Zdzislaw Wawrzak

  • 2946 Citations
1981 …2019
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Research Output 1981 2019

  • 2946 Citations
  • 112 Article
  • 1 Comment/debate
2019

Structural and biochemical characterization of 20-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis strain L2-32

Doden, H. L., Pollet, R. M., Mythen, S. M., Wawrzak, Z., Devendran, S., Cann, I., Koropatkin, N. M. & Ridlon, J. M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 32, p. 12040-12053 14 p.

Research output: Contribution to journalArticle

Open Access
20-Hydroxysteroid Dehydrogenases
Hydrocortisone
Androgens
Bacteria
Oxidoreductases
2018
1 Citation (Scopus)

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

Hargrove, T. Y., Wawrzak, Z., Fisher, P. M., Child, S. A., David Nes, W., Peter Guengerich, F., Waterman, M. R. & Lepesheva, G. I., Jan 1 2018, In : Journal of Biological Chemistry. 293, 50, p. 19344-19353 10 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Cytochrome P-450 Enzyme System
Sterols
Ligands
Catalysis
7 Citations (Scopus)

Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes

Gonzalez, E., Johnson, K. M., Pallan, P. S., Phan, T. T. N., Zhang, W., Lei, L., Wawrzak, Z., Yoshimoto, F. K., Egli, M. & Peter Guengerich, F., Jan 12 2018, In : Journal of Biological Chemistry. 293, 2, p. 541-556 16 p.

Research output: Contribution to journalArticle

Steroid 17-alpha-Hydroxylase
Lyases
Zebrafish
Cytochrome P-450 Enzyme System
Hydroxylation
7 Citations (Scopus)

Novel carbohydrate binding modules in the surface anchored α-amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the human gut

Cockburn, D. W., Suh, C., Medina, K. P., Duvall, R. M., Wawrzak, Z., Henrissat, B. & Koropatkin, N. M., Jan 1 2018, In : Molecular Microbiology. 107, 2, p. 249-264 16 p.

Research output: Contribution to journalArticle

Eubacterium
Amylases
Starch
Carbohydrates
Zea mays
6 Citations (Scopus)

Sterol 14α-Demethylase Structure-Based Design of VNI ((R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives to Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis

Friggeri, L., Hargrove, T. Y., Wawrzak, Z., Blobaum, A. L., Rachakonda, G., Lindsley, C. W., Villalta, F., Nes, W. D., Botta, M., Guengerich, F. P. & Lepesheva, G. I., Jul 12 2018, In : Journal of Medicinal Chemistry. 61, 13, p. 5679-5691 13 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Mycoses
Aspergillus fumigatus
14-alpha Demethylase Inhibitors
Pharmaceutical Preparations
2 Citations (Scopus)

Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress

Guerra, A. J., Zhang, O., Bahr, C. M. E., Huynh, M. H., DelProposto, J., Brown, W. C., Wawrzak, Z., Koropatkin, N. M. & Carruthers, V. B., Dec 1 2018, In : PLoS pathogens. 14, 12, e1007476.

Research output: Contribution to journalArticle

Tryptophan
Perforin
Membranes
Parasites
Clustered Regularly Interspaced Short Palindromic Repeats
5 Citations (Scopus)

Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis

Stogios, P. J., Cox, G., Zubyk, H. L., Evdokimova, E., Wawrzak, Z., Wright, G. D. & Savchenko, A., May 18 2018, In : ACS chemical biology. 13, 5, p. 1322-1332 11 p.

Research output: Contribution to journalArticle

Colistin
Moraxella (Branhamella) catarrhalis
Transferases
Substrates
Enzymes
2017
1 Citation (Scopus)

Biochemical and Structural Analyses of Two Cryptic Esterases in Bacteroides intestinalis and their Synergistic Activities with Cognate Xylanases

Wefers, D., Cavalcante, J. J. V., Schendel, R. R., Deveryshetty, J., Wang, K., Wawrzak, Z., Mackie, R. I., Koropatkin, N. M. & Cann, I., Aug 4 2017, In : Journal of Molecular Biology. 429, 16, p. 2509-2527 19 p.

