Grants per year
Personal profile
Research Interests
My research work is focused on studying the mechanisms that regulate the transcriptional activities of nuclear receptors. Nuclear receptors constitute a large superfamily of transcription factors that regulate a diverse array of biological processes, including development and neoplasia, as well as energy and xenobiotic metabolism. In order to initiate transcription, some more factors are required to interact with nuclear receptors and to regulate their activities. These factors are collectively called "nuclear receptor co-factors". Several co-factors have been identified by our studies. Generating mouse models using gene targeting technology to investigate the functions of these genes is in process.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Pathology, PhD, Nippon Medical School
… → 1997
MD, Medicine, Harbin Medical University
… → 1984
Research interests keywords
- Pathology
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Collaborations and top research areas from the last five years
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Novel functions of PlexinB2 in circulating tumor cell clusters
Liu, H. (PD/PI), Gradishar, W. J. (Co-Investigator) & Jia, Y. (Other)
2/21/25 → 1/31/30
Project: Research project
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Proteomic analysis and targeting of circulating tumor stem cell clusters in breast cancer
Liu, H. (PD/PI), Fang, D. (Other), Jia, Y. (Other) & Shah, A. N. (Other)
1/1/23 → 12/31/27
Project: Research project
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Clinical analysis and therapeutic development of exosomal ACE2
Liu, H. (PD/PI), Liu, H. (PD/PI), Zhang, H. (Co-Investigator) & Jia, Y. (Other)
National Institute of Allergy and Infectious Diseases
7/15/22 → 6/30/27
Project: Research project
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Glycoprotein sialylation of CTC clusters in breast cancer metastasis
Liu, H. (PD/PI), Cristofanilli, M. (Co-Investigator), Dashzeveg, N. K. (Other) & Jia, Y. (Other)
U.S. Army Medical Research and Materiel Command
9/1/20 → 8/31/23
Project: Research project
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Med1 in Liver Metabolism, Regeneration and Cancer
Thimmapaya, B. (PD/PI), Jia, Y. (Co-Investigator), Lukas, T. J. (Co-Investigator), Reddy, J. K. (Co-Investigator) & Zhu, Y. (Co-Investigator)
National Institute of Diabetes and Digestive and Kidney Diseases
7/1/16 → 12/31/18
Project: Research project
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Polycomb group protein Mel18 inhibits hematopoietic stem cell self-renewal through repressing the transcription of self-renewal and proliferation genes
Cai, W., Liu, X., Barajas, S., Xiao, S., Vemula, S., Chen, H., Yang, Y., Bochers, C., Henley, D., Liu, S., Jia, Y., Hong, M., Mays, T. M., Capitano, M. L., Liu, H., Ji, P., Gao, Z., Pasini, D., Wan, J. & Yue, F. & 4 others, , Feb 2025, In: Leukemia. 39, 2, p. 296-307 12 p., 550.Research output: Contribution to journal › Article › peer-review
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PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation
Chen, H., Bai, Y., Kobayashi, M., Xiao, S., Barajas, S., Cai, W., Chen, S., Miao, J., Meke, F. N., Yao, C., Yang, Y., Strube, K., Satchivi, O., Sun, J., Ronnstrand, L., Croop, J. M., Boswell, H. S., Jia, Y., Liu, H. & Li, L. S. & 10 others, , Jan 2024, In: Molecular Cancer Research. 22, 1, p. 94-103 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis
Liu, K., Gao, Q., Jia, Y., Wei, J., Chaudhuri, S. M., Wang, S., Tang, A., Mani, N. L., Iyer, R., Cheng, Y., Gao, B., Lu, W., Sun, Z., Zhang, B., Liu, H. & Fang, D., Sep 20 2024, In: iScience. 27, 9, 110592.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer
Dashzeveg, N. K., Jia, Y., Zhang, Y., Gerratana, L., Patel, P., Shajahan, A., Dandar, T., Ramos, E. K., Almubarak, H. F., Adorno-Cruz, V., Taftaf, R., Schuster, E. J., Scholten, D., Sokolowski, M. T., Reduzzi, C., El-Shennawy, L., Hoffmann, A. D., Manai, M., Zhang, Q. & D’amico, P. & 9 others, , Sep 1 2023, In: Cancer discovery. 13, 9, p. 2050-2071 22 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
Chen, H., Bai, Y., Kobayashi, M., Xiao, S., Cai, W., Barajas, S., Chen, S., Miao, J., Meke, F. N., Vemula, S., Ropa, J. P., Croop, J. M., Boswell, H. S., Wan, J., Jia, Y., Liu, H., Li, L. S., Altman, J. K., Eklund, E. A. & Ji, P. & 6 others, , Jan 19 2023, In: Blood. 141, 3, p. 244-259 16 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations