A Polymorphic MYBPC3 Variant As A Major Risk Factor of Cardiomyopathy in South Asian descendants LUC

Project: Research project

Project Details

Description

We will conduct the analysis of the next generation sequencing data in Aim 2 to evaluate the presence of additional rare and common variants in addition to the MYBPC325 deletion. These studies are designed to evaluate whether additional cardiomyopathic variants contribute to the manifestation of cardiomyopathy and heart failure in gene carriers of MYBPC325. It is estimated that more than 400,000 South Indians live in the Chicago area and that nearly 8% of these individuals are carriers of the MYBPC325 variant. We have experience in whole genome analysis for cardiomyopathy as well as extensive experience derived from genetic testing in cardiomyopathy families.
StatusFinished
Effective start/end date12/1/158/14/16

Funding

  • Loyola University Chicago (LU 207813//15CVGPSD27020012)
  • American Heart Association (LU 207813//15CVGPSD27020012)

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