If you made any changes in Pure, your changes will be visible here soon.

Research Output 1999 2017

2017
10 Citations (Scopus)

A cryptic tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation

Morgan, M. A., Rickels, R. A., Collings, C. K., He, X., Cao, K., Herz, H. M., Cozzolino, K. A., Abshiru, N. A., Marshall, S. A., Rendleman, E. J., Sze, C. C., Piunti, A., Kelleher, N. L., Savas, J. N. & Shilatifard, A., Oct 1 2017, In : Genes and Development. 31, 19, p. 2003-2014 12 p.

Research output: Contribution to journalArticle

Histones
Methylation
Chromatin
Drosophila
Clustered Regularly Interspaced Short Palindromic Repeats
1 Citation (Scopus)

Expression and purification of class 7 semaphorin and its Plexinc1 receptor using baculovirus-mediated mammalian cell gene transduction

Chen, X., Chen, P. H. & He, X., Jan 1 2017, In : Methods in Molecular Biology. 1493, p. 41-56 16 p.

Research output: Contribution to journalArticle

Semaphorins
Baculoviridae
Genes
Cell Culture Techniques
Protein Sorting Signals
2015
17 Citations (Scopus)
Receptor Protein-Tyrosine Kinases
Electron Microscopy
Coloring Agents
Ligands
Phosphotransferases
2014
39 Citations (Scopus)

Evidence for follicle-stimulating hormone receptor as a functional trimer

Jiang, X., Fischer, D., Chen, X., McKenna, S. D., Liu, H., Sriraman, V., Yu, H. N., Goutopoulos, A., Arkinstall, S. & He, X., May 16 2014, In : Journal of Biological Chemistry. 289, 20, p. 14273-14282 10 p.

Research output: Contribution to journalArticle

FSH Receptors
Monomers
Thyrotropin Receptors
Mutagenesis
G-Protein-Coupled Receptors
32 Citations (Scopus)

Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression

Ferrarese, R., Harsh IV, G. R., Yadav, A. K., Bug, E., Maticzka, D., Reichardt, W., Dombrowski, S. M., Miller, T. E., Masilamani, A. P., Dai, F., Kim, H., Hadler, M., Scholtens, D. M., Yu, I. L. Y., Beck, J., Srinivasasainagendra, V., Costa, F., Baxan, N., Pfeifer, D., Von Elverfeldt, D. & 11 others, Backofen, R., Weyerbrock, A., Duarte, C. W., He, X., Prinz, M., Chandler, J. P., Vogel, H., Chakravarti, A., Rich, J. N., Carro, M. S. & Bredel, M., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 2861-2876 16 p.

Research output: Contribution to journalArticle

Glioblastoma
Exons
Annexin A7
Brain
Annexins
76 Citations (Scopus)

Structural biology of glycoprotein hormones and their receptors: Insights to signaling

Jiang, X., Dias, J. A. & He, X., Jan 25 2014, In : Molecular and Cellular Endocrinology. 382, 1, p. 424-451 28 p.

Research output: Contribution to journalReview article

Follicle Stimulating Hormone
Hormones
Glycoproteins
Leucine
Chemical activation
2013

Emerging recognition and activation mechanisms of receptor tyrosine kinases

He, X., Jun 7 2013, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1834, 10, p. 2158-2159 2 p.

Research output: Contribution to journalEditorial

Receptor Protein-Tyrosine Kinases
Chemical activation
76 Citations (Scopus)

Platelet-derived growth factors and their receptors: Structural and functional perspectives

Chen, P. H., Chen, X. & He, X., Jan 1 2013, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1834, 10, p. 2176-2186 11 p.

