• 3039 Citations
1994 …2022
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

Youyang Zhao, Ph.D., is William G. Swartchild, Jr. Distinguished Research Professor and Director of the Program for Lung and Vascular Biology at the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago. He is Professor of Pediatrics, Medicine (Pulmonary and Critical Care Medicine), and Pharmacology at Northwestern University Feinberg School of Medicine, and member of the Feinberg Cardiovascular Research Institute. Dr. Zhao joined Lurie Children’s in July 2017 from the University of Illinois at Chicago, where he started with Assistant Professor in 2003 and became Full Professor of Pharmacology in 2015. Prior to his tenure at UIC, he had 3 year experience in drug discovery at Pharmacia/Pfizer Co. as a senior research scientist. He received his B.S. from Fudan University, Shanghai; and Ph.D. in molecular biology from Shanghai Institute of Biochemistry, the Chinese Academy of Sciences. Dr. Zhao completed his postdoctoral training in molecular biology and cardiovascular biology at Harvard University; Brigham & Women's Hospital, Harvard Medical School; and The University of California, San Diego.

Dr. Youyang Zhao's lab is focused on lung and vascular biology to study the molecular mechanisms of acute lung injury/ARDS, and pulmonary hypertension and identify novel therapeutics for these devastating diseases. Current studies include 1) molecular mechanisms of endothelial regeneration and vascular repair; 2) how aging regulates these processes; 3) how endothelial cells regulate macrophage and neutrophil function for resolution of inflammation; 4) stem/progenitor cells in ALI and PH; 5) mechanisms of obliterative pulmonary vascular remodeling, and right heart failure; 6) lung regeneration; 7) drug discovery and nanomedicine; Also interested in blood-brain-barrier function regulation, pulmonary fibrosis, and cancer metastasis. Positions for Postdoc and Research Assistant Professor are available.

Training Experience

1996Postdoctoral Fellowship, Harvard University
1998Postdoctoral Fellowship, Brigham & Women's Hospital, Harvard Medical School

Education/Academic qualification

PhD, Shanghai Institute of Biochemistry, Chinese Academy of Sciences

… → 1994

Research interests

  • Aging
  • Cardiovascular Diseases
  • Epigenetics
  • Gene Regulation
  • Inflammation
  • Lung Injury
  • Pulmonary Hypertension
  • Regenerative Medicine
  • Respiratory Diseases
  • Stem Cells
  • Translational Research
  • Vascular Biology

Fingerprint Dive into the research topics where Youyang Zhao is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Caveolin 1 Medicine & Life Sciences
Lung Injury Medicine & Life Sciences
Pulmonary Hypertension Medicine & Life Sciences
Lung Medicine & Life Sciences
Endothelial Cells Medicine & Life Sciences
Cardiac Myocytes Medicine & Life Sciences
Adherens Junctions Medicine & Life Sciences
Blood Vessels Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2017 2022

Research Output 1994 2019

  • 3039 Citations
  • 54 Article
  • 4 Review article
  • 1 Chapter
  • 1 Comment/debate

Endothelial Hypoxia-Inducible Factor-1α Is Required for Vascular Repair and Resolution of Inflammatory Lung Injury through Forkhead Box Protein M1

Huang, X., Zhang, X., Zhao, D. X., Yin, J., Hu, G., Evans, C. E. & Zhao, Y., Aug 1 2019, In : American Journal of Pathology. 189, 8, p. 1664-1679 16 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Lung Injury
Blood Vessels
Sepsis
Endothelial Cells
10 Citations (Scopus)

Endothelial and smooth muscle cell interaction via FoxM1 signaling mediates vascular remodeling and pulmonary hypertension

Dai, Z., Zhu, M. M., Peng, Y., Jin, H., Machireddy, N., Qian, Z., Zhang, X. & Zhao, Y. Y., Sep 15 2018, In : American journal of respiratory and critical care medicine. 198, 6, p. 788-802 15 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Cell Communication
Smooth Muscle Myocytes
Endothelial Cells
Cell Proliferation
1 Citation (Scopus)

Sepsis-induced thrombus formation and cell-specific HIFs

Evans, C. E., Spier, A. B. & Zhao, Y. Y., Jan 1 2018, (Accepted/In press) In : Thrombosis Research. 171, p. 187-189 3 p.

Research output: Contribution to journalArticle

Sepsis
Thrombosis
3 Citations (Scopus)

Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in PAH with HIF-2α Inhibitor

Dai, Z., Zhu, M. M., Peng, Y., Machireddy, N., Evans, C. E., Machado, R., Zhang, X. & Zhao, Y-Y., Jun 20 2018, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Heart Failure
Lung
Monocrotaline
Rodentia
6 Citations (Scopus)

YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6

Lv, Y., Kim, K., Sheng, Y., Cho, J., Qian, Z., Zhao, Y-Y., Hu, G., Pan, D., Malik, A. B. & Hu, G., Jun 22 2018, In : Circulation Research. 123, 1, p. 43-56 14 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Blood Vessels
Inflammation
Endothelial Cells
Neutrophils