2nd Kloster Seeon Meeting on BACE Proteases in Health and Disease

Project: Research project

Project Details

Description

Compelling genetic, biochemical, cell biological, animal model, and human studies suggest that
cerebral accumulation of the -amyloid peptide (A) has a critical early role in Alzheimer’s
disease (AD) pathogenesis. The -secretase enzyme BACE1 is the rate-limiting enzyme for A
production. Thus, BACE1 is a prime therapeutic target for the treatment or prevention of AD.
Several BACE1 inhibitor drugs for AD are in clinical trials, but the safety and efficacy of these
agents are unknown. The BACE proteases field comprises very active and diverse areas of research
that have high impact on therapeutic approaches to treat and prevent AD. Here, I propose the 2nd
Kloster Seeon Meeting on BACE Proteases in Health and Disease, September 25-27, 2016, in Bavaria, Germany, which has the following objectives: 1) disseminate the latest information on BACE
proteases research and catalyze discussion among scientists in academia and industry, 2) promote
the training of young scientists, and 3) publish a state-of-the-art review of BACE research to help
advance the field and facilitate the development of safe and effective BACE inhibitor drugs for AD.
The Scientific Program consists of: 1) a Keynote Lecture by Dr. Kari Stefansson (DeCode Genetics),
who recently discovered a mutation in APP that protects against AD by reducing BACE1 cleavage, thus
providing proof of concept for therapeutic BACE1 inhibition, 2) two full days of sessions
comprising 25-minute talks from 24 leading experts in the BACE proteases field, 3) a session of
2-minute flash talks given by 10 selected graduate students and post-doctoral researchers to
introduce their posters, 4) poster sessions on each of two evenings that will enhance the training
experience of students and post-docs, 5) a panel discussion between academic and industry
scientists on the current state of BACE research and drug development, 6) a conclusion and summary
session to remark on the meeting and discuss the direction forward for the field. This meeting is
co-organized by Drs. Stefan Lichtenthaler (Technical University Munich) and Robert Vassar
(Northwestern University), two leading scientists in the BACE proteases field. The 1st Kloster
Seeon Meeting on BACE Proteases in Health and Disease was held at the same location on October 6-8, 2013, and was objectively successful at disseminating the latest BACE research and catalyzing
discussion among BACE scientists. Three years have passed, and significant advances in BACE
research have been made, including new clinical trials, discoveries of novel BACE1 substrates and
functions, different mechanisms of BACE regulation in health and dysregulation in AD, and
identification of new proteolytic activities. Given these new advances, the 2nd Kloster Seeon
Meeting on BACE Proteases in Health and Disease is timely and important for dissemination of the
latest information in the field. Additionally, no other scientific meeting or conference focuses
exclusively on BACE proteases research, making this meeting a unique scientific forum that will
contribute significantly to the of the AD research and drug development fields.
StatusFinished
Effective start/end date7/1/1612/31/17

Funding

  • National Institute on Aging (1R13AG054189-01)

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