Grants per year
Personal profile
Research Interests
My research work is focused on studying the mechanisms that regulate the transcriptional activities of nuclear receptors. Nuclear receptors constitute a large superfamily of transcription factors that regulate a diverse array of biological processes, including development and neoplasia, as well as energy and xenobiotic metabolism. In order to initiate transcription, some more factors are required to interact with nuclear receptors and to regulate their activities. These factors are collectively called "nuclear receptor co-factors". Several co-factors have been identified by our studies. Generating mouse models using gene targeting technology to investigate the functions of these genes is in process.
Education/Academic qualification
Pathology, PhD, Nippon Medical School
… → 1997
MD, Medicine, Harbin Medical University
… → 1984
Research interests keywords
- Pathology
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Collaborations and top research areas from the last five years
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Clinical analysis and therapeutic development of exosomal ACE2
National Institute of Allergy and Infectious Diseases
7/15/22 → 6/30/27
Project: Research project
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Med1 in Liver Metabolism, Regeneration and Cancer
Thimmapaya, B., Jia, Y., Lukas, T. J., Reddy, J. K. & Zhu, Y.
National Institute of Diabetes and Digestive and Kidney Diseases
7/1/16 → 12/31/18
Project: Research project
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Med1 in Liver Metabolism, Regeneration and Cancer
Reddy, J. K., Jia, Y., Lukas, T. J., Thimmapaya, B. & Zhu, Y.
National Institute of Diabetes and Digestive and Kidney Diseases
7/1/13 → 6/30/16
Project: Research project
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Transcriptional Coactivators in Liver Function
Reddy, J. K., Jia, Y. & Jia, Y.
National Institute of Diabetes and Digestive and Kidney Diseases
5/1/09 → 4/30/15
Project: Research project
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Transcriptional Coactivators in Liver Function
Reddy, J. K. & Jia, Y.
National Institute of Diabetes and Digestive and Kidney Diseases
7/22/08 → 4/30/09
Project: Research project
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PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
Chen, H., Bai, Y., Kobayashi, M., Xiao, S., Cai, W., Barajas, S., Chen, S., Miao, J., Meke, F. N., Vemula, S., Ropa, J. P., Croop, J. M., Boswell, H. S., Wan, J., Jia, Y., Liu, H., Li, L. S., Altman, J. K., Eklund, E. A., Ji, P., & 6 others , Jan 19 2023, In: Blood. 141, 3, p. 244-259 16 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Unique molecular signatures sustained in circulating monocytes and regulatory T cells in convalescent COVID-19 patients
Hoffmann, A. D., Weinberg, S. E., Swaminathan, S., Chaudhuri, S., Almubarak, H. F., Schipma, M. J., Mao, C., Wang, X., El-Shennawy, L., Dashzeveg, N. K., Wei, J., Mehl, P. J., Shihadah, L. J., Wai, C. M., Ostiguin, C., Jia, Y., D'Amico, P., Wang, N. R., Luo, Y., Demonbreun, A. R., & 3 others , Jul 2023, In: Clinical Immunology. 252, 109634.Research output: Contribution to journal › Article › peer-review
Open Access -
Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2
El-Shennawy, L., Hoffmann, A. D., Dashzeveg, N. K., McAndrews, K. M., Mehl, P. J., Cornish, D., Yu, Z., Tokars, V. L., Nicolaescu, V., Tomatsidou, A., Mao, C., Felicelli, C. J., Tsai, C. F., Ostiguin, C., Jia, Y., Li, L., Furlong, K., Wysocki, J., Luo, X., Ruivo, C. F., & 16 others , Dec 2022, In: Nature communications. 13, 1, 405.Research output: Contribution to journal › Article › peer-review
Open Access62 Scopus citations -
EGFR inhibition blocks cancer stem cell clustering and lung metastasis of triple negative breast cancer
Liu, X., Adorno-Cruz, V., Chang, Y. F., Jia, Y., Kawaguchi, M., Dashzeveg, N. K., Taftaf, R., Ramos, E. K., Schuster, E. J., El-Shennawy, L., Patel, D., Zhang, Y., Cristofanilli, M. & Liu, H., 2021, In: Theranostics. 11, 13, p. 6632-6643 12 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Hsa-miR-637 inhibits human hepatocyte proliferation by targeting Med1-interacting proteins
Liu, J., Zhu, J., Zhang, X., Jia, Y., Lee, X. & Gao, Z., Jun 2021, In: Liver Research. 5, 2, p. 88-96 9 p.Research output: Contribution to journal › Article › peer-review
Open Access