Xiaonan Li

Personal profile

Research Interests

Development of novel patient derived orthotopic xenograft mouse models, understand tumor biology and identify new diagnostic and/or therapeutic targets, perform comprehensive preclinical drug testing to establish preclinical rational for the initiation of clinical trials.

Nonn.

Training Experience

1990	Residency, Suzhou Medical College/Soochow University, PR.China
1992	Fellowship, Suzhou Medical College/Soochow University, PR.China
2001	Postdoctoral Fellowship, Baylor College Of Medicine

Education/Academic qualification

PhD, Suzhou Medical College/Soochow University

… → 1993

MD, Suzhou Medical College/Soochow University

… → 1985

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8 Similar Profiles

Medulloblastoma Medicine & Life Sciences

Glioma Medicine & Life Sciences

Neoplasms Medicine & Life Sciences

Heterografts Medicine & Life Sciences

Pediatrics Medicine & Life Sciences

Glioblastoma Medicine & Life Sciences

Neoplastic Stem Cells Medicine & Life Sciences

Brain Neoplasms Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2018 2023

2 Active

DTC Shared Resource

James, C. D. & Li, X.

National Cancer Institute

8/10/18 → 7/31/23

Project: Research project

Neoplasms

Medicine

Research

Population

LCH Subaward

Platanias, L. C. & Li, X.

National Cancer Institute

8/10/18 → 7/31/23

Project: Research project

Neoplasms

Medicine

Research

Population

Research Output 1992 2019

2838 Citations
78 Article
2 Comment/debate
1 Review article

4 Citations (Scopus)

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor

Sin-Chan, P., Mumal, I., Suwal, T., Ho, B., Fan, X., Singh, I., Du, Y., Lu, M., Patel, N., Torchia, J., Popovski, D., Fouladi, M., Guilhamon, P., Hansford, J. R., Leary, S., Hoffman, L. M., Mulcahy Levy, J. M., Lassaletta, A., Solano-Paez, P., Rivas, E. & 34 others, Reddy, A., Gillespie, G. Y., Gupta, N., Van Meter, T. E., Nakamura, H., Wong, T. T., Ra, Y. S., Kim, S. K., Massimi, L., Grundy, R. G., Fangusaro, J., Johnston, D., Chan, J., Lafay-Cousin, L., Hwang, E. I., Wang, Y., Catchpoole, D., Michaud, J., Ellezam, B., Ramanujachar, R., Lindsay, H., Taylor, M. D., Hawkins, C. E., Bouffet, E., Jabado, N., Singh, S. K., Kleinman, C. L., Barsyte-Lovejoy, D., Li, X. N., Dirks, P. B., Lin, C. Y., Mack, S. C., Rich, J. N. & Huang, A., Jul 8 2019, In : Cancer Cell. 36, 1, p. 51-67.e7

Research output: Contribution to journal › Article

MicroRNAs

Brain Neoplasms

Neoplasms

Cell Death

Therapeutics

2 Citations (Scopus)

Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design

Rokita, J. L., Rathi, K. S., Cardenas, M. F., Upton, K. A., Jayaseelan, J., Cross, K. L., Pfeil, J., Egolf, L. E., Way, G. P., Farrel, A., Kendsersky, N. M., Patel, K., Gaonkar, K. S., Modi, A., Berko, E. R., Lopez, G., Vaksman, Z., Mayoh, C., Nance, J., McCoy, K. & 49 others, Haber, M., Evans, K., McCalmont, H., Bendak, K., Böhm, J. W., Marshall, G. M., Tyrrell, V., Kalletla, K., Braun, F. K., Qi, L., Du, Y., Zhang, H., Lindsay, H. B., Zhao, S., Shu, J., Baxter, P., Morton, C., Kurmashev, D., Zheng, S., Chen, Y., Bowen, J., Bryan, A. C., Leraas, K. M., Coppens, S. E., Doddapaneni, H. V., Momin, Z., Zhang, W., Sacks, G. I., Hart, L. S., Krytska, K., Mosse, Y. P., Gatto, G. J., Sanchez, Y., Greene, C. S., Diskin, S. J., Vaske, O. M., Haussler, D., Gastier-Foster, J. M., Kolb, E. A., Gorlick, R., Li, X. N., Reynolds, C. P., Kurmasheva, R. T., Houghton, P. J., Smith, M. A., Lock, R. B., Raman, P., Wheeler, D. A. & Maris, J. M., Nov 5 2019, In : Cell reports. 29, 6, p. 1675-1689.e9

