A Therapeutic Strategy for Uterine Factor Infertility using Human Induced Pluripotent Stem Cells (hiPSCs)

Project: Research project

Project Details

Description

We hypothesize that stem cells can be differentiated into endometrium-like cells and utilized to repopulate endometrium in patients with Asherman's syndrome. Specifically, we intend to demonstrate that ESLCs behave as endometrium in an in vivo model.

Our preliminary data suggest that ESLCs behave like normal endometrium in vitro. To expand on this data, this research will demonstrate that ESLC spheroids will decidualize and function like native human endometrium using a xenograft mouse model.

Our secondary objectives include studying and defining patterns of receptor expression, including progesterone and estrogen receptors, as well as signaling pathways, in our xenograft mouse model.
StatusFinished
Effective start/end date8/1/177/31/19

Funding

  • Prelude Fertility, Inc. (Check # 1008175)

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