Zdzislaw Wawrzak

  • 3142 Citations
1981 …2020

Research output per year

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Research Output

  • 3142 Citations
  • 114 Article
  • 1 Comment/debate
2020

A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid

Zhu, W., Doubleday, P. F., Catlin, D. S., Weerawarna, P. M., Butrin, A., Shen, S., Wawrzak, Z., Kelleher, N. L., Liu, D. & Silverman, R. B., Mar 11 2020, In : Journal of the American Chemical Society. 142, 10, p. 4892-4903 12 p.

Research output: Contribution to journalArticle

Structure of galactarate dehydratase, a new fold in an enolase involved in bacterial fitness after antibiotic treatment

Rosas-Lemus, M., Minasov, G., Shuvalova, L., Wawrzak, Z., Kiryukhina, O., Mih, N., Jaroszewski, L., Palsson, B., Godzik, A. & Satchell, K. J. F., Mar 1 2020, In : Protein Science. 29, 3, p. 711-722 12 p.

Research output: Contribution to journalArticle

2019

Structural and biochemical characterization of 20-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis strain L2-32

Doden, H. L., Pollet, R. M., Mythen, S. M., Wawrzak, Z., Devendran, S., Cann, I., Koropatkin, N. M. & Ridlon, J. M., Jan 1 2019, In : Journal of Biological Chemistry. 294, 32, p. 12040-12053 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors

Friggeri, L., Hargrove, T. Y., Wawrzak, Z., Guengerich, F. P. & Lepesheva, G. I., Nov 27 2019, In : Journal of Medicinal Chemistry. 62, 22, p. 10391-10401 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

Hargrove, T. Y., Wawrzak, Z., Fisher, P. M., Child, S. A., David Nes, W., Peter Guengerich, F., Waterman, M. R. & Lepesheva, G. I., Jan 1 2018, In : Journal of Biological Chemistry. 293, 50, p. 19344-19353 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes

Gonzalez, E., Johnson, K. M., Pallan, P. S., Phan, T. T. N., Zhang, W., Lei, L., Wawrzak, Z., Yoshimoto, F. K., Egli, M. & Peter Guengerich, F., Jan 12 2018, In : Journal of Biological Chemistry. 293, 2, p. 541-556 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Novel carbohydrate binding modules in the surface anchored α-amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the human gut

Cockburn, D. W., Suh, C., Medina, K. P., Duvall, R. M., Wawrzak, Z., Henrissat, B. & Koropatkin, N. M., Jan 2018, In : Molecular Microbiology. 107, 2, p. 249-264 16 p.

Research output: Contribution to journalArticle

16 Scopus citations

Sterol 14α-Demethylase Structure-Based Design of VNI ((R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives to Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis

Friggeri, L., Hargrove, T. Y., Wawrzak, Z., Blobaum, A. L., Rachakonda, G., Lindsley, C. W., Villalta, F., Nes, W. D., Botta, M., Guengerich, F. P. & Lepesheva, G. I., Jul 12 2018, In : Journal of Medicinal Chemistry. 61, 13, p. 5679-5691 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress

Guerra, A. J., Zhang, O., Bahr, C. M. E., Huynh, M. H., DelProposto, J., Brown, W. C., Wawrzak, Z., Koropatkin, N. M. & Carruthers, V. B., Dec 2018, In : PLoS pathogens. 14, 12, e1007476.

Research output: Contribution to journalArticle

3 Scopus citations

Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis

Stogios, P. J., Cox, G., Zubyk, H. L., Evdokimova, E., Wawrzak, Z., Wright, G. D. & Savchenko, A., May 18 2018, In : ACS chemical biology. 13, 5, p. 1322-1332 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Biochemical and Structural Analyses of Two Cryptic Esterases in Bacteroides intestinalis and their Synergistic Activities with Cognate Xylanases

Wefers, D., Cavalcante, J. J. V., Schendel, R. R., Deveryshetty, J., Wang, K., Wawrzak, Z., Mackie, R. I., Koropatkin, N. M. & Cann, I., Aug 4 2017, In : Journal of Molecular Biology. 429, 16, p. 2509-2527 19 p.

