Yuzhi Jia

  • 1301 Citations
19962018
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Personal profile

Research Interests



My research work is focused on studying the mechanisms that regulate the transcriptional activities of nuclear receptors. Nuclear receptors constitute a large superfamily of transcription factors that regulate a diverse array of biological processes, including development and neoplasia, as well as energy and xenobiotic metabolism. In order to initiate transcription, some more factors are required to interact with nuclear receptors and to regulate their activities. These factors are collectively called "nuclear receptor co-factors". Several co-factors have been identified by our studies. Generating mouse models using gene targeting technology to investigate the functions of these genes is in process.

Education/Academic qualification

PhD, Nippon Medical School, Japan

… → 1997

MD, Harbin Medical University

… → 1984

Research interests

  • Pathology

Fingerprint Dive into the research topics where Yuzhi Jia is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 14 Similar Profiles
Peroxisome Proliferator-Activated Receptors Medicine & Life Sciences
Mediator Complex Subunit 1 Medicine & Life Sciences
Liver Medicine & Life Sciences
Acyl-CoA Oxidase Medicine & Life Sciences
Genes Medicine & Life Sciences
Cytoplasmic and Nuclear Receptors Medicine & Life Sciences
Hepatocytes Medicine & Life Sciences
Carrier Proteins Medicine & Life Sciences

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Grants 2008 2018

Research Output 1996 2018

  • 1301 Citations
  • 41 Article
  • 2 Comment/debate
  • 2 Review article
  • 1 Chapter
1 Citation (Scopus)

Mouse cardiac Pde1C is a direct transcriptional target of pparα

Shete, V., Liu, N., Jia, Y., Viswakarma, N., Reddy, J. K. & Thimmapaya, B., Dec 1 2018, In : International journal of molecular sciences. 19, 12, 3704.

Research output: Contribution to journalArticle

PPAR alpha
mice
Phosphoric Diester Hydrolases
Mediator Complex
Inverted Repeat Sequences
1 Citation (Scopus)
deletion
metabolism
Cardiomyopathies
Energy Metabolism
mice
10 Citations (Scopus)

Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization

Bai, L., Li, Z., Li, Q., Guan, H., Zhao, S., Liu, R., Wang, R., Zhang, J., Jia, Y., Fan, J., Wang, N., Reddy, J. K., Shyy, J. Y. J. & Liu, E., Aug 1 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 8, p. 1470-1481 12 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Apolipoproteins E
Atherosclerosis
Macrophages
Genes
8 Citations (Scopus)

Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice

Jia, Y., Chang, H. C., Schipma, M. J., Liu, J., Shete, V., Liu, N., Sato, T., Thorp, E. B., Barger, P. M., Zhu, Y. J., Viswakarma, N., Kanwar, Y. S., Ardehali, H., Thimmapaya, B. & Reddy, J. K., Aug 1 2016, In : PloS one. 11, 8, e0160755.

Research output: Contribution to journalArticle

Mediator Complex Subunit 1
cardiomyopathy
Dilated Cardiomyopathy
Ablation
lethal genes

Overexpression of PPARγ induces adipogenic steatosis in mouse primary hepatocytes

Bai, L., Zhang, Y., Xie, C., Wang, R., Zhao, S., Jia, Y. & Liu, E., Jan 1 2016, In : Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 45, 1, p. 68-74 7 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Hepatocytes
Messenger RNA
Inbred C57BL Mouse
Adipocytes