Grants per year
Personal profile
Research Interests
Regulation of Motor Neuron and Dopaminergic Neuron Function in Development and Disease -------- Spinal Motor Neuron Development, Function and Degeneration in SMA and ALS: Spinal Muscular Atrophy (SMA)and Amyotrophic lateral sclerosis (ALS) are characterized by the selective degeneration of spinal motor neurons. As the leading genetic cause of infant mortality, SMA affects one in every eight thousand live births. Our group is interested in studying mechanism regulating motor neuron development and function, as well as why motor neurons specifically degenerate in SMA and ALS. To address these questions, we use a combination of genetic, biochemical and cell biological approaches, and utilize genetically modified mice, induced pluripotent stem (iPS) cells reprogrammed from fibroblasts, and zebrafish as model systems. We focus on the regulation of mitochondrial functions in SMA and ALS pathogenesis. Based on our findings, we hope to develop new therapeutic strategies for treating these diseases.
Dopaminergic Neuron Function and Degeneration in Parkinson's Disease: Dopaminergic neurons located in the ventral midbrain control movement, emotional behavior and reward mechanisms. Dysfunction of these neurons is implicated in Parkinson’s disease, drug addiction, depression and schizophrenia. Our group is interested in the genetic and epigenetic mechanisms regulating dopaminergic neuron functions in disease and aging conditions. We are particularly interested in how aging and mitochondrial oxidative stress contribute to dopaminergic neuron degeneration in Parkinson's disease through transcriptional and epigenetic regulations. We use mouse models, cultured neurons and iPS cells for these studies.
Training Experience
2008 | Postdoctoral Fellowship, Harvard Medical School |
Education/Academic qualification
PhD, Weill Medical College of Cornell University
… → 2002
Research interests
- Aging
- Amyotrophic Lateral Sclerosis
- Developmental Neurobiology
- Neurogenetics
- Parkinson’s Disease
- Spinal Muscular Atrophy
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Network
Grants
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Mouse model studies of TMEM230-linked Parkinson's disease
Northwestern University, National Institute of Neurological Disorders and Stroke
9/30/16 → 7/31/21
Project: Research project
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Mouse model studies of TMEM230-linked Parkinson's disease
Northwestern University, National Institute of Neurological Disorders and Stroke
9/30/16 → 7/31/21
Project: Research project
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Mouse model studies of TMEM230-linked Parkinson's disease
Northwestern University, National Institute of Neurological Disorders and Stroke
9/30/16 → 7/31/21
Project: Research project
Research Output
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Defective expression of mitochondrial, vacuolar H+-ATPase and histone genes in a C. Elegans Model of SMA
Gao, X., Xu, J., Chen, H., Xue, D., Pan, W., Zhou, C., Ma, Y. C. & Ma, L., 2019, In: Frontiers in Genetics. 10, MAY, 410.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export
Edens, B. M., Vissers, C., Su, J., Arumugam, S., Xu, Z., Shi, H., Miller, N., Rojas Ringeling, F., Ming, G. L., He, C., Song, H. & Ma, Y. C., Jul 23 2019, In: Cell reports. 28, 4, p. 845-854.e5Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine–containing mRNAs
Hsu, P. J., Shi, H., Zhu, A. C., Lu, Z., Miller, N., Edens, B. M., Ma, Y. C. & He, C., Jan 1 2019, In: Journal of Biological Chemistry. 294, 52, p. 19889-19895 7 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
RBM-5 modulates U2AF large subunit-dependent alternative splicing in C. elegans
Zhou, C., Gao, X., Hu, S., Gan, W., Xu, J., Ma, Y. C. & Ma, L., Oct 3 2018, In: RNA biology. 15, 10, p. 1295-1308 14 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
RBM-5 modulates U2AF large subunit-dependent alternative splicing in C. elegans
Zhou, C., Gao, X., Hu, S., Gan, W., Xu, J., Ma, Y. C. & Ma, L., Jun 25 2018, In: Unknown Journal.Research output: Contribution to journal › Article › peer-review