Grants per year
Personal profile
Research Interests
My research goal is to identity new targets for therapeutic intervention for liver injury and fibrosis, with a focus on NAFLD and cholestatic liver diseases. Given the emerging understanding of the importance of endoplasmic reticulum stress in a variety of liver diseases, I am particularly interested in the role of the unfolded protein response (UPR), an ER stress-induced adaptive response, in liver injury and fibrogenesis.
Education/Academic qualification
Biochemistry, PhD, The Ohio State University
… → 2009
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Collaborations and top research areas from the last five years
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Grants
- 3 Finished
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The Role of Activating Transcription Factor 4 in Primary Sclerosing Cholangitis
7/1/20 → 6/30/23
Project: Research project
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The Unfolded Protein Response (UPR) in Liver Transplant Patients with Cholestasis
Northwestern Memorial Hospital, Digestive Health Foundation
7/1/20 → 9/30/21
Project: Research project
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Cholestasis and the Unfolded Protein Response
National Institute of Diabetes and Digestive and Kidney Diseases
8/1/17 → 7/31/22
Project: Research project
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Expression of unfolded protein response genes in post-transplantation liver biopsies
Liu, X., Taylor, S. A., Celaj, S., Levitsky, J. & Green, R. M., Dec 2022, In: BMC Gastroenterology. 22, 1, 380.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury
Liu, X., Khalafalla, M., Chung, C., Gindin, Y., Hubchak, S., LeCuyer, B., Kriegermeier, A., Zhang, D., Qiu, W., Ding, X., Fang, D. & Green, R., Nov 1 2022, In: Journal of lipid research. 63, 11, p. 100289 1 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Inositol-requiring enzyme 1α/X-box protein 1 pathway expression is impaired in pediatric cholestatic liver disease explants
Kriegermeier, A., Hyon, A., LeCuyer, B., Hubchak, S., Liu, X. & Green, R. M., Dec 2022, In: PloS one. 17, 12 December, e0279016.Research output: Contribution to journal › Article › peer-review
Open Access -
Mechanisms of liver injury in high fat sugar diet fed mice that lack hepatocyte X-box binding protein 1
Liu, X., Taylor, S. A., Gromer, K. D., Zhang, D., Hubchak, S. C., LeCuyer, B. E., Iwawaki, T., Shi, Z., Rockey, D. C. & Green, R. M., Jan 2022, In: PloS one. 17, 1 January, e0261789.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Hepatic X-Box Binding Protein 1 and Unfolded Protein Response Is Impaired in Weanling Mice With Resultant Hepatic Injury
Kriegermeier, A., Hyon, A., Sommars, M., Hubchak, S., LeCuyer, B., Liu, X., Barish, G. & Green, R. M., Dec 2021, In: Hepatology. 74, 6, p. 3362-3375 14 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations
Datasets
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Hepatic transcriptome profiling of liver-specific Xbp1 knockout mice fed a high fat diet
Liu, X. (Contributor), ArrayExpress, 2016
https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-64824
Dataset
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Expression of unfolded protein response genes in post-transplantation liver biopsies
Liu, X. (Creator), Taylor, S. A. (Creator), Celaj, S. (Creator), Levitsky, J. (Creator) & Green, R. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6143173.v1, https://springernature.figshare.com/collections/Expression_of_unfolded_protein_response_genes_in_post-transplantation_liver_biopsies/6143173/1
Dataset