Keyphrases
Targeted Protein Degradation
80%
Proteolysis Targeting chimera (PROTAC)
70%
SIRT2
63%
Lysine Fatty Acylation
60%
E3 Ligase
58%
Electrophilic
55%
Small Molecules
50%
DCAF16
45%
K-Ras4B
42%
Lysine
42%
Cysteine
42%
Quinone Reductase Induction
41%
Chemical Proteomics
40%
Sirtuin 6 (SIRT6)
39%
Eurycorymbus Cavaleriei
32%
Dichloromethane Extract
32%
Sirtuins
31%
Defatty-acylation
29%
Quinones
28%
NAD(P)
28%
Screening Method
26%
Thiophene
25%
Electrophile
25%
Kelch-like ECH-associated Protein 1 (Keap1)
25%
Protein-like
24%
Glutathione
24%
Diynyl
23%
Biological Function
22%
Quinone Reductase Activity
21%
Echinops
21%
DCAF1
21%
Keap1-Nrf2 Pathway
21%
SIRT2 Inhibitor
21%
Human Disease
20%
Penta
19%
GTPase
19%
Protein-protein Interaction
18%
Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS)
18%
Protein Degradation
18%
Electrophilic Compounds
17%
Covalent Chemistry
17%
Mass Spectrometry
16%
Covalent Ligand
16%
Nuclear Factor Erythroid 2-related Factor 2 (Nrf2)
16%
Ras Proteins
16%
Druggability
16%
Alkylation
16%
Chemical Probes
15%
Oxidative Stress
14%
Sirtuin 1 (SIRT1)
14%
Biochemistry, Genetics and Molecular Biology
Protein Catabolism
100%
Lysine
95%
Small Molecule
76%
Acylation
73%
Proteomics
66%
Cysteine
63%
Electrophilicity
62%
Ubiquitin Ligase
60%
Sirtuin
56%
Proteolysis
52%
SIRT2
51%
T Cell
29%
Transcription Factor Nrf2
25%
Cancer Cell
24%
Glutathione
20%
Enzyme
19%
SIRT6
19%
Biological Functions
19%
Histone
19%
Isoform
18%
Nrf2 Pathway
18%
Proteome
16%
Ubiquitin-Conjugating Enzyme
16%
Oxidative Stress
16%
Posttranslational Modification
15%
Carcinogenesis
15%
Thiophene
14%
N-Terminus
14%
Interactome
13%
Signal Transduction
12%
Amidase
12%
Ras2
11%
Mass Spectrometry
11%
Protein Function
11%
HDAC11
10%
SIRT7
10%
Cell Migration
10%
Antineoplastic Activity
10%
IC50
10%
Secretome
10%
Enzyme Inducer
10%
Protein-Protein Interaction
10%
ADP Ribosylation Factor
10%
MAP2K7
10%
GTPase
10%
Tumor Necrosis Factor
10%
Synapsin I
10%
Nuclear Protein
10%
Sirtuin 1
10%
Monocarboxylate Transporter
10%