Grants per year
Personal profile
Research Interests
My research interest is primarily on the structural mechanisms of activation of the cell-surface receptors in cancer and neural development. We try to obtain atomic-resolution views, using X-ray crystallography and biochemical/biophysical tools, on how the transmembrane receptors recognize their ligands, and how these recognition/activation processes can be modulated for clinical purposes.
Training Experience
| 2008 | Postdoctoral Fellowship, Stanford University |
Education/Academic qualification
PhD, Chinese Academy of Sciences
… → 2000
Research interests
- Angiogenesis
- Biochemistry: Proteins
- Biophysics
- Cancer Biology
- Cell Adhesion Mechanisms
- Neurobiology
- Proteins / Macromolecules
- Structural Biology
Fingerprint Dive into the research topics where Xiaolin He is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Scorpions
Medicine & Life Sciences
Peptides
Medicine & Life Sciences
Receptor Protein-Tyrosine Kinases
Medicine & Life Sciences
Ligands
Medicine & Life Sciences
Macrophage Colony-Stimulating Factor
Medicine & Life Sciences
Platelet-Derived Growth Factor Receptors
Medicine & Life Sciences
Chemical activation
Chemical Compounds
Hormones
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2005 2016
- 5 Finished
Structural Mechanisms in Semaphorin Signaling
National Institute of General Medical Sciences
8/1/11 → 7/31/16
Project: Research project
Structural Biology of Oncoginic Receptor Tyrosine Kinases
National Institute of General Medical Sciences
9/30/09 → 7/31/11
Project: Research project
Structural Mechanisms of Receptor Signaling in Brain Tumor Angiogenesis
9/1/06 → 8/31/08
Project: Research project
Structural Biology of Oncogenic Receptor Tyrosine Kinases
National Institute of General Medical Sciences
8/1/06 → 1/31/12
Project: Research project
Structural Biology of the Obesity Receptor-Ligand Interactions
6/28/05 → 6/30/06
Project: Research project
Research Output 1999 2017
11
Citations
(Scopus)
A cryptic tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation
Morgan, M. A., Rickels, R. A., Collings, C. K., He, X., Cao, K., Herz, H. M., Cozzolino, K. A., Abshiru, N. A., Marshall, S. A., Rendleman, E. J., Sze, C. C., Piunti, A., Kelleher, N. L., Savas, J. N. & Shilatifard, A., Oct 1 2017, In : Genes and Development. 31, 19, p. 2003-2014 12 p.Research output: Contribution to journal › Article
Histones
Methylation
Chromatin
Drosophila
Clustered Regularly Interspaced Short Palindromic Repeats
1
Citation
(Scopus)
Expression and purification of class 7 semaphorin and its Plexinc1 receptor using baculovirus-mediated mammalian cell gene transduction
Chen, X., Chen, P. H. & He, X., Jan 1 2017, In : Methods in Molecular Biology. 1493, p. 41-56 16 p.Research output: Contribution to journal › Article
Semaphorins
Baculoviridae
Genes
Cell Culture Techniques
Protein Sorting Signals
17
Citations
(Scopus)
Structure of Full-Length Human PDGFRβ Bound to Its Activating Ligand PDGF-B as Determined by Negative-Stain Electron Microscopy
Chen, P. H., Unger, V. & He, X., Dec 4 2015, In : Journal of Molecular Biology. 427, 24, p. 3921-3934 14 p.Research output: Contribution to journal › Article
Receptor Protein-Tyrosine Kinases
Electron Microscopy
Coloring Agents
Ligands
Phosphotransferases
39
Citations
(Scopus)
Evidence for follicle-stimulating hormone receptor as a functional trimer
Jiang, X., Fischer, D., Chen, X., McKenna, S. D., Liu, H., Sriraman, V., Yu, H. N., Goutopoulos, A., Arkinstall, S. & He, X., May 16 2014, In : Journal of Biological Chemistry. 289, 20, p. 14273-14282 10 p.Research output: Contribution to journal › Article
FSH Receptors
Monomers
Thyrotropin Receptors
Mutagenesis
G-Protein-Coupled Receptors
33
Citations
(Scopus)
Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression
Ferrarese, R., Harsh IV, G. R., Yadav, A. K., Bug, E., Maticzka, D., Reichardt, W., Dombrowski, S. M., Miller, T. E., Masilamani, A. P., Dai, F., Kim, H., Hadler, M., Scholtens, D. M., Yu, I. L. Y., Beck, J., Srinivasasainagendra, V., Costa, F., Baxan, N., Pfeifer, D., Von Elverfeldt, D. & 11 others, , Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 2861-2876 16 p.Research output: Contribution to journal › Article
Glioblastoma
Exons
Annexin A7
Brain
Annexins