A Novel Approach to Lower Extremity Amputation to Augment Volitional Motor Control and Restore Proprioception

For the duration of this investigation, Northwestern will serve as a study site for a control group of up to 18 patients. Northwestern’s study cohort will include approximately 4-6 patients who require above-knee amputations and approximately 12-14 patients who require below-knee amputations. This subcontract will include the assessment of candidates for elective lower limb amputation, performance of limb amputation with targeted muscle reinnervation (TMR) and/or regenerative peripheral nerve interface (RPNI) and associated follow up activities. Patients participating in this work at Northwestern will also travel to Boston to undergo additional pre- and post-operative project activities at BWH and Massachusetts Institute of Technology (MIT) in this multi-institution collaborative project.