Young A Yoo

  • Research Assistant Professor, Urology
  • 847 Citations
20042020

Research output per year

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Personal profile

Research Interests

The goal of my research is to better understand the biology and the molecular mechanisms which facilitate tumor formation, progression and drug resistance in several types of cancer. I was principal investigator of three projects funded by Korean Science and Engineering Foundation (KOSEF) and Korean Ministry of Health and Welfare (KMHW) and successful in elucidating the role and molecular mechanism of pivotal oncogenic pathways (Sonic hedgehog, TGF-ß and BMPs signaling pathways) in promoting tumor growth, invasion, metastasis and therapy resistance.

The objective of my research is to define the population of cells with stem-like properties that survive therapy and can be a cellular origin of prostate tumor recurrence. Recently, we have successfully demonstrated that castration-resistant Bmi1-expressing tumor cells are implicated in driving lineage plasticity and prostate cancer recurrence in response to androgen deprivation therapy (ADT) using multi-color lineage tracing and re-tracing strategies. We have also shown that pharmaceutical inhibitors against Bmi1 and Sox2 could be highly effective in reducing tumor recurrence and drug resistance. I am currently investigating the functional roles of Bmi1 and Sox2 in driving resistance to anti-androgen therapy and molecular mechanisms underlying this process, as well as the gene networks regulated by Bmi1 and Sox2 in recurrence after ADT. These approaches provided novel therapeutic targets to which drugs can be designed, directly translating to the clinical situation to impact cancer patient survival and outcomes.

Education/Academic qualification

PhD, Korea University

… → 2005

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Grants

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Research Output

  • 847 Citations
  • 19 Article

Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

Han, H., Jain, A. D., Truica, M. I., Izquierdo-Ferrer, J., Anker, J. F., Lysy, B., Sagar, V., Luan, Y., Chalmers, Z. R., Unno, K., Mok, H., Vatapalli, R., Yoo, Y. A., Rodriguez, Y., Kandela, I., Parker, J. B., Chakravarti, D., Mishra, R. K., Schiltz, G. E. & Abdulkadir, S. A., Nov 11 2019, In : Cancer Cell. 36, 5, p. 483-497.e15

Research output: Contribution to journalArticle

  • 6 Scopus citations

    The role of castration-resistant Bmi1+Sox2+ cells in driving recurrence in prostate cancer

    Yoo, Y. A., Vatapalli, R., Lysy, B., Mok, H., Desouki, M. M. & Abdulkadir, S. A., Jan 1 2019, In : Journal of the National Cancer Institute. 111, 3, p. 311-321 11 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Modeling African American prostate adenocarcinoma by inducing defined genetic alterations in organoids

    Unno, K., Roh, M., Yoo, Y. A., Al-Shraideh, Y., Wang, L., Nonn, L. & Abdulkadir, S. A., Feb 7 2017, In : Oncotarget. 8, 31, p. 51264-51276 13 p.

    Research output: Contribution to journalArticle

  • 8 Scopus citations

    Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation

    Yoo, Y. A., Roh, M., Naseem, A. F., Lysy, B., Desouki, M. M., Unno, K. & Abdulkadir, S. A., Oct 5 2016, In : Nature communications. 7, 12943.

    Research output: Contribution to journalArticle

  • 27 Scopus citations

    The effects of sonic hedgehog signaling pathway components on non-small-cell lung cancer progression and clinical outcome

    Hwang, J., Kang, M. H., Yoo, Y. A., Quan, Y. H., Kim, H. K., Oh, S. C. & Choi, Y. H., Aug 21 2014, In : World Journal of Surgical Oncology. 12, 1, 268.

    Research output: Contribution to journalArticle

  • 19 Scopus citations