Yuzhi Jia

  • 1370 Citations
19962020

Research output per year

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Personal profile

Research Interests



My research work is focused on studying the mechanisms that regulate the transcriptional activities of nuclear receptors. Nuclear receptors constitute a large superfamily of transcription factors that regulate a diverse array of biological processes, including development and neoplasia, as well as energy and xenobiotic metabolism. In order to initiate transcription, some more factors are required to interact with nuclear receptors and to regulate their activities. These factors are collectively called "nuclear receptor co-factors". Several co-factors have been identified by our studies. Generating mouse models using gene targeting technology to investigate the functions of these genes is in process.

Education/Academic qualification

PhD, Nippon Medical School

… → 1997

MD, Harbin Medical University

… → 1984

Research interests

  • Pathology

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Grants

Research Output

  • 1370 Citations
  • 41 Article
  • 2 Comment/debate
  • 2 Review article
  • 1 Chapter

Extracellular Domains i and II of cell-surface glycoprotein CD44 mediate its trans-homophilic dimerization and tumor cluster aggregation

Kawaguchi, M., Dashzeveg, N., Cao, Y., Jia, Y., Liu, X., Shen, Y. & Liu, H., Feb 28 2020, In : Journal of Biological Chemistry. 295, 9, p. 2640-2649 10 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Mouse cardiac Pde1C is a direct transcriptional target of pparα

    Shete, V., Liu, N., Jia, Y., Viswakarma, N., Reddy, J. K. & Thimmapaya, B., Dec 2018, In : International journal of molecular sciences. 19, 12, 3704.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    PIMT/NCOA6IP deletion in the mouse heart causes delayed cardiomyopathy attributable to perturbation in energy metabolism

    Jia, Y., Liu, N., Viswakarma, N., Sun, R., Schipma, M. J., Shang, M., Thorp, E. B., Kanwar, Y. S., Thimmapaya, B. & Reddy, J. K., May 16 2018, In : International journal of molecular sciences. 19, 5, 1485.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization

    Bai, L., Li, Z., Li, Q., Guan, H., Zhao, S., Liu, R., Wang, R., Zhang, J., Jia, Y., Fan, J., Wang, N., Reddy, J. K., Shyy, J. Y. J. & Liu, E., Aug 1 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 8, p. 1470-1481 12 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice

    Jia, Y., Chang, H. C., Schipma, M. J., Liu, J., Shete, V., Liu, N., Sato, T., Thorp, E. B., Barger, P. M., Zhu, Y., Viswakarma, N., Kanwar, Y. S., Ardehali, H., Thimmapaya, B. & Reddy, J. K., Aug 2016, In : PloS one. 11, 8, e0160755.

    Research output: Contribution to journalArticle

  • 10 Scopus citations