Erectile dysfunction (ED) affects ~ 50% of men aged 40 to 70 and has a high impact on men’s health and quality of life. Current treatments are ineffective in the difficult to treat prostatectomy (16-82%) and diabetic (56-59%) patients due to injury to the cavernous nerve (CN), which provides innervation to the penis. With denervation the critical smooth muscle (SM) undergoes apoptosis and the penis becomes fibrotic, with increased collagen abundance and a change in subtypes, thus altering the architecture of the corpora cavernosa. This application is significant because we propose a novel integrative approach that targets the 3 main morphological changes that underlie ED, which are CN degeneration, SM apoptosis, and penile fibrosis.
|Effective start/end date||9/1/19 → 6/30/20|
- University of Illinois at Chicago (17662-00//2R01DK101536-06)
- National Institute of Diabetes, Digestive and Kidney Diseases (17662-00//2R01DK101536-06)