Endometriosis is characterized by the abnormal growth of endometrial tissue outside of its normal environment, the uterus. Endometriosis affects approximately 10 percent of women worldwide, is the most frequent cause of chronic pelvic pain, and may lead to infertility. Current models of endometriosis suggest aberrant epigenomic regulation of key transcription factors may lead to broad changes in gene expression which ultimately manifest as the complex spectrum of traits associated with this disease but this hypothesis remains largely untested. Here, we propose integrating transcriptome analyses with genome-wide chromatin regulatory analyses to establish a comprehensive map of the altered transcriptional regulatory landscape in endometriosis. In addition, we will directly evaluate the role of differential GATA and HOX transcription factor expression as key drivers of this altered chromatin environment. Successful completion of this work will provide critically needed answers on the role of these key transcription factors in the pathogenesis of endometriosis. Moreover, we anticipate that the comprehensive map of rewired chromatin regulatory elements will be a valuable resource for endometriosis researchers worldwide and may lead to important new avenues of endometriosis-related research.
|Effective start/end date||9/1/20 → 8/31/22|
- Friends of Prentice (Award 05/26/2020)