Grants per year
Personal profile
Research Interests
My research goal is to identity new targets for therapeutic intervention for liver injury and fibrosis, with a focus on NAFLD and cholestatic liver diseases. Given the emerging understanding of the importance of endoplasmic reticulum stress in a variety of liver diseases, I am particularly interested in the role of the unfolded protein response (UPR), an ER stress-induced adaptive response, in liver injury and fibrogenesis.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biochemistry, PhD, The Ohio State University
… → 2009
Fingerprint
Dive into the research topics where Xiaoying Liu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
The Unfolded Protein Response and Bile Acid Metabolism
Green, R. (PD/PI), Barish, G. D. (Co-Investigator) & Liu, X. (Co-Investigator)
National Institute of Diabetes and Digestive and Kidney Diseases
12/15/24 → 11/30/28
Project: Research project
-
The Unfolded Protein Response (UPR) in Liver Transplant Patients with Cholestasis
Liu, X. (PD/PI)
Northwestern Memorial Hospital, Digestive Health Foundation
7/1/20 → 9/30/21
Project: Research project
-
The Role of Activating Transcription Factor 4 in Primary Sclerosing Cholangitis
Liu, X. (PD/PI)
7/1/20 → 6/30/23
Project: Research project
-
Cholestasis and the Unfolded Protein Response
Green, R. (PD/PI) & Liu, X. (Other)
National Institute of Diabetes and Digestive and Kidney Diseases
8/1/17 → 7/31/22
Project: Research project
-
Expression of unfolded protein response genes in post-transplantation liver biopsies
Liu, X., Taylor, S. A., Celaj, S., Levitsky, J. & Green, R. M., Dec 2022, In: BMC Gastroenterology. 22, 1, 380.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury
Liu, X., Khalafalla, M., Chung, C., Gindin, Y., Hubchak, S., LeCuyer, B., Kriegermeier, A., Zhang, D., Qiu, W., Ding, X., Fang, D. & Green, R., Nov 2022, In: Journal of lipid research. 63, 11, 100289.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Inositol-requiring enzyme 1α/X-box protein 1 pathway expression is impaired in pediatric cholestatic liver disease explants
Kriegermeier, A., Hyon, A., LeCuyer, B., Hubchak, S., Liu, X. & Green, R. M., Dec 2022, In: PloS one. 17, 12 December, e0279016.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Mechanisms of liver injury in high fat sugar diet fed mice that lack hepatocyte X-box binding protein 1
Liu, X., Taylor, S. A., Gromer, K. D., Zhang, D., Hubchak, S. C., LeCuyer, B. E., Iwawaki, T., Shi, Z., Rockey, D. C. & Green, R. M., Jan 2022, In: PloS one. 17, 1 January, e0261789.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Hepatic X-Box Binding Protein 1 and Unfolded Protein Response Is Impaired in Weanling Mice With Resultant Hepatic Injury
Kriegermeier, A., Hyon, A., Sommars, M., Hubchak, S., LeCuyer, B., Liu, X., Barish, G. & Green, R. M., Dec 2021, In: Hepatology. 74, 6, p. 3362-3375 14 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations
Datasets
-
Hepatic transcriptome profiling of liver-specific Xbp1 knockout mice fed a high fat diet
Liu, X. (Contributor), ArrayExpress, 2016
https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-64824
Dataset
-
Expression of unfolded protein response genes in post-transplantation liver biopsies
Liu, X. (Creator), Taylor, S. A. (Creator), Celaj, S. (Creator), Levitsky, J. (Creator) & Green, R. M. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6143173, https://springernature.figshare.com/collections/Expression_of_unfolded_protein_response_genes_in_post-transplantation_liver_biopsies/6143173
Dataset