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Personal profile

Research Interests

My research interest is primarily on the structural mechanisms of activation of the cell-surface receptors in cancer and neural development. We try to obtain atomic-resolution views, using X-ray crystallography and biochemical/biophysical tools, on how the transmembrane receptors recognize their ligands, and how these recognition/activation processes can be modulated for clinical purposes.

Training Experience

2008Postdoctoral Fellowship, Stanford University

Education/Academic qualification

PhD, Chinese Academy of Sciences

… → 2000

Research interests

  • Angiogenesis
  • Biochemistry: Proteins
  • Biophysics
  • Cancer Biology
  • Cell Adhesion Mechanisms
  • Neurobiology
  • Proteins / Macromolecules
  • Structural Biology

Fingerprint Dive into the research topics where Xiaolin He is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Semaphorins Medicine & Life Sciences
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Grants 2005 2016

Research Output 1999 2017

8 Citations (Scopus)

A cryptic tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation

Morgan, M. A., Rickels, R. A., Collings, C. K., He, X., Cao, K., Herz, H. M., Cozzolino, K. A., Abshiru, N. A., Marshall, S. A., Rendleman, E. J., Sze, C. C., Piunti, A., Kelleher, N. L., Savas, J. N. & Shilatifard, A., Oct 1 2017, In : Genes and Development. 31, 19, p. 2003-2014 12 p.

Research output: Contribution to journalArticle

Histones
Methylation
Chromatin
Drosophila
Clustered Regularly Interspaced Short Palindromic Repeats
1 Citation (Scopus)

Expression and purification of class 7 semaphorin and its Plexinc1 receptor using baculovirus-mediated mammalian cell gene transduction

Chen, X., Chen, P. H. & He, X., Jan 1 2017, In : Methods in Molecular Biology. 1493, p. 41-56 16 p.

Research output: Contribution to journalArticle

Semaphorins
Baculoviridae
Genes
Cell Culture Techniques
Protein Sorting Signals
17 Citations (Scopus)
Receptor Protein-Tyrosine Kinases
Electron Microscopy
Coloring Agents
Ligands
Phosphotransferases
39 Citations (Scopus)

Evidence for follicle-stimulating hormone receptor as a functional trimer

Jiang, X., Fischer, D., Chen, X., McKenna, S. D., Liu, H., Sriraman, V., Yu, H. N., Goutopoulos, A., Arkinstall, S. & He, X., May 16 2014, In : Journal of Biological Chemistry. 289, 20, p. 14273-14282 10 p.

Research output: Contribution to journalArticle

FSH Receptors
Monomers
Thyrotropin Receptors
Mutagenesis
G-Protein-Coupled Receptors
31 Citations (Scopus)

Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression

Ferrarese, R., Harsh IV, G. R., Yadav, A. K., Bug, E., Maticzka, D., Reichardt, W., Dombrowski, S. M., Miller, T. E., Masilamani, A. P., Dai, F., Kim, H., Hadler, M., Scholtens, D. M., Yu, I. L. Y., Beck, J., Srinivasasainagendra, V., Costa, F., Baxan, N., Pfeifer, D., Von Elverfeldt, D. & 11 others, Backofen, R., Weyerbrock, A., Duarte, C. W., He, X., Prinz, M., Chandler, J. P., Vogel, H., Chakravarti, A., Rich, J. N., Carro, M. S. & Bredel, M., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 2861-2876 16 p.

Research output: Contribution to journalArticle

Glioblastoma
Exons
Annexin A7
Brain
Annexins