Research output: Contribution to journalReview article

Platelet-Derived Growth Factor Receptors
Platelet-Derived Growth Factor
Chemical activation
Receptor Protein-Tyrosine Kinases
Connective Tissue Cells
73 Citations (Scopus)

The structural basis of R-spondin recognition by LGR5 and RNF43

Chen, P. H., Chen, X., Lin, Z., Fang, D. & He, X., Jun 15 2013, In : Genes and Development. 27, 12, p. 1345-1350 6 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Zinc Fingers
Leucine
Cysteine
Stem Cells
2012

Determination of phenobarbital in human urine and serum using flow injection chemiluminescence

Li, X., Niu, L. C., He, X. L. & Song, Z. H., Jan 1 2012, In : Biomeditsinskaya Khimiya. 58, 1, p. 88-94 7 p.

Research output: Contribution to journalArticle

Chemiluminescence
Phenobarbital
Luminescence
Urine
Injections
12 Citations (Scopus)

Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1

Shim, A. H. R., Chang, R. A., Chen, X., Longnecker, R. M. & He, X., Aug 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 32, p. 12962-12967 6 p.

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor
Human Herpesvirus 4
Down-Regulation
Infectious Mononucleosis
Genome
44 Citations (Scopus)

Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression

Liu, X., Chan, C. B., Qi, Q., Xiao, G., Luo, H. R., He, X. & Ye, K., Oct 11 2012, In : Journal of Medicinal Chemistry. 55, 19, p. 8524-8537 14 p.

Research output: Contribution to journalArticle

Hindlimb Suspension
Structure-Activity Relationship
Nervous System Diseases
Antidepressive Agents
Oral Administration
140 Citations (Scopus)

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

Jiang, X., Liu, H., Chen, X., Chen, P. H., Fischer, D., Sriraman, V., Yu, H. N., Arkinstall, S. & He, X., Jul 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 31, p. 12491-12496 6 p.

Research output: Contribution to journalArticle

FSH Receptors
Follicle Stimulating Hormone
Hormones
Ligands
G-Protein-Coupled Receptors
56 Citations (Scopus)

The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1

Liu, H., Leo, C., Chen, X., Wong, B. R., Williams, L. T., Lin, H. & He, X., Jul 1 2012, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1824, 7, p. 938-945 8 p.

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor
Interleukins
Cytokines
Hydrophobic and Hydrophilic Interactions
Colony-Stimulating Factor Receptors
2011
2 Citations (Scopus)

Determination of phenobarbital in human urine and serum using flow injection chemiluminescence

Li, X., Niu, L. C., He, X. L. & Song, Z. H., Jun 1 2011, In : Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 5, 2, p. 184-187 4 p.

Research output: Contribution to journalArticle

Chemiluminescence
Phenobarbital
Luminescence
Urine
Injections
33 Citations (Scopus)

Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules

Liu, H., Focia, P. J. & He, X., Jan 7 2011, In : Journal of Biological Chemistry. 286, 1, p. 797-805 9 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecule L1
Neural Cell Adhesion Molecules
Adhesion
Cell Adhesion Molecules
Mutagenesis
27 Citations (Scopus)

Maspin, the molecular bridge between the plasminogen activator system and β1 integrin that facilitates cell adhesion

Endsley, M. P., Hu, Y., Deng, Y., He, X., Warejcka, D. J., Twining, S. S., Gonias, S. L. & Zhang, M., Jul 15 2011, In : Journal of Biological Chemistry. 286, 28, p. 24599-24607 9 p.

Research output: Contribution to journalArticle

Plasminogen Activators
Cell adhesion
Cell Adhesion
Integrins
Urokinase Plasminogen Activator Receptors
140 Citations (Scopus)

NFKBIA deletion in glioblastomas

Bredel, M., Scholtens, D. M., Yadav, A. K., Alvarez, A. A., Renfrow, J. J., Chandler, J. P., Yu, I. L. Y., Carro, M. S., Dai, F., Tagge, M. J., Ferrarese, R., Bredel, C., Phillips, H. S., Lukac, P. J., Robe, P. A., Weyerbrock, A., Vogel, H., Dubner, S., Mobley, B., He, X. & 5 others, Scheck, A. C., Sikic, B. I., Aldape, K. D., Chakravarti, A. & Harsh IV, G. R., Feb 17 2011, In : New England Journal of Medicine. 364, 7, p. 627-637 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Epidermal Growth Factor Receptor
Gene Dosage
Neoplasms
Cultured Tumor Cells
2010
88 Citations (Scopus)

Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1

Liu, H., Juo, Z. S., Shim, A. H. R., Focia, P. J., Chen, X., Garcia, K. C. & He, X., Sep 3 2010, In : Cell. 142, 5, p. 749-761 13 p.

