Grants per year
Personal profile
Research Interests
My research interest is primarily on the structural mechanisms of activation of the cell-surface receptors in cancer and neural development. We try to obtain atomic-resolution views, using X-ray crystallography and biochemical/biophysical tools, on how the transmembrane receptors recognize their ligands, and how these recognition/activation processes can be modulated for clinical purposes.
Training Experience
| 2008 | Postdoctoral Fellowship, Stanford University |
Education/Academic qualification
PhD, Chinese Academy of Sciences
… → 2000
Research interests
- Angiogenesis
- Biochemistry: Proteins
- Biophysics
- Cancer Biology
- Cell Adhesion Mechanisms
- Neurobiology
- Proteins / Macromolecules
- Structural Biology
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Grants
- 5 Finished
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Structural Mechanisms in Semaphorin Signaling
National Institute of General Medical Sciences
8/1/11 → 7/31/16
Project: Research project
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Structural Biology of Oncoginic Receptor Tyrosine Kinases
National Institute of General Medical Sciences
9/30/09 → 7/31/11
Project: Research project
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Structural Mechanisms of Receptor Signaling in Brain Tumor Angiogenesis
9/1/06 → 8/31/08
Project: Research project
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Structural Biology of Oncogenic Receptor Tyrosine Kinases
National Institute of General Medical Sciences
8/1/06 → 1/31/12
Project: Research project
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Structural Biology of the Obesity Receptor-Ligand Interactions
6/28/05 → 6/30/06
Project: Research project
Research Output
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A cryptic tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation
Morgan, M. A. J., Rickels, R. A., Collings, C. K., He, X., Cao, K., Herz, H. M., Cozzolino, K. A., Abshiru, N. A., Marshall, S. A., Rendleman, E. J., Sze, C. C., Piunti, A., Kelleher, N. L., Savas, J. N. & Shilatifard, A., Oct 1 2017, In: Genes and Development. 31, 19, p. 2003-2014 12 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Expression and purification of class 7 semaphorin and its Plexinc1 receptor using baculovirus-mediated mammalian cell gene transduction
Chen, X., Chen, P. H. & He, X., 2017, In: Methods in Molecular Biology. 1493, p. 41-56 16 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Structure of Full-Length Human PDGFRβ Bound to Its Activating Ligand PDGF-B as Determined by Negative-Stain Electron Microscopy
Chen, P. H., Unger, V. & He, X., Dec 4 2015, In: Journal of Molecular Biology. 427, 24, p. 3921-3934 14 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Evidence for follicle-stimulating hormone receptor as a functional trimer
Jiang, X., Fischer, D., Chen, X., McKenna, S. D., Liu, H., Sriraman, V., Yu, H. N., Goutopoulos, A., Arkinstall, S. & He, X., May 16 2014, In: Journal of Biological Chemistry. 289, 20, p. 14273-14282 10 p.Research output: Contribution to journal › Article › peer-review
50 Scopus citations -
Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression
Ferrarese, R., Harsh IV, G. R., Yadav, A. K., Bug, E., Maticzka, D., Reichardt, W., Dombrowski, S. M., Miller, T. E., Masilamani, A. P., Dai, F., Kim, H., Hadler, M., Scholtens, D. M., Yu, I. L. Y., Beck, J., Srinivasasainagendra, V., Costa, F., Baxan, N., Pfeifer, D., Von Elverfeldt, D. & 11 others, , Jul 1 2014, In: Journal of Clinical Investigation. 124, 7, p. 2861-2876 16 p.Research output: Contribution to journal › Article › peer-review
46 Scopus citations