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Personal profile

Research Interests

My research interest is primarily on the structural mechanisms of activation of the cell-surface receptors in cancer and neural development. We try to obtain atomic-resolution views, using X-ray crystallography and biochemical/biophysical tools, on how the transmembrane receptors recognize their ligands, and how these recognition/activation processes can be modulated for clinical purposes.

Training Experience

2008Postdoctoral Fellowship, Stanford University

Education/Academic qualification

PhD, Chinese Academy of Sciences

… → 2000

Research interests

  • Angiogenesis
  • Biochemistry: Proteins
  • Biophysics
  • Cancer Biology
  • Cell Adhesion Mechanisms
  • Neurobiology
  • Proteins / Macromolecules
  • Structural Biology

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Grants

Research Output

A cryptic tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation

Morgan, M. A. J., Rickels, R. A., Collings, C. K., He, X., Cao, K., Herz, H. M., Cozzolino, K. A., Abshiru, N. A., Marshall, S. A., Rendleman, E. J., Sze, C. C., Piunti, A., Kelleher, N. L., Savas, J. N. & Shilatifard, A., Oct 1 2017, In : Genes and Development. 31, 19, p. 2003-2014 12 p.

Research output: Contribution to journalArticle

  • 13 Scopus citations

    Expression and purification of class 7 semaphorin and its Plexinc1 receptor using baculovirus-mediated mammalian cell gene transduction

    Chen, X., Chen, P. H. & He, X., Jan 1 2017, In : Methods in Molecular Biology. 1493, p. 41-56 16 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Structure of Full-Length Human PDGFRβ Bound to Its Activating Ligand PDGF-B as Determined by Negative-Stain Electron Microscopy

    Chen, P. H., Unger, V. & He, X., Dec 4 2015, In : Journal of Molecular Biology. 427, 24, p. 3921-3934 14 p.

    Research output: Contribution to journalArticle

  • 20 Scopus citations

    Evidence for follicle-stimulating hormone receptor as a functional trimer

    Jiang, X., Fischer, D., Chen, X., McKenna, S. D., Liu, H., Sriraman, V., Yu, H. N., Goutopoulos, A., Arkinstall, S. & He, X., May 16 2014, In : Journal of Biological Chemistry. 289, 20, p. 14273-14282 10 p.

    Research output: Contribution to journalArticle

  • 43 Scopus citations

    Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression

    Ferrarese, R., Harsh IV, G. R., Yadav, A. K., Bug, E., Maticzka, D., Reichardt, W., Dombrowski, S. M., Miller, T. E., Masilamani, A. P., Dai, F., Kim, H., Hadler, M., Scholtens, D. M., Yu, I. L. Y., Beck, J., Srinivasasainagendra, V., Costa, F., Baxan, N., Pfeifer, D., Von Elverfeldt, D. & 11 others, Backofen, R., Weyerbrock, A., Duarte, C. W., He, X., Prinz, M., Chandler, J. P., Vogel, H., Chakravarti, A., Rich, J. N., Carro, M. S. & Bredel, M., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 2861-2876 16 p.

    Research output: Contribution to journalArticle

  • 37 Scopus citations