Research output: Contribution to journalArticle

Semaphorins
Propellers
Variola virus
Cardiovascular system
Dimerization
87 Citations (Scopus)

Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex

Shim, A. H. R., Liu, H., Focia, P. J., Chen, X., Lin, P. C. & He, X., Jun 22 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11307-11312 6 p.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor Receptors
Platelet-Derived Growth Factor
Proto-Oncogene Proteins c-sis
Cystine
Growth Factor Receptors
2009
40 Citations (Scopus)
Disintegrins
Metalloproteases
Sensory Receptor Cells
adhesion receptor
2008
66 Citations (Scopus)

Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions

Chen, X., Liu, H., Shim, A. H. R., Focia, P. J. & He, X., Jan 1 2008, In : Nature Structural and Molecular Biology. 15, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

Alternative Splicing
Sex Hormone-Binding Globulin
Mutation
Cholinesterases
Brain Diseases
52 Citations (Scopus)
Macrophage Colony-Stimulating Factor
Receptor Protein-Tyrosine Kinases
Ligands
Dimerization
Phagocytes
2007
203 Citations (Scopus)

Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors

Wehrman, T., He, X., Raab, B., Dukipatti, A., Blau, H. & Garcia, K. C., Jan 4 2007, In : Neuron. 53, 1, p. 25-38 14 p.

Research output: Contribution to journalArticle

trkA Receptor
Nerve Growth Factor
Proteins
Binding Sites
Membranes
75 Citations (Scopus)

Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases

Liu, H., Chen, X., Focia, P. J. & He, X., Feb 7 2007, In : EMBO Journal. 26, 3, p. 891-901 11 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Receptor Protein-Tyrosine Kinases
Chemical activation
Immunoglobulins
Epitopes
2006

A dimeric structure of the scorpion toxin BmK M1 at 1.4 Å resolution: Non-proline cis peptide bond and its inntrinsic structural elements

He, X. L., Guan, R. J., Zhang, Y. & Wang, D. C., Mar 1 2006, In : Progress in Biochemistry and Biophysics. 33, 3, p. 231-240 10 p.

Research output: Contribution to journalArticle

Scorpions
Peptides
Dimers
Intrinsic Factor
Crystals
38 Citations (Scopus)

Structural Determinants of Natriuretic Peptide Receptor Specificity and Degeneracy

He, X. L., Dukkipati, A. & Garcia, K. C., Aug 25 2006, In : Journal of Molecular Biology. 361, 4, p. 698-714 17 p.

Research output: Contribution to journalArticle

Natriuretic Peptides
Peptide Receptors
Brain Natriuretic Peptide
Atrial Natriuretic Factor
C-Type Natriuretic Peptide
2005
11 Citations (Scopus)

A new paradigm for hormone recognition and allosteric receptor activation revealed from structural studies of NPR-C

He, X. L., Dukkipati, A., Wang, X. & Garcia, K. C., Jan 1 2005, In : Peptides. 26, 6 SPEC. ISS., p. 1035-1043 9 p.

Research output: Contribution to journalArticle

Chemical activation
Hormones
Natriuretic Peptides
Peptide Receptors
Guanylate Cyclase

Erratum: A TNF receptor family member, TROY, is a coreceptor with nogo receptor in mediating the inhibitory activity of myelin inhibitors (Neuron (February 3, 2005) 45: 3 (345-351))

Park, J. B., Yiu, G., Kaneko, S., Wang, J., Chang, J., He, X. L., Garcia, K. C. & He, Z., Mar 3 2005, In : Neuron. 45, 5, 1 p.

