Grants per year
Personal profile
Research Interests
My research interest is primarily on the structural mechanisms of activation of the cell-surface receptors in cancer and neural development. We try to obtain atomic-resolution views, using X-ray crystallography and biochemical/biophysical tools, on how the transmembrane receptors recognize their ligands, and how these recognition/activation processes can be modulated for clinical purposes.
Training Experience
| 2008 | Postdoctoral Fellowship, Stanford University |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Molecular Biology, Chinese Academy of Sciences
… → 2000
Research interests keywords
- Angiogenesis
- Biochemistry: Proteins
- Biophysics
- Cancer Biology
- Cell Adhesion Mechanisms
- Neurobiology
- Proteins / Macromolecules
- Structural Biology
Fingerprint
Dive into the research topics where Xiaolin He is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Grants
- 10 Finished
-
Structural Studies form Membrane-bound Proteins
He, X. (PD/PI)
10/31/12 → 1/22/16
Project: Research project
-
Structural Mechanisms in Semaphorin Signaling
He, X. (PD/PI)
National Institute of General Medical Sciences
8/1/11 → 7/31/16
Project: Research project
-
Structural Studies for Pharmaceutically Important Targets
He, X. (PD/PI)
10/22/09 → 10/21/12
Project: Research project
-
Structural Biology of Oncoginic Receptor Tyrosine Kinases
He, X. (PD/PI)
National Institute of General Medical Sciences
9/30/09 → 7/31/11
Project: Research project
-
Structural Studies of Interleukin-34 and Its Complex with the Receptor Tyrosine Kinase FMS
He, X. (PD/PI)
7/13/09 → 7/13/11
Project: Research project
-
A cryptic tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation
Morgan, M. A. J., Rickels, R. A., Collings, C. K., He, X., Cao, K., Herz, H. M., Cozzolino, K. A., Abshiru, N. A., Marshall, S. A., Rendleman, E. J., Sze, C. C., Piunti, A., Kelleher, N. L., Savas, J. N. & Shilatifard, A., Oct 1 2017, In: Genes and Development. 31, 19, p. 2003-2014 12 p.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
Expression and purification of class 7 semaphorin and its Plexinc1 receptor using baculovirus-mediated mammalian cell gene transduction
Chen, X., Chen, P. H. & He, X., 2017, In: Methods in Molecular Biology. 1493, p. 41-56 16 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Structure of Full-Length Human PDGFRβ Bound to Its Activating Ligand PDGF-B as Determined by Negative-Stain Electron Microscopy
Chen, P. H., Unger, V. & He, X., Dec 4 2015, In: Journal of Molecular Biology. 427, 24, p. 3921-3934 14 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
Evidence for follicle-stimulating hormone receptor as a functional trimer
Jiang, X., Fischer, D., Chen, X., McKenna, S. D., Liu, H., Sriraman, V., Yu, H. N., Goutopoulos, A., Arkinstall, S. & He, X., May 16 2014, In: Journal of Biological Chemistry. 289, 20, p. 14273-14282 10 p.Research output: Contribution to journal › Article › peer-review
Open Access81 Scopus citations -
Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression
Ferrarese, R., Harsh IV, G. R., Yadav, A. K., Bug, E., Maticzka, D., Reichardt, W., Dombrowski, S. M., Miller, T. E., Masilamani, A. P., Dai, F., Kim, H., Hadler, M., Scholtens, D. M., Yu, I. L. Y., Beck, J., Srinivasasainagendra, V., Costa, F., Baxan, N., Pfeifer, D. & Von Elverfeldt, D. & 11 others, , Jul 1 2014, In: Journal of Clinical Investigation. 124, 7, p. 2861-2876 16 p.Research output: Contribution to journal › Article › peer-review
Open Access78 Scopus citations
Datasets
-
Crystal structure of a synaptic adhesion complex
Chen, X. (Contributor), Liu, H. (Contributor), Shim, A. H. R. (Contributor), Focia, P. J. (Contributor) & He, X. (Contributor), Protein Data Bank (PDB), Jan 15 2008
DOI: 10.2210/pdb3B3Q/pdb, https://www.wwpdb.org/pdb?id=pdb_00003b3q
Dataset
-
Crystal structure of human LGR5-RSPO1-RNF43
Chen, P.-H. (Contributor), Chen, X. (Contributor), Lin, Z. (Contributor), Fang, D. (Contributor) & He, X. (Contributor), Protein Data Bank (PDB), Jun 19 2013
DOI: 10.2210/pdb4KNG/pdb, https://www.wwpdb.org/pdb?id=pdb_00004kng
Dataset
-
3NVN : Molecular mechanism of guidance cue recognition
Liu, H. (Contributor), Juo, Z. S. (Contributor), Shim, A.H.-R. (Contributor), Focia, P. J. (Contributor), Chen, X. (Contributor) & He, X. (Contributor), RCSB-PDB, 2010
DOI: 10.2210/pdb3nvn/pdb, https://www.rcsb.org/structure/3NVN
Dataset
-
Structure of M-CSF bound to the first three domains of FMS
Chen, X. (Contributor), Liu, H. (Contributor), Focia, P. J. (Contributor), Shim, A.H.-R. (Contributor) & He, X. (Contributor), Protein Data Bank (PDB), Dec 9 2008
DOI: 10.2210/pdb3EJJ/pdb, https://www.wwpdb.org/pdb?id=pdb_00003ejj
Dataset
-
4FA8 : Multi-pronged modulation of cytokine signaling
He, X. (Contributor) & Shim, A.H.-R. (Contributor), RCSB-PDB, 2012
DOI: 10.2210/pdb4fa8/pdb, https://www.rcsb.org/structure/4FA8
Dataset