Young A Yoo

  • Research Assistant Professor, Urology
  • 781 Citations
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Personal profile

Research Interests

The goal of my research is to better understand the biology and the molecular mechanisms which facilitate tumor formation, progression and drug resistance in several types of cancer. I was principal investigator of three projects funded by Korean Science and Engineering Foundation (KOSEF) and Korean Ministry of Health and Welfare (KMHW) and successful in elucidating the role and molecular mechanism of pivotal oncogenic pathways (Sonic hedgehog, TGF-ß and BMPs signaling pathways) in promoting tumor growth, invasion, metastasis and therapy resistance.

The objective of my research is to define the population of cells with stem-like properties that survive therapy and can be a cellular origin of prostate tumor recurrence. Recently, we have successfully demonstrated that castration-resistant Bmi1-expressing tumor cells are implicated in driving lineage plasticity and prostate cancer recurrence in response to androgen deprivation therapy (ADT) using multi-color lineage tracing and re-tracing strategies. We have also shown that pharmaceutical inhibitors against Bmi1 and Sox2 could be highly effective in reducing tumor recurrence and drug resistance. I am currently investigating the functional roles of Bmi1 and Sox2 in driving resistance to anti-androgen therapy and molecular mechanisms underlying this process, as well as the gene networks regulated by Bmi1 and Sox2 in recurrence after ADT. These approaches provided novel therapeutic targets to which drugs can be designed, directly translating to the clinical situation to impact cancer patient survival and outcomes.

Education/Academic qualification

PhD, Korea University

… → 2005

Fingerprint Dive into the research topics where Young A Yoo is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Stomach Neoplasms Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Epithelial-Mesenchymal Transition Medicine & Life Sciences
Bone Morphogenetic Protein 2 Medicine & Life Sciences
Castration Medicine & Life Sciences
Small Interfering RNA Medicine & Life Sciences
hydrazine Medicine & Life Sciences
Ribosomal Proteins Medicine & Life Sciences

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Research Output 2004 2019

  • 781 Citations
  • 18 Article
4 Citations (Scopus)

The Role of Castration-Resistant Bmi1+Sox2+ Cells in Driving Recurrence in Prostate Cancer

Yoo, Y. A., Vatapalli, R., Lysy, B., Mok, H., Desouki, M. M. & Abdulkadir, S. A., Mar 1 2019, In : Journal of the National Cancer Institute. 111, 3, p. 311-321 11 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
6 Citations (Scopus)

Modeling African American prostate adenocarcinoma by inducing defined genetic alterations in organoids

Unno, K., Roh, M., Yoo, Y. A., Al-Shraideh, Y., Wang, L., Nonn, L. & Abdulkadir, S. A., Feb 7 2017, In : Oncotarget. 8, 31, p. 51264-51276 13 p.

Research output: Contribution to journalArticle

African Americans
Prostatic Neoplasms
21 Citations (Scopus)

Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation

Yoo, Y. A., Roh, M., Naseem, A. F., Lysy, B., Desouki, M. M., Unno, K. & Abdulkadir, S. A., Oct 5 2016, In : Nature communications. 7, 12943.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The effects of sonic hedgehog signaling pathway components on non-small-cell lung cancer progression and clinical outcome

Hwang, J., Kang, M. H., Yoo, Y. A., Quan, Y. H., Kim, H. K., Oh, S. C. & Choi, Y. H., Aug 21 2014, In : World Journal of Surgical Oncology. 12, 1, 268.

Research output: Contribution to journalArticle

CD44 Antigens
Lymphatic Vessels
Non-Small Cell Lung Carcinoma
Vascular Endothelial Growth Factor D
19 Citations (Scopus)

Progesterone signaling inhibits cervical carcinogenesis in mice

Yoo, Y. A., Son, J., Mehta, F. F., Demayo, F. J., Lydon, J. P. & Chung, S. H., Nov 1 2013, In : American Journal of Pathology. 183, 5, p. 1679-1687 9 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Cervix Uteri