Research output: Contribution to journalComment/debate

Tumor Necrosis Factor Receptors
Myelin Sheath
Neurons
Nogo Receptors
223 Citations (Scopus)

Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo

Zheng, B., Atwal, J., Ho, C., Case, L., He, X. L., Garcia, K. C., Steward, O. & Tessier-Lavigne, M., Jan 25 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 4, p. 1205-1210 6 p.

Research output: Contribution to journalArticle

Pyramidal Tracts
Neurites
Regeneration
Myelin Sheath
Neurons
2004
37 Citations (Scopus)

Structural mechanism governing cis and trans isomeric states and an intramolecular switch for cis/trans isomerization of a non-proline peptide bond observed in crystal structures of scorpion toxins

Guan, R. J., Xiang, Y., He, X. L., Wang, C. G., Wang, M., Zhang, Y., Sundberg, E. J. & Wang, D. C., Aug 27 2004, In : Journal of Molecular Biology. 341, 5, p. 1189-1204 16 p.

Research output: Contribution to journalArticle

Scorpions
Peptides
cis-trans-Isomerases
Neurotoxins
Aspartic Acid
210 Citations (Scopus)

Structure of Nerve Growth Factor Complexed with the Shared Neurotrophin Receptor p75

He, X. L. & Garcia, K. C., May 7 2004, In : Science. 304, 5672, p. 870-875 6 p.

Research output: Contribution to journalArticle

Nerve Growth Factor Receptor
Nerve Growth Factors
Nerve Growth Factor
Receptor Protein-Tyrosine Kinases
Cell Surface Receptors
2003

A New Paradigm of Cytokine Action Revealed by Viral IL-6 Complexed to gp130: Implications for GCSF Interaction with GCSFR

Chow, D. C., Brevnova, L., He, X. L. & Christopher Garcia, K., Nov 7 2003, Handbook of Cell Signaling. Elsevier Inc., Vol. 1-3. p. 259-263 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Interleukin-6
Cytokines
14 Citations (Scopus)

Crystal structure of pokeweed antiviral protein with well-defined sugars from seeds at 1.8 Å resolution

Zeng, Z. H., He, X. L., Li, H. M., Hu, Z. & Wang, D. C., Feb 1 2003, In : Journal of Structural Biology. 141, 2, p. 171-178 8 p.

Research output: Contribution to journalArticle

Seeds
Ribosome Inactivating Proteins
Ribosome Subunits
Acetylglucosamine
Asparagine
184 Citations (Scopus)

Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation

Krogsgaard, M., Prado, N., Adams, E. J., He, X. L., Chow, D. C., Wilson, D. B., Garcia, K. C. & Davis, M. M., Jan 1 2003, In : Molecular Cell. 12, 6, p. 1367-1378 12 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
T-Lymphocytes
Peptides
Half-Life
Hot Temperature
166 Citations (Scopus)

Structure of the Nogo receptor ectodomain: A recognition module implicated in myelin inhibition

He, X. L., Bazan, J. F., McDermott, G., Park, J. B., Wang, K., Tessier-Lavigne, M., He, Z. & Garcia, K. C., Apr 24 2003, In : Neuron. 38, 2, p. 177-185 9 p.

Research output: Contribution to journalArticle

Myelin Sheath
Axons
Leucine
Regeneration
Ligands
2002
25 Citations (Scopus)

A structural template for gp130-cytokine signaling assemblies

Chow, D. C., Brevnova, L., He, X. L., Martick, M. M., Bankovich, A. & Garcia, K. C., Nov 11 2002, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1592, 3, p. 225-235 11 p.

Research output: Contribution to journalReview article

Cytokines
Viral Structures
Interleukin-6
Mutagenesis
Ligands
2 Citations (Scopus)

Purification, crystallization and initial structural solution of a new α-like toxin with cardiac toxicity from scorpion Buthus martensii Karsch

Guan, R. J., He, X. L., Wang, M., Ye-Xiang, Li, G. P. & Wang, D. C., Sep 28 2002, In : Protein and Peptide Letters. 9, 5, p. 441-449 9 p.