Research output: Contribution to journalArticle

5 Scopus citations

Crystal structure of the new investigational drug candidate VT-1598 in complex with Aspergillus fumigatus sterol 14α-demethylase provides insights into its broad-spectrum Antifungal Activity

Hargrove, T. Y., Garvey, E. P., Hoekstra, W. J., Yates, C. M., Wawrzak, Z., Rachakonda, G., Villalta, F. & Lepesheva, G. I., Jul 2017, In : Antimicrobial agents and chemotherapy. 61, 7, e00570-17.

Research output: Contribution to journalArticle

25 Scopus citations

Retraction: Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus (Nature Communications (2016) 7 (11000) DOI: 10.1038/ncomms11000)

Ji, Q., Chen, P. J., Qin, G., Deng, X., Hao, Z., Wawrzak, Z., Yeo, W. S., Quang, J. W., Cho, H., Luo, G. Z., Weng, X., You, Q., Luan, C. H., Yang, X., Bae, T., Yu, K., Jiang, H. & He, C., Feb 6 2017, In : Nature communications. 8, 14331.

Research output: Contribution to journalComment/debate

2 Scopus citations

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

Hargrove, T. Y., Friggeri, L., Wawrzak, Z., Qi, A., Hoekstra, W. J., Schotzinger, R. J., York, J. D., Peter Guengerich, F. & Lepesheva, G. I., Apr 21 2017, In : Journal of Biological Chemistry. 292, 16, p. 6728-6743 16 p.

Research output: Contribution to journalArticle

68 Scopus citations
2016

Clinical candidate VT-1161's antiparasitic effect in vitro, activity in a murine model of Chagas disease, and structural characterization in complex with the target enzyme CYP51 from Trypanosoma cruzi

Hoekstra, W. J., Hargrove, T. Y., Wawrzak, Z., Da Gama Jaen Batista, D., Da Silva, C. F., Nefertiti, A. S. G., Rachakonda, G., Schotzinger, R. J., Villalta, F., Soeiro, M. D. N. C. & Lepesheva, G. I., Feb 2016, In : Antimicrobial agents and chemotherapy. 60, 2, p. 1058-1066 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Crystal structure of nonphosphorylated receiver domain of the stress response regulator RcsB from Escherichia coli

Filippova, E. V., Wawrzak, Z., Ruan, J., Pshenychnyi, S., Schultz, R. M., Wolfe, A. J. & Anderson, W. F., Dec 1 2016, In : Protein Science. 25, 12, p. 2216-2224 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance

Filippova, E. V., Kieser, K. J., Luan, C. H., Wawrzak, Z., Kiryukhina, O., Rubin, E. J. & Anderson, W. F., Jun 1 2016, In : FEBS Journal. p. 2206-2218 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Human sterol 14α-demethylase as a target for anticancer chemotherapy: Towards structure-aided drug design

Hargrove, T. Y., Friggeri, L., Wawrzak, Z., Sivakumaran, S., Yazlovitskaya, E. M., Hiebert, S. W., Guengerich, F. P., Waterman, M. R. & Lepesheva, G. I., Aug 2016, In : Journal of lipid research. 57, 8, p. 1552-1563 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Molecular dissection of xyloglucan recognition in a prominent human gut symbiont

Tauzin, A. S., Kwiatkowski, K. J., Orlovsky, N. I., Smith, C. J., Creagh, A. L., Haynes, C. A., Wawrzak, Z., Brumer, H. & Koropatkin, N. M., Apr 26 2016, In : mBio. 7, 2, e02134-15.

