Xinxin Song

  • 1314 Citations
20072020

Research output per year

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Research Output

2020

Cullin 4-DCAF Proteins in Tumorigenesis

Zhou, Z., Song, X., Wavelet, C. M. & Wan, Y., Jan 1 2020, Advances in Experimental Medicine and Biology. Springer, p. 241-259 19 p. (Advances in Experimental Medicine and Biology; vol. 1217).

Research output: Chapter in Book/Report/Conference proceedingChapter

Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance

Zhou, Z., Song, X., Chi, J. J., Gius, D. R., Huang, Y., Cristofanilli, M. & Wan, Y., Jun 2020, In : Cellular Signalling. 70, 109574.

Research output: Contribution to journalArticle

2018

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc Activity

Song, X., Zhu, S., Chen, P., Hou, W., Wen, Q., Liu, J., Xie, Y., Liu, J., Klionsky, D. J., Kroemer, G., Lotze, M. T., Zeh, H. J., Kang, R. & Tang, D., Aug 6 2018, In : Current Biology. 28, 15, p. 2388-2399.e5

Research output: Contribution to journalArticle

60 Scopus citations

Crosstalk between apoptosis and autophagy is regulated by the arginylated BiP/Beclin-1/p62 complex

Song, X., Lee, D. H., Dilly, A. K., Lee, Y. S., Choudry, H. A., Kwon, Y. T., Bartlett, D. L. & Lee, Y. J., Jul 1 2018, In : Molecular Cancer Research. 16, 7, p. 1077-1091 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice

Song, X., Zhu, S., Xie, Y., Liu, J., Sun, L., Zeng, D., Wang, P., Ma, X., Kroemer, G., Bartlett, D. L., Billiar, T. R., Lotze, M. T., Zeh, H. J., Kang, R. & Tang, D., Apr 2018, In : Gastroenterology. 154, 5, p. 1480-1493 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5

Lee, D. H., Kim, D., Kim, S. T., Jeong, S., Kim, J. L., Shim, S. M., Heo, A. J., Song, X., Guo, Z. S., Bartlett, D. L., Oh, S. C., Lee, J., Saito, Y., Kim, B. Y., Kwon, Y. T. & Lee, Y. J., Nov 2 2018, In : Autophagy. 14, 11, p. 1870-1885 16 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Xie, Y., Zhu, S., Song, X., Sun, X., Fan, Y., Liu, J., Zhong, M., Yuan, H., Zhang, L., Billiar, T. R., Lotze, M. T., Zeh, H. J., Kang, R., Kroemer, G. & Tang, D., Aug 15 2017, In : Cell Reports. 20, 7, p. 1692-1704 13 p.

Research output: Contribution to journalArticle

99 Scopus citations
2016

Autophagy promotes ferroptosis by degradation of ferritin

Hou, W., Xie, Y., Song, X., Sun, X., Lotze, M. T., Zeh, H. J., Kang, R. & Tang, D., Aug 2 2016, In : Autophagy. 12, 8, p. 1425-1428 4 p.

Research output: Contribution to journalLetter

210 Scopus citations

FANCD2 protects against bone marrow injury from ferroptosis

Song, X., Xie, Y., Kang, R., Hou, W., Sun, X., Epperly, M. W., Greenberger, J. S. & Tang, D., Nov 18 2016, In : Biochemical and Biophysical Research Communications. 480, 3, p. 443-449 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ferroptosis: Process and function

Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R. & Tang, D., Mar 1 2016, In : Cell Death and Differentiation. 23, 3, p. 369-379 11 p.

Research output: Contribution to journalReview article

422 Scopus citations

Identification of baicalein as a ferroptosis inhibitor by natural product library screening

Xie, Y., Song, X., Sun, X., Huang, J., Zhong, M., Lotze, M. T., Zeh, H. J., Kang, R. & Tang, D., May 13 2016, In : Biochemical and Biophysical Research Communications. 473, 4, p. 775-780 6 p.

Research output: Contribution to journalArticle

51 Scopus citations

Secretory trail-armed natural killer cell-based therapy: In vitro and in vivo colorectal peritoneal carcinomatosis xenograft

Song, X., Hong, S. H., Kwon, W. T., Bailey, L. M., Basse, P., Bartlett, D. L., Kwon, Y. T. & Lee, Y. J., Jul 1 2016, In : Molecular Cancer Therapeutics. 15, 7, p. 1591-1601 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Hypoxia promotes synergy between mitomycin c and bortezomib through a coordinated process of Bcl-xL phosphorylation and mitochondrial translocation of p53

Song, X., Dilly, A. K., Choudry, H. A., Bartlett, D. L., Kwon, Y. T. & Lee, Y. J., Dec 1 2015, In : Molecular Cancer Research. 13, 12, p. 1533-1543 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mitogen-activated protein kinase inhibition reduces mucin 2 production and mucinous tumor growth

Dilly, A. K., Song, X., Zeh, H. J., Guo, Z. S., Lee, Y. J., Bartlett, D. L. & Choudry, H. A., Oct 1 2015, In : Translational Research. 166, 4, p. 344-354 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
2014

Rapamycin-enhanced mitomycin C-induced apoptotic death is mediated through the S6K1-Bad-Bak pathway in peritoneal carcinomatosis

Song, X., Dilly, A. K., Kim, S. Y., Choudry, H. A. & Lee, Y. J., 2014, In : Cell Death and Disease. 5, 6, e1281.

