Grants per year
Personal profile
Research Interests
Dr. Zheng’s research focuses on identifying epigenomic biomarkers linking environmental exposures and lifestyle behaviors (including air pollution, diet, and physical activity) with various aging-related disease development (including cancer, cardiovascular diseases, and dementia) using data generated from population cohorts and clinical trials. Dr. Zheng specializes in developing bioinformatics software for high-dimensional epigenomic data and conducting bioinformatics analysis using omics/systems biology-based approaches. His recent work has begun to explore the role of methylation in cardiovascular risks/diseases and in virus-associated cancers.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biomedical Informatics, PhD, Northwestern University
… → 2017
Epidemiology and Biostatistics , MS, Northwestern University
… → 2012
Research interests keywords
- Aging
- Bioinformatics
- Cancer Biology
- Cardiovascular Diseases
- Epigenetics
- Systems Biology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Epigenetic study of oral HPV infection-associated oral cancer in people living with HIV in Nigeria
Hou, L., Hou, L., Murphy, R. L., Murphy, R. L., Wang, J., Wang, J., Wei, J., Wei, J., Zheng, Y. & Zheng, Y.
9/16/22 → 8/31/26
Project: Research project
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Epigenomic landscape of individual- and neighborhood-level social disadvantages and cardiovascular health disparity
Hou, L., Hou, L., Jiang, H., Jiang, H., Joyce, B., Joyce, B., Lloyd-Jones, D. M., Lloyd-Jones, D. M., Vaughan, D. E., Vaughan, D. E., Wilkins, J. T., Wilkins, J. T., Zheng, Y. & Zheng, Y.
9/15/22 → 5/31/26
Project: Research project
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West Africa Self-Sampling HPV Based Cervical Cancer Control Program (WA-SS-HCCP) for WLWHA: Barriers, challenges, and needs
Hou, L., Hou, L., Maiga, M., Maiga, M., Kocherginsky, M., Kocherginsky, M., Murphy, R. L., Murphy, R. L., Wei, J., Wei, J., Zheng, Y. & Zheng, Y.
9/7/22 → 8/31/27
Project: Research project
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Mitochondrial DNA, Nuclear DNA Methylation, and Cardiometabolic Disease Traits
Hou, L., Hou, L., Zheng, Y. & Zheng, Y.
Boston University, National Heart, Lung, and Blood Institute
9/1/21 → 6/30/25
Project: Research project
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Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants
Gao, X., Geng, T., Jiang, M., Huang, N., Zheng, Y., Belsky, D. W. & Huang, T., Dec 2023, In: Nature communications. 14, 1, 2277.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Alcohol consumption and epigenetic age acceleration in young adults
Nannini, D. R., Joyce, B. T., Zheng, Y., Gao, T., Wang, J., Liu, L., Jacobs, D. R., Schreiner, P. J., Liu, C., Dai, Q., Horvath, S., Lu, A. T., Yaffe, K., Greenland, P., Lloyd-Jones, D. M. & Hou, L., 2023, In: Aging. 15, 2, p. 371-395 25 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Association of Adverse Childhood Experiences With Accelerated Epigenetic Aging in Midlife
Kim, K., Yaffe, K., Rehkopf, D. H., Zheng, Y., Nannini, D. R., Perak, A. M., Nagata, J. M., Miller, G. E., Zhang, K., Lloyd-Jones, D. M., Joyce, B. T. & Hou, L., Jun 1 2023, In: JAMA network open. 6, 6, p. e2317987Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study
Joyce, B. T., Chen, X., Gao, T., Zheng, Y., Nannini, D. R., Liu, L., Henkle, B. E., Kalhan, R., Washko, G., Kunisaki, K. M., Thyagarajan, B., Vaughan, D. E., Gross, M., Jacobs, D. R., Lloyd-Jones, D. & Hou, L., Jul 1 2023, In: Epigenomics. 15, 13, p. 693-703 11 p.Research output: Contribution to journal › Article › peer-review
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Epigenome-wide DNA methylation in leukocytes and toenail metals: The normative aging study
