A Novel Approach to Lower Extremity Amputation to Augment Volitional Motor Control and Restore Proprioception

Project: Research project

Project Details


For the duration of this investigation, Northwestern will serve as a study site for a control group of up to 18 patients. Northwestern’s study cohort will include approximately 4-6 patients who require above-knee amputations and approximately 12-14 patients who require below-knee amputations. This subcontract will include the assessment of candidates for elective lower limb amputation, performance of limb amputation with targeted muscle reinnervation (TMR) and/or regenerative peripheral nerve interface (RPNI) and associated follow up activities. Patients participating in this work at Northwestern will also travel to Boston to undergo additional pre- and post-operative project activities at BWH and Massachusetts Institute of Technology (MIT) in this multi-institution collaborative project.
Effective start/end date4/15/209/14/21


  • Brigham and Women's Hospital (117951//W81XWH-17-2-0056)
  • U.S. Army Medical Research and Materiel Command (117951//W81XWH-17-2-0056)


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