Research output: Contribution to journalArticle

ferulic acid
Bacteroides
Esterases
Clostridium thermocellum
Bacteria
17 Citations (Scopus)

Crystal structure of the new investigational drug candidate VT-1598 in complex with Aspergillus fumigatus sterol 14α-demethylase provides insights into its broad-spectrum Antifungal Activity

Hargrove, T. Y., Garvey, E. P., Hoekstra, W. J., Yates, C. M., Wawrzak, Z., Rachakonda, G., Villalta, F. & Lepesheva, G. I., Jul 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 7, e00570-17.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Investigational Drugs
Aspergillus fumigatus
Antifungal Agents
Pharmaceutical Preparations
2 Citations (Scopus)

Retraction: Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus (Nature Communications (2016) 7 (11000) DOI: 10.1038/ncomms11000)

Ji, Q., Chen, P. J., Qin, G., Deng, X., Hao, Z., Wawrzak, Z., Yeo, W. S., Quang, J. W., Cho, H., Luo, G. Z., Weng, X., You, Q., Luan, C-H., Yang, X., Bae, T., Yu, K., Jiang, H. & He, C., Feb 6 2017, In : Nature communications. 8, 14331.

Research output: Contribution to journalComment/debate

Signal transduction
staphylococcus
Staphylococcus aureus
Signal Transduction
communication
43 Citations (Scopus)

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

Hargrove, T. Y., Friggeri, L., Wawrzak, Z., Qi, A., Hoekstra, W. J., Schotzinger, R. J., York, J. D., Peter Guengerich, F. & Lepesheva, G. I., Apr 21 2017, In : Journal of Biological Chemistry. 292, 16, p. 6728-6743 16 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Azoles
Candida
Biosynthesis
Sterols
2016
18 Citations (Scopus)

Clinical candidate VT-1161's antiparasitic effect in vitro, activity in a murine model of Chagas disease, and structural characterization in complex with the target enzyme CYP51 from Trypanosoma cruzi

Hoekstra, W. J., Hargrove, T. Y., Wawrzak, Z., Da Gama Jaen Batista, D., Da Silva, C. F., Nefertiti, A. S. G., Rachakonda, G., Schotzinger, R. J., Villalta, F., Soeiro, M. D. N. C. & Lepesheva, G. I., Feb 1 2016, In : Antimicrobial agents and chemotherapy. 60, 2, p. 1058-1066 9 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Antiparasitic Agents
Chagas Disease
Trypanosoma cruzi
Cytochrome P-450 Enzyme System
6 Citations (Scopus)

Crystal structure of nonphosphorylated receiver domain of the stress response regulator RcsB from Escherichia coli

Filippova, E. V., Wawrzak, Z., Ruan, J., Pshenychnyi, S., Schultz, R. M., Wolfe, A. J. & Anderson, W. F., Dec 1 2016, In : Protein Science. 25, 12, p. 2216-2224 9 p.

Research output: Contribution to journalArticle

Desiccation
Dimerization
Biofilms
Microbial Drug Resistance
Cell Division
7 Citations (Scopus)

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance

Filippova, E. V., Kieser, K. J., Luan, C-H., Wawrzak, Z., Kiryukhina, O., Rubin, E. J. & Anderson, W. F., Jun 1 2016, In : FEBS Journal. p. 2206-2218 13 p.

Research output: Contribution to journalArticle

Peptidyl Transferases
Penicillin-Binding Proteins
Microbial Drug Resistance
Mycobacterium tuberculosis
Penicillin V
16 Citations (Scopus)

Human sterol 14α-demethylase as a target for anticancer chemotherapy: Towards structure-aided drug design

Hargrove, T. Y., Friggeri, L., Wawrzak, Z., Sivakumaran, S., Yazlovitskaya, E. M., Hiebert, S. W., Guengerich, F. P., Waterman, M. R. & Lepesheva, G. I., Aug 1 2016, In : Journal of Lipid Research. 57, 8, p. 1552-1563 12 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Chemotherapy
Drug Design
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Drug Therapy
19 Citations (Scopus)

Molecular dissection of xyloglucan recognition in a prominent human gut symbiont

Tauzin, A. S., Kwiatkowski, K. J., Orlovsky, N. I., Smith, C. J., Creagh, A. L., Haynes, C. A., Wawrzak, Z., Brumer, H. & Koropatkin, N. M., Apr 26 2016, In : mBio. 7, 2, e02134-15.