Research output: Contribution to journalArticle

27 Scopus citations

Structural basis for sialoglycan binding by the streptococcus sanguinis SrpA adhesin

Bensing, B. A., Loukachevitch, L. V., Mcculloch, K. M., Yu, H., Vann, K. R., Wawrzak, Z., Anderson, S., Chen, X., Sullam, P. M. & Iverson, T. M., Apr 1 2016, In : Journal of Biological Chemistry. 291, 14, p. 7230-7240 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

Ji, Q., Chen, P. J., Qin, G., Deng, X., Hao, Z., Wawrzak, Z., Yeo, W. S., Quang, J. W., Cho, H., Luo, G. Z., Weng, X., You, Q., Luan, C. H., Yang, X., Bae, T., Yu, K., Jiang, H. & He, C., Mar 18 2016, In : Nature Communications. 7, 11000.

Research output: Contribution to journalArticle

13 Scopus citations

The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity

June, C. M., Muckenthaler, T. J., Schroder, E. C., Klamer, Z. L., Wawrzak, Z., Powers, R. A., Szarecka, A. & Leonard, D. A., Dec 1 2016, In : Protein Science. 25, 12, p. 2152-2163 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Kinetic and structural mechanisms of (5′S)-8,5′-cyclo-2′-deoxyguanosine-induced DNA replication stalling

Xu, W., Ouellette, A. M., Wawrzak, Z., Shriver, S. J., Anderson, S. M. & Zhao, L., Jan 27 2015, In : Biochemistry. 54, 3, p. 639-651 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Structural and kinetic basis of steroid 17α,20-lyase activity in Teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2

Pallan, P. S., Nagy, L. D., Lei, L., Gonzalez, E., Kramlinger, V. M., Azumaya, C. M., Wawrzak, Z., Waterman, M. R., Guengerich, F. P. & Egli, M., Feb 6 2015, In : Journal of Biological Chemistry. 290, 6, p. 3248-3268 21 p.

Research output: Contribution to journalArticle

32 Scopus citations

Structure-functional characterization of cytochrome P450 Sterol 14α-Demethylase (CYP51B) from aspergillus fumigatus and molecular basis for the development of antifungal drugs

Hargrove, T. Y., Wawrzak, Z., Lamb, D. C., Guengerich, F. P. & Lepesheva, G. I., Sep 25 2015, In : Journal of Biological Chemistry. 290, 39, p. 23916-23934 19 p.

Research output: Contribution to journalArticle

64 Scopus citations

VFV as a new effective CYP51 structure-derived drug candidate for chagas disease and visceral leishmaniasis

Lepesheva, G. I., Hargrove, T. Y., Rachakonda, G., Wawrzak, Z., Pomel, S., Cojean, S., Nde, P. N., Nes, W. D., Locuson, C. W., Calcutt, M. W., Waterman, M. R., Daniels, J. S., Loiseau, P. M. & Villalta, F., Nov 1 2015, In : Journal of Infectious Diseases. 212, 9, p. 1439-1448 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

X-ray Crystal Structure of Divalent Metal-Activated β-xylosidase, RS223BX

Jordan, D. B., Braker, J. D., Wagschal, K., Lee, C. C., Chan, V. J., Dubrovska, I., Anderson, S. M. & Wawrzak, Z., Oct 30 2015, In : Applied Biochemistry and Biotechnology. 177, 3, p. 637-648 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Structural basis for rational design of inhibitors targeting Trypanosoma cruzi Sterol 14α-demethylase: Two regions of the enzyme molecule potentiate its inhibition

Friggeri, L., Hargrove, T. Y., Rachakonda, G., Williams, A. D., Wawrzak, Z., Di Santo, R., De Vita, D., Waterman, M. R., Tortorella, S., Villalta, F. & Lepesheva, G. I., Aug 14 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6704-6717 14 p.

