• 629 Citations
20042025

Research output per year

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Personal profile

Research Interests

Understanding the molecular mechanisms by which large, multi-subunit complexes engage in DNA-centric processes using cryo-electron microscopy (cryo-EM) and other biophysical and biochemical approaches. We focus on two main topics: (1) how eukaryotic gene transcription is regulated at different stages, and (2) how various types of DNA damage are repaired and why deficiencies in these repair pathways lead to pathology of cancer predisposition or accelerated aging.

Education/Academic qualification

PhD, Northwestern University

… → 2008

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Grants

Research Output

  • 629 Citations
  • 15 Article
  • 3 Review article
  • 1 Comment/debate

Cryo-EM structure of SWI/SNF complex bound to a nucleosome

Han, Y., Reyes, A. A., Malik, S. & He, Y., Mar 19 2020, In : Nature. 579, 7799, p. 452-455 4 p.

Research output: Contribution to journalArticle

  • 2 Scopus citations

    Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation

    Abdella, R., Aggarwal, M., Okura, T., Lamb, R. A. & He, Y., Mar 3 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4931-4941 11 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Transcription preinitiation complex structure and dynamics provide insight into genetic diseases

    Yan, C., Dodd, T., He, Y., Tainer, J. A., Tsutakawa, S. E. & Ivanov, I., Jun 1 2019, In : Nature Structural and Molecular Biology. 26, 6, p. 397-406 10 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation

    Jackobel, A. J., Han, Y., He, Y. & Knutson, B. A., Aug 8 2018, In : Transcription. 9, 4, p. 255-261 7 p.

    Research output: Contribution to journalComment/debate

  • 2 Scopus citations

    Structural visualization of RNA polymerase III transcription machineries

    Han, Y., Yan, C., Fishbain, S., Ivanov, I. & He, Y., Dec 1 2018, In : Cell Discovery. 4, 1, 40.

    Research output: Contribution to journalArticle

  • 6 Scopus citations