Grants per year
Personal profile
Research Interests
Understanding the molecular mechanisms by which large, multi-subunit complexes engage in DNA-centric processes using cryo-electron microscopy (cryo-EM) and other biophysical and biochemical approaches. We focus on two main topics: (1) how eukaryotic gene transcription is regulated at different stages, and (2) how various types of DNA damage are repaired and why deficiencies in these repair pathways lead to pathology of cancer predisposition or accelerated aging.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Structure and Mechanism of Eukaryotic Transcription Regulation
National Institute of General Medical Sciences
6/1/22 → 3/31/26
Project: Research project
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Structural Cell Biology of DNA Repair Machines
University of California, Lawrence Berkeley National Laboratory, National Cancer Institute
9/21/21 → 8/31/26
Project: Research project
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Structure and Mechanism of Non-Homologous End Joining
National Institute of General Medical Sciences
2/11/20 → 1/31/25
Project: Research project
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Center for Synovial Sarcoma Biology and Therapeutics
Dana-Farber Cancer Institute, National Cancer Institute
9/10/21 → 6/30/23
Project: Research project
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Structural Cell Biology of DNA Repair Machines
University of California, Lawrence Berkeley National Laboratory, National Cancer Institute
9/13/16 → 8/31/21
Project: Research project
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Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex
Patel, A. B., Qing, J., Tam, K. H., Zaman, S., Luiso, M., Radhakrishnan, I. & He, Y., Dec 2023, In: Nature communications. 14, 1, 3061.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ
Chen, S., Vogt, A., Lee, L., Naila, T., McKeown, R., Tomkinson, A. E., Lees-Miller, S. P. & He, Y., Jun 2023, In: Science Advances. 9, 22, eadg2838.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Cryo-EM visualization of state transition during non-homologous end-joining (NHEJ)
Chen, S., Lee, L., Naila, T., McKeown, R., Fishbain, S., Vogt, A., Wang, A., Tomkinson, A. E., Lees-Miller, S. P. & He, Y., Feb 10 2023, In: Biophysical Journal. 122, 3S1, p. 150aResearch output: Contribution to journal › Article › peer-review
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Structure and function of the apical PIKKs in double-strand break repair
Xu, J., Bradley, N. & He, Y., Oct 2023, In: Current Opinion in Structural Biology. 82, 102651.Research output: Contribution to journal › Review article › peer-review
Open Access -
Recovery of particulate methane monooxygenase structure and activity in a lipid bilayer
Koo, C. W., Tucci, F. J., He, Y. & Rosenzweig, A. C., Mar 18 2022, In: Science. 375, 6586, p. 1287-1291 5 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations
Datasets
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Data for EMSL Project 51582 from October 2020
Novikova, I. (Creator), Myers, J. (Creator), He, Y. (Creator), Chen, S. (Creator), Talyzina, A. (Creator), Reyes, A. (Creator) & Marcum, R. (Creator), Environmental Molecular Sciences Laboratory, 2020
DOI: 10.2076377/1931414, https://www.osti.gov/servlets/purl/1931414/
Dataset
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5IYD : Human core-PIC in the initial transcribing state (no IIS)
He, Y. (Contributor), Yan, C. (Contributor), Fang, J. (Contributor), Inouye, C. (Contributor), Tjian, R. (Contributor), Ivanov, I. (Contributor) & Nogales, E. (Contributor), RCSB-PDB, 2016
DOI: 10.2210/pdb5iyd/pdb, https://www.rcsb.org/structure/5IYD
Dataset
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Data for EMSL Project 51582 from May 2021
Novikova, I. (Creator), Myers, J. (Creator), He, Y. (Creator), Chen, S. (Creator), Talyzina, A. (Creator), Reyes, A. (Creator) & Marcum, R. (Creator), Environmental Molecular Sciences Laboratory, 2021
DOI: 10.25582/data.2021-05.2232933/1932647, https://www.osti.gov/servlets/purl/1932647/
Dataset
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Data for EMSL Project 51582 from March 2022
Novikova, I. (Creator), Myers, J. (Creator), He, Y. (Creator), Chen, S. (Creator), Talyzina, A. (Creator), Reyes, A. (Creator) & Marcum, R. (Creator), Environmental Molecular Sciences Laboratory, 2022
DOI: 10.25582/data.2022-03.2445134/1930770, https://www.osti.gov/servlets/purl/1930770/
Dataset
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5IY7 : Human holo-PIC in the open state
He, Y. (Contributor), Yan, C. (Contributor), Fang, J. (Contributor), Inouye, C. (Contributor), Tjian, R. (Contributor), Ivanov, I. (Contributor) & Nogales, E. (Contributor), RCSB-PDB, 2016
DOI: 10.2210/pdb5iy7/pdb, https://www.rcsb.org/structure/5IY7
Dataset