Proper skin structure is crucial to protect humans from environmental stress. This project will examine how the “sticky” protein, desmoglein-1, that holds cells together and provides mechanical strength to skin, can also coordinate skin development and support its proper structure. Desmoglein-1 performs these functions via binding to Tctex-1 (a part of molecular motor) and reorganizing the cell’s cytoskeleton during multilayer skin formation.
|Effective start/end date||7/1/14 → 6/30/15|
- Dermatology Foundation (Letter dated 04/24/2014)