Wang, C., Xu, Z., Qiu, X., Wei, Y., Peralta, A. A., Yazdi, M. D., Jin, T., Li, W., Just, A., Heiss, J., Hou, L., Zheng, Y., Coull, B. A., Kosheleva, A., Sparrow, D., Amarasiriwardena, C., Wright, R. O., Baccarelli, A. A. & Schwartz, J. D., Jan 15 2023, In: Environmental Research. 217, 114797.Research output: Contribution to journal › Article › peer-review
Datasets
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Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature
Liu, C. (Creator), Xu, J. (Contributor), Chen, Y. (Contributor), Guo, X. (Contributor), Zheng, Y. (Contributor), Wang, Q. (Contributor), Chen, Y. (Contributor), Ni, Y. (Creator), Zhu, Y. (Contributor), Joyce, B. (Creator), Baccarelli, A. (Creator), Deng, F. (Contributor), Zhang, W. (Creator), Hou, L. (Contributor), Yahong, C. (Contributor), Qianfei, W. (Contributor), Yiyong, C. (Contributor), Yidan, Z. (Contributor) & Baccarelli, A. (Creator), figshare, 2015
DOI: 10.6084/m9.figshare.c.3610925.v1, https://figshare.com/collections/Characterization_of_genome-wide_H3K27ac_profiles_reveals_a_distinct_PM2_5-associated_histone_modification_signature/3610925/1
Dataset
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Relative contributions of six lifestyle- and health-related exposures to epigenetic aging: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Kim, K. (Creator), Zheng, Y. (Creator), Joyce, B. (Creator), Jiang, H. (Creator), Greenland, P. (Creator), Jacobs, D. R. (Creator), Zhang, K. (Creator), Liu, L. (Creator), Allen, N. B. (Creator), Wilkins, J. T. (Creator), Forrester, S. N. (Creator), Lloyd-Jones, D. M. (Creator), Hou, L. (Creator), Kim, K. (Creator), Greenland, P. (Creator), Lloyd-Jones, D. M. (Creator) & Hou, L. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6086034.v1, https://springernature.figshare.com/collections/Relative_contributions_of_six_lifestyle-_and_health-related_exposures_to_epigenetic_aging_the_Coronary_Artery_Risk_Development_in_Young_Adults_CARDIA_Study/6086034/1
Dataset
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DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma
Zheng, Y. (Contributor), Hlady, R. A. (Creator), Joyce, B. (Creator), Robertson, K. D. (Creator), He, C. (Contributor), Nannini, D. R. (Creator), Kibbe, W. A. (Creator), Achenbach, C. J. (Creator), Murphy, R. L. (Creator), Roberts, L. R. (Creator), Hou, L. (Contributor) & Roberts, L. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4707869.v1, https://springernature.figshare.com/collections/DNA_methylation_of_individual_repetitive_elements_in_hepatitis_C_virus_infection-induced_hepatocellular_carcinoma/4707869/1
Dataset
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Cord blood DNA methylation and adiposity measures in early and mid-childhood
Kresovich, J. K. (Creator), Zheng, Y. (Contributor), Cardenas, A. (Creator), Joyce, B. (Creator), Rifas-Shiman, S. L. (Creator), Oken, E. (Creator), Gillman, M. W. (Creator), Hivert, M. (Contributor), Baccarelli, A. A. (Creator), Hou, L. (Contributor), Cardenas, A. (Creator), Rifas-Shiman, S. (Creator), Oken, E. (Creator) & Baccarelli, A. (Creator), figshare, 2017
DOI: 10.6084/m9.figshare.c.3854227.v1, https://figshare.com/collections/Cord_blood_DNA_methylation_and_adiposity_measures_in_early_and_mid-childhood/3854227/1
Dataset
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Epigenetic age acceleration and metabolic syndrome in the coronary artery risk development in young adults study
Nannini, D. R. (Creator), Joyce, B. (Creator), Zheng, Y. (Contributor), Gao, T. (Creator), Liu, L. (Creator), Yoon, G. (Creator), Huan, T. (Contributor), Ma, J. (Contributor), Jacobs, D. R. (Creator), Wilkins, J. T. (Creator), Ren, J. (Creator), Zhang, K. (Creator), Khan, S. S. (Creator), Allen, N. B. (Contributor), Horvath, S. (Creator), Lloyd-Jones, D. M. (Creator), Greenland, P. (Creator) & Hou, L. (Contributor), figshare, 2019
DOI: 10.6084/m9.figshare.c.4741883.v1, https://springernature.figshare.com/collections/Epigenetic_age_acceleration_and_metabolic_syndrome_in_the_coronary_artery_risk_development_in_young_adults_study/4741883/1
Dataset