Research output: Contribution to journalArticle

26 Scopus citations

Type III effector NleH2 from Escherichia coli O157:H7 str. Sakai features an atypical protein kinase domain

Halavaty, A. S., Anderson, S. M., Wawrzak, Z., Kudritska, M., Skarina, T., Anderson, W. F. & Savchenko, A., Apr 22 2014, In : Biochemistry. 53, 15, p. 2433-2435 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Antitrypanosomal lead discovery: Identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth

Andriani, G., Amata, E., Beatty, J., Clements, Z., Coffey, B. J., Courtemanche, G., Devine, W., Erath, J., Juda, C. E., Wawrzak, Z., Wood, J. T., Lepesheva, G. I., Rodriguez, A. & Pollastri, M. P., Mar 28 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2556-2567 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Complexes of trypanosoma cruzi Sterol 14α-Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: Structural basis for pathogen selectivity

Hargrove, T. Y., Wawrzak, Z., Alexander, P. W., Chaplin, J. H., Keenan, M., Charman, S. A., Perez, C. J., Waterman, M. R., Chatelain, E. & Lepesheva, G. I., Nov 1 2013, In : Journal of Biological Chemistry. 288, 44, p. 31602-31615 14 p.

Research output: Contribution to journalArticle

55 Scopus citations

Recognition of O6-benzyl-2′-deoxyguanosine by a perimidinone-derived synthetic nucleoside: A DNA interstrand stacking interaction

Kowal, E. A., Lad, R. R., Pallan, P. S., Dhummakupt, E., Wawrzak, Z., Egli, M., Sturla, S. J. & Stone, M. P., Aug 1 2013, In : Nucleic acids research. 41, 15, p. 7566-7576 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium

Zheng, H., Beliavsky, A., Tchigvintsev, A., Brunzelle, J. S., Brown, G., Flick, R., Evdokimova, E., Wawrzak, Z., Mahadevan, R., Anderson, W. F., Savchenko, A. & Yakunin, A. F., Jun 1 2013, In : Proteins: Structure, Function and Bioinformatics. 81, 6, p. 1031-1041 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012

Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases

Zhao, L., Pence, M. G., Christov, P. P., Wawrzak, Z., Choi, J. Y., Rizzo, C. J., Egli, M. & Guengerich, F. P., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35516-35526 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni

Zheng, H., Filippova, E. V., Tkaczuk, K. L., Dworzynski, P., Chruszcz, M., Porebski, P. J., Wawrzak, Z., Onopriyenko, O., Kudritska, M., Grimshaw, S., Savchenko, A., Anderson, W. F. & Minor, W., Mar 1 2012, In : Journal of Structural and Functional Genomics. 13, 1, p. 15-26 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Molecular engineering of nanoscale order in organic electro-optic glasses

Hammond, S. R., Sinness, J., Dubbury, S., Firestone, K. A., Benedict, J. B., Wawrzak, Z., Clot, O., Reid, P. J. & Dalton, L. R., Apr 14 2012, In : Journal of Materials Chemistry. 22, 14, p. 6752-6764 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol

Hargrove, T. Y., Wawrzak, Z., Liu, J., Waterman, M. R., David Nes, W. & Lepesheva, G. I., Feb 1 2012, In : Journal of lipid research. 53, 2, p. 311-320 10 p.

Research output: Contribution to journalArticle

53 Scopus citations
2011

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: Crystallographic study of MDR769 HIV-1 protease variants

Yedidi, R. S., Proteasa, G., Martinez, J. L., Vickrey, J. F., Martin, P. D., Wawrzak, Z., Liu, Z., Kovari, I. A. & Kovari, L. C., Jun 1 2011, In : Acta Crystallographica Section D: Biological Crystallography. 67, 6, p. 524-532 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14α-demethylase (CYP51) from Leishmania infantum

Hargrove, T. Y., Wawrzak, Z., Liu, J., Nes, W. D., Waterman, M. R. & Lepesheva, G. I., Jul 29 2011, In : Journal of Biological Chemistry. 286, 30, p. 26838-26848 11 p.

