Control of E1 oligomerization regulates E1 function in papillomavirus DNA replication

Project: Research project

Project Details

Description

To work out how the biochemical activities that CSH characterized in the papillomavirus E1 protein affects the in vivo functions of E1. I will utilize our expertise in analyzing viral DNA replication of the HPV 31 genome in human foreskin keratinocytes during the latent and productive stages of the viral life cycle. I will test the E1 mutants that affect phosphorylation sites and protein-protein interaction sites. I will also provide samples from differentiated and undifferentiated HFKs for analysis of expression levels of cellular proteins that may be involved in regulation of the viral DNA replication.
StatusFinished
Effective start/end date5/1/154/30/20

Funding

  • Cold Spring Harbor Laboratory (55890312 // 5R01AI114897-05)
  • National Institute of Allergy and Infectious Diseases (55890312 // 5R01AI114897-05)

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