Research output: Contribution to journalArticle

Cardiotoxins
Scorpion Venoms
Scorpions
Tromethamine
Synchrotrons
94 Citations (Scopus)

Structural snapshot of aberrant antigen presentation linked to autoimmunity: The immunodominant epitope of MBP complexed with I-Au

He, X. L., Radu, C., Sidney, J., Sette, A., Ward, E. S. & Garcia, K. C., Jan 1 2002, In : Immunity. 17, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

Immunodominant Epitopes
Myelin Basic Protein
Antigen Presentation
Autoimmunity
Peptides
80 Citations (Scopus)

Structure of the immunodominant surface antigen from the toxoplasma gondii SRS superfamily

He, X. L., Grigg, M. E., Boothroyd, J. C. & Garcia, K. C., Jan 1 2002, In : Nature Structural Biology. 9, 8, p. 606-611 6 p.

Research output: Contribution to journalArticle

Immunodominant Epitopes
Toxoplasma
Surface Antigens
GPI-Linked Proteins
Parasites
2001
130 Citations (Scopus)

Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone

He, X. L., Chow, D. C., Martick, M. M. & Garcia, K. C., Aug 31 2001, In : Science. 293, 5535, p. 1657-1662 6 p.

Research output: Contribution to journalArticle

Natriuretic Peptides
Peptide Receptors
Hormones
C-Type Natriuretic Peptide
Cyclic Peptides
47 Citations (Scopus)

Molecular characterization of an anti-epilepsy peptide from the scorpion Buthus martensi Karsch

Wang, C. G., He, X. L., Shao, F., Liu, W., Ling, M. H., Wang, D. C. & Chi, C. W., May 20 2001, In : European Journal of Biochemistry. 268, 8, p. 2480-2485 6 p.

Research output: Contribution to journalArticle

Scorpions
Epilepsy
Peptides
Insects
Amino Acids
46 Citations (Scopus)

Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation

He, X. L., Tabaczewski, P., Ho, J., Stroynowski, I. & Garcia, K. C., Dec 1 2001, In : Structure. 9, 12, p. 1213-1224 12 p.

Research output: Contribution to journalArticle

Antigen Presentation
Peptides
MHC Ib Qa-2 antigen
Ribosomal Proteins
Adaptive Immunity
210 Citations (Scopus)

Structure of an extracellular gp130 cytokine receptor signaling complex

Chow, D. C., He, X. L., Snow, A. L., Rose-John, S. & Christopher Garcia, K., Mar 16 2001, In : Science. 291, 5511, p. 2150-2155 6 p.

Research output: Contribution to journalArticle

Cytokine Receptor gp130
Interleukin-6
Cytokines
Virus Assembly
Human Herpesvirus 8
2000
1 Citation (Scopus)

Crystal structure determination of a neutral neurotoxin BmK M4 from Buthus martensii Karsch at 0.20 nm

He, X., Liu, X., Zeng, Z., Li, H., Wang, M., Zhang, Y. & Wang, D., Dec 1 2000, In : Science in China, Series C: Life Sciences. 43, 1, p. 45-46 2 p.

Research output: Contribution to journalArticle

Buthus martensii
neurotoxins
R Factors
crystal structure
toxin
17 Citations (Scopus)

Structure of a new neurotoxin from the scorpion Buthus martensii Karsch at 1.76 Å

He, X. L., Deng, J. P., Wang, M., Zhang, Y. & Wang, D. C., Jan 1 2000, In : Acta Crystallographica Section D: Biological Crystallography. 56, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

Scorpions
Neurotoxins
Poisons
Static Electricity
Insects
1999
76 Citations (Scopus)

Crystal structures of two α-like scorpion toxins: Non-proline cis peptide bonds and implications for new binding site selectivity on the sodium channel

He, X. L., Li, H. M., Zeng, Z. H., Liu, X. Q., Wang, M. & Wang, D. C., Sep 10 1999, In : Journal of Molecular Biology. 292, 1, p. 125-135 11 p.

Research output: Contribution to journalArticle

Scorpions
Sodium Channels
Binding Sites
Peptides
R Factors