Grants per year
Personal profile
Research Interests
Youyang Zhao, Ph.D., is William G. Swartchild, Jr. Distinguished Research Professor and Director of the Program for Lung and Vascular Biology at the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago. He is Professor of Pediatrics, Medicine (Pulmonary and Critical Care Medicine), and Pharmacology at Northwestern University Feinberg School of Medicine, and member of the Feinberg Cardiovascular Research Institute. Dr. Zhao joined Lurie Children’s in July 2017 from the University of Illinois at Chicago, where he started with Assistant Professor in 2003 and became Full Professor of Pharmacology in 2015. Prior to his tenure at UIC, he had 3 year experience in drug discovery at Pharmacia/Pfizer Co. as a senior research scientist. He received his B.S. from Fudan University, Shanghai; and Ph.D. in molecular biology from Shanghai Institute of Biochemistry, the Chinese Academy of Sciences. Dr. Zhao completed his postdoctoral training in molecular biology and cardiovascular biology at Harvard University; Brigham & Women's Hospital, Harvard Medical School; and The University of California, San Diego.
Dr. Youyang Zhao's lab is focused on lung and vascular biology to study the molecular mechanisms of acute lung injury/ARDS, and pulmonary hypertension and identify novel therapeutics for these devastating diseases. Current studies include 1) molecular mechanisms of endothelial regeneration and vascular repair; 2) how aging regulates these processes; 3) how endothelial cells regulate macrophage and neutrophil function for resolution of inflammation; 4) stem/progenitor cells in ALI and PH; 5) mechanisms of obliterative pulmonary vascular remodeling, and right heart failure; 6) lung regeneration; 7) drug discovery and nanomedicine; Also interested in blood-brain-barrier function regulation, pulmonary fibrosis, and cancer metastasis. Positions for Postdoc and Research Assistant Professor are available.
Training Experience
| 1996 | Postdoctoral Fellowship, Harvard University |
| 1998 | Postdoctoral Fellowship, Brigham & Women's Hospital, Harvard Medical School |
Education/Academic qualification
PhD, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
… → 1994
Research interests
- Aging
- Cardiovascular Diseases
- Epigenetics
- Gene Regulation
- Inflammation
- Lung Injury
- Pulmonary Hypertension
- Regenerative Medicine
- Respiratory Diseases
- Stem Cells
- Translational Research
- Vascular Biology
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Grants
GCN2 regulates pulmonary vascular remodeling and pulmonary arterial hypertension (M. Zhu Fellowship)
1/1/19 → 12/30/20
Project: Research project
Targeting smooth muscle progenitor cells for treatment of pulmonary arterial hypertension
National Heart, Lung, and Blood Institute
6/1/18 → 5/31/22
Project: Research project
Targeting smooth muscle progenitor cells for treatment of pulmonary arterial hypertension
National Heart, Lung, and Blood Institute
6/1/18 → 5/31/22
Project: Research project
Novel mechanisms of obliterative pulmonary vascular remodeling and sever pulmonary arterial hypertension
National Heart, Lung, and Blood Institute
9/1/17 → 6/30/20
Project: Research project
Novel mechanisms of obliterative pulmonary vascular remodeling and sever pulmonary arterial hypertension
National Heart, Lung, and Blood Institute
9/1/17 → 6/30/20
Project: Research project
Research Output
BET in pulmonary arterial hypertension: Exploration of BET inhibitors to reverse vascular remodeling
Dai, Z. & Zhao, Y. Y., Oct 1 2019, In : American journal of respiratory and critical care medicine. 200, 7, p. 806-808 3 p.Research output: Contribution to journal › Editorial
Open Access
2
Scopus
citations
Endothelial Hypoxia-Inducible Factor-1α Is Required for Vascular Repair and Resolution of Inflammatory Lung Injury through Forkhead Box Protein M1
Huang, X., Zhang, X., Zhao, D. X., Yin, J., Hu, G., Evans, C. E. & Zhao, Y. Y., Aug 2019, In : American Journal of Pathology. 189, 8, p. 1664-1679 16 p.Research output: Contribution to journal › Article
2
Scopus
citations
The stimulation of thrombosis by hypoxia
Gupta, N., Zhao, Y. Y. & Evans, C. E., Sep 2019, In : Thrombosis research. 181, p. 77-83 7 p.Research output: Contribution to journal › Review article
15
Scopus
citations
Endothelial and smooth muscle cell interaction via FoxM1 signaling mediates vascular remodeling and pulmonary hypertension
Dai, Z., Zhu, M. M., Peng, Y., Jin, H., Machireddy, N., Qian, Z., Zhang, X. & Zhao, Y. Y., Sep 15 2018, In : American journal of respiratory and critical care medicine. 198, 6, p. 788-802 15 p.Research output: Contribution to journal › Article
22
Scopus
citations
Sepsis-induced thrombus formation and cell-specific HIFs
Evans, C. E., Spier, A. B. & Zhao, Y. Y., Jan 1 2018, (Accepted/In press) In : Thrombosis Research. 171, p. 187-189 3 p.Research output: Contribution to journal › Article
1
Scopus
citations