A MnSOD Acetylation Mutant Mouse for Luminal B Endocrine Resistant Breast Cancer

  • Gius, David R (PD/PI)

Project: Research project

Project Details


Estrogen recepter positive (ER+) invasive ductal cancers are the most common human breast malignancies and are grouped into Luminal A versus Luminal B tumors. Luminal B, as compared to Luminal A tumors, exhibit a higher proliferative capacity (io.e., high Ki-67), are poorly differentiated, and display a significant increased risk of recurrence. It is becoming increasingly clear that a subgroup of Luminal B tumors, which account for the most deaths from breast malignancies, exhibit an endocrine resistant tumor phenotype. Thus, it is proposed that this resistance observed in tumors exhibiting a loss of SIRT3 signature may explain the increased risk of a tumor recurrence in this subgroup of women who are actively on antihormonal therapy.
Effective start/end date9/1/158/31/19


  • Northwestern Memorial Hospital (Exhibit B.11)


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