Grants per year
Personal profile
Research Interests
Understanding the molecular mechanisms by which large, multi-subunit complexes engage in DNA-centric processes using cryo-electron microscopy (cryo-EM) and other biophysical and biochemical approaches. We focus on two main topics: (1) how eukaryotic gene transcription is regulated at different stages, and (2) how various types of DNA damage are repaired and why deficiencies in these repair pathways lead to pathology of cancer predisposition or accelerated aging.
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Structure and Mechanism of Non-Homologous End Joining
National Institute of General Medical Sciences
2/11/20 → 1/31/25
Project: Research project
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Structural Cell Biology of DNA Repair Machines
University of California, Lawrence Berkeley National Laboratory, National Cancer Institute
9/13/16 → 8/31/21
Project: Research project
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Structural Basis of Human Transcription Promoter Proximal Pausing
1/1/16 → 12/31/18
Project: Research project
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C-064: Toward the Visualization of Spliceosomal Intermediates
Searle Funds at The Chicago Community Trust
1/1/11 → 1/31/18
Project: Research project
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PDR-098: Proteomic and Structural Alysis of Human RNA Pol III Transcription Machinery
Searle Funds at The Chicago Community Trust
1/1/11 → 11/30/17
Project: Research project
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Structural basis of long-range to short-range synaptic transition in NHEJ
Chen, S., Lee, L., Naila, T., Fishbain, S., Wang, A., Tomkinson, A. E., Lees-Miller, S. P. & He, Y., May 13 2021, In: Nature. 593, 7858, p. 294-298 5 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Structure and Function of Chromatin Remodelers
Reyes, A. A., Marcum, R. D. & He, Y., Jul 9 2021, In: Journal of Molecular Biology. 433, 14, 166929.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Structure of the human Mediator-bound transcription preinitiation complex
Abdella, R., Talyzina, A., Chen, S., Inouye, C. J., Tjian, R. & He, Y., Apr 2 2021, In: Science. 372, 6537, p. 52-56 5 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms
Mashtalir, N., Suzuki, H., Farrell, D. P., Sankar, A., Luo, J., Filipovski, M., D'Avino, A. R., St. Pierre, R., Valencia, A. M., Onikubo, T., Roeder, R. G., Han, Y., He, Y., Ranish, J. A., DiMaio, F., Walz, T. & Kadoch, C., Oct 29 2020, In: Cell. 183, 3, p. 802-817.e24Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Cryo-EM structure of SWI/SNF complex bound to a nucleosome
Han, Y., Reyes, A. A., Malik, S. & He, Y., Mar 19 2020, In: Nature. 579, 7799, p. 452-455 4 p.Research output: Contribution to journal › Article › peer-review
41 Scopus citations