A Pilot Study to Define Colistin Population PK and Interrogate Renal TD

Project: Research project

Description

Lung infections are a significant cause of reduced quality of life and early death in persons living the CF. Infections start early in life and are typically treated with multiple lifetime courses of antibiotics. Increased antibiotic exposures lead to drug resistance and need to use of drugs with increasing side effects. Colistin is a drug that has been used clinically for bacteria with resistance to multiple drugs. Use of colisitin has not been well studied in patients with CF with a unique drug metabolism profile. This study will aim to define a dosing strategy specific to patients with CF.
StatusActive
Effective start/end date11/1/1710/31/19

Funding

  • Cystic Fibrosis Foundation Therapeutics, Inc. (PRICKE17A0-I)

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Colistin
Kidney
Pharmaceutical Preparations
Population
Anti-Bacterial Agents
Multiple Drug Resistance
Infection
Drug Resistance
Quality of Life
Bacteria
Lung