• 1194 Citations
19952019
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Research Output 1995 2019

2003
17 Citations (Scopus)

Membrane lymphotoxin is required for resistance to Theiler's virus infection

Lin, X., Ma, X., Rodriguez, M., Feng, X., Zoecklein, L., Fu, Y. X. & Roos, R. P., Aug 1 2003, In : International Immunology. 15, 8, p. 955-962 8 p.

Research output: Contribution to journalReview article

Theilovirus
Lymphotoxin-alpha
Virus Diseases
Membranes
Tumor Necrosis Factor-alpha
2002
147 Citations (Scopus)

Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis

Sun, Y., Lin, X., Chen, H. M., Wu, Q., Subudhi, S. K., Chen, L. & Fu, Y. X., Feb 1 2002, In : Journal of Immunology. 168, 3, p. 1457-1465 9 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Monoclonal Antibodies
T-Lymphocytes
Adoptive Transfer
Therapeutics
18 Citations (Scopus)

Transgenic expression of Theiler's murine encephalomyelitis virus genes in H-2b mice inhibits resistance to virus-induced demyelination

Lin, X., Njenga, M. K., Johnson, A. J., Pavelko, K. D., David, C. S., Pease, L. R. & Rodriguez, M., Jul 23 2002, In : Journal of virology. 76, 15, p. 7799-7811 13 p.

Research output: Contribution to journalArticle

Theilovirus
Demyelinating Diseases
Viruses
gene expression
viruses
2001
52 Citations (Scopus)

Signal via lymphotoxin-βR on bone marrow stromal cells is required for an early checkpoint of NK cell development

Wu, Q., Sun, Y., Wang, J., Lin, X., Wang, Y., Pegg, L. E., Fütterer, A., Pfeffer, K. & Fu, Y. X., Feb 1 2001, In : Journal of Immunology. 166, 3, p. 1684-1689 6 p.

Research output: Contribution to journalArticle

Lymphotoxin-alpha
Mesenchymal Stromal Cells
Natural Killer Cells
Stromal Cells
Immune System
2000
31 Citations (Scopus)

TGF-β2 reduces demyelination, virus antigen expression, and macrophage recruitment in a viral model of multiple sclerosis

Drescher, K. M., Murray, P. D., Lin, X., Carlino, J. A. & Rodriguez, M., Mar 15 2000, In : Journal of Immunology. 164, 6, p. 3207-3213 7 p.

Research output: Contribution to journalArticle

Demyelinating Diseases
Multiple Sclerosis
Macrophages
Viruses
Antigens
7 Citations (Scopus)

The CD4-mediated immune response is critical in determining the outcome of infection using Theiler's viruses with VP1 capsid protein point mutations

Rodriguez, M., Roos, R. P., McGavern, D., Zoecklein, L., Pavelko, K., Sang, H. & Lin, X., Sep 15 2000, In : Virology. 275, 1, p. 9-19 11 p.

Research output: Contribution to journalArticle

Capsid Proteins
Point Mutation
Viruses
Demyelinating Diseases
Infection
1999
29 Citations (Scopus)

Absence of spontaneous central nervous system remyelination in class II- deficient mice infected with Theiler's virus

Njenga, M. K., Murray, P. D., McGavern, D., Lin, X., Drescher, K. M. & Rodriguez, M., Jan 1999, In : Journal of neuropathology and experimental neurology. 58, 1, p. 78-91 14 p.

Research output: Contribution to journalArticle

Theilovirus
Central Nervous System
Demyelinating Diseases
Virus Diseases
Neurologic Manifestations
25 Citations (Scopus)

A Theiler's virus alternatively initiated protein inhibits the generation of H-2K-restricted virus-specific cytotoxicity

Lin, X., Roos, R. P., Pease, L. R., Wettstein, P. & Rodriguez, M., Jan 1 1999, In : Journal of Immunology. 162, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

Theilovirus
Viruses
Central Nervous System
Demyelinating Diseases
Proteins
1998
97 Citations (Scopus)

CD4+ and CD8+ T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis

Murray, P. D., Pavelko, K. D., Leibowitz, J., Lin, X. & Rodriguez, M., Sep 1 1998, In : Journal of virology. 72, 9, p. 7320-7329 10 p.

