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Personal profile

Research Interests

Large numbers of genes turn on and off in temporally and spatially precise patterns in the brain to regulate neural circuit development and refinement. The Yang laboratory is interested in the chromatin mechanisms operating in the nucleus that organize functional neural circuits. We are studying how developmental signals or sensory experience in vivo activate these chromatin mechanisms to orchestrate programs of gene expression in the brain. Our model system is the mouse cerebellum, a hindbrain structure important for motor coordination and motor learning. A major goal is to elucidate how chromatin mechanisms and gene expression networks pattern the neural circuits underlying motor behavior and learning and memory.

The laboratory deploys next-generation molecular neuroscience approaches including epigenetics and chromatin conformation profiling using massive parallel sequencing, single-cell sequencing, and bioinformatics, as well as systems neuroscience tools including optogenetics, in vivo two-photon calcium imaging, and mouse behavior.

Education/Academic qualification

PhD, Harvard Medical School

Fingerprint Dive into the research topics where Yue Yang is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 15 Similar Profiles
Ubiquitin Medicine & Life Sciences
Neurons Medicine & Life Sciences
Ubiquitin-Protein Ligases Medicine & Life Sciences
Brain Medicine & Life Sciences
Anaphase-Promoting Complex-Cyclosome Medicine & Life Sciences
Synapses Medicine & Life Sciences
Cerebellar Cortex Medicine & Life Sciences
Ligases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2006 2019

Publisher Correction: Sensory experience remodels genome architecture in neural circuit to drive motor learning (Nature, (2019), 569, 7758, (708-713), 10.1038/s41586-019-1190-7)

Yamada, T., Yang, Y., Valnegri, P., Juric, I., Abnousi, A., Markwalter, K. H., Guthrie, A. N., Godec, A., Oldenborg, A., Hu, M., Holy, T. E. & Bonni, A., Jun 13 2019, In : Nature. 570, 7760, p. E33

Research output: Contribution to journalComment/debate

Open Access
Learning
Genome
5 Citations (Scopus)

Sensory experience remodels genome architecture in neural circuit to drive motor learning

Yamada, T., Yang, Y., Valnegri, P., Juric, I., Abnousi, A., Markwalter, K. H., Guthrie, A. N., Godec, A., Oldenborg, A., Hu, M., Holy, T. E. & Bonni, A., May 30 2019, In : Nature. 569, 7758, p. 708-713 6 p.

Research output: Contribution to journalLetter

Chromatin
Learning
Genome
Neurons
Brain
12 Citations (Scopus)

RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain

Valnegri, P., Huang, J., Yamada, T., Yang, Y., Mejia, L. A., Cho, H. Y., Oldenborg, A. & Bonni, A., Dec 1 2017, In : Nature communications. 8, 1, 1271.

Research output: Contribution to journalArticle

synapses
Ubiquitin
Synapses
Neurons
brain
34 Citations (Scopus)

Chromatin remodeling inactivates Activity genes and regulates neural coding

Yang, Y., Yamada, T., Hill, K. K., Hemberg, M., Reddy, N. C., Cho, H. Y., Guthrie, A. N., Oldenborg, A., Heiney, S. A., Ohmae, S., Medina, J. F., Holy, T. E. & Bonni, A., Jul 15 2016, In : Science. 353, 6296, p. 300-306 7 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Neuronal Plasticity
Neurons
Genes
Mi-2 Nucleosome Remodeling and Deacetylase Complex
46 Citations (Scopus)

Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain

Yamada, T., Yang, Y., Hemberg, M., Yoshida, T., Cho, H. Y., Murphy, J. P., Fioravante, D., Regehr, W. G., Gygi, S. P., Georgopoulos, K. & Bonni, A., Jul 2 2014, In : Neuron. 83, 1, p. 122-134 13 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Mi-2 Nucleosome Remodeling and Deacetylase Complex
Cerebellar Cortex
RNA Interference
Brain