Research output: Contribution to journalArticle

Polysaccharides
Dissection
Bacteroidetes
Carrier Proteins
Staphylococcal Protein A
13 Citations (Scopus)

Structural basis for sialoglycan binding by the streptococcus sanguinis SrpA adhesin

Bensing, B. A., Loukachevitch, L. V., Mcculloch, K. M., Yu, H., Vann, K. R., Wawrzak, Z., Anderson, S., Chen, X., Sullam, P. M. & Iverson, T. M., Apr 1 2016, In : Journal of Biological Chemistry. 291, 14, p. 7230-7240 11 p.

Research output: Contribution to journalArticle

Platelets
Streptococcus
Blood Platelets
Endocarditis
Ligands
13 Citations (Scopus)

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

Ji, Q., Chen, P. J., Qin, G., Deng, X., Hao, Z., Wawrzak, Z., Yeo, W. S., Quang, J. W., Cho, H., Luo, G. Z., Weng, X., You, Q., Luan, C. H., Yang, X., Bae, T., Yu, K., Jiang, H. & He, C., Mar 18 2016, In : Nature Communications. 7, 11000.

Research output: Contribution to journalArticle

Signal transduction
staphylococcus
Staphylococcus aureus
Signal Transduction
Phosphotransferases
8 Citations (Scopus)

The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity

June, C. M., Muckenthaler, T. J., Schroder, E. C., Klamer, Z. L., Wawrzak, Z., Powers, R. A., Szarecka, A. & Leonard, D. A., Dec 1 2016, In : Protein Science. 25, 12, p. 2152-2163 12 p.

Research output: Contribution to journalArticle

doripenem
Carbapenems
Substitution reactions
Acinetobacter baumannii
Catalytic Domain
2015
7 Citations (Scopus)

Kinetic and structural mechanisms of (5′S)-8,5′-cyclo-2′-deoxyguanosine-induced DNA replication stalling

Xu, W., Ouellette, A. M., Wawrzak, Z., Shriver, S. J., Anderson, S. M. & Zhao, L., Jan 27 2015, In : Biochemistry. 54, 3, p. 639-651 13 p.

Research output: Contribution to journalArticle

DNA Replication
Kinetics
DNA-Directed DNA Polymerase
DNA
Sulfolobus solfataricus
31 Citations (Scopus)

Structural and kinetic basis of steroid 17α,20-lyase activity in Teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2

Pallan, P. S., Nagy, L. D., Lei, L., Gonzalez, E., Kramlinger, V. M., Azumaya, C. M., Wawrzak, Z., Waterman, M. R., Guengerich, F. P. & Egli, M., Feb 6 2015, In : Journal of Biological Chemistry. 290, 6, p. 3248-3268 21 p.

Research output: Contribution to journalArticle

Steroid 17-alpha-Hydroxylase
Lyases
Pregnenolone
Fish
Cytochrome P-450 Enzyme System
57 Citations (Scopus)

Structure-functional characterization of cytochrome P450 Sterol 14α-Demethylase (CYP51B) from aspergillus fumigatus and molecular basis for the development of antifungal drugs

Hargrove, T. Y., Wawrzak, Z., Lamb, D. C., Guengerich, F. P. & Lepesheva, G. I., Sep 25 2015, In : Journal of Biological Chemistry. 290, 39, p. 23916-23934 19 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Aspergillus fumigatus
Aspergillus
Cytochrome P-450 Enzyme System
Pharmaceutical Preparations
37 Citations (Scopus)

VFV as a new effective CYP51 structure-derived drug candidate for chagas disease and visceral leishmaniasis

Lepesheva, G. I., Hargrove, T. Y., Rachakonda, G., Wawrzak, Z., Pomel, S., Cojean, S., Nde, P. N., Nes, W. D., Locuson, C. W., Calcutt, M. W., Waterman, M. R., Daniels, J. S., Loiseau, P. M. & Villalta, F., Nov 1 2015, In : Journal of Infectious Diseases. 212, 9, p. 1439-1448 10 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Chagas Disease
14-alpha Demethylase Inhibitors
Sterol 14-Demethylase
Trypanosomatina
9 Citations (Scopus)

X-ray Crystal Structure of Divalent Metal-Activated β-xylosidase, RS223BX

Jordan, D. B., Braker, J. D., Wagschal, K., Lee, C. C., Chan, V. J., Dubrovska, I., Anderson, S. M. & Wawrzak, Z., Oct 30 2015, In : Applied Biochemistry and Biotechnology. 177, 3, p. 637-648 12 p.