Research output: Contribution to journalArticle

nervous system diseases
sclerosis
Demyelinating Diseases
Nervous System Diseases
Multiple Sclerosis
15 Citations (Scopus)

Molecular characterization of a nondemyelinating variant of Daniel's strain of Theiler's virus isolated from a persistently infected glioma cell line

Lin, X., Sato, S., Patick, A. K., Pease, L. R., Roos, R. P. & Rodriguez, M., Feb 1 1998, In : Journal of virology. 72, 2, p. 1262-1269 8 p.

Research output: Contribution to journalArticle

Theilovirus
Demyelinating Diseases
Glioma
cell lines
Viruses
95 Citations (Scopus)

Perforin-dependent neurologic injury in a viral model of multiple sclerosis

Murray, P. D., McGavern, D. B., Lin, X., Njenga, M. K., Leibowitz, J., Pease, L. R. & Rodriguez, M., Sep 15 1998, In : Journal of Neuroscience. 18, 18, p. 7306-7314 9 p.

Research output: Contribution to journalArticle

Nervous System Trauma
Perforin
Demyelinating Diseases
Multiple Sclerosis
Theilovirus
31 Citations (Scopus)

Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent vital or major myelin antigenic specificity

Lin, X., Pease, L. R., Murray, P. D. & Rodriguez, M., Jun 1 1998, In : Journal of Immunology. 160, 11, p. 5661-5668 8 p.

Research output: Contribution to journalArticle

Theilovirus
Virus Diseases
Myelin Sheath
Epitopes
Central Nervous System
1997
48 Citations (Scopus)

Brain-infiltrating cytolytic T lymphocytes specific for Theiler's virus recognize H2Db molecules complexed with a viral VP2 peptide lacking a consensus anchor residue

Borson, N. D., Paul, C., Lin, X., Nevala, W. K., Strausbauch, M. A., Rodriguez, M. & Wettstein, P. J., Jul 1 1997, In : Journal of Virology. 71, 7, p. 5244-5250 7 p.

Research output: Contribution to journalArticle

Theilovirus
T-lymphocytes
peptides
T-Lymphocytes
brain
29 Citations (Scopus)

Differential generation of class I H-2D- versus H-2K-restricted cytotoxicity against a demyelinating virus following central nervous system infection

Lin, X., Pease, L. R. & Rodriguez, M., Apr 21 1997, In : European Journal of Immunology. 27, 4, p. 963-970 8 p.

Research output: Contribution to journalArticle

Central Nervous System Infections
Cytotoxic T-Lymphocytes
Viruses
Central Nervous System
Theilovirus
1996
63 Citations (Scopus)

Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice

Kariuki Njenga, M., Pavelko, K. D., Baisch, J., Lin, X., David, C., Leibowitz, J. & Rodriguez, M., Feb 27 1996, In : Journal of Virology. 70, 3, p. 1729-1737 9 p.

Research output: Contribution to journalArticle

Theilovirus
major histocompatibility complex
Demyelinating Diseases
Major Histocompatibility Complex
viruses
1995
39 Citations (Scopus)

VP1 and VP2 Capsid Proteins of Theiler's Virus Are Targets of H-2D-Restricted Cytotoxic Lymphocytes in the Central Nervous System of B10 Mice

LIN, XIAOQI., THIEMANN, ROGER., PEASE, LARRY. R. & RODRIGUEZ, MOSES., Dec 1 1995, In : Virology. 214, 1, p. 91-99 9 p., 79951.

Research output: Contribution to journalArticle

Theilovirus
Capsid Proteins
Central Nervous System
Lymphocytes
Protein Sorting Signals