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Young Kwang Chae

  • 1509 Citations
20072021
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Personal profile

Research Interests

Personalized Cancer Therapy, Precision Medicine, Early Phase Clinical Trials, First-in-Human Study, Novel Combination Cancer Therapy, Targeted therapy, Immunotherapy, Biomarker Study, Novel Drug Development, Novel Drug Delivery System, Adaptive Clinical Trials Design, Cell Signaling Pathway, Immune Checkpoint Pathway

Training Experience

2011Residency, Albert Einstein Medical Center
2014Fellowship, University of Texas/MD Anderson Cancer Center

Education/Academic qualification

MBA, Johns Hopkins University

… → 2007

MPH, Johns Hopkins University

… → 2007

MD, Seoul National University

… → 2002

Keywords

  • Oncology

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2013 2021

Prot #D6070C00004: A Multiarm, Open-label, Multicenter, Phase 1b/2 Study to Evaluate Novel Combination Therapies in Subjects with Previously Treated Advanced EGFRm NSCLC

Chae, Y. K.

ICON Clinical Research, LLC, MedImmune, LLC

12/3/18 → 12/3/21

Project: Research project

NU 17Z01 (Freenome) - Blood Biomarker Analysis in Patients with Solid Tumors or Lymphoma

Chae, Y. K.

Freenome Holdings, Inc.

12/21/17 → 12/21/20

Project: Research project

NU 17Z01 (Lexent Bio) - Blood Biomarker Analysis in Patients with Solid Tumors or Lymphoma

Chae, Y. K.

Lexent Bio, Inc.

12/14/17 → 12/14/20

Project: Research project

NU 17Z01 - Blood Biomarker Analysis in Patients with Solid Tumors or Lymphoma

Chae, Y. K.

Biodesix, Inc.

12/14/17 → 12/14/20

Project: Research project

Prot #D419NC00001: A Phase 1 Study of Durvalumab and IPH2201 in Adult Subjects with Select Advanced Solid Tumors

Carneiro Filho, B. A. & Chae, Y. K.

MedImmune, LLC

2/6/17 → 2/6/20

Project: Research project

Research Output 2007 2019

A phase I dose-escalation study of veliparib combined with carboplatin and etoposide in patients with extensive-stage small cell lung cancer and other solid tumors

Atrafi, F., Groen, H. J. M., Byers, L. A., Garralda, E., Lolkema, M. P., Sangha, R. S., Viteri, S., Chae, Y. K., Ross Camidge, D., Gabrail, N. Y., Hu, B., Tian, T., Nuthalapati, S., Hoening, E., He, L., Komarnitsky, P. & Calles, A., Jan 15 2019, In : Clinical Cancer Research. 25, 2, p. 496-505 10 p.

Research output: Contribution to journal › Article

Open Access
Carboplatin
Small Cell Lung Carcinoma
Etoposide
Neoplasms
Disease Progression

Association of Tumor Mutational Burden With DNA Repair Mutations and Response to Anti–PD-1/PD-L1 Therapy in Non–Small-Cell Lung Cancer

Chae, Y. K., Davis, A. A., Raparia, K., Agte, S., Pan, A., Mohindra, N. A., Villaflor, V. M. & Giles, F., Mar 1 2019, In : Clinical Lung Cancer. 20, 2, p. 88-96.e6

Research output: Contribution to journal › Article

Tumor Burden
Non-Small Cell Lung Carcinoma
DNA Repair
Ligands
Mutation

Deep and Durable Response with Combination CTLA-4 and PD-1 Blockade in Mismatch Repair (MMR)-proficient Endometrial Cancer

Oh, M. S. & Chae, Y. K., Feb 1 2019, In : Journal of Immunotherapy. 42, 2, p. 51-54 4 p.

Research output: Contribution to journal › Article

DNA Mismatch Repair
Endometrial Neoplasms
Immunotherapy
Ligands
Neoplasms

Metaplastic breast cancers: Genomic profiling, mutational burden and tumor-infiltrating lymphocytes

Tray, N., Taff, J., Singh, B., Suh, J., Ngo, N., Kwa, M., Troxel, A. B., Chae, Y. K., Kurzrock, R., Patel, S. P., Sharon, E., Denkert, C., Ross, J. S. & Adams, S., Apr 1 2019, In : Breast. 44, p. 29-32 4 p.

Research output: Contribution to journal › Article

Tumor-Infiltrating Lymphocytes
Breast Neoplasms
Triple Negative Breast Neoplasms
Biomarkers
Drug Therapy

Mutations in DNA repair genes are associated with increased neoantigen burden and a distinct immunophenotype in lung squamous cell carcinoma

Chae, Y. K., Anker, J. F., Oh, M. S., Bais, P., Namburi, S., Agte, S., Giles, F. J. & Chuang, J. H., Dec 1 2019, In : Scientific Reports. 9, 1, 3235.

Research output: Contribution to journal › Article

Open Access
DNA Repair
Squamous Cell Carcinoma
Lung
Mutation
Genes