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2017

A cryptic tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation

Morgan, M. A. J., Rickels, R. A., Collings, C. K., He, X., Cao, K., Herz, H. M., Cozzolino, K. A., Abshiru, N. A., Marshall, S. A., Rendleman, E. J., Sze, C. C., Piunti, A., Kelleher, N. L., Savas, J. N. & Shilatifard, A., Oct 1 2017, In : Genes and Development. 31, 19, p. 2003-2014 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Expression and purification of class 7 semaphorin and its Plexinc1 receptor using baculovirus-mediated mammalian cell gene transduction

Chen, X., Chen, P. H. & He, X., Jan 1 2017, In : Methods in Molecular Biology. 1493, p. 41-56 16 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Structure of Full-Length Human PDGFRβ Bound to Its Activating Ligand PDGF-B as Determined by Negative-Stain Electron Microscopy

Chen, P. H., Unger, V. & He, X., Dec 4 2015, In : Journal of Molecular Biology. 427, 24, p. 3921-3934 14 p.

Research output: Contribution to journalArticle

19 Scopus citations
2014

Evidence for follicle-stimulating hormone receptor as a functional trimer

Jiang, X., Fischer, D., Chen, X., McKenna, S. D., Liu, H., Sriraman, V., Yu, H. N., Goutopoulos, A., Arkinstall, S. & He, X., May 16 2014, In : Journal of Biological Chemistry. 289, 20, p. 14273-14282 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression

Ferrarese, R., Harsh IV, G. R., Yadav, A. K., Bug, E., Maticzka, D., Reichardt, W., Dombrowski, S. M., Miller, T. E., Masilamani, A. P., Dai, F., Kim, H., Hadler, M., Scholtens, D. M., Yu, I. L. Y., Beck, J., Srinivasasainagendra, V., Costa, F., Baxan, N., Pfeifer, D., Von Elverfeldt, D. & 11 others, Backofen, R., Weyerbrock, A., Duarte, C. W., He, X., Prinz, M., Chandler, J. P., Vogel, H., Chakravarti, A., Rich, J. N., Carro, M. S. & Bredel, M., Jul 1 2014, In : Journal of Clinical Investigation. 124, 7, p. 2861-2876 16 p.

Research output: Contribution to journalArticle

36 Scopus citations
2013

The structural basis of R-spondin recognition by LGR5 and RNF43

Chen, P. H., Chen, X., Lin, Z., Fang, D. & He, X., Jun 15 2013, In : Genes and Development. 27, 12, p. 1345-1350 6 p.

Research output: Contribution to journalArticle

78 Scopus citations
2012

Determination of phenobarbital in human urine and serum using flow injection chemiluminescence

Li, X., Niu, L. C., He, X. L. & Song, Z. H., 2012, In : Biomeditsinskaya Khimiya. 58, 1, p. 88-94 7 p.

Research output: Contribution to journalArticle

Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1

Shim, A. H. R., Chang, R. A., Chen, X., Longnecker, R. & He, X., Aug 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 32, p. 12962-12967 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression

Liu, X., Chan, C. B., Qi, Q., Xiao, G., Luo, H. R., He, X. & Ye, K., Oct 11 2012, In : Journal of Medicinal Chemistry. 55, 19, p. 8524-8537 14 p.

Research output: Contribution to journalArticle

45 Scopus citations

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

Jiang, X., Liu, H., Chen, X., Chen, P. H., Fischer, D., Sriraman, V., Yu, H. N., Arkinstall, S. & He, X., Jul 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 31, p. 12491-12496 6 p.

Research output: Contribution to journalArticle

150 Scopus citations

The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1

Liu, H., Leo, C., Chen, X., Wong, B. R., Williams, L. T., Lin, H. & He, X., Jul 1 2012, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1824, 7, p. 938-945 8 p.

