Zhuoli Zhang

  • 1285 Citations
20042022
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Personal profile

Research Interests

Dr. Zhang’s translational imaging laboratory (80% effort) at the Robert H. Lurie Comprehensive Cancer Center has all the state-of-the art equipment for cancer research. Dr. Zhang’s research focuses on novel image-guided cancer immunotherapy including natural killer and dendritic cell-based immunotherapy, image-guided small molecular inhibitor and antibody immunotherapy, image-guided combination therapies of local ablation and targeted immunotherapy, image-guided drug delivery for cancer. Zhang team works on rabbit, mouse and rat tumor models to optimize and develop MRI sequences for the assessment of therapeutic response. Dr. Zhang joined the Quantitative Imaging Core Lab (QICL, 20% effort) of Northwestern University for clinical trials since March, 2014. As Manager of Quality and Regulatory Affairs of QICL, Dr. Zhang been working with Dr. Vahid Yaghmai in setting up business models as well as drafting necessary documentations including Imaging Protocol Development, Imaging Acquisition Site Credentialing and Training, Quality Control (QC) protocol, and Image Analysis and Interpretation. QICL provides a comprehensive set of quantitative imaging services for clinical and research purposes, in particular in oncology and for evaluation of responses to cancer therapies. To date, the QICL has reviewed imaging protocols and analyzed images for over 100 industry- and investigator-initiated clinical trials. Under the guidance and leadership of Dr. Vahid Yaghmai, QICL will establish the most comprehensive solution to help execute efficient and effective imaging clinical phase 1-3 trials.

Education/Academic qualification

PhD, Fourth Military Medical University, China

… → 2002

MA, Xi'an Jiatong University

… → 1996

MD, Xi'an Jiatong University

… → 1988

Keywords

  • Cell Imaging
  • Clinical Trial Methodology
  • Liver Cancer
  • Oncology
  • Pancreatic Cancer
  • Prostate Cancer
  • Radiology
  • Colon / Rectal Cancer

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Magnetic Resonance Imaging Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
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Magnetic resonance Chemical Compounds
Tumors Chemical Compounds
Liver Medicine & Life Sciences
Magnetic resonance imaging Chemical Compounds
Pancreatic Neoplasms Medicine & Life Sciences

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Grants 2011 2022

Pancreatic Neoplasms
Immunotherapy
Dendritic Cells
Vaccines
Magnetic Resonance Imaging
Electroporation
Liver
Neoplasms
Planning Techniques
Hot Temperature
Microspheres
Liver
Neoplasms
sorafenib
Liver Neoplasms

Research Output 2004 2019

  • 1285 Citations
  • 97 Article
  • 7 Review article
  • 1 Conference contribution

Iron-Oxide Nanocluster Labeling of Clostridium novyi-NT Spores for MR Imaging–Monitored Locoregional Delivery to Liver Tumors in Rat and Rabbit Models

Ji, J., Park, W. R., Cho, S., Yang, Y., Li, W., Harris, K., Huang, X., Gu, S., Kim, D-H., Zhang, Z. & Larson, A. C., Jan 1 2019, In : Journal of Vascular and Interventional Radiology.

Research output: Contribution to journalArticle

Clostridium
Spores
Magnetic Resonance Spectroscopy
Rabbits
Liver

MYH9 promotes growth and metastasis via activation of MAPK/AKT signaling in colorectal cancer

Wang, B., Qi, X., Liu, J., Zhou, R., Lin, C., Shangguan, J., Zhang, Z., Zhao, L. & Li, G., Jan 1 2019, In : Journal of Cancer. 10, 4, p. 874-884 11 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Neoplasm Metastasis
Growth
Cell Movement
Nonmuscle Myosin Type IIA

Non-invasive dynamic monitoring initiation and growth of pancreatic tumor in the LSL-Kras G12D/+ ;LSL-Trp53 R172H/+ ;Pdx-1-Cre (KPC) transgenic mouse model

Hu, S., Pan, L., Shangguan, J., Figini, M., Eresen, A., Sun, C., Wang, B., Ma, Q., Hu, C., Yaghmai, V., Velichko, Y., Yang, J. & Zhang, Z., Feb 1 2019, In : Journal of Immunological Methods. 465, p. 1-6 6 p.

Research output: Contribution to journalArticle

Transgenic Mice
Growth
Magnetic Resonance Imaging
Neoplasms
Pancreatic Neoplasms

Value of CT spectral imaging in the differential diagnosis of thymoma and mediastinal lymphoma

Xie, Y., Zhang, S., Liu, J., Liang, X., Zhang, X., Zhang, Y., Zhang, Z. & Zhou, J., Mar 1 2019, In : The British journal of radiology. 92, 1095, 1 p.

Research output: Contribution to journalArticle

Thymoma
Iodine
Lymphoma
Differential Diagnosis
Sensitivity and Specificity

18 F-FDG PET biomarkers help detect early metabolic response to irreversible electroporation and predict therapeutic outcomes in a rat liver tumor model

Wang, X., Su, Z., Lyu, T., Figini, M., Procissi, D., Shangguan, J., Sun, C., Wang, B., Shang, N., Gu, S., Ma, Q., Gordon, A. C., Lin, K., Wang, J., Lewandowski, R. J., Salem, R., Yaghmai, V., Larson, A. C. & Zhang, Z., Apr 1 2018, In : Radiology. 287, 1, p. 137-145 9 p.

Research output: Contribution to journalArticle

Electroporation
Fluorodeoxyglucose F18
Positron-Emission Tomography
Biomarkers
Liver