Grants per year
Personal profile
Research Interests
Our group uses high-throughput genomic technologies and computational modeling to examine the regulation of gene transcription and RNA translation underlying oncogenic processes. We aim at revealing novel cancer therapeutic strategies for precision medicine and immunotherapy.
Research Interests
We use high-throughput genomic technologies and computational modeling to study the regulation of gene transcription and RNA translation underlying oncogenic processes. We aim at revealing novel cancer therapeutic strategies for precision medicine and immunotherapy.
Training Experience
| 2017 | Postdoctoral Fellowship, Harvard Medical School |
| 2017 | Postdoctoral Fellowship, Broad Institute of MIT and Harvard |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Computational Genomics, PhD, Rutgers University
… → 2012
Computational Genomics, PhD, Rutgers University.
… → 2012
Research interests keywords
- Bioinformatics
- Cancer Biology
- Computational Biology
- Gene Regulation
- Genomic Medicine/Personalized Medicine
- Genomics
- Inflammation
- Molecular Biology
- Pharmacogenomics
- Systems Biology
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Phenotypic marker-guided development of selective antimetastasis therapeutic leads
Huang, S., Ji, Z., Mendillo, M. L. & Qiang, W.
7/1/22 → 6/30/27
Project: Research project
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An ultra-low-input RNase footprinting assay to quantify cytosolic and mitochondrial translation simultaneously
National Heart, Lung, and Blood Institute
1/17/22 → 12/31/25
Project: Research project
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Mosquito LV Purchase Subproject for SP0057518
National Institute of General Medical Sciences
8/1/20 → 5/31/25
Project: Research project
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Characterizing functional translation in putative 'noncoding' regions of a genome
National Institute of General Medical Sciences
8/1/20 → 5/31/25
Project: Research project
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Dissecting Inflammatory Regulatory Network Mediating Metastasis in Triple-Negative Breast Cancers
Northwestern Memorial Hospital
9/1/18 → 8/31/20
Project: Research project
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Erratum: Low-input RNase footprinting for simultaneous quantification of cytosolic and mitochondrial translation
Li, Q., Yang, H., Stroup, E. K., Wang, H. & Ji, Z., Mar 2022, In: Genome research. 32, 3, p. 545-557 13 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Minimizing Molecular Misidentification in Imaging Low-Abundance Protein Interactions Using Spectroscopic Single-Molecule Localization Microscopy
Zhang, Y., Wang, G., Huang, P., Sun, E., Kweon, J., Li, Q., Zhe, J., Ying, L. L. & Zhang, H. F., Oct 11 2022, In: Analytical Chemistry. 94, 40, p. 13834-13841 8 p.Research output: Contribution to journal › Article › peer-review
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Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer
Ouspenskaia, T., Law, T., Clauser, K. R., Klaeger, S., Sarkizova, S., Aguet, F., Li, B., Christian, E., Knisbacher, B. A., Le, P. M., Hartigan, C. R., Keshishian, H., Apffel, A., Oliveira, G., Zhang, W., Chen, S., Chow, Y. T., Ji, Z., Jungreis, I., Shukla, S. A., & 9 others, Feb 2022, In: Nature biotechnology. 40, 2, p. 209-217 9 p.Research output: Contribution to journal › Article › peer-review
52 Scopus citations -
A PRC2-independent function for EZH2 in regulating rRNA 2′-O methylation and IRES-dependent translation
Yi, Y., Li, Y., Meng, Q., Li, Q., Li, F., Lu, B., Shen, J., Fazli, L., Zhao, D., Li, C., Jiang, W., Wang, R., Liu, Q., Szczepanski, A., Li, Q., Qin, W., Weiner, A. B., Lotan, T. L., Ji, Z., Kalantry, S., & 7 others, Apr 2021, In: Nature Cell Biology. 23, 4, p. 341-354 14 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells
Qadir, A. S., Guégan, J. P., Ginestier, C., Chaibi, A., Bessede, A., Charafe-Jauffret, E., Macario, M., Lavoué, V., Rouge, T. D. L. M., Law, C., Vilker, J., Wang, H., Stroup, E., Schipma, M. J., Bridgeman, B., Murmann, A. E., Ji, Z., Legembre, P. & Peter, M. E., Nov 19 2021, In: iScience. 24, 11, 103348.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations
Datasets
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Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy
Basher, F. (Contributor), Dhar, P. (Contributor), Wang, X. (Creator), Wainwright, D. A. (Creator), Zhang, B. (Creator), Sosman, J. A. (Creator), Ji, Z. (Creator) & Wu, J. D. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.c.5014769.v2, https://springernature.figshare.com/collections/Antibody_targeting_tumor-derived_soluble_NKG2D_ligand_sMIC_reprograms_NK_cell_homeostatic_survival_and_function_and_enhances_melanoma_response_to_PDL1_blockade_therapy/5014769/2
Dataset
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Additional file of Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy
Basher, F. (Contributor), Dhar, P. (Contributor), Wang, X. (Creator), Wainwright, D. A. (Creator), Zhang, B. (Creator), Sosman, J. A. (Creator), Ji, Z. (Creator) & Wu, J. D. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12872204.v1, https://springernature.figshare.com/articles/dataset/Additional_file_of_Antibody_targeting_tumor-derived_soluble_NKG2D_ligand_sMIC_reprograms_NK_cell_homeostatic_survival_and_function_and_enhances_melanoma_response_to_PDL1_blockade_therapy/12872204/1
Dataset
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Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy
Basher, F. (Contributor), Dhar, P. (Contributor), Wang, X. (Creator), Wainwright, D. A. (Creator), Zhang, B. (Creator), Sosman, J. A. (Creator), Ji, Z. (Creator) & Wu, J. D. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.c.5014769.v1, https://springernature.figshare.com/collections/Antibody_targeting_tumor-derived_soluble_NKG2D_ligand_sMIC_reprograms_NK_cell_homeostatic_survival_and_function_and_enhances_melanoma_response_to_PDL1_blockade_therapy/5014769/1
Dataset
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Additional file 1 of Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy
Basher, F. (Contributor), Dhar, P. (Contributor), Wang, X. (Creator), Wainwright, D. A. (Creator), Zhang, B. (Creator), Sosman, J. A. (Creator), Ji, Z. (Creator) & Wu, J. D. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12456779.v1, https://springernature.figshare.com/articles/Additional_file_1_of_Antibody_targeting_tumor-derived_soluble_NKG2D_ligand_sMIC_reprograms_NK_cell_homeostatic_survival_and_function_and_enhances_melanoma_response_to_PDL1_blockade_therapy/12456779/1
Dataset
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Additional file 1 of Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy
Basher, F. (Contributor), Dhar, P. (Contributor), Wang, X. (Creator), Wainwright, D. A. (Creator), Zhang, B. (Creator), Sosman, J. A. (Creator), Ji, Z. (Creator) & Wu, J. D. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12456779, https://springernature.figshare.com/articles/Additional_file_1_of_Antibody_targeting_tumor-derived_soluble_NKG2D_ligand_sMIC_reprograms_NK_cell_homeostatic_survival_and_function_and_enhances_melanoma_response_to_PDL1_blockade_therapy/12456779
Dataset