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Personal profile

Research Interests

Large numbers of genes turn on and off in temporally and spatially precise patterns in the brain to regulate neural circuit development and refinement. The Yang laboratory is interested in the chromatin mechanisms operating in the nucleus that organize functional neural circuits. We are studying how developmental signals or sensory experience in vivo activate these chromatin mechanisms to orchestrate programs of gene expression in the brain. Our model system is the mouse cerebellum, a hindbrain structure important for motor coordination and motor learning. A major goal is to elucidate how chromatin mechanisms and gene expression networks pattern the neural circuits underlying motor behavior and learning and memory.

The laboratory deploys next-generation molecular neuroscience approaches including epigenetics and chromatin conformation profiling using massive parallel sequencing, single-cell sequencing, and bioinformatics, as well as systems neuroscience tools including optogenetics, in vivo two-photon calcium imaging, and mouse behavior.

Education/Academic qualification

PhD, Harvard Medical School

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Research Output

Publisher Correction: Sensory experience remodels genome architecture in neural circuit to drive motor learning (Nature, (2019), 569, 7758, (708-713), 10.1038/s41586-019-1190-7)

Yamada, T., Yang, Y., Valnegri, P., Juric, I., Abnousi, A., Markwalter, K. H., Guthrie, A. N., Godec, A., Oldenborg, A., Hu, M., Holy, T. E. & Bonni, A., Jun 13 2019, In : Nature. 570, 7760, p. E33

Research output: Contribution to journalComment/debate

Open Access
  • Sensory experience remodels genome architecture in neural circuit to drive motor learning

    Yamada, T., Yang, Y., Valnegri, P., Juric, I., Abnousi, A., Markwalter, K. H., Guthrie, A. N., Godec, A., Oldenborg, A., Hu, M., Holy, T. E. & Bonni, A., May 30 2019, In : Nature. 569, 7758, p. 708-713 6 p.

    Research output: Contribution to journalLetter

  • 9 Scopus citations

    RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain

    Valnegri, P., Huang, J., Yamada, T., Yang, Y., Mejia, L. A., Cho, H. Y., Oldenborg, A. & Bonni, A., Dec 1 2017, In : Nature communications. 8, 1, 1271.

    Research output: Contribution to journalArticle

  • 13 Scopus citations

    Chromatin remodeling inactivates Activity genes and regulates neural coding

    Yang, Y., Yamada, T., Hill, K. K., Hemberg, M., Reddy, N. C., Cho, H. Y., Guthrie, A. N., Oldenborg, A., Heiney, S. A., Ohmae, S., Medina, J. F., Holy, T. E. & Bonni, A., Jul 15 2016, In : Science. 353, 6296, p. 300-306 7 p.

    Research output: Contribution to journalArticle

  • 36 Scopus citations

    Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain

    Yamada, T., Yang, Y., Hemberg, M., Yoshida, T., Cho, H. Y., Murphy, J. P., Fioravante, D., Regehr, W. G., Gygi, S. P., Georgopoulos, K. & Bonni, A., Jul 2 2014, In : Neuron. 83, 1, p. 122-134 13 p.

    Research output: Contribution to journalArticle

  • 49 Scopus citations