A Master Role of Symmetric Arginine Dimethylation in Lupus Autoantibody Response

Project: Research project

Description

Systemic lupus erythematosus is the result of the loss of immune tolerance to misguided recognitions and autoantibody production against a large number of “self” antigens. This study investigates a causal disease model in which the “self-proteins” of a major class of lupus antigens are chemically modified and subsequently become misrecognized by our own immune cells as “non-self”. We will use molecular tools of mass spectrometry and protein arrays to dissect the antigen determinants in a form of chemical modification that incites autoimmune responses.
StatusActive
Effective start/end date5/15/184/30/20

Funding

  • National Institute of Allergy and Infectious Diseases (5R21AI131087-02)

Fingerprint

Autoantibodies
Arginine
Antigens
Protein Array Analysis
Immune Tolerance
Autoantigens
Autoimmunity
Systemic Lupus Erythematosus
Mass Spectrometry
Proteins