Grants per year
Personal profile
Research Interests
Dr. Zheng’s research focuses on identifying epigenomic biomarkers linking environmental exposures and lifestyle behaviors (including air pollution, diet, and physical activity) with various aging-related disease development (including cancer, cardiovascular diseases, and dementia) using data generated from population cohorts and clinical trials. Dr. Zheng specializes in developing bioinformatics software for high-dimensional epigenomic data and conducting bioinformatics analysis using omics/systems biology-based approaches. His recent work has begun to explore the role of methylation in cardiovascular risks/diseases and in virus-associated cancers.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biomedical Informatics, PhD, Northwestern University Feinberg School of Medicine
… → 2017
Epidemiology and Biostatistics , MS, Northwestern University Feinberg School of Medicine
… → 2012
Research interests keywords
- Aging
- Bioinformatics
- Cancer Biology
- Cardiovascular Diseases
- Epigenetics
- Systems Biology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Early mid-life environmental toxicant exposures and AD/ADRD risk in CARDIA
Hou, L. (PD/PI), Wang, J. (Co-Investigator) & Zheng, Y. (Co-Investigator)
University of Pennsylvania, National Institute on Aging
9/30/24 → 8/31/25
Project: Research project
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Blood mitochondrial DNA biomarkers of midlife cognitive decline and adverse brain imaging changes – A longitudinal investigation in the CARDIA population-based cohort study
Hou, L. (PD/PI), Hou, L. (PD/PI), Joyce, B. (Co-Investigator), Joyce, B. (Co-Investigator), Wang, J. (Co-Investigator), Wang, J. (Co-Investigator), Zheng, Y. (Co-Investigator) & Zheng, Y. (Co-Investigator)
5/1/24 → 4/30/26
Project: Research project
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Repetitive element and gene methylation biomarker for cervical cancer
Zheng, Y. (Co-Investigator)
National Institute of Biomedical Imaging and Bioengineering
9/15/23 → 7/31/28
Project: Research project
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Molecular Determinants of Atherosclerotic Cardiovascular Disease in Multi-ethnic Populations
Hou, L. (PD/PI) & Zheng, Y. (Co-Investigator)
University of Texas Health Science Center at Houston, National Heart, Lung, and Blood Institute
4/1/23 → 3/31/27
Project: Research project
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Epigenetic study of oral HPV infection-associated oral cancer in people living with HIV in Nigeria
Hou, L. (PD/PI), Hou, L. (PD/PI), Murphy, R. L. (PD/PI), Murphy, R. L. (PD/PI), Cooper, L. A. D. (Co-Investigator), Wang, J. (Co-Investigator), Wang, J. (Co-Investigator), Wei, J.-J. (Co-Investigator), Wei, J.-J. (Co-Investigator), Zheng, Y. (Co-Investigator) & Zheng, Y. (Co-Investigator)
9/16/22 → 8/31/26
Project: Research project
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Analytical performance of the ScreenFire HPV RS Zebra BioDome assay on four different qPCR platforms
Wang, J., Imade, G., Akanmu, A. S., Musa, J., Anorlu, R., Zheng, Y., Joyce, B., Adewole, I., Morhason-Bello, I. O., Belinson, J., Maiga, M., Gursel, D. B., Sagay, A. S., Ogunsola, F. T., Murphy, R. L. & Hou, L., Dec 2025, In: Infectious Agents and Cancer. 20, 1, 28.Research output: Contribution to journal › Article › peer-review
Open Access -
Assessment of Relative Contributions of Lifestyle, Behavioral and Biological Risk Factors for Cervical Human Papillomavirus Infections in Female Sex Workers
Morhason-Bello, I., Kim, K., Bello, Y., Zheng, Y., Oyerinde, S., Idowu, O. C., Pavón, M. Á., Baisley, K., Wang, J., Fowotade, A., Maiga, M., Jonah, M., Christian, E. N., Ogunbiyi, O., Adewole, I., Hou, L., Francis, S. C. & Watson-Jones, D., Apr 2025, In: Viruses. 17, 4, 485.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Associations of long-term exposure to temperature with coronary artery calcification risk among middle-aged adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study
Zhao, D., Yao, J., Li, Y., Jacobs, D. R., Zheng, Y., Liu, C., Fu, Y., Deangelis, M. M., Lloyd-Jones, D., Hou, L. & Zhang, K., Feb 25 2025, In: Science of the Total Environment. 966, 178675.Research output: Contribution to journal › Article › peer-review
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Cell-free DNA methylation-based inflammation score as a marker for hepatocellular carcinoma among people living with HIV
Kim, K., Zheng, Y., Joyce, B. T., Nannini, D. R., Wang, J., Qu, Y., Hawkins, C. A., Okeke, E., Lesi, O. A., Roberts, L. R., Gursel, D. B., Abdulkareem, F. B., Akanmu, A. S., Duguru, M. J., Davwar, P., Nyam, D. P., Adisa, R. A., Imade, G., Wei, J. J. & Kocherginsky, M. & 9 others, , Jun 2025, In: Hepatology International. 19, 3, p. 596-606 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Developing a Novel Index for Individual-Level Social Determinants and Cardiovascular Diseases in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Gao, T., Zheng, Y., Joyce, B., Liu, L., Liu, L., Kiefe, C., Forrester, S., Yu, B., Bhatt, A., Gordon-Larsen, P., Lloyd-Jones, D. M., Zhang, K. & Hou, L., Mar 2025, In: International journal of environmental research and public health. 22, 3, 422.Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Datasets