Research output: Contribution to journalArticle

Xylosidases
Cations
Catalytic Domain
Crystal structure
Positive ions
2014
23 Citations (Scopus)

Structural basis for rational design of inhibitors targeting Trypanosoma cruzi Sterol 14α-demethylase: Two regions of the enzyme molecule potentiate its inhibition

Friggeri, L., Hargrove, T. Y., Rachakonda, G., Williams, A. D., Wawrzak, Z., Di Santo, R., De Vita, D., Waterman, M. R., Tortorella, S., Villalta, F. & Lepesheva, G. I., Aug 14 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6704-6717 14 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Trypanosoma cruzi
Antiparasitic Agents
14-alpha Demethylase Inhibitors
Enzymes
5 Citations (Scopus)

Type III effector NleH2 from Escherichia coli O157:H7 str. Sakai features an atypical protein kinase domain

Halavaty, A. S., Anderson, S. M., Wawrzak, Z., Kudritska, M., Skarina, T., Anderson, W. F. & Savchenko, A., Apr 22 2014, In : Biochemistry. 53, 15, p. 2433-2435 3 p.

Research output: Contribution to journalArticle

Enterohemorrhagic Escherichia coli
Escherichia coli O157
Dimerization
Glycine
Protein Kinases
2013
55 Citations (Scopus)

Antitrypanosomal lead discovery: Identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth

Andriani, G., Amata, E., Beatty, J., Clements, Z., Coffey, B. J., Courtemanche, G., Devine, W., Erath, J., Juda, C. E., Wawrzak, Z., Wood, J. T., Lepesheva, G. I., Rodriguez, A. & Pollastri, M. P., Mar 28 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2556-2567 12 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
14-alpha Demethylase Inhibitors
Parasites
Ligands
Chagas Disease
51 Citations (Scopus)

Complexes of trypanosoma cruzi Sterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: Structural basis for pathogen selectivity

Hargrove, T. Y., Wawrzak, Z., Alexander, P. W., Chaplin, J. H., Keenan, M., Charman, S. A., Perez, C. J., Waterman, M. R., Chatelain, E. & Lepesheva, G. I., Nov 1 2013, In : Journal of Biological Chemistry. 288, 44, p. 31602-31615 14 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Chagas Disease
Trypanosoma cruzi
Pathogens
Pharmaceutical Preparations
12 Citations (Scopus)

Recognition of O6-benzyl-2′-deoxyguanosine by a perimidinone-derived synthetic nucleoside: A DNA interstrand stacking interaction

Kowal, E. A., Lad, R. R., Pallan, P. S., Dhummakupt, E., Wawrzak, Z., Egli, M., Sturla, S. J. & Stone, M. P., Aug 1 2013, In : Nucleic acids research. 41, 15, p. 7566-7576 11 p.

Research output: Contribution to journalArticle

Deoxyguanosine
Nucleosides
DNA
Cytosine
Guanine
12 Citations (Scopus)

Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium

Zheng, H., Beliavsky, A., Tchigvintsev, A., Brunzelle, J. S., Brown, G., Flick, R., Evdokimova, E., Wawrzak, Z., Mahadevan, R., Anderson, W. F., Savchenko, A. & Yakunin, A. F., Jun 1 2013, In : Proteins: Structure, Function and Bioinformatics. 81, 6, p. 1031-1041 11 p.

Research output: Contribution to journalArticle

Succinate-Semialdehyde Dehydrogenase (NADP+)
Succinate-Semialdehyde Dehydrogenase
Salmonella
Salmonella typhimurium
NAD
2012
14 Citations (Scopus)

Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases

Zhao, L., Pence, M. G., Christov, P. P., Wawrzak, Z., Choi, J. Y., Rizzo, C. J., Egli, M. & Guengerich, F. P., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35516-35526 11 p.

Research output: Contribution to journalArticle

DNA Adducts
DNA-Directed DNA Polymerase
Base Pairing
Crystal structure
Vinyl Chloride
3 Citations (Scopus)

Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni

Zheng, H., Filippova, E. V., Tkaczuk, K. L., Dworzynski, P., Chruszcz, M., Porebski, P. J., Wawrzak, Z., Onopriyenko, O., Kudritska, M., Grimshaw, S., Savchenko, A., Anderson, W. F. & Minor, W., Mar 1 2012, In : Journal of Structural and Functional Genomics. 13, 1, p. 15-26 12 p.

