Grants per year
Personal profile
Research Interests
Understanding the molecular mechanisms by which large, multi-subunit complexes engage in DNA-centric processes using cryo-electron microscopy (cryo-EM) and other biophysical and biochemical approaches. We focus on two main topics: (1) how eukaryotic gene transcription is regulated at different stages, and (2) how various types of DNA damage are repaired and why deficiencies in these repair pathways lead to pathology of cancer predisposition or accelerated aging.
Fingerprint
Dive into the research topics where Yuan He is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 2 Similar Profiles
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants
-
Structure and Mechanism of Non-Homologous End Joining
National Institute of General Medical Sciences
2/11/20 → 1/31/25
Project: Research project
-
Structural Cell Biology of DNA Repair Machines
University of California, Lawrence Berkeley National Laboratory, National Cancer Institute
9/13/16 → 8/31/21
Project: Research project
-
Structural Basis of Human Transcription Promoter Proximal Pausing
1/1/16 → 12/31/18
Project: Research project
-
C-064: Toward the Visualization of Spliceosomal Intermediates
Searle Funds at The Chicago Community Trust
1/1/11 → 1/31/18
Project: Research project
-
PDR-098: Proteomic and Structural Alysis of Human RNA Pol III Transcription Machinery
Searle Funds at The Chicago Community Trust
1/1/11 → 11/30/17
Project: Research project
Research Output
-
A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms
Mashtalir, N., Suzuki, H., Farrell, D. P., Sankar, A., Luo, J., Filipovski, M., D'Avino, A. R., St. Pierre, R., Valencia, A. M., Onikubo, T., Roeder, R. G., Han, Y., He, Y., Ranish, J. A., DiMaio, F., Walz, T. & Kadoch, C., Oct 29 2020, In: Cell. 183, 3, p. 802-817.e24Research output: Contribution to journal › Article › peer-review
-
Cryo-EM structure of SWI/SNF complex bound to a nucleosome
Han, Y., Reyes, A. A., Malik, S. & He, Y., Mar 19 2020, In: Nature. 579, 7799, p. 452-455 4 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Structural insights into the evolutionarily conserved BAF chromatin remodeling complex
Marcum, R. D., Reyes, A. A. & He, Y., Jul 2020, In: Biology. 9, 7, p. 1-9 9 p., 146.Research output: Contribution to journal › Review article › peer-review
Open Access -
Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation
Abdella, R., Aggarwal, M., Okura, T., Lamb, R. A. & He, Y., Mar 3 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4931-4941 11 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Cryo-electron microscopy structure of a nucleosome-bound SWI/SNF chromatin remodeling complex
Han, Y., Reyes, A. A., Malik, S. & He, Y., Oct 16 2019, In: Unknown Journal.Research output: Contribution to journal › Article › peer-review