Research output: Contribution to journalArticle

65 Scopus citations
2010

Crystal structures of Trypanosoma brucei sterol 14α-demethylase and implications for selective treatment of human infections

Lepesheva, G. I., Park, H. W., Hargrove, T. Y., Vanhollebeke, B., Wawrzak, Z., Harp, J. M., Sundaramoorthy, M., Nes, W. D., Pays, E., Chaudhuri, M., Villalta, F. & Waterman, M. R., Jan 15 2010, In : Journal of Biological Chemistry. 285, 3, p. 1773-1780 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Structural insights into inhibition of sterol 14α-demethylase in the human pathogen Trypanosoma cruzi

Lepesheva, G. I., Hargrove, T. Y., Anderson, S., Kleshchenko, Y., Furtak, V., Wawrzak, Z., Villalta, F. & Waterman, M. R., Aug 13 2010, In : Journal of Biological Chemistry. 285, 33, p. 25582-25590 9 p.

Research output: Contribution to journalArticle

112 Scopus citations

The first crystal structure of a gramicidin complex with sodium: High-resolution study of a nonstoichiometric gramicidin D-NaI complex

Olczak, A., Główka, M. L., Szczesio, M., Bojarska, J., Wawrzak, Z. & Duax, W. L., Aug 1 2010, In : Acta Crystallographica Section D: Biological Crystallography. 66, 8, p. 874-880 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2008

Crystal structure of tricyclo-DNA: An unusual compensatory change of two adjacent backbone torsion angles

Pallan, P. S., Ittig, D., Héroux, A., Wawrzak, Z., Leumann, C. J. & Egli, M., Feb 11 2008, In : Chemical Communications. 7, p. 883-885 3 p.

Research output: Contribution to journalArticle

27 Scopus citations

Structure and DNA binding of alkylation response protein AidB

Bowles, T., Metz, A. H., O'Quin, J., Wawrzak, Z. & Eichman, B. F., Oct 7 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 40, p. 15299-15304 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Structure of the two-subsite β-d-xylosidase from Selenomonas ruminantium in complex with 1,3-bis[tris(hydroxymethyl)methylamino]propane

Brunzelle, J. S., Jordan, D. B., McCaslin, D. R., Olczak, A. & Wawrzak, Z., Jun 1 2008, In : Archives of biochemistry and biophysics. 474, 1, p. 157-166 10 p.

Research output: Contribution to journalArticle

43 Scopus citations
2007

A convergent coordination chemistry-based approach to dissymmetric macrocyclic cofacial porphyrin complexes

Oliveri, C. G., Heo, J., Nguyen, S. B. T., Mirkin, C. A. & Wawrzak, Z., Sep 17 2007, In : Inorganic chemistry. 46, 19, p. 7716-7718 3 p.

Research output: Contribution to journalArticle

21 Scopus citations

Nonstoichiometric complex of gramicidin D with KI at 0.80 Å resolution

Olczak, A., Główka, M. L., Szczesio, M., Bojarska, J., Duax, W. L., Burkhart, B. M. & Wawrzak, Z., Feb 21 2007, In : Acta Crystallographica Section D: Biological Crystallography. 63, 3, p. 319-327 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2006

2′-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H

Li, F., Sarkhel, S., Wilds, C. J., Wawrzak, Z., Prakash, T. P., Manoharan, M. & Egli, M., Apr 4 2006, In : Biochemistry. 45, 13, p. 4141-4152 12 p.

Research output: Contribution to journalArticle

33 Scopus citations
8 Scopus citations

Supramolecular allosteric cofacial porphyrin complexes

Oliveri, C. G., Gianneschi, N. C., Nguyen, S. B. T., Mirkin, C. A., Stern, C. L., Wawrzak, Z. & Pink, M., Dec 20 2006, In : Journal of the American Chemical Society. 128, 50, p. 16286-16296 11 p.

Research output: Contribution to journalArticle

106 Scopus citations