Research output: Contribution to journalArticle

Phosphoglycerate Kinase
Crystal structure
Bacillus anthracis
Campylobacter jejuni
Bacilli
31 Citations (Scopus)

Molecular engineering of nanoscale order in organic electro-optic glasses

Hammond, S. R., Sinness, J., Dubbury, S., Firestone, K. A., Benedict, J. B., Wawrzak, Z., Clot, O., Reid, P. J. & Dalton, L. R., Apr 14 2012, In : Journal of Materials Chemistry. 22, 14, p. 6752-6764 13 p.

Research output: Contribution to journalArticle

Electrooptical effects
Glass
X ray diffraction
Thin films
Crystallography
47 Citations (Scopus)

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol

Hargrove, T. Y., Wawrzak, Z., Liu, J., Waterman, M. R., David Nes, W. & Lepesheva, G. I., Feb 1 2012, In : Journal of Lipid Research. 53, 2, p. 311-320 10 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Sterols
Azoles
Substrates
Leishmania infantum
2011
19 Citations (Scopus)

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: Crystallographic study of MDR769 HIV-1 protease variants

Yedidi, R. S., Proteasa, G., Martinez, J. L., Vickrey, J. F., Martin, P. D., Wawrzak, Z., Liu, Z., Kovari, I. A. & Kovari, L. C., Jun 1 2011, In : Acta Crystallographica Section D: Biological Crystallography. 67, 6, p. 524-532 9 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Mutation
Protease Inhibitors
Static Electricity
Drug Resistance
64 Citations (Scopus)

Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14α-demethylase (CYP51) from Leishmania infantum

Hargrove, T. Y., Wawrzak, Z., Liu, J., Nes, W. D., Waterman, M. R. & Lepesheva, G. I., Jul 29 2011, In : Journal of Biological Chemistry. 286, 30, p. 26838-26848 11 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Leishmania infantum
Sterols
Substrates
Lanosterol
2010
94 Citations (Scopus)

Crystal structures of Trypanosoma brucei sterol 14α-demethylase and implications for selective treatment of human infections

Lepesheva, G. I., Park, H. W., Hargrove, T. Y., Vanhollebeke, B., Wawrzak, Z., Harp, J. M., Sundaramoorthy, M., Nes, W. D., Pays, E., Chaudhuri, M., Villalta, F. & Waterman, M. R., Jan 15 2010, In : Journal of Biological Chemistry. 285, 3, p. 1773-1780 8 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Antiparasitic Agents
Trypanosoma brucei brucei
Biosynthesis
Pathogens
105 Citations (Scopus)

Structural insights into inhibition of sterol 14α-demethylase in the human pathogen Trypanosoma cruzi

Lepesheva, G. I., Hargrove, T. Y., Anderson, S. M., Kleshchenko, Y., Furtak, V., Wawrzak, Z., Villalta, F. & Waterman, M. R., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25582-25590 9 p.

Research output: Contribution to journalArticle

Sterol 14-Demethylase
Trypanosoma cruzi
Pathogens
Chagas Disease
Pharmaceutical Preparations
8 Citations (Scopus)

The first crystal structure of a gramicidin complex with sodium: High-resolution study of a nonstoichiometric gramicidin D-NaI complex

Olczak, A., Główka, M. L., Szczesio, M., Bojarska, J., Wawrzak, Z. & Duax, W. L., Aug 1 2010, In : Acta Crystallographica Section D: Biological Crystallography. 66, 8, p. 874-880 7 p.

Research output: Contribution to journalArticle

Gramicidin
Sodium
Ions
Rubidium
Alkali Metals
2008
24 Citations (Scopus)

Crystal structure of tricyclo-DNA: An unusual compensatory change of two adjacent backbone torsion angles

Pallan, P. S., Ittig, D., Héroux, A., Wawrzak, Z., Leumann, C. J. & Egli, M., Feb 11 2008, In : Chemical Communications. 7, p. 883-885 3 p.

Research output: Contribution to journalArticle

Torsional stress
DNA
Crystal structure
RNA
14 Citations (Scopus)

Structure and DNA binding of alkylation response protein AidB

Bowles, T., Metz, A. H., O'Quin, J., Wawrzak, Z. & Eichman, B. F., Oct 7 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 40, p. 15299-15304 6 p.

