Advancing treatment and understanding of immunotherapy in glioblastoma

This U19 NIH grant application focuses on making clinically meaningful advances in the treatment of glioblastoma (GBM) patients, the most malignant form of a primary brain tumor that remains virtually incurable. Over 13.000 people succumb to this disease in the United States every year. Recent examples of well-known patients are Senator Robert Kennedy, Senator John McCain and Beau Biden, the older son of the president-elect Joe Biden. Immunotherapy has been a major advance over the last decade in the treatment of the previously most aggressive solid tumors. However, for GBM an immunological strategy needs to overcome a series of additional obstacles.