Research output: Contribution to journal › Article

Open Access

Pediatrics

Heterografts

Tumors

Histology

Clinical Trials

Relevance of a TCGA-derived Glioblastoma Subtype Gene-Classifier among Patient Populations

Teo, W. Y., Sekar, K., Seshachalam, P., Shen, J., Chow, W. Y., Lau, C. C., Yang, H. K., Park, J., Kang, S. G., Li, X., Nam, D. H. & Hui, K. M., Dec 1 2019, In : Scientific reports. 9, 1, 7442.

Research output: Contribution to journal › Article

Open Access

Glioblastoma

temozolomide

Population

Genes

Heterografts

9 Citations (Scopus)

Resolving medulloblastoma cellular architecture by single-cell genomics

Hovestadt, V., Smith, K. S., Bihannic, L., Filbin, M. G., Shaw, M. K. L., Baumgartner, A., DeWitt, J. C., Groves, A., Mayr, L., Weisman, H. R., Richman, A. R., Shore, M. E., Goumnerova, L., Rosencrance, C., Carter, R. A., Phoenix, T. N., Hadley, J. L., Tong, Y., Houston, J., Ashmun, R. A. & 31 others, DeCuypere, M., Sharma, T., Flasch, D., Silkov, A., Ligon, K. L., Pomeroy, S. L., Rivera, M. N., Rozenblatt-Rosen, O., Rusert, J. M., Wechsler-Reya, R. J., Li, X. N., Peyrl, A., Gojo, J., Kirchhofer, D., Lötsch, D., Czech, T., Dorfer, C., Haberler, C., Geyeregger, R., Halfmann, A., Gawad, C., Easton, J., Pfister, S. M., Regev, A., Gajjar, A., Orr, B. A., Slavc, I., Robinson, G. W., Bernstein, B. E., Suvà, M. L. & Northcott, P. A., Aug 1 2019, In : Nature. 572, 7767, p. 74-79 6 p.

Research output: Contribution to journal › Article

Medulloblastoma

Genomics

Neoplasms

Cerebellar Neoplasms

Population Groups

1 Citation (Scopus)

The molecular landscape of ETMR at diagnosis and relapse

Lambo, S., Gröbner, S. N., Rausch, T., Waszak, S. M., Schmidt, C., Gorthi, A., Romero, J. C., Mauermann, M., Brabetz, S., Krausert, S., Buchhalter, I., Koster, J., Zwijnenburg, D. A., Sill, M., Hübner, J. M., Mack, N., Schwalm, B., Ryzhova, M., Hovestadt, V., Papillon-Cavanagh, S. & 45 others, Chan, J. A., Landgraf, P., Ho, B., Milde, T., Witt, O., Ecker, J., Sahm, F., Sumerauer, D., Ellison, D. W., Orr, B. A., Darabi, A., Haberler, C., Figarella-Branger, D., Wesseling, P., Schittenhelm, J., Remke, M., Taylor, M. D., Gil-da-Costa, M. J., Łastowska, M., Grajkowska, W., Hasselblatt, M., Hauser, P., Pietsch, T., Uro-Coste, E., Bourdeaut, F., Masliah-Planchon, J., Rigau, V., Alexandrescu, S., Wolf, S., Li, X. N., Schüller, U., Snuderl, M., Karajannis, M. A., Giangaspero, F., Jabado, N., von Deimling, A., Jones, D. T. W., Korbel, J. O., von Hoff, K., Lichter, P., Huang, A., Bishop, A. J. R., Pfister, S. M., Korshunov, A. & Kool, M., Dec 12 2019, In : Nature. 576, 7786, p. 274-280 7 p.

Research output: Contribution to journal › Article

Recurrence

Neoplasms

Nucleotides

Topoisomerase Inhibitors

Chromosomal Instability