African American Cardiovascular pharmacogenetic CONsorTium (ACCOuNT): discovery and translation

Project: Research project

Project Details

Description

The vast majority of pharmacogenomic studies have been conducted on exclusively European decent populations, thereby precluding the discovery and translation of African American specific genetic variation into precision medicine. This imbalance in discovery and translational science has hindered our ability to deliver precision medicine to 1 in 7 Americans. Currently several academic medical institutions are incorporating Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines into practice. Without accounting for new variants found exclusively in African Americans, clinical recommendations based solely on genetic biomarkers found in European populations could result in misclassification of drug response in African Americans. Furthermore, there are several well-established, clinically actionable pharmacogenomic associations (such as the antiplatelet agent, Clopidogrel) that completely lack discovery efforts in African Americans. Without both discovery and translational efforts in African Americans, precision medicine for all will not be a reality. As such, we formed a Transdisciplinary Collaborative Center (TCC) dubbed ACCOuNT (African American Cardiovascular pharmacogenetic Consortium) to discover novel genetic variants in African Americans related to clinically actionable cardiovascular phenotypes and to incorporating African American specific SNPs into clinical recommendations, which can be delivered to physicians at the point of care. We have partnered with academic institutions, patient organizations, and African American community leaders in both Chicago and in the District of Columbia (DC) to developed our focused effort in precision medicine. The TCC will consist of four cores (Administrative, Consortium, Implementation, and Data Analysis and Harmonization) as well as two research projects focused on discovery and translation of genetic findings. The primary aims of this proposal are: 1) Establish an African Ancestry pharmacog
StatusFinished
Effective start/end date8/19/165/31/22

Funding

  • National Institute on Minority Health and Health Disparities (5U54MD010723-05)

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