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Personal profile

Research Interests

The overarching goal of Wan laboratory is to define the molecular mechanisms of breast tumor initiation, progression, and metastasis, and to identify novel targets for therapeutic development. Particularly, the laboratory seeks to address how defects in the ubiquitin-proteasome system and other posttranslational modifiers such as protein methyltransferase and poly (ADP-ribose) polymerase would result in genomic instability, abnormal cell cycle, and aberrant signaling that predispose otherwise normal cells to become cancerous tumor cells or promote cancer metastasis. The research approaches in Wan laboratory include biochemical, cell biological, genetic, protein structural analyses as well as the use of breast cancer animal models and analyses of clinical specimens.

Training Experience

2003Postdoctoral Fellowship, Harvard University

Education/Academic qualification

PhD, Cornell University

… → 1997

Fingerprint Dive into the research topics where Yong Wan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 19 Similar Profiles
Anaphase-Promoting Complex-Cyclosome Medicine & Life Sciences
Carcinogenesis Medicine & Life Sciences
Breast Neoplasms Medicine & Life Sciences
Cell Cycle Medicine & Life Sciences
Proteolysis Medicine & Life Sciences
Ubiquitin Medicine & Life Sciences
Ubiquitination Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

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Grants 2017 2023

Neoplasms
Medicine
Research
Population
Estrogens
Carcinogenesis
Tamoxifen
Breast Neoplasms
Ubiquitin-Protein Ligases
Carcinogenesis
Methylation
Breast Neoplasms
Breast
Ubiquitination

Research Output 1995 2019

  • 2137 Citations
  • 43 Article
  • 8 Review article
  • 2 Comment/debate
1 Citation (Scopus)

A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy

Zhou, Z., Feng, Z., Hu, D., Yang, P., Gur, M., Bahar, I., Cristofanilli, M., Gradishar, W. J., Xie, X. Q. & Wan, Y., Jun 1 2019, In : EBioMedicine. 44, p. 98-111 14 p.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Methylation
Tumors
Molecules
Genes

A novel strategy to block mitotic progression for targeted therapy

Chi, J. J., Li, H., Zhou, Z., Izquierdo-Ferrer, J., Xue, Y., Wavelet, C. M., Schiltz, G. E., Zhang, B., Cristofanilli, M., Lu, X., Bahar, I. & Wan, Y., Nov 2019, In : EBioMedicine. 49, p. 40-54 15 p.

Research output: Contribution to journalArticle

Open Access
Degradation
Tumors
Cells
Neoplasms
Breast Neoplasms

ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4

Zou, H., Chen, H., Zhou, Z., Wan, Y. & Liu, Z., Dec 28 2019, In : Cancer Letters. 467, p. 19-28 10 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Proteins
Ubiquitin-Protein Ligases
Ubiquitination
2 Citations (Scopus)

CD73: An emerging checkpoint for cancer immunotherapy

Chen, S., Wainwright, D. A., Wu, J. D., Wan, Y., Matei, D. E., Zhang, Y. & Zhang, B., Jan 1 2019, In : Immunotherapy. 11, 11, p. 983-997 15 p.

Research output: Contribution to journalReview article

Immunotherapy
Neoplasms
Adenosine
Immunity
Carcinogenesis
2 Citations (Scopus)

Epithelial mutations in endometriosis: Link to ovarian cancer

Bulun, S. E., Wan, Y. & Matei, D. E., Feb 14 2019, In : Endocrinology. 160, 3, p. 626-638 13 p.

Research output: Contribution to journalReview article

Endometriosis
Ovarian Neoplasms
Mutation
Epithelial Cells
Estrogens