Research output: Contribution to journalArticle

62 Scopus citations
2011

Determination of phenobarbital in human urine and serum using flow injection chemiluminescence

Li, X., Niu, L. C., He, X. L. & Song, Z. H., Jun 1 2011, In : Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 5, 2, p. 184-187 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules

Liu, H., Focia, P. J. & He, X., Jan 7 2011, In : Journal of Biological Chemistry. 286, 1, p. 797-805 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Maspin, the molecular bridge between the plasminogen activator system and β1 integrin that facilitates cell adhesion

Endsley, M. P., Hu, Y., Deng, Y., He, X., Warejcka, D. J., Twining, S. S., Gonias, S. L. & Zhang, M., Jul 15 2011, In : Journal of Biological Chemistry. 286, 28, p. 24599-24607 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

NFKBIA deletion in glioblastomas

Bredel, M., Scholtens, D. M., Yadav, A. K., Alvarez, A. A., Renfrow, J. J., Chandler, J. P., Yu, I. L. Y., Carro, M. S., Dai, F., Tagge, M. J., Ferrarese, R., Bredel, C., Phillips, H. S., Lukac, P. J., Robe, P. A., Weyerbrock, A., Vogel, H., Dubner, S., Mobley, B., He, X. & 5 others, Scheck, A. C., Sikic, B. I., Aldape, K. D., Chakravarti, A. & Harsh IV, G. R., Feb 17 2011, In : New England Journal of Medicine. 364, 7, p. 627-637 11 p.

Research output: Contribution to journalArticle

144 Scopus citations
2010

Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1

Liu, H., Juo, Z. S., Shim, A. H. R., Focia, P. J., Chen, X., Garcia, K. C. & He, X., Sep 3 2010, In : Cell. 142, 5, p. 749-761 13 p.

Research output: Contribution to journalArticle

93 Scopus citations

Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex

Shim, A. H. R., Liu, H., Focia, P. J., Chen, X., Lin, P. C. & He, X., Jun 22 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11307-11312 6 p.

Research output: Contribution to journalArticle

94 Scopus citations
2009
42 Scopus citations
2008

Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions

Chen, X., Liu, H., Shim, A. H. R., Focia, P. J. & He, X., Jan 1 2008, In : Nature Structural and Molecular Biology. 15, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

69 Scopus citations
53 Scopus citations
2007

Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors

Wehrman, T., He, X., Raab, B., Dukipatti, A., Blau, H. & Garcia, K. C., Jan 4 2007, In : Neuron. 53, 1, p. 25-38 14 p.

Research output: Contribution to journalArticle

213 Scopus citations

Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases

Liu, H., Chen, X., Focia, P. J. & He, X., Feb 7 2007, In : EMBO Journal. 26, 3, p. 891-901 11 p.

Research output: Contribution to journalArticle

80 Scopus citations
2006

A dimeric structure of the scorpion toxin BmK M1 at 1.4 Å resolution: Non-proline cis peptide bond and its inntrinsic structural elements

He, X. L., Guan, R. J., Zhang, Y. & Wang, D. C., Mar 1 2006, In : Progress in Biochemistry and Biophysics. 33, 3, p. 231-240 10 p.

Research output: Contribution to journalArticle

Structural Determinants of Natriuretic Peptide Receptor Specificity and Degeneracy

He, X. L., Dukkipati, A. & Garcia, K. C., Aug 25 2006, In : Journal of Molecular Biology. 361, 4, p. 698-714 17 p.

Research output: Contribution to journalArticle

40 Scopus citations
2005

A new paradigm for hormone recognition and allosteric receptor activation revealed from structural studies of NPR-C

He, X. L., Dukkipati, A., Wang, X. & Garcia, K. C., Jun 2005, In : Peptides. 26, 6 SPEC. ISS., p. 1035-1043 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo

Zheng, B., Atwal, J., Ho, C., Case, L., He, X. L., Garcia, K. C., Steward, O. & Tessier-Lavigne, M., Jan 25 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 4, p. 1205-1210 6 p.

Research output: Contribution to journalArticle

227 Scopus citations
2004

Structural mechanism governing cis and trans isomeric states and an intramolecular switch for cis/trans isomerization of a non-proline peptide bond observed in crystal structures of scorpion toxins

Guan, R. J., Xiang, Y., He, X. L., Wang, C. G., Wang, M., Zhang, Y., Sundberg, E. J. & Wang, D. C., Aug 27 2004, In : Journal of Molecular Biology. 341, 5, p. 1189-1204 16 p.

Research output: Contribution to journalArticle

37 Scopus citations

Structure of Nerve Growth Factor Complexed with the Shared Neurotrophin Receptor p75

He, X. L. & Garcia, K. C., May 7 2004, In : Science. 304, 5672, p. 870-875 6 p.