Research output: Contribution to journalArticle

8 Scopus citations

Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer

Song, X., Kim, S. Y., Zhang, L., Tang, D., Bartlett, D. L., Kwon, Y. T. & Lee, Y. J., Jan 1 2014, In : Cell Death and Disease. 5, 10, e1504.

Research output: Contribution to journalArticle

29 Scopus citations

Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death

Kim, S. Y., Song, X., Zhang, L., Bartlett, D. L. & Lee, Y. J., Mar 15 2014, In : Biochemical Pharmacology. 88, 2, p. 178-188 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Role of Bcl-xL/Beclin-1 in synergistic apoptotic effects of secretory TRAIL-armed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells

Kim, S. Y., Lee, D. H., Song, X., Bartlett, D. L., Kwon, Y. T. & Lee, Y. J., Oct 14 2014, In : Apoptosis. 19, 11, p. 1603-1615 13 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013
10 Scopus citations

Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells

Song, X., Kim, S. Y., Zhou, Z., Lagasse, E., Kwon, Y. T. & Lee, Y. J., Apr 2013, In : Cell Death and Disease. 4, 4, e577.

Research output: Contribution to journalArticle

18 Scopus citations

Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells

Kim, S. Y., Kang, J. W., Song, X., Kim, B. K., Yoo, Y. D., Kwon, Y. T. & Lee, Y. J., Apr 2013, In : Cellular Signalling. 25, 4, p. 961-969 9 p.

Research output: Contribution to journalArticle

141 Scopus citations
2012

Breast Cancer Stem Cell-Like Cells Are More Sensitive to Ionizing Radiation than Non-Stem Cells: Role of ATM

Kim, S. Y., Rhee, J. G., Song, X., Prochownik, E. V., Spitz, D. R. & Lee, Y. J., Nov 21 2012, In : PLoS One. 7, 11, e50423.

Research output: Contribution to journalArticle

23 Scopus citations

Hyperthermia-enhanced TRAIL- and mapatumumab-induced apoptotic death is mediated through mitochondria in human colon cancer cells

Song, X., Kim, H. C., Kim, S. Y., Basse, P., Park, B. H., Lee, B. C. & Lee, Y. J., May 2012, In : Journal of Cellular Biochemistry. 113, 5, p. 1547-1558 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

The role of Bcl-xL in synergistic induction of apoptosis by mapatumumab and oxaliplatin in combination with hyperthermia on human colon cancer

Song, X., Kim, S. Y. & Lee, Y. J., Dec 2012, In : Molecular Cancer Research. 10, 12, p. 1567-1579 13 p.

Research output: Contribution to journalArticle

23 Scopus citations
2011

A tritherapy combination of a fusion protein vaccine with immune-modulating doses of sequential chemotherapies in an optimized regimen completely eradicates large tumors in mice

Song, X., Guo, W., Cui, J., Qian, X., Yi, L., Chang, M., Cai, Q. & Zhao, Q., Mar 1 2011, In : International Journal of Cancer. 128, 5, p. 1129-1138 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2009

Combination of all-trans retinoic acid and a human papillomavirus therapeutic vaccine suppresses the number and function of immature myeloid cells and enhances antitumor immunity

Song, X., Ye, D., Liu, B., Cui, J., Zhao, X., Yi, L., Liang, J., Song, J., Zhang, Z. & Zhao, Q., 2009, In : Cancer Science. 100, 2, p. 334-340 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
2008

A novel therapeutic fusion protein vaccine by two different families of heat shock proteins linked with HPV16 E7 generates potent antitumor immunity and antiangiogenesis

Liu, B., Ye, D., Song, X., Zhao, X., Yi, L., Song, J., Zhang, Z. & Zhao, Q., Mar 4 2008, In : Vaccine. 26, 10, p. 1387-1396 10 p.

Research output: Contribution to journalArticle

41 Scopus citations
2007

Immunological protection against HPV16 E7-expressing human esophageal cancer cell challenge by a novel HPV16-E6/E7 fusion protein based-vaccine in a Hu-PBL-SCID mouse model

Lu, Y., Zhang, Z., Liu, Q., Liu, B., Song, X., Wang, M., Zhao, X. & Zhao, Q., 2007, In : Biological and Pharmaceutical Bulletin. 30, 1, p. 150-156 7 p.

Research output: Contribution to journalArticle

19 Scopus citations