Grants per year
Personal profile
Research Interests
Large numbers of genes turn on and off in temporally and spatially precise patterns in the brain to regulate neural circuit development and refinement. The Yang laboratory is interested in the chromatin mechanisms operating in the nucleus that organize functional neural circuits. We are studying how developmental signals or sensory experience in vivo activate these chromatin mechanisms to orchestrate programs of gene expression in the brain. Our model system is the mouse cerebellum, a hindbrain structure important for motor coordination and motor learning. A major goal is to elucidate how chromatin mechanisms and gene expression networks pattern the neural circuits underlying motor behavior and learning and memory.
The laboratory deploys next-generation molecular neuroscience approaches including epigenetics and chromatin conformation profiling using massive parallel sequencing, single-cell sequencing, and bioinformatics, as well as systems neuroscience tools including optogenetics, in vivo two-photon calcium imaging, and mouse behavior.
Education/Academic qualification
PhD, Harvard Medical School
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Grants
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Mechanisms of Genome Organization in Brain Development and Behavior
National Institute on Drug Abuse
9/30/20 → 8/31/25
Project: Research project
Research Output
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The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
Goodman, J. V., Yamada, T., Yang, Y., Kong, L., Wu, D. Y., Zhao, G., Gabel, H. W. & Bonni, A., Dec 1 2020, In: Nature communications. 11, 1, 3419.Research output: Contribution to journal › Article › peer-review
Open Access -
Publisher Correction: Sensory experience remodels genome architecture in neural circuit to drive motor learning (Nature, (2019), 569, 7758, (708-713), 10.1038/s41586-019-1190-7)
Yamada, T., Yang, Y., Valnegri, P., Juric, I., Abnousi, A., Markwalter, K. H., Guthrie, A. N., Godec, A., Oldenborg, A., Hu, M., Holy, T. E. & Bonni, A., Jun 13 2019, In: Nature. 570, 7760, p. E33Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Sensorimotor Coding of Vermal Granule Neurons in the Developing Mammalian Cerebellum
Markwalter, K. H., Yang, Y., Holy, T. E. & Bonni, A., Aug 21 2019, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 34, p. 6626-6643 18 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Sensory experience remodels genome architecture in neural circuit to drive motor learning
Yamada, T., Yang, Y., Valnegri, P., Juric, I., Abnousi, A., Markwalter, K. H., Guthrie, A. N., Godec, A., Oldenborg, A., Hu, M., Holy, T. E. & Bonni, A., May 30 2019, In: Nature. 569, 7758, p. 708-713 6 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
Valnegri, P., Huang, J., Yamada, T., Yang, Y., Mejia, L. A., Cho, H. Y., Oldenborg, A. & Bonni, A., Dec 1 2017, In: Nature communications. 8, 1, 1271.Research output: Contribution to journal › Article › peer-review
17 Scopus citations