Grants per year
Personal profile
Research Interests
Understanding the molecular mechanisms by which large, multi-subunit complexes engage in DNA-centric processes using cryo-electron microscopy (cryo-EM) and other biophysical and biochemical approaches. We focus on two main topics: (1) how eukaryotic gene transcription is regulated at different stages, and (2) how various types of DNA damage are repaired and why deficiencies in these repair pathways lead to pathology of cancer predisposition or accelerated aging.
Education/Academic qualification
PhD, Northwestern University
… → 2008
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Grants
Structure and Mechanism of Non-Homologous End Joining
National Institute of General Medical Sciences
2/11/20 → 1/31/25
Project: Research project
Structural Cell Biology of DNA Repair Machines
University of California, Lawrence Berkeley National Laboratory, National Cancer Institute
9/13/16 → 8/31/21
Project: Research project
Structural Basis of Human Transcription Promoter Proximal Pausing
1/1/16 → 12/31/18
Project: Research project
PDR-098: Proteomic and Structural Alysis of Human RNA Pol III Transcription Machinery
Searle Funds at The Chicago Community Trust
1/1/11 → 11/30/17
Project: Research project
C-064: Toward the Visualization of Spliceosomal Intermediates
Searle Funds at The Chicago Community Trust
1/1/11 → 1/31/18
Project: Research project
Research Output
Cryo-EM structure of SWI/SNF complex bound to a nucleosome
Han, Y., Reyes, A. A., Malik, S. & He, Y., Mar 19 2020, In : Nature. 579, 7799, p. 452-455 4 p.Research output: Contribution to journal › Article
10
Scopus
citations
Structural insights into the evolutionarily conserved BAF chromatin remodeling complex
Marcum, R. D., Reyes, A. A. & He, Y., Jul 2020, In : Biology. 9, 7, p. 1-9 9 p., 146.Research output: Contribution to journal › Review article
Open Access
Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation
Abdella, R., Aggarwal, M., Okura, T., Lamb, R. A. & He, Y., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4931-4941 11 p.Research output: Contribution to journal › Article
4
Scopus
citations
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases
Yan, C., Dodd, T., He, Y., Tainer, J. A., Tsutakawa, S. E. & Ivanov, I., Jun 1 2019, In : Nature Structural and Molecular Biology. 26, 6, p. 397-406 10 p.Research output: Contribution to journal › Article
11
Scopus
citations
Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation
Jackobel, A. J., Han, Y., He, Y. & Knutson, B. A., Aug 8 2018, In : Transcription. 9, 4, p. 255-261 7 p.Research output: Contribution to journal › Comment/debate
2
Scopus
citations