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Additional file 4: Table S4. of Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature
Liu, C. (Creator), Xu, J. (Contributor), Chen, Y. (Contributor), Guo, X. (Contributor), Zheng, Y. (Contributor), Wang, Q. (Contributor), Chen, Y. (Contributor), Ni, Y. (Creator), Zhu, Y. (Contributor), Joyce, B. T. (Creator), Baccarelli, A. (Creator), Deng, F. (Contributor), Zhang, W. (Creator) & Hou, L. (Contributor), figshare, 2015
DOI: 10.6084/m9.figshare.c.3610925_d2, https://springernature.figshare.com/articles/dataset/Additional_file_4_Table_S4_of_Characterization_of_genome-wide_H3K27ac_profiles_reveals_a_distinct_PM2_5-associated_histone_modification_signature/4361933
Dataset
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HIMA2: high-dimensional mediation analysis and its application in epigenome-wide DNA methylation data
Perera, C. (Creator), Zhang, H. (Creator), Zheng, Y. (Creator), Hou, L. (Creator), Qu, A. (Creator), Zheng, C. (Creator), Xie, K. (Creator) & Liu, L. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6116632, https://springernature.figshare.com/collections/HIMA2_high-dimensional_mediation_analysis_and_its_application_in_epigenome-wide_DNA_methylation_data/6116632
Dataset
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DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function
Matías-García, P. R. (Creator), Ward-Caviness, C. K. (Creator), Raffield, L. M. (Creator), Gao, X. (Creator), Zhang, Y. (Creator), Wilson, R. (Creator), Gào, X. (Creator), Nano, J. (Creator), Bostom, A. (Creator), Colicino, E. (Creator), Correa, A. (Creator), Coull, B. (Creator), Eaton, C. (Creator), Hou, L. (Creator), Just, A. C. (Creator), Kunze, S. (Creator), Lange, L. (Creator), Lange, E. (Creator), Lin, X. (Creator), Liu, S. (Creator), Nwanaji-Enwerem, J. C. (Creator), Reiner, A. (Creator), Shen, J. (Creator), Schöttker, B. (Creator), Vokonas, P. (Creator), Zheng, Y. (Creator), Young, B. (Creator), Schwartz, J. (Creator), Horvath, S. (Creator), Lu, A. (Creator), Whitsel, E. A. (Creator), Koenig, W. (Creator), Adamski, J. (Creator), Winkelmann, J. (Creator), Brenner, H. (Creator), Baccarelli, A. A. (Creator), Gieger, C. (Creator), Peters, A. (Creator), Franceschini, N. (Creator) & Waldenberger, M. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5449971.v1, https://springernature.figshare.com/collections/DNAm-based_signatures_of_accelerated_aging_and_mortality_in_blood_are_associated_with_low_renal_function/5449971/1
Dataset
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Effects of Particulate Matter Exposure on Blood 5-hydroxymethylation: Results from the Beijing Truck Driver Air Pollution Study
Sanchez-Guerra, M. (Creator), Zheng, Y. (Contributor), Osorio-Yanez, C. (Contributor), Zhong, J. (Creator), Chervona, Y. (Creator), Wang, S. (Creator), Chang, D. (Creator), McCracken, J. P. (Creator), Díaz, A. (Contributor), Bertazzi, P. A. (Creator), Koutrakis, P. (Creator), Kang, C.-M. (Contributor), Zhang, X. (Creator), Zhang, W. (Creator), Byun, H.-M. (Contributor), Schwartz, J. (Creator), Hou, L. (Contributor) & Baccarelli, A. A. (Creator), figshare, 2015
DOI: 10.6084/m9.figshare.1412840.v1, https://figshare.com/articles/Effects_of_Particulate_Matter_Exposure_on_Blood_5_hydroxymethylation_Results_from_the_Beijing_Truck_Driver_Air_Pollution_Study/1412840/1
Dataset
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Additional file 1 of DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function
Matías-García, P. R. (Creator), Ward-Caviness, C. K. (Creator), Raffield, L. M. (Creator), Gao, X. (Creator), Zhang, Y. (Creator), Wilson, R. (Creator), Gào, X. (Creator), Nano, J. (Creator), Bostom, A. (Creator), Colicino, E. (Creator), Correa, A. (Creator), Coull, B. (Creator), Eaton, C. (Creator), Hou, L. (Creator), Just, A. C. (Creator), Kunze, S. (Creator), Lange, L. (Creator), Lange, E. (Creator), Lin, X. (Creator), Liu, S. (Creator), Nwanaji-Enwerem, J. C. (Creator), Reiner, A. (Creator), Shen, J. (Creator), Schöttker, B. (Creator), Vokonas, P. (Creator), Zheng, Y. (Creator), Young, B. (Creator), Schwartz, J. (Creator), Horvath, S. (Creator), Lu, A. (Creator), Whitsel, E. A. (Creator), Koenig, W. (Creator), Adamski, J. (Creator), Winkelmann, J. (Creator), Brenner, H. (Creator), Baccarelli, A. A. (Creator), Gieger, C. (Creator), Peters, A. (Creator), Franceschini, N. (Creator) & Waldenberger, M. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.14722140, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_DNAm-based_signatures_of_accelerated_aging_and_mortality_in_blood_are_associated_with_low_renal_function/14722140
Dataset