Grants per year
Personal profile
Research Interests
My research interest is primarily on the structural mechanisms of activation of the cell-surface receptors in cancer and neural development. We try to obtain atomic-resolution views, using X-ray crystallography and biochemical/biophysical tools, on how the transmembrane receptors recognize their ligands, and how these recognition/activation processes can be modulated for clinical purposes.
Training Experience
| 2008 | Postdoctoral Fellowship, Stanford University |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Molecular Biology, Chinese Academy of Sciences
… → 2000
Research interests keywords
- Angiogenesis
- Biochemistry: Proteins
- Biophysics
- Cancer Biology
- Cell Adhesion Mechanisms
- Neurobiology
- Proteins / Macromolecules
- Structural Biology
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Grants
- 10 Finished
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Structural Studies form Membrane-bound Proteins
He, X. (PD/PI)
10/31/12 → 1/22/16
Project: Research project
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Structural Mechanisms in Semaphorin Signaling
He, X. (PD/PI)
National Institute of General Medical Sciences
8/1/11 → 7/31/16
Project: Research project
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Structural Studies for Pharmaceutically Important Targets
He, X. (PD/PI)
10/22/09 → 10/21/12
Project: Research project
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Structural Biology of Oncoginic Receptor Tyrosine Kinases
He, X. (PD/PI)
National Institute of General Medical Sciences
9/30/09 → 7/31/11
Project: Research project
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Structural Studies of Interleukin-34 and Its Complex with the Receptor Tyrosine Kinase FMS
He, X. (PD/PI)
7/13/09 → 7/13/11
Project: Research project
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Photoacoustic imaging of kidney fibrosis for assessing pretransplant organ quality
Hysi, E., He, X., Fadhel, M. N., Zhang, T., Krizova, A., Ordon, M., Farcas, M., Pace, K. T., Mintsopoulos, V., Lee, W. L., Kolios, M. C. & Yuen, D. A., May 2020, In: JCI Insight. 5, 10, e136995.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
A cryptic tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation
Morgan, M. A. J., Rickels, R. A., Collings, C. K., He, X., Cao, K., Herz, H. M., Cozzolino, K. A., Abshiru, N. A., Marshall, S. A., Rendleman, E. J., Sze, C. C., Piunti, A., Kelleher, N. L., Savas, J. N. & Shilatifard, A., Oct 1 2017, In: Genes and Development. 31, 19, p. 2003-2014 12 p.Research output: Contribution to journal › Article › peer-review
Open Access50 Scopus citations -
Expression and purification of class 7 semaphorin and its Plexinc1 receptor using baculovirus-mediated mammalian cell gene transduction
Chen, X., Chen, P. H. & He, X., 2017, In: Methods in Molecular Biology. 1493, p. 41-56 16 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Structure of Full-Length Human PDGFRβ Bound to Its Activating Ligand PDGF-B as Determined by Negative-Stain Electron Microscopy
Chen, P. H., Unger, V. & He, X., Dec 4 2015, In: Journal of Molecular Biology. 427, 24, p. 3921-3934 14 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
Evidence for follicle-stimulating hormone receptor as a functional trimer
Jiang, X., Fischer, D., Chen, X., McKenna, S. D., Liu, H., Sriraman, V., Yu, H. N., Goutopoulos, A., Arkinstall, S. & He, X., May 16 2014, In: Journal of Biological Chemistry. 289, 20, p. 14273-14282 10 p.Research output: Contribution to journal › Article › peer-review
Open Access86 Scopus citations
Datasets
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4MQW : Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31)
Jiang, X. (Contributor), Chen, X. (Contributor), Liu, H. (Contributor) & He, X. (Contributor), RCSB-PDB, 2014
DOI: 10.2210/pdb4mqw/pdb, https://www.rcsb.org/structure/4MQW
Dataset
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4FA8 : Multi-pronged modulation of cytokine signaling
He, X. (Contributor) & Shim, A.H.-R. (Contributor), RCSB-PDB, 2012
DOI: 10.2210/pdb4fa8/pdb, https://www.rcsb.org/structure/4FA8
Dataset
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4KNG : Crystal structure of human LGR5-RSPO1-RNF43
Chen, P.-H. (Contributor), He, X. (Contributor) & He, X. (Contributor), RCSB-PDB, 2013
DOI: 10.2210/pdb4kng/pdb, https://www.rcsb.org/structure/4KNG
Dataset
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Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31)
Jiang, X. (Contributor), Fischer, D. (Contributor), Chen, X. (Contributor), McKenna, S. D. (Contributor), Liu, H. (Contributor), Sriraman, V. (Contributor), Yu, H. N. (Contributor), Goutopoulos, A. (Contributor), Arkinstall, S. (Contributor) & He, X. (Contributor), Protein Data Bank (PDB), Apr 9 2014
DOI: 10.2210/pdb4MQW/pdb, https://www.wwpdb.org/pdb?id=pdb_00004mqw
Dataset
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3B3Q : Crystal structure of a synaptic adhesion complex
Chen, X. (Contributor), Liu, H. (Contributor), Shim, A. H. R. (Contributor), Focia, P. J. (Contributor) & He, X. (Contributor), RCSB-PDB, 2008
DOI: 10.2210/pdb3b3q/pdb, https://www.rcsb.org/structure/3B3Q
Dataset