• 2295 Citations
19952020

Research output per year

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Personal profile

Research Interests

The overarching goal of Wan laboratory is to define the molecular mechanisms of breast tumor initiation, progression, and metastasis, and to identify novel targets for therapeutic development. Particularly, the laboratory seeks to address how defects in the ubiquitin-proteasome system and other posttranslational modifiers such as protein methyltransferase and poly (ADP-ribose) polymerase would result in genomic instability, abnormal cell cycle, and aberrant signaling that predispose otherwise normal cells to become cancerous tumor cells or promote cancer metastasis. The research approaches in Wan laboratory include biochemical, cell biological, genetic, protein structural analyses as well as the use of breast cancer animal models and analyses of clinical specimens.

Training Experience

2003Postdoctoral Fellowship, Harvard University

Education/Academic qualification

PhD, Cornell University

… → 1997

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Grants

  • Research Output

    • 2295 Citations
    • 47 Article
    • 8 Review article
    • 2 Comment/debate
    • 1 Chapter

    Cullin 4-DCAF Proteins in Tumorigenesis

    Zhou, Z., Song, X., Wavelet, C. M. & Wan, Y., Jan 1 2020, Advances in Experimental Medicine and Biology. Springer, p. 241-259 19 p. (Advances in Experimental Medicine and Biology; vol. 1217).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability

    Zhou, Z., Zhou, H., Ponzoni, L., Luo, A., Zhu, R., He, M., Huang, Y., Guan, K. L., Bahar, I., Liu, Z. & Wan, Y., Jun 15 2020, In : Cancer Research. 80, 12, p. 2550-2563 14 p.

    Research output: Contribution to journalArticle

  • Finding the unicorn, a new mouse model of midfacial clefting

    Lantz, B., White, C., Liu, X., Wan, Y., Gabriel, G., Lo, C. W. Y. & Szabo-Rogers, H. L., Jan 2020, In : Genes. 11, 1, 83.

    Research output: Contribution to journalArticle

    Open Access
  • Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance

    Zhou, Z., Song, X., Chi, J. J., Gius, D. R., Huang, Y., Cristofanilli, M. & Wan, Y., Jun 2020, In : Cellular Signalling. 70, 109574.

    Research output: Contribution to journalArticle

  • A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy

    Zhou, Z., Feng, Z., Hu, D., Yang, P., Gur, M., Bahar, I., Cristofanilli, M., Gradishar, W. J., Xie, X. Q. & Wan, Y., Jun 2019, In : EBioMedicine. 44, p. 98-111 14 p.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations