Our overall hypotheses are that Polycomb Group proteins interact with AR and regulate AR signaling as AR co-regulators in PCa and CRPC, and overexpression of histone methyltransferase EZH2 may promote androgen independent growth and CRPC. As EZH2, BMI1, RING1B and other PcG proteins are upregulated in prostate cancer, and PcG proteins are essential for development, stem cell maintenance, and cancer progression, to understand how PcG proteins are involved in prostate cancer progression will greatly benefit the current prostate cancer research and therapy. Based on our preliminary data which imply a function and regulation network among PRC2, PRC1 and AR in PCa, we propose the following specific aims to approaches to examine our hypotheses.
|Effective start/end date||7/1/18 → 5/20/19|
- Prostate Cancer Foundation (AGMT 1/16/19)