concentration

28 Citations (Scopus)

Continuous exposure of airway epithelial cells to hydrogen peroxide: Protection by KGF

Chapman, K. E., Waters, C. M. & Miller, W. M., Jun 13 2002, In : Journal of Cellular Physiology. 192, 1, p. 71-80 10 p.

Research output: Contribution to journal › Article

Fibroblast Growth Factor 7

Acoustic impedance

Electric Impedance

Hydrogen Peroxide

Epithelial Cells

44 Citations (Scopus)

Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation

Hevehan, D. L., Miller, W. M. & Papoutsakis, E. T., Mar 1 2002, In : Blood. 99, 5, p. 1627-1637 11 p.

Research output: Contribution to journal › Article

STAT Transcription Factors

STAT3 Transcription Factor

Phosphorylation

Proteins

Protein Isoforms

15 Citations (Scopus)

Effects of osmoprotectant compounds on NCAM polysialylation under hyperosmotic stress and elevated pCO₂

Schmelzer, A. E. & Miller, W. M., Feb 15 2002, In : Biotechnology and Bioengineering. 77, 4, p. 359-368 10 p.

Research output: Contribution to journal › Article

Neural Cell Adhesion Molecules

Betaine

Betaines

Amino acids

Cell adhesion

45 Citations (Scopus)

Higher pH promotes megakaryocytic maturation and apoptosis

Yang, H., Miller, W. M. & Papoutsakis, E. T., Jan 1 2002, In : Stem Cells. 20, 4, p. 320-328 9 p.

Research output: Contribution to journal › Article

Apoptosis

Ploidies

Bone Marrow

Proton-Motive Force

Serum-Free Culture Media

46 Citations (Scopus)

Hyperosmotic stress and elevated pCO₂ alter monoclonal antibody charge distribution and monosaccharide content

Schmelzer, A. E. & Miller, W. M., Apr 22 2002, In : Biotechnology Progress. 18, 2, p. 346-353 8 p.

Research output: Contribution to journal › Article

Monosaccharides

osmolality

monosaccharides

Osmolar Concentration

monoclonal antibodies

37 Citations (Scopus)

Selected amino acids protect hybridoma and CHO cells from elevated carbon dioxide and osmolality

DeZengotita, V. M., Abston, L. R., Schmelzer, A. E., Shaw, S. & Miller, W. M., Jun 30 2002, In : Biotechnology and Bioengineering. 78, 7, p. 741-752 12 p.

Research output: Contribution to journal › Article

CHO Cells

Hybridomas

Carbon Dioxide

Osmolar Concentration

Amino acids

2001

4 Citations (Scopus)

Model-based estimation of myeloid hematopoietic progenitor cells in ex vivo cultures for cell and gene therapies

Yang, H., Papoutsakis, E. T. & Miller, W. M., Jan 7 2001, In : Biotechnology and Bioengineering. 72, 2, p. 144-155 12 p.

Research output: Contribution to journal › Article

Myeloid Progenitor Cells

Gene therapy

Cell- and Tissue-Based Therapy

Hematopoietic Stem Cells

Genetic Therapy

178 Citations (Scopus)

Modeling pO₂ distributions in the bone marrow hematopoietic compartment. I. Krogh's model

Chow, D. C., Wenning, L. A., Miller, W. M. & Papoutsakis, E. T., Jan 1 2001, In : Biophysical Journal. 81, 2, p. 675-684 10 p.

Research output: Contribution to journal › Article

Bone Marrow

Hematopoietic Stem Cells

Stem Cells

Adipocytes

Bone Marrow Cells

216 Citations (Scopus)

Modeling pO₂ distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models

Chow, D. C., Wenning, L. A., Miller, W. M. & Papoutsakis, E. T., Jan 1 2001, In : Biophysical Journal. 81, 2, p. 685-696 12 p.

Research output: Contribution to journal › Article

Bone Marrow

Oxygen

Erythroid Cells

Megakaryocytes

Cell Lineage

42 Citations (Scopus)

Oxygen tension modulates the expression of cytokine receptors, transcription factors, and lineage-specific markers in cultured human megakaryocytes

Mostafa, S. S., Papoutsakis, E. T. & Miller, W. M., Jul 12 2001, In : Experimental Hematology. 29, 7, p. 873-883 11 p.

Research output: Contribution to journal › Article

Cytokine Receptors

Megakaryocytes

GATA Transcription Factors

N-Methylaspartate

Transcription Factors

2000

2 Citations (Scopus)

Cell density-dependent proliferation in frequently-fed peripheral blood mononuclear cell cultures

Patel, S. D., Miller, W. M., Winter, J. N. & Papoutsakis, E. T., Jan 1 2000, In : Cytotherapy. 2, 4, p. 267-280 14 p.

Research output: Contribution to journal › Article

Blood Cells

Cell Culture Techniques

Cell Count

Granulocyte Precursor Cells

Lactic Acid