Yuzhi Jia

  • 1335 Citations
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Personal profile

Research Interests

My research work is focused on studying the mechanisms that regulate the transcriptional activities of nuclear receptors. Nuclear receptors constitute a large superfamily of transcription factors that regulate a diverse array of biological processes, including development and neoplasia, as well as energy and xenobiotic metabolism. In order to initiate transcription, some more factors are required to interact with nuclear receptors and to regulate their activities. These factors are collectively called "nuclear receptor co-factors". Several co-factors have been identified by our studies. Generating mouse models using gene targeting technology to investigate the functions of these genes is in process.

Education/Academic qualification

PhD, Nippon Medical School, Japan

… → 1997

MD, Harbin Medical University

… → 1984

Research interests

  • Pathology

Fingerprint Dive into the research topics where Yuzhi Jia is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 16 Similar Profiles
Peroxisome Proliferator-Activated Receptors Medicine & Life Sciences
Mediator Complex Subunit 1 Medicine & Life Sciences
Liver Medicine & Life Sciences
Genes Medicine & Life Sciences
Acyl-CoA Oxidase Medicine & Life Sciences
Cytoplasmic and Nuclear Receptors Medicine & Life Sciences
Nuclear Receptor Coactivators Medicine & Life Sciences
Hepatocytes Medicine & Life Sciences

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Grants 2008 2018

Research Output 1996 2018

  • 1335 Citations
  • 40 Article
  • 2 Comment/debate
  • 2 Review article
  • 1 Chapter
1 Citation (Scopus)

Mouse cardiac Pde1C is a direct transcriptional target of pparα

Shete, V., Liu, N., Jia, Y., Viswakarma, N., Reddy, J. K. & Thimmapaya, B., Dec 2018, In : International journal of molecular sciences. 19, 12, 3704.

Research output: Contribution to journalArticle

PPAR alpha
Phosphoric Diester Hydrolases
Mediator Complex
Inverted Repeat Sequences
2 Citations (Scopus)
Energy Metabolism
11 Citations (Scopus)

Mediator 1 Is Atherosclerosis Protective by Regulating Macrophage Polarization

Bai, L., Li, Z., Li, Q., Guan, H., Zhao, S., Liu, R., Wang, R., Zhang, J., Jia, Y., Fan, J., Wang, N., Reddy, J. K., Shyy, J. Y. J. & Liu, E., Aug 1 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 8, p. 1470-1481 12 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Apolipoproteins E
9 Citations (Scopus)

Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice

Jia, Y., Chang, H. C., Schipma, M. J., Liu, J., Shete, V., Liu, N., Sato, T., Thorp, E. B., Barger, P. M., Zhu, Y. J., Viswakarma, N., Kanwar, Y. S., Ardehali, H., Thimmapaya, B. & Reddy, J. K., Aug 2016, In : PloS one. 11, 8, e0160755.

Research output: Contribution to journalArticle

Mediator Complex Subunit 1
Dilated Cardiomyopathy
lethal genes

Overexpression of PPARγ induces adipogenic steatosis in mouse primary hepatocytes

Bai, L., Zhang, Y., Xie, C., Wang, R., Zhao, S., Jia, Y. & Liu, E., Jan 1 2016, In : Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 45, 1, p. 68-74 7 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Messenger RNA
Inbred C57BL Mouse