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Investigations of the protein aggregation inhibitor NU-9 and its derivatives: mode of action and impact on Alzheimer’s disease and related dementias
Klein, W. L. (PD/PI), Ozdinler, H. (PD/PI) & Silverman, R. B. (PD/PI)
9/30/24 → 7/31/29
Project: Research project
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Novel Protein Aggregation Inhibitors and Upper Motor Neuron Stabilizers for ALS and other Neurodegenerative Diseases
Ozdinler, H. (PD/PI), Ozdinler, H. (PD/PI), Ozdinler, H. (PD/PI) & Silverman, R. B. (PD/PI)
8/1/19 → 9/29/24
Project: Research project
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Silverman Subproject for Novel Protein Aggregation Inhibitors and Upper Motor Neuron Stabilizers for ALS and other Neurodegenerative Diseases
Silverman, R. B. (PD/PI), Silverman, R. B. (PD/PI) & Silverman, R. B. (PD/PI)
8/1/19 → 9/29/24
Project: Research project
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Protein Aggregation Inhibitors for ALS Therapy
Silverman, R. B. (PD/PI) & Morimoto, R. I. (Co-PD/PI)
U.S. Army Medical Research and Materiel Command
7/1/10 → 6/30/13
Project: Research project
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Prot#AB19001: A Prospective, Multicenter, Randomised, Double-Blind, Placebo-Controlled, Parallel Groups, Phase 3 Study to Compare the Efficacy and Safety of Masitinib in Combination with Riluzole Versus Placebo in Combination with Riluzole in the Treatmen
Ajroud-Driss, S. (PD/PI)
2/26/21 → 12/31/24
Project: Research project
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The Mevalonate Pathway In Streptococcus
Silverman, R. B. (PD/PI)
Albert Einstein College of Medicine, Inc., National Institute of Allergy and Infectious Diseases
4/1/06 → 3/31/11
Project: Research project
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Synthesis of Compounds for the Treatment of ALS
Silverman, R. B. (PD/PI)
11/1/06 → 4/30/07
Project: Research project
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U01-NS066912 - Therapeutic Candidates for Huntington's Disease: From Lead to IND
Silverman, R. B. (PD/PI)
Massachusetts General Hospital, National Institute of Neurological Disorders and Stroke
4/1/11 → 12/31/12
Project: Research project
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Selective Inhibition of Neuronal Nitric Oxide Synthase
Silverman, R. B. (PD/PI)
National Institute of General Medical Sciences
3/1/11 → 8/31/15
Project: Research project
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Development of New Chemical Entity Therapeutics for ALS
Silverman, R. B. (PD/PI)
Cambria Biosciences LLC, ALS Association
9/1/07 → 2/14/11
Project: Research project
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Selective Inhibition of Neuronal Nitric Oxide Synthase
Silverman, R. B. (PD/PI)
National Institute of General Medical Sciences
3/8/07 → 2/28/11
Project: Research project
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Chemistry of Life Processes Predoctoral Training Program
Silverman, R. B. (PD/PI) & Kelleher, N. L. (Co-PD/PI)
National Institute of General Medical Sciences
7/1/13 → 6/30/16
Project: Research project
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A Novel Calcium Channel Antagonist for Neuroprotection in Parkinson's Disease
Surmeier Jr, D. J. (PD/PI) & Silverman, R. B. (Co-PD/PI)
National Institute of Neurological Disorders and Stroke
9/1/12 → 6/30/14
Project: Research project
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Optimization and Development of beta-glucocerebrosidase modulators for Parkinson's Disease
Krainc, D. (PD/PI), Silverman, R. B. (Co-PD/PI) & Zheng, J. (Co-PD/PI)
Silverstein Foundation for Parkinson's with GBA
11/27/17 → 11/30/19
Project: Research project
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New Inactivators of GABA Aminotransferase for Addiction
Silverman, R. B. (PD/PI) & Kelleher, N. L. (Co-PD/PI)
National Institute on Drug Abuse
1/1/11 → 4/30/16
Project: Research project
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HTS-022: Identification of Protein Sequestration Inhibitors for Treating ALS
Schiltz, G. E. (Co-PD/PI) & Silverman, R. B. (Subproject PI)
Searle Funds at The Chicago Community Trust
1/1/11 → 12/31/17
Project: Research project
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Identification of a Novel L-Type Calcium Channel Antagonist for Neuroprotection in PD
Surmeier Jr, D. J. (PD/PI) & Silverman, R. B. (Co-Investigator)
11/1/08 → 10/31/11
Project: Research project
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An Integrated Open-Access HT Preparative Chromatography System for Molecular Medicine at Northwestern University
Scheidt, K. A. (PD/PI), Meade, T. J. (Co-PD/PI), Silverman, R. B. (Co-PD/PI) & Watterson, D. M. (Co-PD/PI)
National Center for Research Resources
2/1/09 → 1/31/14
Project: Research project
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Lead Identification of Novel Negative Allosteric Modulators of Cav1.3 L-Type Calcium Channels as a Disease Modifying Therapy for PD
Surmeier Jr, D. J. (PD/PI), Silverman, R. B. (Co-Investigator), Vanoye, C. G. (Co-Investigator) & Xie, Z. (Other)
Michael J. Fox Foundation for Parkinson's Research
8/1/21 → 7/31/23
Project: Research project
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Chemistry of Life Processes Predoctoral Training Program
Kelleher, N. L. (PD/PI), Silverman, R. B. (PD/PI), Thomson, R. J. (Co-Investigator) & Silverman, R. B. (Other)
National Institute of General Medical Sciences
7/1/18 → 9/30/23
Project: Research project
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Ornithine Aminotransferase Inactivation, a New Approach for Treatment of Cancers
Silverman, R. B. (PD/PI) & Silverman, R. B. (PD/PI)
4/15/21 → 3/31/26
Project: Research project
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New Inactivators of GABA Aminotransferase for Epilepsy and Neuropathic Pain
Silverman, R. B. (PD/PI) & Silverman, R. B. (PD/PI)
National Institute of Neurological Disorders and Stroke
7/15/21 → 6/30/26
Project: Research project
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Selective inhibition of nitric oxide synthase for multiple indications
Silverman, R. B. (PD/PI), Silverman, R. B. (PD/PI) & Surmeier Jr, D. J. (Other)
National Institute of General Medical Sciences
5/1/19 → 4/30/24
Project: Research project
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CardioExcyte 96 System for Pharmacology Research at Northwestern University
George, A. L. (PD/PI), Abdulkadir, S. A. (Other), Ardehali, H. (Other), Arora, R. K. (Other), Burridge, P. (Other), Kearney, J. A. (Other), McNally, E. M. (Other), Schiltz, G. E. (Other), Silverman, R. B. (Other), Watterson, D. M. (Other) & Wilsbacher, L. D. (Other)
Office of the Director, National Institutes of Health
6/15/20 → 6/30/25
Project: Research project