Grants per year
Personal profile
Research Interests
Youyang Zhao, Ph.D., is William G. Swartchild, Jr. Distinguished Research Professor and Director of the Program for Lung and Vascular Biology at the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago. He is Professor of Pediatrics, Medicine (Pulmonary and Critical Care Medicine), and Pharmacology at Northwestern University Feinberg School of Medicine, and member of the Feinberg Cardiovascular Research Institute. Dr. Zhao joined Lurie Children’s in July 2017 from the University of Illinois at Chicago, where he started with Assistant Professor in 2003 and became Full Professor of Pharmacology in 2015. Prior to his tenure at UIC, he had 3 year experience in drug discovery at Pharmacia/Pfizer Co. as a senior research scientist. He received his B.S. from Fudan University, Shanghai; and Ph.D. in molecular biology from Shanghai Institute of Biochemistry, the Chinese Academy of Sciences. Dr. Zhao completed his postdoctoral training in molecular biology and cardiovascular biology at Harvard University; Brigham & Women's Hospital, Harvard Medical School; and The University of California, San Diego.
Dr. Youyang Zhao's lab is focused on lung and vascular biology to study the molecular mechanisms of acute lung injury/ARDS, and pulmonary hypertension and identify novel therapeutics for these devastating diseases. Current studies include 1) molecular mechanisms of endothelial regeneration and vascular repair; 2) how aging regulates these processes; 3) how endothelial cells regulate macrophage and neutrophil function for resolution of inflammation; 4) stem/progenitor cells in ALI and PH; 5) mechanisms of obliterative pulmonary vascular remodeling, and right heart failure; 6) lung regeneration; 7) drug discovery and nanomedicine; Also interested in blood-brain-barrier function regulation, pulmonary fibrosis, and cancer metastasis. Positions for Postdoc and Research Assistant Professor are available.
Training Experience
1996 | Postdoctoral Fellowship, Harvard University |
1998 | Postdoctoral Fellowship, Brigham & Women's Hospital, Harvard Medical School |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Molecular Biology, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
… → 1994
Research interests keywords
- Aging
- Cardiovascular Diseases
- Epigenetics
- Gene Regulation
- Inflammation
- Lung Injury
- Pulmonary Hypertension
- Regenerative Medicine
- Respiratory Diseases
- Stem Cells
- Translational Research
- Vascular Biology
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Grants
- 19 Finished
-
Novel mechanisms of endothelial Injury in the pathogenesis of ARDS
Zhao, Y. (PD/PI)
National Heart, Lung, and Blood Institute, National Institutes of Health
5/1/20 → 4/30/24
Project: Research project
-
GCN2 regulates pulmonary vascular remodeling and pulmonary arterial hypertension (M. Zhu Fellowship)
Zhao, Y. (PD/PI)
1/1/19 → 12/30/20
Project: Research project
-
GCN2 regulates pulmonary vascular remodeling and pulmonary arterial hypertension (M. Zhu Fellowship)
Zhao, Y. (PD/PI)
1/1/19 → 12/30/20
Project: Research project
-
Targeting smooth muscle progenitor cells for treatment of pulmonary arterial hypertension
Zhao, Y. (PD/PI)
National Heart, Lung, and Blood Institute
6/1/18 → 5/31/22
Project: Research project
-
Targeting smooth muscle progenitor cells for treatment of pulmonary arterial hypertension
Zhao, Y. (PD/PI)
National Heart, Lung, and Blood Institute
6/1/18 → 5/31/22
Project: Research project
-
Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction
Filipp, M., Ge, Z.-D., DeBerge, M. P., Lantz, C., Glinton, K., Gao, P., Smolgovsky, S., Dai, J., Zhao, Y., Yvan-Charvet, L., Alcaide, P., Weinberg, S. E., Schiattarella, G. G., Hill, J. A., Feinstein, M. J., Shah, S. J. & Thorp, E. B., 2025, (Accepted/In press) In: Circulation.Research output: Contribution to journal › Article › peer-review
-
CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation
Chen, J., Ding, Y., Jiang, C., Qu, R., Wren, J. D., Georgescu, C., Wang, X., Reuter, D. N., Liu, B., Giles, C. B., Mayr, C. H., Schiller, H. B., Dai, J., Stipp, C. S., Subramaniyan, B., Wang, J., Zuo, H., Huang, C., Fung, K. M. & Rice, H. C. & 9 others, , May 10 2024, In: Circulation research. 134, 10, p. 1330-1347 18 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
An unexpected role of neutrophils in clearing apoptotic hepatocytes in vivo
Cao, L., Ma, L., Zhao, J., Wang, X., Fang, X., Li, W., Qi, Y., Tang, Y., Liu, J., Peng, S., Yang, L., Zhou, L., Li, L., Hu, X., Ji, Y., Hou, Y., Zhao, Y., Zhang, X., Zhao, Y. Y. & Zhao, Y. & 4 others, , Sep 20 2023, In: eLife. 12Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Egln1Tie2Cre Mice Exhibit Similar Therapeutic Responses to Sildenafil, Ambrisentan, and Treprostinil as Pulmonary Arterial Hypertension (PAH) Patients, Supporting Egln1Tie2Cre Mice as a Useful PAH Model
Peng, Y., Dai, J. & Zhao, Y. Y., Feb 2023, In: International journal of molecular sciences. 24, 3, 2391.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Endothelial FoxM1 reactivates aging-impaired endothelial regeneration for vascular repair and resolution of inflammatory lung injury
Huang, X., Zhang, X., Machireddy, N., Evans, C. E., Trewartha, S. D., Hu, G., Fang, Y., Mutlu, G. M., Wu, D. & Zhao, Y. Y., 2023, In: Science translational medicine. 15, 709, eabm5755.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations