Zdzislaw Wawrzak

  • 2925 Citations
1981 …2018
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Sterol 14-Demethylase Medicine & Life Sciences
Conformations Chemical Compounds
Crystal structure Chemical Compounds
scytalone dehydratase Medicine & Life Sciences
Steroids Medicine & Life Sciences
Catalytic Domain Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Progesterone Medicine & Life Sciences

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Grants 2007 2018

Research Output 1981 2018

  • 2925 Citations
  • 111 Article
  • 1 Comment/debate
1 Citation (Scopus)

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

Hargrove, T. Y., Wawrzak, Z., Fisher, P. M., Child, S. A., David Nes, W., Peter Guengerich, F., Waterman, M. R. & Lepesheva, G. I., Jan 1 2018, In : Journal of Biological Chemistry. 293, 50, p. 19344-19353 10 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Cytochrome P-450 Enzyme System
Sterols
Ligands
Catalysis
7 Citations (Scopus)

Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes

Gonzalez, E., Johnson, K. M., Pallan, P. S., Phan, T. T. N., Zhang, W., Lei, L., Wawrzak, Z., Yoshimoto, F. K., Egli, M. & Peter Guengerich, F., Jan 12 2018, In : Journal of Biological Chemistry. 293, 2, p. 541-556 16 p.

Research output: Contribution to journalArticle

Steroid 17-alpha-Hydroxylase
Lyases
Zebrafish
Cytochrome P-450 Enzyme System
Hydroxylation
7 Citations (Scopus)

Novel carbohydrate binding modules in the surface anchored α-amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the human gut

Cockburn, D. W., Suh, C., Medina, K. P., Duvall, R. M., Wawrzak, Z., Henrissat, B. & Koropatkin, N. M., Jan 1 2018, In : Molecular Microbiology. 107, 2, p. 249-264 16 p.

Research output: Contribution to journalArticle

Eubacterium
Amylases
Starch
Carbohydrates
Zea mays
5 Citations (Scopus)

Sterol 14α-Demethylase Structure-Based Design of VNI ((R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives to Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis

Friggeri, L., Hargrove, T. Y., Wawrzak, Z., Blobaum, A. L., Rachakonda, G., Lindsley, C. W., Villalta, F., Nes, W. D., Botta, M., Guengerich, F. P. & Lepesheva, G. I., Jul 12 2018, In : Journal of Medicinal Chemistry. 61, 13, p. 5679-5691 13 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Mycoses
Aspergillus fumigatus
14-alpha Demethylase Inhibitors
Pharmaceutical Preparations
1 Citation (Scopus)

Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress

Guerra, A. J., Zhang, O., Bahr, C. M. E., Huynh, M. H., DelProposto, J., Brown, W. C., Wawrzak, Z., Koropatkin, N. M. & Carruthers, V. B., Dec 1 2018, In : PLoS pathogens. 14, 12, e1007476.

Research output: Contribution to journalArticle

Tryptophan
Perforin
Membranes
Parasites
Clustered Regularly Interspaced Short Palindromic Repeats