Research output: Contribution to journalArticle

217 Scopus citations
2003

Crystal structure of pokeweed antiviral protein with well-defined sugars from seeds at 1.8 Å resolution

Zeng, Z. H., He, X. L., Li, H. M., Hu, Z. & Wang, D. C., Feb 1 2003, In : Journal of Structural Biology. 141, 2, p. 171-178 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation

Krogsgaard, M., Prado, N., Adams, E. J., He, X. L., Chow, D. C., Wilson, D. B., Garcia, K. C. & Davis, M. M., Dec 2003, In : Molecular cell. 12, 6, p. 1367-1378 12 p.

Research output: Contribution to journalArticle

187 Scopus citations

Structure of the Nogo receptor ectodomain: A recognition module implicated in myelin inhibition

He, X. L., Bazan, J. F., McDermott, G., Park, J. B., Wang, K., Tessier-Lavigne, M., He, Z. & Garcia, K. C., Apr 24 2003, In : Neuron. 38, 2, p. 177-185 9 p.

Research output: Contribution to journalArticle

166 Scopus citations
2002

Purification, crystallization and initial structural solution of a new α-like toxin with cardiac toxicity from scorpion Buthus martensii Karsch

Guan, R. J., He, X. L., Wang, M., Ye-Xiang, Li, G. P. & Wang, D. C., Sep 28 2002, In : Protein and Peptide Letters. 9, 5, p. 441-449 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Structural snapshot of aberrant antigen presentation linked to autoimmunity: The immunodominant epitope of MBP complexed with I-Au

He, X. L., Radu, C., Sidney, J., Sette, A., Ward, E. S. & Garcia, K. C., Jan 1 2002, In : Immunity. 17, 1, p. 83-94 12 p.

Research output: Contribution to journalArticle

95 Scopus citations

Structure of the immunodominant surface antigen from the toxoplasma gondii SRS superfamily

He, X. L., Grigg, M. E., Boothroyd, J. C. & Garcia, K. C., Jan 1 2002, In : Nature Structural Biology. 9, 8, p. 606-611 6 p.

Research output: Contribution to journalArticle

83 Scopus citations
2001

Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone

He, X. L., Chow, D. C., Martick, M. M. & Garcia, K. C., Aug 31 2001, In : Science. 293, 5535, p. 1657-1662 6 p.

Research output: Contribution to journalArticle

130 Scopus citations

Molecular characterization of an anti-epilepsy peptide from the scorpion Buthus martensi Karsch

Wang, C. G., He, X. L., Shao, F., Liu, W., Ling, M. H., Wang, D. C. & Chi, C. W., May 20 2001, In : European Journal of Biochemistry. 268, 8, p. 2480-2485 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation

He, X. L., Tabaczewski, P., Ho, J., Stroynowski, I. & Garcia, K. C., Dec 1 2001, In : Structure. 9, 12, p. 1213-1224 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Structure of an extracellular gp130 cytokine receptor signaling complex

Chow, D. C., He, X. L., Snow, A. L., Rose-John, S. & Christopher Garcia, K., Mar 16 2001, In : Science. 291, 5511, p. 2150-2155 6 p.

Research output: Contribution to journalArticle

212 Scopus citations
2000

Crystal structure determination of a neutral neurotoxin BmK M4 from Buthus martensii Karsch at 0.20 nm

He, X., Liu, X., Zeng, Z., Li, H., Wang, M., Zhang, Y. & Wang, D., Dec 1 2000, In : Science in China, Series C: Life Sciences. 43, 1, p. 45-46 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Structure of a new neurotoxin from the scorpion Buthus martensii Karsch at 1.76 Å

He, X. L., Deng, J. P., Wang, M., Zhang, Y. & Wang, D. C., Jan 1 2000, In : Acta Crystallographica Section D: Biological Crystallography. 56, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
1999

Crystal structures of two α-like scorpion toxins: Non-proline cis peptide bonds and implications for new binding site selectivity on the sodium channel

He, X. L., Li, H. M., Zeng, Z. H., Liu, X. Q., Wang, M. & Wang, D. C., Sep 10 1999, In : Journal of Molecular Biology. 292, 1, p. 125-135 11 p.

Research output: Contribution to journalArticle

76 Scopus citations