Research output: Contribution to journalArticle

Flavin-Adenine Dinucleotide
Alkylating Agents
Alkylation
DNA Repair
DNA Mutational Analysis
39 Citations (Scopus)

Structure of the two-subsite β-d-xylosidase from Selenomonas ruminantium in complex with 1,3-bis[tris(hydroxymethyl)methylamino]propane

Brunzelle, J. S., Jordan, D. B., McCaslin, D. R., Olczak, A. & Wawrzak, Z., Jun 1 2008, In : Archives of biochemistry and biophysics. 474, 1, p. 157-166 10 p.

Research output: Contribution to journalArticle

Selenomonas
Xylosidases
Dimers
Extremities
X Ray Crystallography
2007
20 Citations (Scopus)

A convergent coordination chemistry-based approach to dissymmetric macrocyclic cofacial porphyrin complexes

Oliveri, C. G., Heo, J., Nguyen, S., Mirkin, C. A. & Wawrzak, Z., Sep 17 2007, In : Inorganic Chemistry. 46, 19, p. 7716-7718 3 p.

Research output: Contribution to journalArticle

Porphyrins
porphyrins
chemistry
synthesis
stimuli
8 Citations (Scopus)

Nonstoichiometric complex of gramicidin D with KI at 0.80 Å resolution

Olczak, A., Główka, M. L., Szczesio, M., Bojarska, J., Duax, W. L., Burkhart, B. M. & Wawrzak, Z., Feb 21 2007, In : Acta Crystallographica Section D: Biological Crystallography. 63, 3, p. 319-327 9 p.

Research output: Contribution to journalArticle

Gramicidin
Cations
Iodides
Synchrotrons
R Factors
2006
30 Citations (Scopus)

2′-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H

Li, F., Sarkhel, S., Wilds, C. J., Wawrzak, Z., Prakash, T. P., Manoharan, M. & Egli, M., Apr 4 2006, In : Biochemistry. 45, 13, p. 4141-4152 12 p.

Research output: Contribution to journalArticle

Ribonuclease H
Conformations
RNA
Acids
Processing
8 Citations (Scopus)
Acetone
Lithium
Dimers
acetone
lithium
94 Citations (Scopus)

Supramolecular allosteric cofacial porphyrin complexes

Oliveri, C. G., Gianneschi, N., Nguyen, S., Mirkin, C. A., Stern, C. L., Wawrzak, Z. & Pink, M., Dec 20 2006, In : Journal of the American Chemical Society. 128, 50, p. 16286-16296 11 p.

Research output: Contribution to journalArticle

phosphine
Porphyrins
Nicotinyl Alcohol
Ligands
Metals
2005
38 Citations (Scopus)

Crystal structure of a luteoviral RNA pseudoknot and model for a minimal ribosomal frameshifting motif

Pallan, P. S., Marshall, W. S., Harp, J., Jewett, F. C., Wawrzak, Z., Brown, B. A., Rich, A. & Egli, M., Aug 30 2005, In : Biochemistry. 44, 34, p. 11315-11322 8 p.

Research output: Contribution to journalArticle

Ribosomal Frameshifting
Solanum tuberosum
Viruses
Crystal structure
RNA
7 Citations (Scopus)

Structure of gramicidin D-RbCl complex at atomic resolution from low-temperature synchrotron data: Interactions of double-stranded gramicidin channel contents and cations with channel wall

Głowka, M. L., Olczak, A., Bojarska, J., Szczesio, M., Duax, W. L., Burkhart, B. M., Pangborn, W. A., Langs, D. A. & Wawrzak, Z., Apr 1 2005, In : Acta Crystallographica Section D: Biological Crystallography. 61, 4, p. 433-441 9 p.

Research output: Contribution to journalArticle

Gramicidin
Synchrotrons
Cations
Temperature
Rubidium
71 Citations (Scopus)

"Wide-open" 1.3 Å structure of a multidrug-resistant HIV-1 protease as a drug target

Martin, P., Vickrey, J. F., Proteasa, G., Jimenez, Y. L., Wawrzak, Z., Winters, M. A., Merigan, T. C. & Kovari, L. C., Dec 1 2005, In : Structure. 13, 12, p. 1887-1895 9 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Mutation
Pharmaceutical Preparations
Protease Inhibitors
Codon